TDR Targets

Basic information

Technical information

TDR Targets ID: 570145
Name: cyanomethyl 4-chlorobenzenesulfonate
MW: 231.656 | Formula: C8H6ClNO3S
H donors: 0 H acceptors: 3 LogP: 1.62 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#CCOS(=O)(=O)c1ccc(cc1)Cl
InChi: 1S/C8H6ClNO3S/c9-7-1-3-8(4-2-7)14(11,12)13-6-5-10/h1-4H,6H2
InChiKey: HUBNRULYPBPVCR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-chlorobenzenesulfonic acid cyanomethyl ester
4-chlorobenzenesulfonylglycolic acid nitrile
56000-13-6
p-Chlorobenzenesulfonylglycolic acid nitrile
Benzenesulfonic acid, 4-chloro-, cyanomethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0546	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0095	0.0336
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0148	0.1677	0.4062
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.025	0.1466
Echinococcus granulosus	intermediate filament protein	0.0027	0.0144	0.051
Echinococcus granulosus	lamin	0.0027	0.0144	0.051
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0577	0.7098	1
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0039	0.0299	0.0134
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0095	0.0558
Echinococcus multilocularis	musashi	0.0027	0.0144	0.0144
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0095	0.0558
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0361	0.0312
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0574	0.2032
Leishmania major	oxidoreductase-like protein	0.0039	0.0299	0.0134
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0361	0.0312
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0546	0.1933
Loa Loa (eye worm)	oxidoreductase	0.0039	0.0299	0.1058
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0323	0.1144
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0039	0.0299	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0299	0.1058
Trichomonas vaginalis	hypothetical protein	0.0577	0.7098	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0546	0.3207
Leishmania major	mitochondrial DNA polymerase beta	0.0313	0.376	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0095	0.0336
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0095	0.0336
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0118	0.1298	0.4593
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0039	0.0299	0.0134
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0317	0.0201
Brugia malayi	jmjC domain containing protein	0.0097	0.1025	0.3627
Onchocerca volvulus	Alhambra homolog	0.0029	0.0178	0.0944
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0252	0.0891
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0095	0.0095
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0421	0.2474
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0546	0.3207
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0095	0.0336
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0039	0.0299	0.1058
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0039	0.0299	0.0175
Echinococcus granulosus	lamin dm0	0.0027	0.0144	0.051
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0039	0.0299	0.0134
Brugia malayi	nuclear hormone receptor	0.0023	0.0095	0.0336
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0317	1
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0178	0.0628
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0144	0.051
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0039	0.0299	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0095	0.0336
Schistosoma mansoni	hypothetical protein	0.0035	0.025	0.1466
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0095	0.0095
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0095	0.0336
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0039	0.0299	0.0134
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0421	0.149
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0095	0.0336
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0256	0.0906
Schistosoma mansoni	hypothetical protein	0.0029	0.0178	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0239	0.2826	1
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0039	0.0299	0.0175
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0095	0.0095
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0095	0.0336
Echinococcus multilocularis	lamin	0.0027	0.0144	0.0144
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0144	0.051
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0361	0.0312
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0546	0.0839
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.0317	1
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0039	0.0299	0.1755
Echinococcus multilocularis	survival motor neuron protein 1	0.0239	0.2826	0.2826
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0095	0.0336
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0095	0.0336
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0577	0.7098	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0159	0.1818	0.6434
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0444	0.157
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0095	0.0558
Echinococcus multilocularis	lamin dm0	0.0027	0.0144	0.0144
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0039	0.0299	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0095	0.0336
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0546	0.0364
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0095	0.0336
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0095	0.0336
Schistosoma mansoni	hypothetical protein	0.0049	0.0421	0.2474
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0577	0.7098	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0144	0.0846
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0178	0.0178
Brugia malayi	steroid hormone receptor	0.0023	0.0095	0.0336
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0313	0.376	1
Trypanosoma brucei	oxidoreductase-like protein	0.0039	0.0299	0.0134
Schistosoma mansoni	dihydropteridine reductase	0.0039	0.0299	0.1755
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0252	0.0323
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0159	0.1818	0.6434
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0577	0.7098	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.0363	0.0163
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0095	0.0095
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0095	0.0336
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0361	0.0312
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0421	0.1491
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.1025	0.3627
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0159	0.1818	0.1818
Brugia malayi	acetyltransferase, GNAT family protein	0.015	0.1703	0.6026
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0095	0.0336
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0095	0.0336
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0252	0.0323
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0095	0.0336
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0095	0.0336
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0546	0.0364
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0144	0.051
Onchocerca volvulus		0.0027	0.0144	0.0562
Brugia malayi	ecdysteroid receptor	0.0023	0.0095	0.0336
Brugia malayi	hypothetical protein	0.0035	0.025	0.0883
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0095	0.0336
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0256	0.0906
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.0363	0.0163
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0421	0.149
Onchocerca volvulus		0.0049	0.0421	0.3732
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0095	0.0336
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0178	0.1043
Echinococcus multilocularis	peregrin	0.0033	0.0224	0.0224
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0178	0.0628
Loa Loa (eye worm)	acetyltransferase	0.015	0.1703	0.6026
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0095	0.0558
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0095	0.0095
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0039	0.0299	0.0134
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0039	0.0299	0.1058
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0095	0.0336
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.0363	0.1285
Schistosoma mansoni	coup transcription factor	0.0023	0.0095	0.0558
Schistosoma mansoni	alpha-glucosidase	0.0137	0.1538	0.903
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0256	0.1503
Brugia malayi	jmjC domain containing protein	0.0036	0.0256	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0178	0.0628
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0226	0.08
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0252	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0095	0.0336
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0546	0.0364
Leishmania major	pteridine reductase 1	0.0039	0.0299	0.0134
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0106	0.1145	0.1145
Mycobacterium ulcerans	hypothetical protein	0.0165	0.1888	0.2338
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0577	0.7098	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0252	0.0252
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0252	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0095	0.0336
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0095	0.0336
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0159	0.1818	0.6434
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.1025	0.1025
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0095	0.0095
Schistosoma mansoni	lamin	0.0027	0.0144	0.0846
Echinococcus granulosus	peregrin	0.0033	0.0224	0.0793
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0148	0.1677	0.4062
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0039	0.0299	0.0175
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0252	0.0891
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0095	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0095	0.0336
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0256	0.0256
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0039	0.0299	0.1058
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0039	0.0299	0.0134
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0146	0.165	0.5838
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0095	0.0336
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0095	0.0336
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0095	0.0336
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0144	0.051
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0313	0.376	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.015	0.1703	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0095	0.0336
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0323	0.0323
Trypanosoma brucei	pteridine reductase 1	0.0039	0.0299	0.0134
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0095	0.0336
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0095	0.0336
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.015	0.1703	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0138	0.0488
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0159	0.1818	0.1818
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0095	0.0336
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0054	0.0483	0.0659
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0546	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0095	0.0336
Brugia malayi	PHD-finger family protein	0.0029	0.0178	0.0628
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0095	0.0336
Onchocerca volvulus		0.0039	0.0299	0.2333
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0095	0.0336
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.0363	0.0268
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0577	0.7098	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0095	0.0095
Brugia malayi	intermediate filament protein	0.0027	0.0144	0.051
Brugia malayi	hypothetical protein	0.0239	0.2826	1
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0095	0.0558
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0095	0.0095
Echinococcus granulosus	survival motor neuron protein 1	0.0239	0.2826	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0095	0.0558
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0095	0.0558
Onchocerca volvulus		0.0092	0.097	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0095	0.0558
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0577	0.7098	1
Brugia malayi	Bromodomain containing protein	0.0033	0.0224	0.0793
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0095	0.0336
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.0363	0.0268
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0095	0.0558
Schistosoma mansoni	lamin	0.0027	0.0144	0.0846
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.0363	0.0268
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0095	0.0558
Toxoplasma gondii	hypothetical protein	0.005	0.0443	0.0384
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0039	0.0299	0.0134
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0039	0.0299	0.0175
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0095	0.0336
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0039	0.0299	0.0299
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0095	0.0336
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0095	0.0336
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0256	0.1503
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.0774	0.4546
Schistosoma mansoni	alpha-glucosidase	0.0137	0.1538	0.903
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0313	0.376	1
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0095	0.0558
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0095	0.0336
Schistosoma mansoni	alpha glucosidase	0.0035	0.0252	0.1479
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0165	0.1888	0.2338
Schistosoma mansoni	retinoic acid receptor RXR	0.0118	0.1298	0.7623
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0577	0.7098	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.025	0.025
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0226	0.08
Onchocerca volvulus		0.0027	0.0144	0.0562
Schistosoma mansoni	hypothetical protein	0.0033	0.0226	0.1328
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0148	0.1677	0.4062
Onchocerca volvulus		0.0039	0.0299	0.2333
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0039	0.0299	0.7348
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0421	0.149
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.025	0.0883
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0421	0.149

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 171487

Bibliographic References

No literature references available for this target.

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Detailed information for compound 570145