Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0681 | 0.2423 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0066 | 0.0657 | 0.1041 |
Echinococcus granulosus | zinc finger protein | 0.0043 | 0.0193 | 0.0205 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2809 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0103 | 0.1426 | 0.2428 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0066 | 0.0657 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0122 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1234 | 0.1312 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0122 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0122 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0122 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.0657 | 0.2338 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.0681 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.5628 | 0.6424 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1041 | 0.1087 |
Echinococcus multilocularis | geminin | 0.0171 | 0.2809 | 0.492 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.0681 | 0.1084 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0241 | 0.0857 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0122 | 0.0018 |
Plasmodium vivax | SET domain protein, putative | 0.0066 | 0.0657 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0122 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.1038 | 0.1068 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0103 | 0.1426 | 0.5078 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0122 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0122 | 0.0018 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0681 | 0.2423 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0122 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.5628 | 0.6424 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0122 | 0.0018 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.005 | 0.0327 | 0.0447 |
Echinococcus granulosus | muscleblind protein | 0.0308 | 0.5628 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0131 | 0.2004 | 0.3469 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0122 | 0.0018 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0122 | 0.0077 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0122 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.0681 | 0.1084 |
Schistosoma mansoni | bromodomain containing protein | 0.0139 | 0.2165 | 0.7708 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0253 | 0.45 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0066 | 0.0657 | 0.0623 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0122 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0681 | 0.2423 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0122 | 0.0434 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.005 | 0.0327 | 0.1164 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0079 | 0.0931 | 0.1535 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.0681 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0122 | 0.0018 |
Echinococcus granulosus | geminin | 0.0171 | 0.2809 | 0.492 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.2501 | 0.2786 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0079 | 0.0931 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1426 | 0.1535 |
Schistosoma mansoni | lipoxygenase | 0.0091 | 0.1172 | 0.4172 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2809 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0681 | 0.2423 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0122 | 0.0018 |
Onchocerca volvulus | 0.0066 | 0.0657 | 0.0541 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0122 | 0.0018 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0131 | 0.2004 | 0.3469 |
Brugia malayi | PHD-finger family protein | 0.0055 | 0.0434 | 0.0363 |
Schistosoma mansoni | zinc finger protein | 0.0043 | 0.0193 | 0.0687 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0103 | 0.1426 | 0.5078 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.013 | 0.1974 | 0.3414 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0066 | 0.0657 | 0.2338 |
Schistosoma mansoni | lipoxygenase | 0.013 | 0.1974 | 0.7025 |
Brugia malayi | Muscleblind-like protein | 0.0308 | 0.5628 | 0.6417 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0038 | 0.0079 | 0.0282 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.0681 | 0.0651 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1148 | 0.1211 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0122 | 0.0077 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0045 | 0.0241 | 0.0156 |
Brugia malayi | Pre-SET motif family protein | 0.0458 | 0.8702 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0103 | 0.1426 | 0.2428 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0458 | 0.8702 | 1 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0122 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0063 | 0.0607 | 0.0952 |
Trichomonas vaginalis | set domain proteins, putative | 0.0521 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0308 | 0.5628 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.013 | 0.1974 | 0.3414 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.005 | 0.0327 | 0.0447 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.0681 | 0.0651 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0681 | 0.2423 |
Echinococcus multilocularis | zinc finger protein | 0.0043 | 0.0193 | 0.0205 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0122 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0308 | 0.5628 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0165 | 0.2694 | 0.2998 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.0681 | 0.0668 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0038 | 0.0079 | 0.0282 |
Brugia malayi | RNA binding protein | 0.0067 | 0.0681 | 0.0651 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.