Detailed information for compound 57001

Basic information

Technical information
  • TDR Targets ID: 57001
  • Name: 3-[3,5-dibromo-4-(4-hydroxy-3-propan-2-ylphen oxy)phenyl]propanoic acid
  • MW: 458.141 | Formula: C18H18Br2O4
  • H donors: 2 H acceptors: 3 LogP: 5.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCc1cc(Br)c(c(c1)Br)Oc1ccc(c(c1)C(C)C)O
  • InChi: 1S/C18H18Br2O4/c1-10(2)13-9-12(4-5-16(13)21)24-18-14(19)7-11(8-15(18)20)3-6-17(22)23/h4-5,7-10,21H,3,6H2,1-2H3,(H,22,23)
  • InChiKey: DGODJDXDANWOEP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[3,5-dibromo-4-(4-hydroxy-3-isopropyl-phenoxy)phenyl]propanoic acid
  • 3-[3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl]propanoic acid
  • 3-[3,5-dibromo-4-(4-hydroxy-3-propan-2-yl-phenoxy)phenyl]propanoic acid
  • 3-[3,5-dibromo-4-(4-hydroxy-3-isopropyl-phenoxy)phenyl]propionic acid
  • OEF

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thyroid hormone receptor beta-1 Starlite/ChEMBL References
Homo sapiens thyroid hormone receptor, alpha Starlite/ChEMBL References
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi Nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi Nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Loa Loa (eye worm) nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_156853 All targets in OG5_156853
Brugia malayi Nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis ecdysone induced protein 78C Thyroid hormone receptor beta-1   461 aa 372 aa 29.3 %
Brugia malayi nuclear hormone receptor Thyroid hormone receptor beta-1   461 aa 405 aa 26.7 %
Onchocerca volvulus Thyroid hormone receptor beta-1   461 aa 383 aa 25.6 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Brugia malayi photoreceptor-specific nuclear receptor Thyroid hormone receptor beta-1   461 aa 409 aa 24.7 %
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 Thyroid hormone receptor beta-1   461 aa 377 aa 24.1 %
Loa Loa (eye worm) hypothetical protein Thyroid hormone receptor beta-1   461 aa 397 aa 25.4 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, alpha 451 aa 372 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0066
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0036 0.0128 0.1045
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.1258 0.2214
Mycobacterium ulcerans short-chain dehydrogenase 0.0036 0.0128 0.0183
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0271 0.3088 0.5433
Mycobacterium ulcerans dehydrogenase 0.0036 0.0128 0.0183
Echinococcus granulosus retinol dehydrogenase 11 0.0036 0.0128 0.0122
Schistosoma mansoni carbonyl reductase 0.0036 0.0128 0.0122
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.009 0.0803 0.0955
Brugia malayi hypothetical protein 0.01 0.0938 0.165
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Brugia malayi nuclear hormone receptor family member nhr-6 0.009 0.0803 0.1412
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Mycobacterium tuberculosis Probable oxidoreductase 0.0585 0.7028 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0036 0.0128 0.0122
Brugia malayi hypothetical protein 0.01 0.0938 0.165
Brugia malayi Nuclear hormone receptor family member nhr-1 0.019 0.2064 0.3632
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.019 0.2064 0.2513
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0095 0.0866 0.1525
Loa Loa (eye worm) dehydrogenase 0.0036 0.0128 0.0282
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.2658 0.5832
Toxoplasma gondii oxidoreductase, putative 0.0036 0.0128 0.1177
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Loa Loa (eye worm) carbonic anhydrase 3 0.0123 0.1228 0.2695
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0036 0.0128 0.025
Brugia malayi photoreceptor-specific nuclear receptor 0.019 0.2064 0.3632
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Echinococcus multilocularis carbonyl reductase 1 0.0036 0.0128 0.0099
Echinococcus granulosus tar DNA binding protein 0.0126 0.1258 0.1517
Trypanosoma brucei RNA helicase, putative 0.0435 0.5145 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0123 0.1228 0.148
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Loa Loa (eye worm) hypothetical protein 0.0271 0.3088 0.6776
Brugia malayi nuclear hormone receptor 0.019 0.2064 0.3632
Leishmania major short chain dehydrogenase-like protein 0.0036 0.0128 0.1045
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3254 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.019 0.2064 0.4529
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1424 1
Brugia malayi Common central domain of tyrosinase family protein 0.0271 0.3088 0.5433
Brugia malayi MH2 domain containing protein 0.0237 0.2658 0.4676
Loa Loa (eye worm) hypothetical protein 0.019 0.2064 0.4529
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1424 0.2026
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0036 0.0128 0.0099
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0128 0.1045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Brugia malayi hypothetical protein 0.0042 0.0202 0.0355
Brugia malayi Dehydrogenases, short chain protein 2 0.0036 0.0128 0.0226
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.1177
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Toxoplasma gondii carbonyl reductase 1, putative 0.0036 0.0128 0.1177
Toxoplasma gondii oxidoreductase, putative 0.0036 0.0128 0.1177
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Echinococcus granulosus carbonic anhydrase II 0.0123 0.1228 0.148
Loa Loa (eye worm) nuclear hormone receptor 0.009 0.0803 0.1761
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0036 0.0128 0.0183
Mycobacterium ulcerans ketoacyl reductase 0.0036 0.0128 0.0183
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.019 0.2064 0.2513
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0036 0.0128 0.0226
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.009 0.0803 0.1412
Trypanosoma brucei oxidoreductase-like protein 0.0036 0.0128 0.025
Brugia malayi orphan nuclear receptor NR2E1 0.009 0.0803 0.1412
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0093 0.0164
Echinococcus granulosus steroid dehydrogenase 0.0036 0.0128 0.0122
Brugia malayi ecdysteroid receptor 0.019 0.2064 0.3632
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Brugia malayi nuclear hormone receptor 0.009 0.0803 0.1412
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.0803 0.2278
Schistosoma mansoni tyrosinase precursor 0.0271 0.3088 0.3778
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0095 0.0866 1
Onchocerca volvulus 0.0043 0.0217 0.0299
Loa Loa (eye worm) TAR-binding protein 0.0126 0.1258 0.2761
Echinococcus multilocularis FTZ F1 alpha 0.019 0.2064 0.204
Loa Loa (eye worm) oxidoreductase 0.0036 0.0128 0.0282
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0036 0.0128 0.1177
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.003 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.019 0.2064 0.3632
Schistosoma mansoni RAR-like nuclear receptor 0.019 0.2064 0.2513
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Echinococcus multilocularis carbonic anhydrase II 0.0123 0.1228 0.1202
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0128 0.1045
Trypanosoma cruzi phosphomannose isomerase, putative 0.0095 0.0866 0.7056
Brugia malayi hypothetical protein 0.0036 0.0128 0.0226
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0123 0.1228 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.019 0.2064 0.2513
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.019 0.2064 0.204
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3254 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3254 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0066
Schistosoma mansoni hypothetical protein 0.0042 0.0202 0.0213
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0202 0.0173
Loa Loa (eye worm) ShTK domain-containing protein 0.0271 0.3088 0.6776
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1258 0.1517
Brugia malayi Nuclear hormone receptor family member nhr-31 0.019 0.2064 0.3632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3254 1
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0095 0.0866 0.1901
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1424 0.1878
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.019 0.2064 0.2513
Mycobacterium ulcerans short-chain dehydrogenase 0.0036 0.0128 0.0183
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0036 0.0128 0.0122
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Loa Loa (eye worm) hypothetical protein 0.019 0.2064 0.4529
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.019 0.2064 0.3632
Echinococcus granulosus WW domain containing oxidoreductase 0.0036 0.0128 0.0122
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0036 0.0128 0.025
Echinococcus granulosus carbonyl reductase 1 0.0036 0.0128 0.0122
Echinococcus granulosus hypothetical protein 0.0036 0.0128 0.0122
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0051 0.0321 0.149
Loa Loa (eye worm) hypothetical protein 0.01 0.0938 0.2057
Loa Loa (eye worm) hypothetical protein 0.019 0.2064 0.4529
Loa Loa (eye worm) oxidoreductase 0.0036 0.0128 0.0282
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.01 0.0938 0.1121
Echinococcus multilocularis transient receptor potential cation channel 0.0036 0.0128 0.0099
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0036 0.0128 0.1177
Onchocerca volvulus 0.009 0.0803 0.2278
Echinococcus granulosus ecdysone induced protein 78C 0.019 0.2064 0.2513
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.0803 0.0955
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0304 0.3498 0.3479
Echinococcus multilocularis oxidoreductase 0.0036 0.0128 0.0099
Echinococcus multilocularis conserved hypothetical protein 0.0036 0.0128 0.0099
Schistosoma mansoni hypothetical protein 0.0435 0.5145 0.632
Leishmania major pteridine reductase 1 0.0036 0.0128 0.1045
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Brugia malayi hypothetical protein 0.009 0.0803 0.1412
Mycobacterium ulcerans oxidoreductase 0.0036 0.0128 0.0183
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.0803 0.0955
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.01 0.0938 0.1121
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.1258 0.2761
Onchocerca volvulus 0.009 0.0803 0.2278
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Brugia malayi oxidoreductase 0.0036 0.0128 0.0226
Onchocerca volvulus Protein ultraspiracle homolog 0.019 0.2064 0.654
Schistosoma mansoni tyrosinase precursor 0.0271 0.3088 0.3778
Loa Loa (eye worm) oxidoreductase 0.0036 0.0128 0.0282
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0036 0.0128 0.1045
Loa Loa (eye worm) oxidoreductase 0.0036 0.0128 0.0282
Echinococcus multilocularis carbonyl reductase 1 0.0036 0.0128 0.0099
Brugia malayi nuclear receptor NHR-88 0.009 0.0803 0.1412
Plasmodium falciparum steroid dehydrogenase, putative 0.0036 0.0128 0.1177
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Brugia malayi nuclear receptor RXR 0.009 0.0803 0.1412
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.019 0.2064 0.4529
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0095 0.0866 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.1177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.019 0.2064 0.4529
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.0803 0.0955
Loa Loa (eye worm) oxidoreductase 0.0036 0.0128 0.0282
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0095 0.0866 0.1233
Mycobacterium ulcerans short chain dehydrogenase 0.0585 0.7028 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0128 0.1045
Echinococcus granulosus carbonyl reductase 1 0.0036 0.0128 0.0122
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Entamoeba histolytica hypothetical protein 0.0042 0.0202 0.0236
Loa Loa (eye worm) hypothetical protein 0.01 0.0938 0.2057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.019 0.2064 0.204
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.1177
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0271 0.3088 0.5433
Schistosoma mansoni hypothetical protein 0.0033 0.0093 0.0078
Loa Loa (eye worm) hypothetical protein 0.0049 0.0286 0.0628
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Echinococcus granulosus retinol dehydrogenase 11 0.0036 0.0128 0.0122
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0036 0.0128 0.0099
Loa Loa (eye worm) hypothetical protein 0.01 0.0938 0.2057
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0036 0.0128 0.0183
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Onchocerca volvulus Bile acid receptor homolog 0.019 0.2064 0.654
Loa Loa (eye worm) nuclear receptor NHR-67 0.009 0.0803 0.1761
Echinococcus multilocularis microtubule associated protein 2 0.0672 0.8124 0.8118
Echinococcus multilocularis geminin 0.0165 0.175 0.1726
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0036 0.0128 0.0122
Brugia malayi TAR-binding protein 0.0126 0.1258 0.2214
Trypanosoma cruzi phosphomannose isomerase, putative 0.0095 0.0866 0.7056
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0036 0.0128 0.0226
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0036 0.0128 0.1045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.019 0.2064 0.204
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0128 0.025
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.019 0.2064 0.204
Brugia malayi Nuclear hormone receptor family member nhr-25 0.019 0.2064 0.3632
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0036 0.0128 0.025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.019 0.2064 0.3632
Brugia malayi RNA binding protein 0.0126 0.1258 0.2214
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0128 0.025
Loa Loa (eye worm) hypothetical protein 0.0378 0.4422 0.9704
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Brugia malayi Nuclear hormone receptor-like 1 0.0478 0.5683 1
Schistosoma mansoni retinal dehydrogenase 0.0036 0.0128 0.0122
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.019 0.2064 0.2513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3254 1
Brugia malayi Nuclear hormone receptor-like 1 0.0388 0.4557 0.8018
Loa Loa (eye worm) nuclear receptor nhr-7B 0.009 0.0803 0.1761
Leishmania major hypothetical protein, conserved 0.0036 0.0128 0.1045
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Echinococcus granulosus nuclear receptor nhr 48 0.009 0.0803 0.0955
Loa Loa (eye worm) DR-78 0.009 0.0803 0.1761
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.009 0.0803 0.0775
Leishmania major dehydrogenase-like protein 0.0036 0.0128 0.1045
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0123 0.1228 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.003 0.0053
Echinococcus multilocularis ecdysone induced protein 78C 0.019 0.2064 0.204
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0123 0.1228 0.148
Brugia malayi hypothetical protein 0.009 0.0803 0.1412
Echinococcus granulosus thyroid hormone receptor alpha 0.009 0.0803 0.0955
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1258 0.1517
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.0803 0.0775
Entamoeba histolytica phosphomannose isomerase, putative 0.0095 0.0866 0.2361
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0036 0.0128 0.1045
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.3254 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0036 0.0128 0.0183
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0036 0.0128 0.0282
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-41 0.019 0.2064 0.3632
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.019 0.2064 0.4529
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0036 0.0128 0.1045
Schistosoma mansoni microtubule-associated protein tau 0.0672 0.8124 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Leishmania major phosphomannose isomerase 0.0095 0.0866 0.7056
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0271 0.3088 0.5433
Echinococcus granulosus retinoic acid receptor rxr beta a 0.019 0.2064 0.2513
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0036 0.0128 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3254 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0036 0.0128 0.1045
Leishmania major 3-keto-dihydrosphingosine reductase 0.0036 0.0128 0.1045
Schistosoma mansoni nuclear receptor 0.009 0.0803 0.0955
Brugia malayi Steroid receptor seven-up type 2 0.019 0.2064 0.3632
Mycobacterium ulcerans dehydrogenase/reductase 0.0036 0.0128 0.0183
Schistosoma mansoni thyroid hormone receptor 0.0494 0.5886 0.7235
Echinococcus multilocularis steroid dehydrogenase 0.0036 0.0128 0.0099
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0036 0.0128 0.0099
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.009 0.0803 0.0775
Schistosoma mansoni retinoid-x-receptor (RXR) 0.01 0.0938 0.1121
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0036 0.0128 0.1045
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0036 0.0128 0.1045
Brugia malayi dehydrogenases, short chain protein 2 0.0036 0.0128 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-49 0.019 0.2064 0.3632
Echinococcus multilocularis retinol dehydrogenase 11 0.0036 0.0128 0.0099
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0286 0.0504
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0036 0.0128 0.1045
Echinococcus granulosus carbonyl reductase 1 0.0036 0.0128 0.0122
Onchocerca volvulus 0.0271 0.3088 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Brugia malayi nuclear receptor NHR-88 0.019 0.2064 0.3632
Brugia malayi nuclear receptor NHR-67 0.009 0.0803 0.1412
Schistosoma mansoni carbonyl reductase 0.0036 0.0128 0.0122
Echinococcus granulosus oxidoreductase 0.0036 0.0128 0.0122
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0095 0.0866 0.0839
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.019 0.2064 0.204
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Loa Loa (eye worm) hypothetical protein 0.019 0.2064 0.4529
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.003 0.0053
Schistosoma mansoni mannose-6-phosphate isomerase 0.0095 0.0866 0.1034
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.1177
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.019 0.2064 0.2513
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.019 0.2064 0.204
Mycobacterium ulcerans short-chain type oxidoreductase 0.0036 0.0128 0.0183
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0036 0.0128 0.1045
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.0803 0.2278
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0128 0.1045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.019 0.2064 0.2513
Brugia malayi nuclear receptor RXR 0.01 0.0938 0.165
Schistosoma mansoni retinoid-x-receptor (RXR) 0.019 0.2064 0.2513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.019 0.2064 0.4529
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3254 1
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0128 0.1045
Brugia malayi ecdysone receptor 0.009 0.0803 0.1412
Leishmania major short chain dehydrogenase, putative 0.0036 0.0128 0.1045
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1258 0.1517
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0128 0.1045
Brugia malayi Nuclear hormone receptor-like 1 0.0388 0.4557 0.8018
Echinococcus multilocularis retinol dehydrogenase 13 0.0036 0.0128 0.0099
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0036 0.0128 0.0122
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0036 0.0128 0.1045
Brugia malayi conserved hypotetical protein 0.009 0.0803 0.1412
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0036 0.0128 0.0226
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.2658 0.5832
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Loa Loa (eye worm) steroid hormone receptor 0.019 0.2064 0.4529
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.1177
Leishmania major carbonic anhydrase-like protein 0.0123 0.1228 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0036 0.0128 0.1045
Loa Loa (eye worm) hypothetical protein 0.01 0.0938 0.2057
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0128 0.1045
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0036 0.0128 0.1045
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0036 0.0128 0.0122
Entamoeba histolytica hypothetical protein 0.0042 0.0202 0.0236
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0202 0.0213
Mycobacterium ulcerans oxidoreductase 0.0036 0.0128 0.0183
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.009 0.0803 0.0955
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0123 0.1228 0.2695
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Loa Loa (eye worm) dehydrogenase 0.0036 0.0128 0.0282
Echinococcus multilocularis thyroid hormone receptor alpha 0.0494 0.5886 0.5874
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.0803 0.0775
Brugia malayi ShTK domain containing protein 0.0271 0.3088 0.5433
Schistosoma mansoni hypothetical protein 0.0165 0.175 0.2126
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0128 0.1177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.019 0.2064 0.4529
Trypanosoma brucei carbonic anhydrase-like protein 0.0123 0.1228 0.2387
Onchocerca volvulus 0.0271 0.3088 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0036 0.0128 0.0226
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0304 0.3498 0.4285
Onchocerca volvulus 0.0271 0.3088 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0128 0.1045
Brugia malayi Nuclear hormone receptor family member nhr-14 0.019 0.2064 0.3632
Leishmania major hypothetical protein, conserved 0.0036 0.0128 0.1045
Echinococcus granulosus mannose 6 phosphate isomerase 0.0095 0.0866 0.1034
Leishmania major hypothetical protein, conserved 0.0036 0.0128 0.1045
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0036 0.0128 0.1045
Entamoeba histolytica hypothetical protein 0.0042 0.0202 0.0236
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.019 0.2064 0.3632
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0036 0.0128 0.1045
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0095 0.0866 0.2361
Loa Loa (eye worm) cytochrome P450 family protein 0.0073 0.0593 0.1302
Loa Loa (eye worm) hypothetical protein 0.019 0.2064 0.4529
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.019 0.2064 0.2513
Loa Loa (eye worm) oxidoreductase 0.0036 0.0128 0.0282
Echinococcus granulosus nuclear receptor 2DBD gamma 0.019 0.2064 0.2513
Schistosoma mansoni thyroid hormone receptor 0.0494 0.5886 0.7235
Schistosoma mansoni carbonyl reductase 0.0036 0.0128 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0286 0.0628
Echinococcus multilocularis steroid dehydrogenase 0.0036 0.0128 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3254 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0036 0.0128 0.0122
Echinococcus multilocularis nuclear receptor nhr 48 0.009 0.0803 0.0775
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Echinococcus granulosus FTZ F1 alpha 0.019 0.2064 0.2513
Mycobacterium ulcerans ketoacyl reductase 0.0036 0.0128 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.019 0.2064 0.3632
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0036 0.0128 0.0183
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Schistosoma mansoni zinc finger protein 0.009 0.0803 0.0955
Schistosoma mansoni hypothetical protein 0.0304 0.3498 0.4285
Brugia malayi Nuclear hormone receptor family member nhr-40 0.019 0.2064 0.3632
Echinococcus multilocularis tar DNA binding protein 0.0126 0.1258 0.1232
Trypanosoma cruzi short chain dehydrogenase, putative 0.0036 0.0128 0.1045
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0036 0.0128 0.1177
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0036 0.0128 0.025
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Echinococcus multilocularis retinol dehydrogenase 11 0.0036 0.0128 0.0099
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0202 0.0213
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Onchocerca volvulus 0.0271 0.3088 1
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Schistosoma mansoni Tr4/Tr2 (homologue) 0.019 0.2064 0.2513
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Loa Loa (eye worm) hypothetical protein 0.0271 0.3088 0.6776
Schistosoma mansoni nuclear hormone receptor 0.019 0.2064 0.2513
Loa Loa (eye worm) hypothetical protein 0.019 0.2064 0.4529
Mycobacterium ulcerans short-chain dehydrogenase 0.0036 0.0128 0.0183
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0036 0.0128 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.019 0.2064 0.4529
Brugia malayi tailless protein 0.009 0.0803 0.1412
Echinococcus granulosus geminin 0.0165 0.175 0.2126
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0028 0.003 0.0066
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0036 0.0128 0.1045
Schistosoma mansoni steroid hormone receptor ad4bp 0.019 0.2064 0.2513
Brugia malayi dehydrogenases, short chain protein 9 0.0036 0.0128 0.0226
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0388 0.4557 1
Brugia malayi Nuclear hormone receptor E75 0.009 0.0803 0.1412
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0128 0.1045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0286 0.0504
Leishmania major hypothetical protein, conserved 0.0036 0.0128 0.1045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Leishmania major short chain dehydrogenase, putative 0.0036 0.0128 0.1045
Echinococcus granulosus carbonyl reductase 1 0.0036 0.0128 0.0122
Schistosoma mansoni nuclear receptor nhr-48 0.009 0.0803 0.0955
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0128 0.1045
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0128 0.1045
Echinococcus granulosus hypothetical protein 0.0036 0.0128 0.0122
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.009 0.0803 0.0955
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.019 0.2064 0.3632
Mycobacterium ulcerans ketoacyl reductase 0.0036 0.0128 0.0183
Loa Loa (eye worm) tyrosinase 1 0.0271 0.3088 0.6776
Brugia malayi steroid hormone receptor 0.019 0.2064 0.3632
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0095 0.0866 0.1901
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1258 0.1517
Leishmania major hypothetical protein, conserved 0.0036 0.0128 0.1045
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Loa Loa (eye worm) hypothetical protein 0.019 0.2064 0.4529
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0128 0.025
Mycobacterium ulcerans carveol-like dehydrogenase 0.0036 0.0128 0.0183
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0128 0.025
Loa Loa (eye worm) RNA binding protein 0.0126 0.1258 0.2761
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Schistosoma mansoni nuclear receptor 0.009 0.0803 0.0955
Brugia malayi Retinol dehydrogenase 12 0.0036 0.0128 0.0226
Echinococcus granulosus microtubule associated protein 2 0.0672 0.8124 1
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Brugia malayi Cytochrome P450 family protein 0.0073 0.0593 0.1044
Schistosoma mansoni hypothetical protein 0.0165 0.175 0.2126
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0282
Leishmania major oxidoreductase-like protein 0.0036 0.0128 0.1045
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0036 0.0128 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0036 0.0128 0.0183
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0036 0.0128 0.0122
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.3254 0.5
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0036 0.0128 0.025
Loa Loa (eye worm) oxidoreductase 0.0036 0.0128 0.0282
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0043 0.0221 0.0297
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0123 0.1228 0.2161
Loa Loa (eye worm) oxidoreductase 0.0036 0.0128 0.0282
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.0803 0.0775
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Echinococcus multilocularis carbonyl reductase 1 0.0036 0.0128 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1258 0.1517
Schistosoma mansoni coup transcription factor 0.019 0.2064 0.2513
Loa Loa (eye worm) hypothetical protein 0.01 0.0938 0.2057
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Brugia malayi nuclear hormone receptor family member odr-7 0.009 0.0803 0.1412
Echinococcus multilocularis carbonyl reductase 1 0.0036 0.0128 0.0099
Trypanosoma cruzi short chain dehydrogenase, putative 0.0036 0.0128 0.1045
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0036 0.0128 0.1045
Brugia malayi hypothetical protein 0.0036 0.0128 0.0226
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0271 0.3088 0.5433
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Mycobacterium ulcerans short chain dehydrogenase 0.0036 0.0128 0.0183
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0036 0.0128 0.1177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3254 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0036 0.0128 0.025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.019 0.2064 0.654
Leishmania major short chain dehydrogenase/reductase, putative 0.0036 0.0128 0.1045
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0128 0.0226
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Schistosoma mansoni nuclear hormone receptor 0.009 0.0803 0.0955
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.01 0.0938 0.091
Loa Loa (eye worm) ShTK domain-containing protein 0.0271 0.3088 0.6776
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0036 0.0128 0.0099
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Schistosoma mansoni retinoic acid receptor RXR 0.019 0.2064 0.2513
Brugia malayi Nuclear hormone receptor E75 0.009 0.0803 0.1412
Trypanosoma brucei phosphomannose isomerase 0.0095 0.0866 0.1684
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0036 0.0128 0.0183
Schistosoma mansoni nuclear hormone receptor 0.009 0.0803 0.0955
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.0205
Toxoplasma gondii phosphomannose isomerase type I protein 0.0095 0.0866 1
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0051 0.0321 0.028
Loa Loa (eye worm) oxidoreductase 0.0036 0.0128 0.0282
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0095 0.0866 0.1525
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0066
Onchocerca volvulus 0.019 0.2064 0.654
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Leishmania major quinonoid dihydropteridine reductase 0.0036 0.0128 0.1045
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3254 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.003 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0128 0.1045
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.019 0.2064 0.2513
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0123 0.1228 0.2161
Entamoeba histolytica hypothetical protein 0.0042 0.0202 0.0236
Loa Loa (eye worm) hypothetical protein 0.009 0.0803 0.1761
Schistosoma mansoni steroid dehydrogenase 0.0036 0.0128 0.0122
Schistosoma mansoni short chain dehydrogenase 0.0036 0.0128 0.0122
Loa Loa (eye worm) hypothetical protein 0.019 0.2064 0.4529

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10 Inhibition of thyroid hormone receptor alpha (unknown origin) ChEMBL. 17467994
IC50 (binding) = 10.6 Inhibition of human thyroid hormone receptor beta 1 ChEMBL. 17524652
IC50 (binding) = 10.6 Inhibition of thyroid hormone receptor beta (unknown origin) ChEMBL. 17467994
IC50 (binding) = 0.025 nM Concentration of the compound required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor beta) was determined ChEMBL. 12699376
IC50 (binding) = 0.025 nM Concentration of the compound required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor beta) was determined ChEMBL. 12699376
IC50 (binding) = 0.1 nM Concentration of the compound required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor alpha) was determined ChEMBL. 12699376
IC50 (binding) = 0.1 nM Concentration of the compound required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor alpha) was determined ChEMBL. 12699376
IC50 (binding) = 0.11 nM Ability to inhibit the bound [125I]-L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro. ChEMBL. 7861417
IC50 (binding) = 0.11 nM Ability to inhibit the bound [125I]-L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro. ChEMBL. 7861417
IC50 (binding) > 5 uM In vitro inhibition of bound [125I]-L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor ChEMBL. 7861417
IC50 (binding) > 5 uM In vitro inhibition of bound [125I]-L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor ChEMBL. 7861417
Log IC50 (binding) = 10 Inhibition of thyroid hormone receptor alpha (unknown origin) ChEMBL. 17467994
Log IC50 (binding) = 10.6 Inhibition of human thyroid hormone receptor beta 1 ChEMBL. 17524652
Log IC50 (binding) = 10.6 Inhibition of thyroid hormone receptor beta (unknown origin) ChEMBL. 17467994
Ratio (binding) = 4 Ratio of concentration of the compound required to inhibit 50% of I-T3 binding to hTR-alpha1 to that of concentration of the compound required to inhibit 50% of I-T3 binding to hTR-beta1 was determined ChEMBL. 12699376
Ratio (binding) = 4 Ratio of concentration of the compound required to inhibit 50% of I-T3 binding to hTR-alpha1 to that of concentration of the compound required to inhibit 50% of I-T3 binding to hTR-beta1 was determined ChEMBL. 12699376

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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