Detailed information for compound 571056

Basic information

Technical information
  • TDR Targets ID: 571056
  • Name: benzoic acid; 1,3,7-trimethylpurine-2,6-dione
  • MW: 316.312 | Formula: C15H16N4O4
  • H donors: 1 H acceptors: 5 LogP: 1.02 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccccc1.Cn1cnc2c1c(=O)n(C)c(=O)n2C
  • InChi: 1S/C8H10N4O2.C7H6O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2;8-7(9)6-4-2-1-3-5-6/h4H,1-3H3;1-5H,(H,8,9)
  • InChiKey: VXXKVQICUHMECR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzoic acid; caffeine
  • caffeine benzoate
  • benzoic acid; 1,3,7-trimethylxanthine
  • EINECS 227-257-3

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0142 0.015
Loa Loa (eye worm) acetyltransferase 0.0156 0.4039 0.4263
Loa Loa (eye worm) hypothetical protein 0.0022 0.0185 0.0195
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0341 0.0251
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0185 0.0086
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0142 0.0058
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.3525 0.372
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0341 0.1858
Schistosoma mansoni hypothetical protein 0.005 0.1012 0.096
Onchocerca volvulus 0.0028 0.038 0.0209
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0142 0.0379
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.1012 0.0918
Loa Loa (eye worm) hypothetical protein 0.0094 0.2254 0.2378
Echinococcus multilocularis dual specificity 0.0094 0.2268 0.2187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0975 0.088
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.4287 0.4431
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0185 0.0195
Schistosoma mansoni thyroid hormone receptor 0.0156 0.4055 0.4177
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0966 0.0913
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.1012 0.0918
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.1012 0.0918
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0185 0.0195
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0185 0.0195
Loa Loa (eye worm) hypothetical protein 0.0022 0.0185 0.0195
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0879 0.7587
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0966 0.0913
Onchocerca volvulus 0.0053 0.109 0.0974
Loa Loa (eye worm) hypothetical protein 0.0022 0.0185 0.0195
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0185 0.0195
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.4287 0.4431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0185 0.0195
Echinococcus multilocularis tumor protein p63 0.0363 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.1012 0.1068
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0142 0.0041
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0185 0.0082
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.4039 0.4263
Brugia malayi hypothetical protein 0.0345 0.9476 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0401
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0094 0.2268 0.2292
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0185 0.0082
Loa Loa (eye worm) hypothetical protein 0.016 0.4144 0.4374
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0185 0.0082
Echinococcus granulosus lamin dm0 0.0028 0.038 0.0279
Schistosoma mansoni hypothetical protein 0.0135 0.3432 0.3518
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0185 0.0082
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0094 0.2268 0.2292
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0185 0.0086
Echinococcus multilocularis geminin 0.0348 0.9564 0.956
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0879 0.6078
Brugia malayi steroid hormone receptor 0.0022 0.0185 0.0195
Loa Loa (eye worm) hypothetical protein 0.0022 0.0185 0.0195
Onchocerca volvulus 0.025 0.6743 0.7059
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.1125 0.1187
Schistosoma mansoni hypothetical protein 0.005 0.1012 0.096
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.1125 0.1082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0467 0.0384
Loa Loa (eye worm) intermediate filament protein 0.0028 0.038 0.0401
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0142 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1379 0.2703
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.1012 0.1068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0185 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0185 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3525 0.3617
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.3914 0.385
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0975 0.088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0975 0.088
Schistosoma mansoni hypothetical protein 0.005 0.1012 0.096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0156 0.4055 0.3993
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1379 0.135
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0104 0.0109
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.2694 0.2844
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1379 0.1288
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0975 0.1029
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0341 0.232
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0341 0.232
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.038 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0185 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0975 0.0921
Schistosoma mansoni hypothetical protein 0.0348 0.9564 1
Echinococcus multilocularis lamin 0.0028 0.038 0.0279
Entamoeba histolytica hypothetical protein 0.0094 0.2268 1
Leishmania major hypothetical protein, conserved 0.0027 0.0341 0.0251
Onchocerca volvulus 0.0028 0.038 0.0209
Plasmodium vivax glutathione reductase, putative 0.0054 0.1125 1
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3525 0.3617
Echinococcus granulosus dual specificity 0.0094 0.2268 0.2187
Plasmodium falciparum glutathione reductase 0.0054 0.1125 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0142 0.0582
Toxoplasma gondii exonuclease III APE 0.002 0.0142 0.0304
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1379 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0185 0.0195
Toxoplasma gondii hypothetical protein 0.0056 0.1172 0.8382
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0185 0.0082
Schistosoma mansoni hypothetical protein 0.0348 0.9564 1
Echinococcus multilocularis tar DNA binding protein 0.0138 0.3525 0.3457
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0975 0.088
Schistosoma mansoni thyroid hormone receptor 0.0156 0.4055 0.4177
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0142 0.0082
Loa Loa (eye worm) hypothetical protein 0.0094 0.2254 0.2378
Brugia malayi Pre-SET motif family protein 0.0032 0.0467 0.0493
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0341 0.232
Echinococcus multilocularis musashi 0.0028 0.038 0.0279
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0094 0.2268 0.2393
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0142 0.0041
Echinococcus multilocularis lamin dm0 0.0028 0.038 0.0279
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.3526 0.7254
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0185 0.0082
Loa Loa (eye worm) glutathione reductase 0.0054 0.1125 0.1187
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0769 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0185 0.0195
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.3526 0.7254
Brugia malayi ecdysteroid receptor 0.0022 0.0185 0.0195
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0142 0.0039
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1379 0.1288
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.1125 0.1032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0467 0.2849
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.4287 0.4431
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.9546 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.3128 0.6411
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0104 0.5
Brugia malayi intermediate filament protein 0.0028 0.038 0.0401
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.3526 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0467 0.0384
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0185 0.0195
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0879 0.1167
Brugia malayi hypothetical protein 0.0027 0.0341 0.036
Brugia malayi Pre-SET motif family protein 0.022 0.5871 0.6196
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.1125 0.2165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0185 0.0195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0467 0.0384
Trypanosoma brucei trypanothione reductase 0.0054 0.1125 0.1082
Schistosoma mansoni lamin 0.0028 0.038 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0185 0.0195
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.4039 0.416
Loa Loa (eye worm) hypothetical protein 0.0028 0.0365 0.0385
Brugia malayi nuclear hormone receptor 0.0022 0.0185 0.0195
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0142 0.0379
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3525 0.3617
Brugia malayi Latrophilin receptor protein 2 0.005 0.1012 0.1068
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0135 0.3432 0.3364
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0185 0.0086
Plasmodium vivax SET domain protein, putative 0.0032 0.0467 0.3556
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0185 0.0082
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1379 0.1348
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.2268 0.2292
Echinococcus granulosus geminin 0.0348 0.9564 0.956
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0341 0.0251
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0185 0.0082
Loa Loa (eye worm) hypothetical protein 0.0109 0.2694 0.2844
Toxoplasma gondii thioredoxin reductase 0.0054 0.1125 0.8012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0185 0.0195
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.2268 0.2292
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.1273 0.1238
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.1012 0.1068
Loa Loa (eye worm) hypothetical protein 0.0032 0.0467 0.0493
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0185 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0185 0.0082
Schistosoma mansoni hypothetical protein 0.0109 0.2694 0.2738
Brugia malayi nuclear receptor NHR-88 0.0022 0.0185 0.0195
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0879 0.0783
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0185 0.0195
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0966 0.0913
Schistosoma mansoni intermediate filament proteins 0.0028 0.038 0.0292
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0341 0.0251
Brugia malayi RNA binding protein 0.0138 0.3525 0.372
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0185 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0142 0.0041
Echinococcus granulosus GPCR family 2 0.005 0.1012 0.0918
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.1012 0.0918
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.3526 0.7254
Loa Loa (eye worm) hypothetical protein 0.0022 0.0185 0.0195
Loa Loa (eye worm) RNA binding protein 0.0138 0.3525 0.372
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0185 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0975 0.0921
Loa Loa (eye worm) hypothetical protein 0.0053 0.109 0.115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0185 0.0195
Brugia malayi Calcitonin receptor-like protein seb-1 0.016 0.4144 0.4374
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0185 0.0082
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0185 0.0086
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.3128 0.6411
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0142 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1379 0.1348
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0467 0.0367
Schistosoma mansoni ap endonuclease 0.002 0.0142 0.0041
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0142 1
Echinococcus granulosus lamin 0.0028 0.038 0.0279
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0142 0.0039
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.4039 0.3977
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0185 0.0195
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0185 0.0195
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0185 0.0082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0185 0.0195
Mycobacterium ulcerans hypothetical protein 0.0183 0.4821 1
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.9546 1
Brugia malayi TAR-binding protein 0.0138 0.3525 0.372
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0185 0.0082
Echinococcus granulosus intermediate filament protein 0.0028 0.038 0.0279
Loa Loa (eye worm) hypothetical protein 0.0345 0.9476 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0975 0.0921
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0467 0.0384
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.3128 0.6411
Schistosoma mansoni ap endonuclease 0.002 0.0142 0.0041
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.5871 0.6196
Schistosoma mansoni lamin 0.0028 0.038 0.0292
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.3525 0.372
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.2268 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0434 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0185 0.0195
Brugia malayi glutathione reductase 0.0054 0.1125 0.1187
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.3128 0.6411
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0185 0.0086
Schistosoma mansoni coup transcription factor 0.0022 0.0185 0.0086
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0185 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.2268 0.2287
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3525 0.3617
Plasmodium falciparum thioredoxin reductase 0.0054 0.1125 1
Brugia malayi Protein kinase domain containing protein 0.0094 0.2268 0.2393
Onchocerca volvulus 0.0345 0.9476 1
Schistosoma mansoni tar DNA-binding protein 0.0138 0.3525 0.3617
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0142 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0185 0.0195
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0467 0.0367
Onchocerca volvulus 0.0032 0.0467 0.0304
Leishmania major trypanothione reductase 0.0054 0.1125 0.1082
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.9546 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0769 0.6513
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0185 0.0195
Loa Loa (eye worm) hypothetical protein 0.0027 0.0341 0.036
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.1125 0.1032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0185 0.0086
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0879 0.1167
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0185 0.0086
Brugia malayi Thioredoxin reductase 0.0054 0.1125 0.1187
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0966 0.0913
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1379 0.2703
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0142 0.0082
Schistosoma mansoni hypothetical protein 0.005 0.1012 0.096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1379 0.2703
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0975 0.1029
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.3128 0.6411
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.038 0.0401
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0135 0.3432 0.3364
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0185 0.0195
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.1125 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0185 0.0086
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.9546 1
Mycobacterium tuberculosis Probable reductase 0.0124 0.3128 0.6411
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0185 0.0195
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0769 0.2948
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0185 0.0195
Echinococcus granulosus tar DNA binding protein 0.0138 0.3525 0.3457
Entamoeba histolytica protein kinase, putative 0.0094 0.2268 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1379 0.2703
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.4821 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0185 0.0195
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.016 0.4144 0.4374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0185 0.0195
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0185 0.0195
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0467 0.0367
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0142 0.015
Brugia malayi hypothetical protein 0.0018 0.0065 0.0068
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0185 0.0082
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0185 0.0082
Trichomonas vaginalis set domain proteins, putative 0.025 0.6743 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0879 0.6078
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.109 0.1042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.016 0.4144 0.4374
Echinococcus multilocularis GPCR, family 2 0.005 0.1012 0.0918
Entamoeba histolytica protein kinase, putative 0.0094 0.2268 1
Loa Loa (eye worm) TAR-binding protein 0.0138 0.3525 0.372

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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