TDR Targets

Basic information

Technical information

TDR Targets ID: 57133
Name: 5-ethoxy-N-pyridin-3-yl-6-(trifluoromethyl)-2 ,3-dihydroindole-1-carboxamide
MW: 351.323 | Formula: C17H16F3N3O2
H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1
InChi: 1S/C17H16F3N3O2/c1-2-25-15-8-11-5-7-23(14(11)9-13(15)17(18,19)20)16(24)22-12-4-3-6-21-10-12/h3-4,6,8-10H,2,5,7H2,1H3,(H,22,24)
InChiKey: LVJUXRYTNUQELA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-ethoxy-N-(3-pyridyl)-6-(trifluoromethyl)indoline-1-carboxamide
5-ethoxy-N-(3-pyridyl)-6-(trifluoromethyl)-1-indolinecarboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Serotonin receptor	Get druggable targets OG5_135430	All targets in OG5_135430

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Leishmania major	adenine aminohydrolase	0.0268	0.2688	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.1757	0.1757
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Trypanosoma cruzi	AMP deaminase 2, putative	0.0087	0.0761	0.5
Onchocerca volvulus	Peroxidase homolog	0.0954	0.9999	0.9999
Loa Loa (eye worm)	animal heme peroxidase	0.0954	0.9999	0.9999
Onchocerca volvulus		0.0087	0.0761	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Schistosoma mansoni	lamin	0.003	0.0148	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Onchocerca volvulus		0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Brugia malayi	Dopamine receptor	0.0017	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Schistosoma mansoni	adenosine deaminase-related	0.0268	0.2688	0.2684
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.0268	0.2688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	melatonin receptor type 1A	0.0017	0.0005	0.0005
Brugia malayi	G-protein coupled receptor	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Brugia malayi	Animal haem peroxidase family protein	0.0954	0.9999	0.9999
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0017	0.0005	0.0005
Trypanosoma brucei	AMP deaminase, putative	0.0087	0.0761	0.5
Loa Loa (eye worm)	AMP deaminase	0.0087	0.0761	0.0761
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2688	0.2688
Brugia malayi	sulfakinin receptor protein	0.0017	0.0005	0.0005
Echinococcus multilocularis	geminin	0.0188	0.1828	0.1824
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0254	0.0249
Brugia malayi	Animal haem peroxidase family protein	0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Echinococcus granulosus	peroxidasin	0.0955	1	1
Plasmodium falciparum	adenosine deaminase	0.0268	0.2688	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Schistosoma mansoni	AMP deaminase	0.0087	0.0761	0.0756
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0268	0.2688	1
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Brugia malayi	G-protein coupled receptor	0.0017	0.0005	0.0005
Trichomonas vaginalis	adenosine deaminase, putative	0.0268	0.2688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Onchocerca volvulus	Peroxidasin homolog	0.0954	0.9999	0.9999
Brugia malayi	neuropeptide F receptor	0.0017	0.0005	0.0005
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.0087	0.0761	0.5
Onchocerca volvulus		0.003	0.0148	0.0142
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0017	0.0005	0.0005
Entamoeba histolytica	adenosine deaminase, putative	0.0268	0.2688	1
Brugia malayi	Adenosine/AMP deaminase family protein	0.0268	0.2688	0.2688
Brugia malayi	RE15519p	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Echinococcus granulosus	hypothetical protein	0.085	0.8885	0.8884
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.0087	0.0761	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0254	0.0249
Onchocerca volvulus		0.0954	0.9999	0.9999
Echinococcus multilocularis	lamin	0.003	0.0148	0.0142
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0017	0.0005	0.0005
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.0268	0.2688	0.5
Brugia malayi	adenosine monophosphate deaminase	0.0087	0.0761	0.0761
Brugia malayi	neuropeptide F receptor	0.0017	0.0005	0.0005
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0005	0.0005
Brugia malayi	follicle stimulating hormone receptor	0.0017	0.0005	0.0005
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Entamoeba histolytica	AMP deaminase, putative	0.0087	0.0761	0.2082
Loa Loa (eye worm)	hypothetical protein	0.003	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Trypanosoma brucei	AMP deaminase, putative	0.0087	0.0761	0.5
Brugia malayi	hypothetical protein	0.0954	0.9999	0.9999
Brugia malayi	Dopamine receptor protein 2	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0017	0.0005	0.0005
Onchocerca volvulus		0.0954	0.9999	0.9999
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0017	0.0005	0.0005
Plasmodium vivax	adenosine deaminase, putative	0.0268	0.2688	1
Brugia malayi	Animal haem peroxidase family protein	0.0954	0.9999	0.9999
Entamoeba histolytica	adenosine deaminase, putative	0.0268	0.2688	1
Schistosoma mansoni	peroxidasin	0.0955	1	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0761	0.0761
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0254	0.0249
Entamoeba histolytica	AMP deaminase, putative	0.0087	0.0761	0.2082
Trypanosoma cruzi	AMP deaminase, putative	0.0087	0.0761	0.5
Echinococcus granulosus	geminin	0.0188	0.1828	0.1824
Echinococcus granulosus	adenosine deaminase	0.0268	0.2688	0.2684
Brugia malayi	hypothetical protein	0.004	0.0254	0.0254
Schistosoma mansoni	amine GPCR	0.0383	0.3912	0.3909
Schistosoma mansoni	hypothetical protein	0.0188	0.1828	0.1824
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0148	0.0148
Schistosoma mansoni	hypothetical protein	0.0057	0.044	0.0434
Treponema pallidum	adenosine deaminase	0.0268	0.2688	0.5
Brugia malayi	AKH receptor	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0181	0.1757	0.1757
Brugia malayi	GnHR receptor homolog	0.0017	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0181	0.1757	0.1757
Echinococcus multilocularis	peroxidasin	0.0955	1	1
Brugia malayi	putative neuropeptide receptor	0.0017	0.0005	0.0005
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Echinococcus multilocularis	conserved hypothetical protein	0.0833	0.8709	0.8708
Brugia malayi	ORL1-like opioid receptor	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Onchocerca volvulus	Dual oxidase homolog	0.0954	0.9999	0.9999
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0017	0.0005	0.0005
Brugia malayi	Melatonin receptor type 1A	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Mycobacterium ulcerans	adenosine deaminase	0.0268	0.2688	0.5
Onchocerca volvulus	AMP deaminase 2 homolog	0.0087	0.0761	0.0756
Echinococcus multilocularis	adenosine deaminase	0.0268	0.2688	0.2684
Trypanosoma brucei	AMP deaminase, putative	0.0087	0.0761	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	neuropeptide F receptor	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Onchocerca volvulus	Peroxidase homolog	0.0954	0.9999	0.9999
Brugia malayi	Animal haem peroxidase family protein	0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0955	1	1
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0005	0.0005
Brugia malayi	Serotonin receptor	0.0572	0.5925	0.5925
Schistosoma mansoni	peroxidasin	0.0954	0.9999	0.9999
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Trypanosoma cruzi	AMP deaminase, putative	0.0087	0.0761	0.5
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Brugia malayi	G protein-coupled receptor F59B2.13	0.0017	0.0005	0.0005
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Schistosoma mansoni	hypothetical protein	0.004	0.0254	0.0249
Brugia malayi	intermediate filament protein	0.003	0.0148	0.0148
Echinococcus multilocularis	AMP deaminase 2	0.0087	0.0761	0.0756
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Brugia malayi	Blistered cuticle protein 3	0.0954	0.9999	0.9999
Brugia malayi	larval opioid receptor	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.0087	0.0761	0.5
Trypanosoma cruzi	AMP deaminase, putative	0.0087	0.0761	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Trichomonas vaginalis	adenosine deaminase, putative	0.0268	0.2688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Schistosoma mansoni	adenosine deaminase	0.0268	0.2688	0.2684
Brugia malayi	G protein-coupled receptor	0.0017	0.0005	0.0005
Loa Loa (eye worm)	blistered cuticle protein 3	0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Brugia malayi	Serotonin receptor	0.0017	0.0005	0.0005
Schistosoma mansoni	lamin	0.003	0.0148	0.0142
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0017	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Trypanosoma cruzi	AMP deaminase, putative	0.0087	0.0761	0.5
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Onchocerca volvulus	Chorion peroxidase homolog	0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Onchocerca volvulus	Peroxidasin homolog	0.0955	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Brugia malayi	Animal haem peroxidase family protein	0.0954	0.9999	0.9999
Loa Loa (eye worm)	animal heme peroxidase	0.0954	0.9999	0.9999
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0268	0.2688	1
Echinococcus granulosus	intermediate filament protein	0.003	0.0148	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Echinococcus granulosus	lamin	0.003	0.0148	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Echinococcus granulosus	lamin dm0	0.003	0.0148	0.0142
Brugia malayi	Dopamine receptor protein 1	0.0017	0.0005	0.0005
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	G-protein coupled receptor	0.0017	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0188	0.1828	0.1824
Onchocerca volvulus	Adenosine deaminase homolog	0.0268	0.2688	0.2684
Trypanosoma cruzi	AMP deaminase, putative	0.0087	0.0761	0.5
Echinococcus multilocularis	musashi	0.003	0.0148	0.0142
Brugia malayi	putative neuropeptide receptor NPR1	0.0017	0.0005	0.0005
Echinococcus multilocularis	lamin dm0	0.003	0.0148	0.0142
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0017	0.0005	0.0005
Onchocerca volvulus		0.003	0.0148	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0954	0.9999	0.9999
Brugia malayi	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0181	0.1757	0.1757
Echinococcus granulosus	AMP deaminase 2	0.0087	0.0761	0.0756
Schistosoma mansoni	intermediate filament proteins	0.003	0.0148	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Loa Loa (eye worm)	animal heme peroxidase	0.0954	0.9999	0.9999

Activities

Activity type	Activity value	Assay description	Source	Reference
Change (functional)	= 0 %	Percentage change unpunished lever presses from mean score on 6-8 rats at 5 mg/kg po1h pretest	ChEMBL.	9572885
Change (functional)	= 1 %	Percentage change unpunished lever presses from mean score on 6-8 rats at 2 mg/kg po1h pretest	ChEMBL.	9572885
Change (functional)	= 3 %	Percentage change unpunished lever presses from mean score on 6-8 rats at 0.2 mg/kg po1h pretest	ChEMBL.	9572885
Change (functional)	= 3 %	Percentage change unpunished lever presses from mean score on 6-8 rats at 0.5 mg/kg po1h pretest	ChEMBL.	9572885
Change (functional)	= 4 %	Percentage change unpunished lever presses from mean score on 6-8 rats at 1 mg/kg po1h pretest	ChEMBL.	9572885
Change (functional)	= 5 %	Percentage change punished lever presses from mean score on 6-8 rats at 0.2 mg/kg po1h pretest	ChEMBL.	9572885
Change (functional)	= 24 %	Percentage change punished lever presses from mean score on 6-8 rats(P<0.001) at 2 mg/kg po1h pretest	ChEMBL.	9572885
Change (functional)	= 31 %	Percentage change punished lever presses from mean score on 6-8 rats(P<0.001) at 0.5 mg/kg po1h pretest	ChEMBL.	9572885
Change (functional)	= 31 %	Percentage change punished lever presses from mean score on 6-8 rats(P<0.001) at 5 mg/kg po1h pretest	ChEMBL.	9572885
Change (functional)	= 33 %	Percentage change punished lever presses from mean score on 6-8 rats(P<0.001) at 1 mg/kg po1h pretest	ChEMBL.	9572885
ID50 (functional)	= 1 mg kg-1	The dose required to reverse mCPP (7 mg/kg ip administration 30 min pretest)- induced hypolocomotion in rat by 50 %	ChEMBL.	9572885
Ki (binding)	= -8.2	Binding affinity towards cloned human 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells using [3H]-mesulergine as radioligand	ChEMBL.	9572885
Ki (binding)	= -5.8	Binding affinity towards human 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells using [3H]-ketanserin as radioligand	ChEMBL.	9572885
Log Ki (binding)	= 5.8	Binding affinity towards human 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells using [3H]-ketanserin as radioligand	ChEMBL.	9572885
Log Ki (binding)	= 8.2	Binding affinity towards cloned human 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells using [3H]-mesulergine as radioligand	ChEMBL.	9572885
Selectivity (binding)	= 275	Selectivity is the ratio of binding affinity against human 5-HT2C receptor to 5-HT2A receptor expressed in HEK 293 cells	ChEMBL.	9572885

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL41510
PubChem: 10498110

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 57133