Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Protein farnesyltransferase | Starlite/ChEMBL | References |
Homo sapiens | protein geranylgeranyltransferase type I, beta subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | protein farnesyltransferase beta subunit | protein geranylgeranyltransferase type I, beta subunit | 377 aa | 361 aa | 26.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gliotactin | 0.0262 | 0.1094 | 0.1094 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0262 | 0.1094 | 0.1094 |
Brugia malayi | Carboxylesterase family protein | 0.0262 | 0.1094 | 0.1094 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0258 | 0.1068 | 0.9759 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0262 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | carboxylesterase | 0.0262 | 0.1094 | 0.1094 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0258 | 0.1068 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.1094 | 0.1094 |
Brugia malayi | hypothetical protein | 0.0262 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.1094 | 0.1094 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.011 | 0.0045 | 1 |
Echinococcus granulosus | neuroligin | 0.0262 | 0.1094 | 0.1094 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0262 | 0.1094 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1553 | 1 | 1 |
Trypanosoma brucei | lanosterol synthase | 0.011 | 0.0045 | 1 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0104 | 0 | 0.5 |
Leishmania major | farnesyltransferase beta subunit | 0.0104 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0262 | 0.1094 | 0.1094 |
Brugia malayi | Carboxylesterase family protein | 0.0262 | 0.1094 | 0.1094 |
Giardia lamblia | Prenyltransferase | 0.0104 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0262 | 0.1094 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0262 | 0.1094 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1553 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0262 | 0.1094 | 0.1094 |
Echinococcus granulosus | carboxylesterase 5A | 0.1553 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0262 | 0.1094 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.1094 | 0.1094 |
Brugia malayi | Carboxylesterase family protein | 0.0262 | 0.1094 | 0.1094 |
Onchocerca volvulus | 0.0262 | 0.1094 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1553 | 1 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0104 | 0 | 0.5 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0258 | 0.1068 | 0.1068 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0258 | 0.1068 | 0.1068 |
Brugia malayi | Carboxylesterase family protein | 0.0262 | 0.1094 | 0.1094 |
Onchocerca volvulus | 0.0262 | 0.1094 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0262 | 0.1094 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1553 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0262 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.1553 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.1094 | 0.1094 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0262 | 0.1094 | 0.1094 |
Schistosoma mansoni | acetylcholinesterase | 0.0262 | 0.1094 | 0.1094 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0262 | 0.1094 | 0.1094 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.011 | 0.0045 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0262 | 0.1094 | 0.1094 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0258 | 0.1068 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.1094 | 0.1094 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0104 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0262 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.1094 | 0.1094 |
Loa Loa (eye worm) | carboxylesterase | 0.0262 | 0.1094 | 0.1094 |
Echinococcus granulosus | acetylcholinesterase | 0.1553 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0262 | 0.1094 | 0.1094 |
Echinococcus multilocularis | acetylcholinesterase | 0.1553 | 1 | 1 |
Onchocerca volvulus | 0.0262 | 0.1094 | 0.5 | |
Onchocerca volvulus | 0.0262 | 0.1094 | 0.5 | |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0258 | 0.1068 | 0.1068 |
Onchocerca volvulus | 0.0262 | 0.1094 | 0.5 | |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0258 | 0.1068 | 0.1068 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0262 | 0.1094 | 0.1094 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0262 | 0.1094 | 0.1094 |
Brugia malayi | Carboxylesterase family protein | 0.1553 | 1 | 1 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0258 | 0.1068 | 0.1068 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1553 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0262 | 0.1094 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 3.5 nM | Concentration needed to reduce 50% of farnesylation in NIH3T3 H-ras cell line | ChEMBL. | 12699757 |
EC50 (functional) | = 3.5 nM | Concentration needed to reduce 50% of farnesylation in NIH3T3 H-ras cell line | ChEMBL. | 12699757 |
IC50 (binding) | = 0.84 nM | Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase | ChEMBL. | 12699757 |
IC50 (binding) | = 0.84 nM | Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTase | ChEMBL. | 12699757 |
IC50 (binding) | > 10 nM | Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I | ChEMBL. | 12699757 |
IC50 (binding) | > 10 nM | Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine GGTase-I | ChEMBL. | 12699757 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 12699757 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.