Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0012 | 0.0035 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0022 | 0.0064 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.003 | 0.0155 | 0.0414 |
Brugia malayi | Cation transporter family protein | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | ACC-1 protein | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.0603 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.003 | 0.0155 | 0.0149 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.003 | 0.0155 | 0.0149 |
Echinococcus granulosus | smad | 0.0018 | 0.0012 | 0.0015 |
Schistosoma mansoni | smad | 0.0018 | 0.0012 | 0.0035 |
Brugia malayi | MH2 domain containing protein | 0.0262 | 0.2806 | 0.7785 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.3602 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0319 | 0.3452 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0271 | 0.2902 | 0.8053 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.003 | 0.0155 | 0.0368 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0054 | 0.0048 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.003 | 0.0155 | 0.0414 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0012 | 0.0017 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0236 | 0.064 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.003 | 0.0155 | 0.0368 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0262 | 0.2806 | 0.7785 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0169 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0236 | 0.0684 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.003 | 0.0155 | 0.0414 |
Echinococcus granulosus | glycine receptor subunit beta | 0.003 | 0.0155 | 0.0368 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.0558 | 0.0552 |
Schistosoma mansoni | Smad4 | 0.0018 | 0.0012 | 0.0035 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0.0155 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0397 | 0.1088 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.0558 | 0.1364 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.003 | 0.0155 | 0.0414 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0012 | 0.0017 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.006 | 0.049 | 0.1196 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0125 | 0.033 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.006 | 0.049 | 0.1196 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0183 | 0.053 |
Echinococcus multilocularis | Smad4 | 0.0018 | 0.0012 | 0.0006 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0125 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.003 | 0.0155 | 0.0368 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0006 | 0.0017 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.003 | 0.0155 | 0.0149 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0012 | 0.0017 |
Loa Loa (eye worm) | ACC-1 protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0018 | 0.0012 | 0.0015 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0052 | 0.0407 | 0.1116 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0.0155 | 0.0449 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0052 | 0.0397 | 0.0392 |
Brugia malayi | hypothetical protein | 0.0332 | 0.3602 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0052 | 0.0407 | 0.0402 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.003 | 0.0155 | 0.0368 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0052 | 0.0407 | 0.118 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0052 | 0.0407 | 0.0991 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.2424 | 0.6723 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0.0155 | 0.0449 |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.2785 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.003 | 0.0155 | 0.0368 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0207 | 0.217 | 0.2166 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0.0155 | 0.0449 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0183 | 0.0177 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0434 | 0.1191 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0259 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Onchocerca volvulus | 0.0332 | 0.3602 | 1 | |
Echinococcus granulosus | nAChR subunit | 0.003 | 0.0155 | 0.0368 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.003 | 0.0155 | 0.0149 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.006 | 0.049 | 0.0485 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0262 | 0.2806 | 0.7785 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.003 | 0.0155 | 0.0149 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.003 | 0.0066 |
Onchocerca volvulus | 0.0033 | 0.0183 | 0.0081 | |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0183 | 0.0492 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0407 | 0.1116 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.003 | 0.0155 | 0.0368 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.0022 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0697 | 0.1921 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.003 | 0.0155 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.032 | 0.0873 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.006 | 0.049 | 0.142 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.006 | 0.049 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0407 | 0.1116 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0091 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0236 | 0.064 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0012 | 0.0035 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.003 | 0.0155 | 0.0449 |
Onchocerca volvulus | 0.0261 | 0.2785 | 0.763 | |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0006 | 0.0017 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0.0155 | 0.0449 |
Echinococcus granulosus | glycine receptor subunit beta | 0.003 | 0.0155 | 0.0368 |
Brugia malayi | Cation transporter family protein | 0.003 | 0.0155 | 0.0414 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0052 | 0.0407 | 0.0732 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0125 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.003 | 0.0155 | 0.0149 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.003 | 0.0155 | 0.0149 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0052 | 0.0407 | 0.0991 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0125 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0018 | 0.0012 | 0.0015 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0091 | 0.021 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0018 | 0.0012 | 0.0017 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.003 | 0.0155 | 0.0368 |
Brugia malayi | Smad1 | 0.0018 | 0.0012 | 0.0017 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0012 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0429 | 0.1177 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0018 | 0.0012 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0344 | 0.0939 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0121 | 0.0319 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.003 | 0.0155 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0125 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.2902 | 0.8053 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0434 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.003 | 0.0155 | 0.0149 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.003 | 0.0155 | 0.0414 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.003 | 0.0155 | 0.0414 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.003 | 0.0155 | 0.0149 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0091 | 0.0085 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0052 | 0.0407 | 0.0402 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.003 | 0.0155 | 0.0449 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0052 | 0.0397 | 0.0966 |
Loa Loa (eye worm) | LGC-31 protein | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus granulosus | Smad4 | 0.0018 | 0.0012 | 0.0015 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0207 | 0.217 | 0.5346 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0054 | 0.0118 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0183 | 0.053 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0125 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.075 | 0.207 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0183 | 1 |
Onchocerca volvulus | 0.0054 | 0.0429 | 0.0796 | |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.003 | 0.0155 | 0.0368 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0407 | 0.118 |
Echinococcus granulosus | tumor protein p63 | 0.0372 | 0.4055 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.003 | 0.0155 | 0.0149 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus multilocularis | smad | 0.0018 | 0.0012 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.003 | 0.0155 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.003 | 0.0155 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.003 | 0.0155 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0054 | 0.0156 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0006 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.003 | 0.0155 | 0.0368 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0183 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0012 | 0.0017 |
Onchocerca volvulus | 0.0052 | 0.0407 | 0.0732 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0259 | 0.0626 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.003 | 0.0155 | 0.0414 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.003 | 0.0155 | 0.0414 |
Echinococcus multilocularis | tumor protein p63 | 0.0372 | 0.4055 | 0.4051 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0018 | 0.0012 | 0.0006 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0022 | 0.0064 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.0022 | 0.004 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0067 | 0.0194 |
Loa Loa (eye worm) | MBCTL1 | 0.006 | 0.049 | 0.1347 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0067 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.0397 | 0.1151 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0052 | 0.0407 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.003 | 0.0155 | 0.0449 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0012 | 0.0035 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.006 | 0.049 | 0.1347 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0155 | 0.0414 |
Brugia malayi | mbt repeat family protein | 0.0052 | 0.0407 | 0.1116 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0429 | 0.1244 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0289 | 0.0787 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.029 | 0.079 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.003 | 0.0155 | 0.0414 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0.0155 | 0.0449 |
Schistosoma mansoni | nAChR subunit | 0.003 | 0.0155 | 0.0449 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.003 | 0.0155 | 0.0414 |
Loa Loa (eye worm) | Smad1 | 0.0018 | 0.0012 | 0.0017 |
Echinococcus multilocularis | nAChR subunit | 0.003 | 0.0155 | 0.0149 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0006 | 0.0017 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0018 | 0.0012 | 0.0017 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.2424 | 0.6723 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0434 | 0.1191 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0018 | 0.0012 | 0.0035 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.003 | 0.0155 | 0.0449 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.003 | 0.0155 | 0.0414 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0434 | 0.1191 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.0397 | 0.1151 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0125 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.049 | 0.1347 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.003 | 0.0155 | 0.0368 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0125 | 1 |
Brugia malayi | Cation transporter family protein | 0.003 | 0.0155 | 0.0414 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.