Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0017 | 0.4794 | 0.5556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0009 | 0.0513 | 0.0513 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0017 | 0.4794 | 0.4794 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0017 | 0.4794 | 0.4794 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.4794 | 0.4794 |
Schistosoma mansoni | flap endonuclease-1 | 0.0024 | 0.8628 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0017 | 0.4794 | 0.4794 |
Onchocerca volvulus | 0.0017 | 0.4794 | 1 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0017 | 0.4794 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.4794 | 0.4794 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0017 | 0.4794 | 0.5556 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0017 | 0.4794 | 0.4794 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0017 | 0.4794 | 0.4794 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.4794 | 0.5556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0017 | 0.4794 | 0.4794 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.4794 | 0.4794 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0017 | 0.4794 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0017 | 0.4794 | 0.5556 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0009 | 0.0513 | 0.0595 |
Brugia malayi | ecdysteroid receptor | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0513 | 0.0513 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.4794 | 0.4794 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.4794 | 0.5556 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4794 | 0.4794 |
Plasmodium falciparum | flap endonuclease 1 | 0.0027 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4794 | 0.4794 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0017 | 0.4794 | 0.4794 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.4794 | 0.5556 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0027 | 1 | 0.5 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0027 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0009 | 0.0513 | 0.0513 |
Echinococcus granulosus | FTZ F1 alpha | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0017 | 0.4794 | 0.4794 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0009 | 0.0513 | 0.0513 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0017 | 0.4794 | 0.4794 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0017 | 0.4794 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.4794 | 0.4794 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0027 | 1 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0017 | 0.4794 | 0.4794 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0513 | 0.0513 |
Entamoeba histolytica | Flap nuclease, putative | 0.0027 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | nuclear receptor NHR-88 | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0017 | 0.4794 | 0.4794 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.0513 | 0.0513 |
Schistosoma mansoni | nuclear hormone receptor | 0.0017 | 0.4794 | 0.5556 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0513 | 0.0513 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.0513 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0513 | 0.0513 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4794 | 0.4794 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0017 | 0.4794 | 0.4794 |
Schistosoma mansoni | coup transcription factor | 0.0017 | 0.4794 | 0.5556 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0017 | 0.4794 | 0.5556 |
Echinococcus granulosus | flap endonuclease 1 | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4794 | 0.4794 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.4794 | 0.4794 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.4794 | 0.4794 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.4794 | 0.4794 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0.0513 | 0.0595 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0513 | 0.0513 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0017 | 0.4794 | 0.5556 |
Brugia malayi | nuclear receptor RXR | 0.0009 | 0.0513 | 0.0513 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0513 | 0.0513 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0017 | 0.4794 | 0.5556 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0017 | 0.4794 | 0.5556 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0027 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | steroid hormone receptor | 0.0017 | 0.4794 | 0.4794 |
Brugia malayi | nuclear hormone receptor | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0513 | 0.0513 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0017 | 0.4794 | 0.5556 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0017 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.4794 | 0.4794 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0027 | 1 | 0.5 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0027 | 1 | 1 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0027 | 1 | 0.5 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0027 | 1 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0027 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.4794 | 0.4794 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.