Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.000918329 | 0.00970037 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0187448 | 1 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.000918329 | 0.00970037 | 1 |
Onchocerca volvulus | 0.000918329 | 0.00970037 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.000918329 | 0.00970037 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.000918329 | 0.00970037 | 1 |
Leishmania major | oxidoreductase-like protein | 0.000918329 | 0.00970037 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0187448 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0187448 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0187448 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0187448 | 1 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.000918329 | 0.00970037 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0187448 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.000918329 | 0.00970037 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.000918329 | 0.00970037 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0187448 | 1 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.000918329 | 0.00970037 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.000918329 | 0.00970037 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0187448 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.000918329 | 0.00970037 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.000918329 | 0.00970037 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.000918329 | 0.00970037 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.000918329 | 0.00970037 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.000918329 | 0.00970037 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.000918329 | 0.00970037 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0187448 | 1 | 1 |
Onchocerca volvulus | 0.000918329 | 0.00970037 | 1 | |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.000918329 | 0.00970037 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.000918329 | 0.00970037 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.000918329 | 0.00970037 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.000918329 | 0.00970037 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.000918329 | 0.00970037 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.000918329 | 0.00970037 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1240 ng/ml | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 as [3H]hypoxanthine uptake | ChEMBL. | 8786363 |
IC50 (functional) | = 1680 ng/ml | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 as [3H]hypoxanthine uptake | ChEMBL. | 8786363 |
IC50 (binding) | = 2500 nM | Displacement of [3H]SCH23390 from rat dopamine D1 receptor | ChEMBL. | 17228858 |
IC50 (binding) | = 6800 nM | Displacement of [3H]raclopride from rat dopamine D2 receptor | ChEMBL. | 17228858 |
IC50 (binding) | = 16500 nM | Displacement of [3H]DA from rat DAT | ChEMBL. | 17228858 |
IC50 (binding) | = 16.5 uM | Inhibition of dopamine transporter-mediated [3H]dopamine uptake in Wistar rat striatal synaptosomes by liquid scintillation spectrometry | ChEMBL. | 8676127 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 8786363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.