Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Onchocerca volvulus | 0.0154 | 0.6611 | 1 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.095 | 0.1002 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0101 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0225 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0606 | 0.0545 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1713 | 0.1806 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.1766 | 0.1713 |
Brugia malayi | hypothetical protein | 0.0154 | 0.6611 | 0.6972 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.9481 | 0.9478 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.4083 | 0.4307 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.9481 | 0.9478 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.4083 | 0.4307 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7498 | 0.7482 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4083 | 0.4083 |
Schistosoma mansoni | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.7498 | 0.7482 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0064 | 0.0064 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.1766 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0606 | 0.0545 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1713 | 0.1806 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.4083 | 0.4307 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.4083 | 0.4045 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.6611 | 0.6611 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.9481 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.9481 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.4083 | 0.4307 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.4083 | 0.4045 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.095 | 0.095 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0225 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.1766 | 0.1713 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.9481 | 0.9481 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0225 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4083 | 0.4083 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.9481 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.4083 | 0.4045 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1713 | 0.1713 |
Schistosoma mansoni | lamin | 0.0027 | 0.0606 | 0.0545 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.9481 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.1766 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.1766 | 0.1863 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.095 | 0.0891 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0.4083 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.1766 | 0.1713 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0064 | 0.0064 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.9481 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0606 | 0.0545 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0064 | 0.0068 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.9481 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.1766 | 0.1713 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0606 | 0.0545 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0606 | 0.0606 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.4083 | 0.4045 |
Echinococcus multilocularis | geminin | 0.0173 | 0.7498 | 0.7482 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.4083 | 0.4045 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.4083 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.9481 | 0.9478 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0606 | 0.0639 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0606 | 0.0545 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.1766 | 0.1713 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.1766 | 0.1766 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0606 | 0.0545 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0606 | 0.0606 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.4083 | 0.4307 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0606 | 0.0545 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4083 | 0.4083 |
Brugia malayi | hypothetical protein | 0.0104 | 0.422 | 0.4451 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0064 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1713 | 0.1713 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0606 | 0.0639 |
Echinococcus granulosus | geminin | 0.0173 | 0.7498 | 0.7482 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.9481 | 0.9478 |
Schistosoma mansoni | lamin | 0.0027 | 0.0606 | 0.0545 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0606 | 0.0606 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.9481 | 0.9481 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.8 nM | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | ChEMBL. | 12039560 |
Ki (binding) | = 9 nM | Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes | ChEMBL. | 12039560 |
Ki (binding) | = 48 nM | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | ChEMBL. | 12039560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.