Detailed information for compound 570353

Basic information

Technical information
  • TDR Targets ID: 570353
  • Name: 2-sec-butyl-4,5-dihydrothiazole
  • MW: 143.25 | Formula: C7H13NS
  • H donors: 0 H acceptors: 0 LogP: 1.74 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C1=NCCS1)C
  • InChi: 1S/C7H13NS/c1-3-6(2)7-8-4-5-9-7/h6H,3-5H2,1-2H3
  • InChiKey: SAWWKXMIPYUIBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-butan-2-yl-4,5-dihydro-1,3-thiazole
  • 2-sec-butyl-2-thiazoline
  • 2-(sec-butyl)-4,5-dihydrothiazole
  • 56367-27-2
  • 4,5-Dihydro-2-(1-methylpropyl)thiazole
  • Thiazole, 4,5-dihydro-2-(1-methylpropyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0046 0.6591 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0046 0.6591 1
Brugia malayi Cytochrome P450 family protein 0.0046 0.6591 0.6591
Leishmania major hypothetical protein, conserved 0.0024 0.1868 0.2009
Echinococcus granulosus cytochrome P450 2K1 0.0046 0.6591 0.6342
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0046 0.6591 1
Leishmania major cytochrome p450-like protein 0.0046 0.6591 1
Brugia malayi cytochrome P450 0.0046 0.6591 0.6591
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0681 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.6591 0.6342
Brugia malayi jmjC domain containing protein 0.0057 0.9041 0.9041
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0046 0.6591 1
Brugia malayi Cytochrome P450 family protein 0.0046 0.6591 0.6591
Brugia malayi hypothetical protein 0.0024 0.1868 0.1868
Trypanosoma brucei cytochrome P450, putative 0.0046 0.6591 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0046 0.6591 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0046 0.6591 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.6162 0.5881
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0681 0.0681
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0046 0.6591 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0046 0.6591 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0046 0.6591 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0046 0.6591 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0046 0.6591 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.6162 0.5881
Brugia malayi jmjC domain containing protein 0.0057 0.9041 0.9041
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0046 0.6591 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0046 0.6591 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0046 0.6591 1
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.6591 1
Loa Loa (eye worm) TAR-binding protein 0.0062 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.9041 0.8971
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.1868 0.5
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0046 0.6591 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0046 0.6591 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0046 0.6591 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.6591 0.6342
Giardia lamblia DINP protein human, muc B family 0.0019 0.0681 0.5
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0046 0.6591 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0046 0.6591 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0046 0.6591 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.6162 0.6162
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0046 0.6591 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0046 0.6591 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0681 0.0681
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0046 0.6591 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.6162 0.5881
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0046 0.6591 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0046 0.6591 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0046 0.6591 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0046 0.6591 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0046 0.6591 1
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0046 0.6591 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.9041 0.8971
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0046 0.6591 1
Trypanosoma cruzi cytochrome P450, putative 0.0046 0.6591 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.1868 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0046 0.6591 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.9041 0.8971
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0046 0.6591 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0046 0.6591 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0046 0.6591 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0046 0.6591 1
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.1868 0.2009
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0046 0.6591 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.6591 0.6342
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0046 0.6591 1
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.9041 0.8971
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0046 0.6591 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0046 0.6591 1
Loa Loa (eye worm) RNA binding protein 0.0062 1 1
Leishmania major cytochrome p450-like protein 0.0046 0.6591 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.1868 0.1274
Mycobacterium leprae putative cytochrome p450 0.0046 0.6591 0.5
Loa Loa (eye worm) CYP4Cod1 0.0046 0.6591 0.6342
Schistosoma mansoni hypothetical protein 0.0046 0.6591 0.6342
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.9041 0.8971
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0046 0.6591 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0046 0.6591 1
Brugia malayi Cytochrome P450 family protein 0.0046 0.6591 0.6591
Echinococcus multilocularis tar DNA binding protein 0.0062 1 1
Schistosoma mansoni jumonji domain containing protein 0.0057 0.9041 0.8971
Loa Loa (eye worm) cytochrome P450 0.0046 0.6591 0.6342
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.1868 0.5
Leishmania major cytochrome p450-like protein 0.0046 0.6591 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.6162 0.5881
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.1868 0.2009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.6162 0.5881
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 1 1
Echinococcus granulosus tar DNA binding protein 0.0062 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0046 0.6591 0.5
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0046 0.6591 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.6162 0.5881
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0681 0.5
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0046 0.6591 1
Brugia malayi Cytochrome P450 family protein 0.0046 0.6591 0.6591
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0046 0.6591 1
Brugia malayi TAR-binding protein 0.0062 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.9041 0.8971
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.6162 0.5881
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0681 0.5
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0046 0.6591 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0046 0.6591 1
Echinococcus multilocularis 0.0046 0.6591 0.6342
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0046 0.6591 1
Schistosoma mansoni cytochrome P450 0.0046 0.6591 0.6342
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.1868 0.2009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.9041 0.8971
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.6162 0.5881

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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