Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0146 | 0.0462 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0201 | 0.0637 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0046 | 0.0292 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0171 | 0.1829 | 0.5943 |
Schistosoma mansoni | thyroid hormone receptor | 0.0171 | 0.1829 | 0.5943 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.085 | 0.1834 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0201 | 0.0637 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0201 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0108 | 0.1056 | 0.334 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.1554 | 0.505 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0146 | 0.0462 |
Loa Loa (eye worm) | carboxylesterase | 0.0046 | 0.0292 | 0.0922 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0201 | 0.0637 |
Schistosoma mansoni | gliotactin | 0.0046 | 0.0292 | 0.0947 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0247 | 0.2767 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0201 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0146 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0201 | 0.0637 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0239 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0292 | 0.0922 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0201 | 0.0637 |
Brugia malayi | hypothetical protein | 0.0279 | 0.316 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.3077 | 0.9737 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0279 | 0.316 | 0.682 |
Echinococcus multilocularis | acetylcholinesterase | 0.0273 | 0.3077 | 0.3077 |
Schistosoma mansoni | acetylcholinesterase | 0.0046 | 0.0292 | 0.0947 |
Echinococcus granulosus | neuroligin | 0.0046 | 0.0292 | 0.0629 |
Echinococcus multilocularis | acetylcholinesterase | 0.0273 | 0.3077 | 0.3077 |
Brugia malayi | hypothetical protein | 0.003 | 0.0091 | 0.0289 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0046 | 0.0292 | 0.0292 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0239 | 0.0516 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0046 | 0.0292 | 0.0292 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0046 | 0.0292 | 0.0629 |
Schistosoma mansoni | survival motor neuron protein | 0.0057 | 0.0426 | 0.1384 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0292 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0292 | 0.0922 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0292 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1056 | 0.334 |
Brugia malayi | Carboxylesterase family protein | 0.0273 | 0.3077 | 0.9737 |
Onchocerca volvulus | 0.0046 | 0.0292 | 0.6572 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0046 | 0.0292 | 0.0947 |
Onchocerca volvulus | 0.0039 | 0.0201 | 0.4538 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.1436 | 0.1436 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.085 | 0.085 |
Onchocerca volvulus | 0.0046 | 0.0292 | 0.6572 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0273 | 0.3077 | 0.9737 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0201 | 0.0637 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0046 | 0.0292 | 0.0292 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0046 | 0.0292 | 0.0947 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0091 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.0635 | 0.2062 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0057 | 0.0426 | 0.1347 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0312 | 0.0312 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0635 | 0.2008 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0279 | 0.316 | 0.316 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0046 | 0.0292 | 0.0629 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0922 | 0.2919 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0046 | 0.0292 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0273 | 0.3077 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0201 | 0.0637 |
Onchocerca volvulus | 0.0039 | 0.0201 | 0.4538 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0273 | 0.3077 | 0.6641 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0292 | 0.0922 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0201 | 0.0654 |
Echinococcus granulosus | acetylcholinesterase | 0.0273 | 0.3077 | 0.6641 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0091 | 0.0289 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0292 | 0.0922 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0046 | 0.0292 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.0941 | 0.3058 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0273 | 0.3077 | 0.3077 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0292 | 0.0922 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.1436 | 0.3099 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.316 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0091 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0046 | 0.0292 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.3077 | 0.9737 |
Echinococcus multilocularis | neuroligin | 0.0046 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | carboxylesterase | 0.0273 | 0.3077 | 0.9737 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.0444 | 0.1441 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0201 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0146 | 0.0315 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.0922 | 0.0922 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0201 | 0.0637 |
Onchocerca volvulus | 0.0046 | 0.0292 | 0.6572 | |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0292 | 0.0922 |
Echinococcus granulosus | tumor protein p63 | 0.0399 | 0.4634 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0146 | 0.0475 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.022 | 0.0716 |
Onchocerca volvulus | 0.0039 | 0.0201 | 0.4538 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0046 | 0.0292 | 0.0629 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0201 | 0.0201 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0239 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0239 | 0.0756 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0239 | 0.4169 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.022 | 0.0716 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.0922 | 0.2919 |
Onchocerca volvulus | 0.0046 | 0.0292 | 0.6572 | |
Brugia malayi | Carboxylesterase family protein | 0.0273 | 0.3077 | 0.9737 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0201 | 0.0637 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0201 | 0.0637 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0201 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0146 | 0.0146 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0046 | 0.0292 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.0462 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0201 | 0.0637 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0108 | 0.1056 | 0.334 |
Onchocerca volvulus | 0.0057 | 0.0426 | 0.9599 | |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0146 | 0.0475 |
Onchocerca volvulus | 0.0046 | 0.0292 | 0.6572 | |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0239 | 0.0516 |
Brugia malayi | Carboxylesterase family protein | 0.0046 | 0.0292 | 0.0922 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0149 | 0.1554 | 0.3354 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.0201 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0239 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0292 | 0.0922 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0355 | 0.1122 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0097 | 0.0922 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0.0292 | 0.0351 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0201 | 0.0434 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0201 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0146 | 0.0315 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | carboxylesterase | 0.0046 | 0.0292 | 0.0922 |
Echinococcus granulosus | acetylcholinesterase | 0.0273 | 0.3077 | 0.6641 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0108 | 0.1056 | 0.334 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0146 | 0.0146 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0146 | 0.0462 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.0922 | 0.1991 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0426 | 0.1384 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0146 | 0.0475 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0171 | 0.1829 | 0.1829 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0201 | 0.0654 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0292 | 0.0922 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0046 | 0.0292 | 0.0947 |
Echinococcus multilocularis | tumor protein p63 | 0.0399 | 0.4634 | 0.4634 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0239 | 0.0776 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.022 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0201 | 0.0637 |
Onchocerca volvulus | 0.0058 | 0.0444 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0292 | 0.0922 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0046 | 0.0292 | 0.0947 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0146 | 0.0315 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0149 | 0.1554 | 0.1554 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0.0292 | 0.0351 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.0635 | 0.2008 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0444 | 0.1404 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.022 | 0.0716 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0239 | 0.0239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.