Detailed information for compound 569490

Basic information

Technical information
  • TDR Targets ID: 569490
  • Name: 6,7-dimethoxy-2-(2-thienyl)-3,1-benzoxazin-4- one
  • MW: 289.306 | Formula: C14H11NO4S
  • H donors: 0 H acceptors: 1 LogP: 2.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2nc(oc(=O)c2cc1OC)c1cccs1
  • InChi: 1S/C14H11NO4S/c1-17-10-6-8-9(7-11(10)18-2)15-13(19-14(8)16)12-4-3-5-20-12/h3-7H,1-2H3
  • InChiKey: XMPVZWXWJBMOPQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6,7-dimethoxy-2-thiophen-2-yl-3,1-benzoxazin-4-one
  • 6,7-Dimethoxy-2-thiophen-2-yl-benzo[d][1,3]oxazin-4-one
  • BAS 06636565
  • 6,7-dimethoxy-2-(2-thienyl)-4H-3,1-benzoxazine-2-one
  • NSC723410
  • SMR000073519
  • Oprea1_270433
  • ZINC00041221
  • 6,7-dimethoxy-2-(2-thienyl)-4H-3,1-benzoxazin-4-one
  • MLS000099266
  • JS-1107
  • SDCCGMLS-0018335.P002
  • AA-768/34978010
  • IDI1_013830
  • Maybridge3_002443

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0039 0.0908 0.1044
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0023 0.0026
Echinococcus granulosus histone lysine methyltransferase setb 0.007 0.2185 0.2883
Mycobacterium ulcerans hypothetical protein 0.0039 0.0908 0.5
Trypanosoma brucei protein kinase, putative 0.0062 0.1826 1
Brugia malayi jmjC domain containing protein 0.0017 0.0023 0.0026
Loa Loa (eye worm) hypothetical protein 0.0039 0.0908 0.1044
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.2526 0.3332
Brugia malayi jmjC domain containing protein 0.0017 0.0023 0.0026
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0839 0.1106
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0833 0.1099
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0839 0.1106
Brugia malayi MAP kinase sur-1 0.0062 0.1826 0.2098
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1826 0.2409
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1826 0.1009
Brugia malayi beta-lactamase family protein 0.0039 0.0908 0.1044
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0661 0.0872
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0908 0.491
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0908 0.1198
Leishmania major hypothetical protein, conserved 0.0039 0.0908 0.491
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.2143 0.2462
Brugia malayi jmjC domain containing protein 0.0017 0.0023 0.0026
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0839 0.1106
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.2438 0.3215
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.042 0.2202
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0091 0.3046 1
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0833 0.4493
Trichomonas vaginalis set domain proteins, putative 0.0262 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0908 0.491
Loa Loa (eye worm) hypothetical protein 0.0093 0.3126 0.3592
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.2185 0.2883
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0023 0.003
Trichomonas vaginalis protein kinase inhibitor, putative 0.0066 0.2002 0.1202
Brugia malayi beta-lactamase 0.0039 0.0908 0.1044
Loa Loa (eye worm) hypothetical protein 0.0039 0.0908 0.1044
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0833 0.4493
Loa Loa (eye worm) hypothetical protein 0.0036 0.0796 0.0914
Mycobacterium leprae Probable lipase LipE 0.0039 0.0908 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0661 0.3538
Brugia malayi Bromodomain containing protein 0.0164 0.6018 0.6915
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0023 0.003
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0796 0.0914
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0203 0.7581 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1826 0.2098
Schistosoma mansoni zinc finger protein 0.0043 0.1064 0.1404
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1826 0.1009
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.1972 0.2601
Loa Loa (eye worm) hypothetical protein 0.0089 0.2956 0.3396
Brugia malayi hypothetical protein 0.0027 0.042 0.0483
Brugia malayi Bromodomain containing protein 0.0084 0.2738 0.3146
Brugia malayi PHD-finger family protein 0.0055 0.1541 0.1771
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.042 0.2202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0908 0.1198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0203 0.7581 1
Brugia malayi hypothetical protein 0.0077 0.2438 0.2801
Loa Loa (eye worm) hypothetical protein 0.0027 0.042 0.0483
Leishmania major hypothetical protein, conserved 0.0033 0.0682 0.3653
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.2438 0.3215
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0908 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0908 0.1044
Loa Loa (eye worm) beta-lactamase 0.0039 0.0908 0.1044
Brugia malayi jmjC domain containing protein 0.0017 0.0023 0.0026
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0833 0.0957
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1826 0.2409
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.1329 0.1754
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.1329 0.1754
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.1826 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.2438 0.3215
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0833 0.4493
Schistosoma mansoni hypothetical protein 0.0033 0.0682 0.0899
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0833 1
Brugia malayi Augmenter of liver regeneration 0.0037 0.0833 0.0957
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.2143 0.2826
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.2185 0.2883
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0833 0.915
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.042 0.4901
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0203 0.7581 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.4651 0.6135
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0203 0.7581 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2185 0.2511
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0908 0.1044
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.1329 0.1754
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1826 0.2409
Mycobacterium ulcerans beta-lactamase 0.0039 0.0908 0.5
Onchocerca volvulus 0.0039 0.0908 0.0265
Echinococcus granulosus phd:f box containing protein 0.0017 0.0023 0.003
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.1826 1
Leishmania major hypothetical protein, conserved 0.0027 0.042 0.2202
Brugia malayi hypothetical protein 0.0017 0.0028 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.8703 1
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0833 0.4493
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0023 0.003
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.1826 1
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0023 0.003
Brugia malayi jmjC domain containing protein 0.0069 0.2143 0.2462
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0026
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0194 0.0256
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0023 0.0026
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0023 0.003
Schistosoma mansoni bromodomain containing protein 0.0139 0.4971 0.6557
Schistosoma mansoni hypothetical protein 0.0066 0.2002 0.264
Brugia malayi Pre-SET motif family protein 0.023 0.8703 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0203 0.7581 1
Onchocerca volvulus 0.0039 0.0908 0.0265
Schistosoma mansoni hypothetical protein 0.0045 0.1159 0.1528
Loa Loa (eye worm) hypothetical protein 0.0053 0.1481 0.1702
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0908 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1826 1
Echinococcus granulosus dnaJ subfamily C 6 0.0066 0.2002 0.264
Loa Loa (eye worm) hypothetical protein 0.0039 0.0908 0.1044
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1826 1
Echinococcus multilocularis dnaJ subfamily C 6 0.0066 0.2002 0.264
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0023 0.0026
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0023 0.003
Schistosoma mansoni zinc finger protein 0.0033 0.0682 0.0899
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0203 0.7581 0.8711
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0908 0.1198
Schistosoma mansoni hypothetical protein 0.0077 0.2438 0.3215
Brugia malayi Pre-SET motif family protein 0.0033 0.0661 0.0759
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.042 0.2202
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0833 0.1099
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.1972 0.2601
Toxoplasma gondii ABC1 family protein 0.0039 0.0908 0.491
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.042 0.4901
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.1826 1
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0023 0.003
Echinococcus multilocularis zinc finger protein 0.0043 0.1064 0.1404
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0833 0.4493
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0023 0.003
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0893 0.1027
Trypanosoma cruzi ISWI complex protein 0.0033 0.0682 0.3653
Schistosoma mansoni hypothetical protein 0.0036 0.0796 0.105
Mycobacterium ulcerans lipase LipD 0.0039 0.0908 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1481 0.1702
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0661 0.0872
Echinococcus granulosus zinc finger protein 0.0043 0.1064 0.1404
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0908 0.5
Brugia malayi jmjC domain containing protein 0.0065 0.1972 0.2266
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0026
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.1826 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0661 0.0872
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.2143 0.2826
Leishmania major hypothetical protein, conserved 0.0037 0.0833 0.4493
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1481 0.1702
Loa Loa (eye worm) hypothetical protein 0.0039 0.0908 0.1044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.007 0.2185 0.2883
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1826 0.2409
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.9499 1
Trypanosoma brucei ISWI complex protein 0.0033 0.0682 0.3653
Schistosoma mansoni jumonji domain containing protein 0.0065 0.1972 0.2601
Loa Loa (eye worm) hypothetical protein 0.0039 0.0908 0.1044
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.042 0.4485
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1826 0.1009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0203 0.7581 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.3046 0.35
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.4651 0.6135
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0023 0.003
Onchocerca volvulus 0.0039 0.0908 0.0265
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1481 0.1702
Plasmodium vivax SET domain protein, putative 0.0033 0.0661 0.7205
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.1826 1
Loa Loa (eye worm) DnaJ domain-containing protein 0.0066 0.2002 0.23
Trypanosoma cruzi ISWI complex protein 0.0033 0.0682 0.3653
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0155 0.5636 0.6476
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0908 0.1044
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0023 0.003
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0839 0.1106
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.1972 0.2601
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0611 0.0806
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0908 0.491
Brugia malayi DnaJ domain containing protein 0.0066 0.2002 0.23
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0194 0.0256
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.2526 0.3332
Loa Loa (eye worm) hypothetical protein 0.0084 0.2744 0.3153
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1826 0.1009
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.2143 0.2826
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1826 0.2409
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0023 0.003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0203 0.7581 0.8711
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.1826 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0908 0.1198
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.1159 0.1331
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0091 0.3046 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0908 1
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0833 0.4493
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0203 0.7581 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.042 0.2202

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.242 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.009 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.