Detailed information for compound 570371

Basic information

Technical information
  • TDR Targets ID: 570371
  • Name: 2-[4-[2-hydroxy-3-(isopropylamino)propoxy]phe nyl]acetic acid
  • MW: 267.321 | Formula: C14H21NO4
  • H donors: 3 H acceptors: 3 LogP: -1.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(COc1ccc(cc1)CC(=O)O)CNC(C)C
  • InChi: 1S/C14H21NO4/c1-10(2)15-8-12(16)9-19-13-5-3-11(4-6-13)7-14(17)18/h3-6,10,12,15-16H,7-9H2,1-2H3,(H,17,18)
  • InChiKey: PUQIRTNPJRFRCZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethanoic acid
  • 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetic acid
  • H117-04
  • 56392-14-4
  • 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzeneacetic acid
  • Atenolol acid
  • Benzeneacetic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-
  • H 117/04
  • Metoprolol acid
  • SL 77-010
  • (4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl)acetic acid
  • 4-(2'-Hydroxy-3'-isopropylaminopropoxy)phenylacetic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0242 0.806 1
Leishmania major cathepsin L-like protease 0.0023 0.0288 0.0516
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.1453 0.1612
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0023 0.0288 0.2022
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0034 0.0683 0.0683
Brugia malayi Cathepsin L-like precursor 0.0023 0.0288 0.0358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0288 0.2022
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0055 0.1426 0.1579
Schistosoma mansoni cytochrome P450 reductase 0.0055 0.1426 0.1426
Onchocerca volvulus 0.0154 0.4964 1
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.1233 0.1233
Brugia malayi RNA binding protein 0.0065 0.1781 0.2209
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0288 1
Leishmania major cathepsin L-like protease 0.0023 0.0288 0.0516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0288 0.0516
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0227 0.0312
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0433 0.0537
Loa Loa (eye worm) doublecortin family protein 0.002 0.0183 0.0227
Trypanosoma brucei RNA helicase, putative 0.0104 0.3189 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Schistosoma mansoni hypothetical protein 0.0173 0.5629 0.5629
Plasmodium vivax vivapain-2 0.0023 0.0288 0.0397
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.1213 0.2156
Loa Loa (eye worm) hypothetical protein 0.0055 0.1453 0.1802
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.1453 0.1612
Leishmania major cysteine peptidase A (CPA) 0.0023 0.0288 0.0516
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0055 0.1426 0.1579
Plasmodium vivax flavodoxin domain containing protein 0.0049 0.1205 0.166
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0433 0.0523
Plasmodium falciparum cysteine proteinase falcipain 3 0.0023 0.0288 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0021 0.0227 0.0062
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Brugia malayi flavodoxin family protein 0.0055 0.1426 0.177
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.6301 0.7767
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0288 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Plasmodium vivax unspecified product 0.0205 0.6744 0.9288
Brugia malayi FAD binding domain containing protein 0.0034 0.0683 0.0848
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0288 0.0358
Brugia malayi hypothetical protein 0.002 0.0183 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0288 0.2022
Brugia malayi Doublecortin family protein 0.002 0.0183 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0433 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0433 0.0537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Onchocerca volvulus Peroxidase homolog 0.0027 0.0433 0.0523
Toxoplasma gondii flavodoxin domain-containing protein 0.0027 0.0447 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Brugia malayi mbt repeat family protein 0.0049 0.1213 0.1505
Brugia malayi flavodoxin family protein 0.0021 0.0227 0.0281
Schistosoma mansoni rab6-interacting 0.002 0.0183 0.0183
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.1213 0.1213
Brugia malayi Blistered cuticle protein 3 0.0027 0.0433 0.0537
Onchocerca volvulus 0.0023 0.0288 0.0221
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0055 0.1426 0.405
Loa Loa (eye worm) FAD binding domain-containing protein 0.0055 0.1426 0.177
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0288 0.0288
Loa Loa (eye worm) RNA binding protein 0.0065 0.1781 0.2209
Schistosoma mansoni peroxidasin 0.0027 0.0433 0.0433
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Plasmodium falciparum nitric oxide synthase, putative 0.0055 0.1426 0.1757
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0023 0.0288 0.0149
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1233 0.1529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0288 0.0516
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Echinococcus granulosus cysteine protease 0.0023 0.0288 0.0134
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0288 0.2022
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0023 0.0288 0.0358
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0288 0.2022
Trypanosoma cruzi cysteine protease, putative 0.0023 0.0288 0.2022
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1781 0.1781
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0023 0.0288 0.0149
Echinococcus granulosus geminin 0.0173 0.5629 0.6914
Plasmodium vivax vivapain-2 0.0023 0.0288 0.0397
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.1453 0.1453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Plasmodium vivax vivapain-1 0.0219 0.7261 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.3667 0.4423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0055 0.1426 0.405
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.0288 0.0134
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0433 0.0537
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0288 0.0516
Brugia malayi FAD binding domain containing protein 0.0055 0.1426 0.177
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0021 0.0227 0.1588
Loa Loa (eye worm) ctsf protein 0.0023 0.0288 0.0358
Brugia malayi hypothetical protein 0.0154 0.4964 0.6159
Treponema pallidum flavodoxin 0.0021 0.0227 0.5
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0055 0.1426 0.405
Brugia malayi Peroxidasin 0.0027 0.0433 0.0537
Giardia lamblia Nitric oxide synthase, inducible 0.0049 0.1205 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0288 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0288 0.0516
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0049 0.1205 0.8159
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.1213 0.1308
Schistosoma mansoni hypothetical protein 0.002 0.0183 0.0183
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Echinococcus granulosus peroxidasin 0.0027 0.0433 0.0318
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Onchocerca volvulus Cathepsin F homolog 0.0023 0.0288 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Brugia malayi Cathepsin L-like precursor 0.0023 0.0288 0.0358
Entamoeba histolytica cysteine proteinase 2 0.0023 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0055 0.1426 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Onchocerca volvulus 0.0023 0.0288 0.0221
Trypanosoma cruzi p450 reductase, putative 0.0055 0.1426 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Leishmania major cathepsin L-like protease 0.0023 0.0288 0.0516
Echinococcus granulosus cathepsin l1 0.0023 0.0288 0.0134
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0433 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0055 0.1426 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0433 0.0537
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0433 0.0537
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0055 0.1426 0.1964
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0055 0.1426 0.405
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0219 0.7261 1
Schistosoma mansoni hypothetical protein 0.0104 0.3189 0.3189
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0288 0.2022
Loa Loa (eye worm) hypothetical protein 0.002 0.0183 0.0227
Echinococcus multilocularis cysteine protease 0.0023 0.0288 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Trichomonas vaginalis sulfite reductase, putative 0.0055 0.1426 1
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0288 0.0516
Schistosoma mansoni diflavin oxidoreductase 0.0027 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0154 0.4964 0.6159
Loa Loa (eye worm) hypothetical protein 0.0023 0.0288 0.0358
Echinococcus multilocularis peroxidasin 0.0027 0.0433 0.0318
Loa Loa (eye worm) cysteine protease 0.0023 0.0288 0.0358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Loa Loa (eye worm) flavodoxin family protein 0.0021 0.0227 0.0281
Echinococcus granulosus methionine synthase reductase 0.0034 0.0683 0.0635
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0288 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1781 0.1781
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0021 0.0227 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0055 0.1426 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.1453 0.1802
Echinococcus granulosus cathepsin L 0.0023 0.0288 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.1213 0.1308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Leishmania major p450 reductase, putative 0.0055 0.1426 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.6301 0.7767
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.1213 0.1213
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0288 0.0288
Onchocerca volvulus 0.0049 0.1213 0.2156
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0055 0.1426 0.177
Loa Loa (eye worm) MBCTL1 0.0055 0.1453 0.1802
Echinococcus granulosus cathepsin L cysteine protease 0.0023 0.0288 0.0134
Schistosoma mansoni NADPH flavin oxidoreductase 0.0028 0.0462 0.0462
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.1213 0.1213
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.806 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1781 0.2209
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0055 0.1426 0.1579
Schistosoma mansoni rab6-interacting 0.002 0.0183 0.0183
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0288 1
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0288 0.0221
Giardia lamblia Hypothetical protein 0.0049 0.1205 0.5
Onchocerca volvulus 0.0023 0.0288 0.0221
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0288 0.0134
Schistosoma mansoni polycystin 1-related 0.002 0.0183 0.0183
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0288 0.0134
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.1453 0.1612
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.1453 0.1612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0288 0.0516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0288 0.0516
Leishmania major cathepsin L-like protease 0.0023 0.0288 0.0516
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1781 0.2209
Echinococcus multilocularis methionine synthase reductase 0.0034 0.0683 0.0635
Loa Loa (eye worm) hypothetical protein 0.0049 0.1213 0.1505
Onchocerca volvulus 0.0027 0.0433 0.0523
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0288 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Plasmodium vivax vivapain-3 0.0023 0.0288 0.0397
Schistosoma mansoni lipoxygenase 0.0082 0.2408 0.2408
Leishmania major cathepsin L-like protease 0.0023 0.0288 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Schistosoma mansoni hypothetical protein 0.0173 0.5629 0.5629
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1781 0.2029
Brugia malayi Cathepsin L-like precursor 0.0023 0.0288 0.0358
Onchocerca volvulus 0.0049 0.1233 0.2196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0288 0.2022
Echinococcus multilocularis geminin 0.0173 0.5629 0.6914
Brugia malayi Cathepsin L-like precursor 0.0023 0.0288 0.0358
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0055 0.1426 0.1579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0288 0.2022
Leishmania major cathepsin L-like protease 0.0023 0.0288 0.0516
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.1213 0.1308
Plasmodium vivax unspecified product 0.0219 0.7261 1
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0433 0.0537
Chlamydia trachomatis sulfite reductase 0.0034 0.0683 0.5
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0433 0.0523
Schistosoma mansoni loxhd1 0.002 0.0183 0.0183
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0288 0.0288
Echinococcus multilocularis cysteine protease 0.0023 0.0288 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0288 0.0516
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0288 1
Leishmania major cathepsin L-like protease 0.0023 0.0288 0.0516
Onchocerca volvulus 0.0027 0.0433 0.0523
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1781 0.2209
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1781 0.1781
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0021 0.0227 0.1588
Schistosoma mansoni hypothetical protein 0.0049 0.1233 0.1233
Leishmania major cytochrome P450 reductase, putative 0.0049 0.1205 0.8159
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0055 0.1426 1
Brugia malayi mbt repeat family protein 0.0049 0.1213 0.1505
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.0288 0.0134
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0021 0.0227 0.1588
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0433 0.0537
Schistosoma mansoni peroxidasin 0.0027 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Echinococcus granulosus tar DNA binding protein 0.0065 0.1781 0.2029
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0288 0.2022
Onchocerca volvulus 0.0023 0.0288 0.0221
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0183 0.0252
Onchocerca volvulus 0.0023 0.0288 0.0221
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0288 0.0358
Loa Loa (eye worm) FAD binding domain-containing protein 0.0034 0.0683 0.0848
Toxoplasma gondii flavodoxin domain-containing protein 0.0027 0.0447 1
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0288 0.0221
Brugia malayi hypothetical protein 0.0242 0.806 1
Loa Loa (eye worm) fibroinase 0.0023 0.0288 0.0358
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.1213 0.1505
Onchocerca volvulus 0.0023 0.0288 0.0221
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0288 0.0288
Leishmania major cathepsin L-like protease 0.0023 0.0288 0.0516
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1781 0.1781
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0288 0.0358
Onchocerca volvulus 0.0023 0.0288 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Echinococcus multilocularis cathepsin L 0.0023 0.0288 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1781 0.1781
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0288 0.0134
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0433 0.0537
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.1213 0.1308
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0055 0.1426 1
Brugia malayi hypothetical protein 0.0027 0.0433 0.0537
Brugia malayi TAR-binding protein 0.0065 0.1781 0.2209
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0433 0.0523
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Brugia malayi Cathepsin L-like precursor 0.0023 0.0288 0.0358
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.3667 0.4423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0288 0.0209
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0183 0.0227
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0433 0.0537
Brugia malayi hypothetical protein 0.002 0.0183 0.0227
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0288 0.0358
Onchocerca volvulus Peroxidase homolog 0.0027 0.0433 0.0523
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0288 0.0516
Loa Loa (eye worm) hypothetical protein 0.0027 0.0433 0.0537
Onchocerca volvulus 0.0027 0.0433 0.0523
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0288 0.0358
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.806 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0288 0.0516
Entamoeba histolytica cysteine protease, putative 0.0023 0.0288 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0023 0.0288 1
Schistosoma mansoni lipoxygenase 0.0118 0.3667 0.3667

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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