Detailed information for compound 569765

Basic information

Technical information
  • TDR Targets ID: 569765
  • Name: [(3S,5S,8R,9S,10S,13R,17R)-3-(4-benzoylbenzoy l)oxy-10-formyl-14-hydroxy-13-methyl-17-(5-ox o-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17 -dodecahydro-1H-cyclopenta[a]phenanthren-5-yl ] 4-benzoylbenzoate
  • MW: 820.921 | Formula: C51H48O10
  • H donors: 1 H acceptors: 7 LogP: 7.71 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C[C@@]12CC[C@@H](C[C@]2(CC[C@@H]2[C@@H]1CC[C@]1(C2(O)CC[C@@H]1C1=CC(=O)OC1)C)OC(=O)c1ccc(cc1)C(=O)c1ccccc1)OC(=O)c1ccc(cc1)C(=O)c1ccccc1
  • InChi: 1S/C51H48O10/c1-48-24-21-41-42(51(48,58)27-23-40(48)38-28-43(53)59-30-38)22-26-50(61-47(57)37-18-14-35(15-19-37)45(55)33-10-6-3-7-11-33)29-39(20-25-49(41,50)31-52)60-46(56)36-16-12-34(13-17-36)44(54)32-8-4-2-5-9-32/h2-19,28,31,39-42,58H,20-27,29-30H2,1H3/t39-,40+,41-,42+,48+,49-,50-,51?/m0/s1
  • InChiKey: QMOUPVXLEAZWSV-XJVPNXMOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-benzoylbenzoic acid [(3S,5S,8R,9S,10S,13R,17R)-3-[(4-benzoylphenyl)-oxomethoxy]-10-formyl-14-hydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-5-yl] ester
  • [(3S,5S,8R,9S,10S,13R,17R)-14-hydroxy-10-methanoyl-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[4-(phenylcarbonyl)phenyl]carbonyloxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-5-yl] 4-(phenylcarbonyl)benzoate
  • 4-benzoylbenzoic acid [(3S,5S,8R,9S,10S,13R,17R)-3-(4-benzoylbenzoyl)oxy-10-formyl-14-hydroxy-17-(5-keto-2H-furan-3-yl)-13-methyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-5-yl] ester
  • strophanthidin 3,5-bis-p-benzoyl benzoate
  • [(3S,5S,8R,9S,10S,13R,17R)-3-[4-(benzoyl)benzoyl]oxy-10-formyl-14-hydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-5-yl] 4-(benzoyl)benzoate
  • 4-(oxo-phenylmethyl)benzoic acid [(3S,5S,8R,9S,10S,13R,17R)-10-formyl-14-hydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[oxo-[4-(oxo-phenylmethyl)phenyl]methoxy]-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-5-yl] ester
  • 4-(benzoyl)benzoic acid [(3S,5S,8R,9S,10S,13R,17R)-3-[4-(benzoyl)benzoyl]oxy-10-formyl-14-hydroxy-17-(5-keto-2H-furan-3-yl)-13-methyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-5-yl] ester
  • [(3S,5S,8R,9S,10S,13R,17R)-14-hydroxy-10-methanoyl-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-(4-phenylcarbonylphenyl)carbonyloxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-5-yl] 4-phenylcarbonylbenzoate
  • 55601-19-9
  • Card-20(22)-enolide, 3,5-bis((4-benzoylbenzoyl)oxy)-14-hydroxy-19-oxo-, (3beta,5beta)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0149 0.3055 0.6768
Brugia malayi Pre-SET motif family protein 0.0211 0.4506 1
Brugia malayi Cytochrome P450 family protein 0.0051 0.0811 0.1801
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0418 0.5154
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0051 0.0811 1
Leishmania major DNA polymerase eta, putative 0.0045 0.0663 0.8166
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0072 0.0885
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0034 0.0418 0.5154
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0072 0.0885
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Brugia malayi Latrophilin receptor protein 2 0.0047 0.071 0.1575
Echinococcus multilocularis neuropeptide receptor A26 0.0449 1 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0034 0.0418 0.1762
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0651 0.1646
Mycobacterium leprae Conserved hypothetical protein 0.0034 0.0418 0.026
Echinococcus multilocularis tar DNA binding protein 0.0187 0.3953 0.3953
Leishmania major DNA polymerase eta, putative 0.0032 0.0354 0.4362
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0034 0.0418 0.5154
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0072 0.0302
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0811 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.071 0.1575
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0034 0.0418 0.5154
Loa Loa (eye worm) glutathione reductase 0.0047 0.0709 0.154
Echinococcus granulosus dna polymerase eta 0.0045 0.0663 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3953 1
Mycobacterium leprae putative cytochrome p450 0.0034 0.0418 0.026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0072 0.0302
Treponema pallidum NADH oxidase 0.0016 0 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.3055 0.6781
Loa Loa (eye worm) acetyltransferase 0.0146 0.2986 0.6613
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0072 0.0885
Brugia malayi cytochrome P450 0.0034 0.0418 0.0928
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0072 0.0121
Trypanosoma brucei unspecified product 0.0019 0.0072 0.0885
Brugia malayi Cytochrome P450 family protein 0.0051 0.0811 0.1801
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0453 0.5582
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0034 0.0418 0.5154
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0072 0.0885
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0811 0.1769
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0072 0.0182
Echinococcus multilocularis 0.0034 0.0418 0.0418
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0324 0.0821
Echinococcus granulosus tar DNA binding protein 0.0187 0.3953 0.3953
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0034 0.0418 0.1762
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0613 0.8646
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.3055 0.6768
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0453 0.0874
Plasmodium falciparum thioredoxin reductase 0.0047 0.0709 1
Echinococcus granulosus GPCR family 2 0.0047 0.071 0.071
Brugia malayi RNA binding protein 0.0187 0.3953 0.8772
Echinococcus granulosus cytochrome P450 2K1 0.0034 0.0418 0.0418
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0709 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0072 0.1353
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.2098 0.8837
Toxoplasma gondii thioredoxin reductase 0.0047 0.0709 1
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.197 0.4371
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0072 0.0072
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0709 0.154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0651 0.1646
Brugia malayi glutathione reductase 0.0047 0.0709 0.1573
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0072 0.0159
Loa Loa (eye worm) hypothetical protein 0.0102 0.197 0.435
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0651 0.0651
Schistosoma mansoni hypothetical protein 0.0047 0.071 0.1796
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.071 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0663 0.147
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3953 1
Trichomonas vaginalis set domain proteins, putative 0.0241 0.5181 1
Schistosoma mansoni hypothetical protein 0.0102 0.197 0.4983
Loa Loa (eye worm) CYP4Cod1 0.0051 0.0811 0.1769
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0034 0.0418 0.5154
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0034 0.0418 0.5154
Schistosoma mansoni inositol monophosphatase 0.0036 0.0453 0.1146
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.2374 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0651 0.1646
Loa Loa (eye worm) RNA binding protein 0.0187 0.3953 0.8767
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0034 0.0418 0.5154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0324 0.0821
Schistosoma mansoni cytochrome P450 0.0034 0.0418 0.1058
Trypanosoma brucei trypanothione reductase 0.0047 0.0709 0.8734
Leishmania major DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0651 0.0651
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0034 0.0418 0.1762
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0034 0.0418 0.5154
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0072 0.0139
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0613 0.1183
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0034 0.0418 0.1762
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0453 0.0874
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0663 0.8166
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0034 0.0418 0.1762
Loa Loa (eye worm) hypothetical protein 0.0047 0.071 0.1543
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0034 0.0418 0.5154
Loa Loa (eye worm) inositol-1 0.0036 0.0453 0.097
Brugia malayi Cytochrome P450 family protein 0.0109 0.2131 0.4728
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0651 0.1444
Plasmodium falciparum glutathione reductase 0.0047 0.0709 1
Brugia malayi Inositol-1 0.0036 0.0453 0.1005
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0034 0.0418 0.5154
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.2098 0.8837
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0709 0.2985
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0034 0.0418 0.1762
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0324 0.4578
Trypanosoma brucei cytochrome P450, putative 0.0051 0.0811 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0613 0.1183
Echinococcus multilocularis dna polymerase eta 0.0045 0.0663 0.0663
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0034 0.0418 0.5154
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.2986 0.6626
Brugia malayi RNA recognition motif domain containing protein 0.0187 0.3953 0.8772
Leishmania major cytochrome p450-like protein 0.0034 0.0418 0.5154
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0613 0.8646
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0072 0.0885
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0324 0.0821
Leishmania major trypanothione reductase 0.0047 0.0709 0.8734
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.2986 0.2986
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0324 0.0821
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.3055 0.6781
Leishmania major cytochrome p450-like protein 0.0034 0.0418 0.5154
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0072 0.0885
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0811 0.1769
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Leishmania major cytochrome p450-like protein 0.0051 0.0811 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0299 0.0299
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.071 0.071
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0072 0.0139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.4506 1
Schistosoma mansoni DNA polymerase eta 0.0045 0.0663 0.1676
Plasmodium vivax SET domain protein, putative 0.003 0.0324 0.4578
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0034 0.0418 0.5154
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0366 0.1542
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3953 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0034 0.0418 0.5154
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0034 0.0418 0.1762
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0651 0.0651
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0453 0.831
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0663 0.8166
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.2374 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0324 0.0324
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0418 0.5154
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0034 0.0418 0.5154
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0324 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0709 0.0709
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.053 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0072 0.0072
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0 0.5
Mycobacterium tuberculosis Probable reductase 0.0107 0.2098 0.8837
Brugia malayi TAR-binding protein 0.0187 0.3953 0.8772
Onchocerca volvulus 0.0241 0.5181 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0187 0.3953 0.8767
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.2374 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.2098 0.8625
Loa Loa (eye worm) hypothetical protein 0.003 0.0324 0.0684
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0034 0.0418 0.5154
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0453 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0034 0.0418 0.5154
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0034 0.0418 0.1762
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0034 0.0418 0.5154
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0453 0.5582
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.2892 0.2892
Schistosoma mansoni hypothetical protein 0.0047 0.071 0.1796
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0709 0.8734
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.071 0.1543
Echinococcus multilocularis GPCR, family 2 0.0047 0.071 0.071
Schistosoma mansoni inositol monophosphatase 0.0036 0.0453 0.1146
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3953 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0034 0.0418 0.1762
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0034 0.0418 0.1762
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0034 0.0418 0.1762
Brugia malayi Cytochrome P450 family protein 0.0034 0.0418 0.0928
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.2098 0.8837
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0354 0.4994
Schistosoma mansoni hypothetical protein 0.0047 0.071 0.1796
Echinococcus granulosus neuropeptide receptor A26 0.0449 1 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0034 0.0418 0.5154
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0034 0.0418 0.1762
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0034 0.0418 0.1762
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0034 0.0418 0.1762
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.071 0.071
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0034 0.0418 0.1762
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0613 0.0613
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0651 0.1411
Plasmodium vivax glutathione reductase, putative 0.0047 0.0709 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0034 0.0418 0.1762
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.2986 0.7554
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0651 0.0651
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Toxoplasma gondii cytochrome p450 superfamily protein 0.0034 0.0418 0.5901
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0709 0.0709
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Loa Loa (eye worm) hypothetical protein 0.0045 0.0663 0.1437
Loa Loa (eye worm) cytochrome P450 family protein 0.0109 0.2131 0.4708
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0034 0.0418 0.1762
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0453 0.0453
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0453 0.5582
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0034 0.0418 0.1762
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0034 0.0418 0.5154
Brugia malayi Pre-SET motif family protein 0.003 0.0324 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.053 1
Schistosoma mansoni hypothetical protein 0.0047 0.071 0.1796
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.071 0.071
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0072 0.0182
Brugia malayi Thioredoxin reductase 0.0047 0.0709 0.1573
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0034 0.0418 0.1762
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0034 0.0418 0.5154
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0034 0.0418 0.1762
Schistosoma mansoni tar DNA-binding protein 0.0187 0.3953 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0324 0.0324
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.2374 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0034 0.0418 0.5154
Loa Loa (eye worm) cytochrome P450 0.0034 0.0418 0.0893
Schistosoma mansoni hypothetical protein 0.0034 0.0418 0.1058
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.2098 0.8837
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0453 0.0874
Echinococcus granulosus dna polymerase kappa 0.0019 0.0072 0.0072
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.053 0.7484
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0453 0.5582
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0034 0.0418 0.5154
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0034 0.0418 0.5154
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0453 0.0453
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0613 0.8646
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0811 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0354 0.4362
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.2098 0.8837
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0072 0.0072
Loa Loa (eye worm) TAR-binding protein 0.0187 0.3953 0.8767
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0453 0.5582
Echinococcus multilocularis neuropeptide s receptor 0.0449 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0453 0.6391
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.0885

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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