Detailed information for compound 572920

Basic information

Technical information
  • TDR Targets ID: 572920
  • Name: 6-methylchromene-2-thione
  • MW: 176.235 | Formula: C10H8OS
  • H donors: 0 H acceptors: 0 LogP: 2.87 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)ccc(=S)o2
  • InChi: 1S/C10H8OS/c1-7-2-4-9-8(6-7)3-5-10(12)11-9/h2-6H,1H3
  • InChiKey: SSRXJDKHMCDORD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methyl-1-benzopyran-2-thione
  • 6-methylthionecoumarin
  • 6-methyl-2-chromenethione
  • 60257-28-5
  • 2H-1-Benzopyran-2-thione, 6-methyl-
  • 6-MTC

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0028 0.011 0.0293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0273 0.0273
Entamoeba histolytica hypothetical protein 0.0072 0.0695 0.1653
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0048 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0273 0.0592
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4084 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0048 0.006
Leishmania major hypothetical protein, conserved 0.0041 0.0273 0.0592
Brugia malayi RNA, U transporter 1 0.0084 0.0844 0.2775
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0183 0.216 0.555
Brugia malayi beta-lactamase family protein 0.0041 0.0273 0.0842
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0053 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0418 0.0417
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.011 0.011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0391 0.1243
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0272 0.0271
Echinococcus multilocularis cpg binding protein 0.0036 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0252
Brugia malayi beta-lactamase family protein 0.0041 0.0273 0.0842
Echinococcus multilocularis snurportin 1 0.0315 0.3893 0.3892
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0048 0.006
Mycobacterium ulcerans lipase LipD 0.0041 0.0273 0.0509
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0275 0.0619
Entamoeba histolytica hypothetical protein 0.0026 0.0087 0.0156
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0127 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0275 0.0597
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0273 0.0701
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0357 0.4455 1
Echinococcus granulosus intestinal type alkaline phosphatase 0.0183 0.2156 0.2156
Onchocerca volvulus 0.005 0.0399 0.3322
Echinococcus multilocularis neuropeptide receptor A26 0.0522 0.6636 0.6636
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.034 0.4229 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0273 0.0613
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.064 0.064
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.044 0.2163
Brugia malayi jmjC domain containing protein 0.0174 0.2032 0.6794
Echinococcus granulosus cpg binding protein 0.0036 0.0217 0.0217
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0171 0.0171
Onchocerca volvulus Alhambra homolog 0.0033 0.0171 0.1267
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0369 0.0821
Trypanosoma brucei mitochondrial DNA polymerase beta 0.034 0.4229 1
Loa Loa (eye worm) hypothetical protein 0.002 0 0.0001
Brugia malayi follicle stimulating hormone receptor 0.0239 0.2899 0.9727
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0273 0.0562
Brugia malayi Importin beta-1 subunit 0.0029 0.0127 0.0348
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0418 0.1332
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.1863 0.4374
Echinococcus multilocularis alkaline phosphatase 0.0183 0.2156 0.2156
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0048 0.0083
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0695 0.0695
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.008 0.0789 0.2027
Schistosoma mansoni cpg binding protein 0.0032 0.0164 0.0164
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0107 0.0187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.081 0.0809
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.011 0.011
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.1861 0.4113
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0127 0.0244
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0048 0.0058
Schistosoma mansoni protein phosphatase 2C 0.0028 0.011 0.011
Leishmania major hypothetical protein, conserved 0.0041 0.0273 0.0593
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.044 0.044
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0679 0.1745
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.011 0.011
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0273 0.0592
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0124
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0273 0.0613
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0174 0.2032 0.2032
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.064 0.1344
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0273 0.0509
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.064 0.064
Toxoplasma gondii hypothetical protein 0.0028 0.0107 0.1056
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0273 0.0509
Brugia malayi hypothetical protein 0.0245 0.298 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0308 0.0791
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0418 0.0417
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.011 0.0206
Echinococcus multilocularis peregrin 0.0035 0.0206 0.0206
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.011 0.0284
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0679 0.0679
Echinococcus granulosus RUN 0.0022 0.003 0.003
Toxoplasma gondii PUL domain-containing protein 0.0041 0.0273 0.3174
Echinococcus granulosus alkaline phosphatase 0.0183 0.2156 0.2156
Echinococcus granulosus tar DNA binding protein 0.0071 0.0679 0.0679
Leishmania major importin beta-1 subunit, putative 0.0024 0.0053 0.0069
Onchocerca volvulus 0.0024 0.0048 0.016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0273 0.0509
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.298 0.298
Brugia malayi RNA binding protein 0.0071 0.0679 0.2218
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.011 0.1104
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0053 0.0072
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0048 0.0058
Echinococcus multilocularis RUN 0.0022 0.003 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0273 0.0613
Loa Loa (eye worm) hypothetical protein 0.0081 0.081 0.208
Mycobacterium tuberculosis Conserved hypothetical protein 0.0179 0.2103 0.4663
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0041 0.0273 0.0614
Schistosoma mansoni microtubule-associated protein tau 0.0777 1 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.1959 0.5032
Brugia malayi Doublecortin family protein 0.0022 0.003 0.0023
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.216 0.216
Loa Loa (eye worm) hypothetical protein 0.0041 0.0273 0.0701
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0558 0.0558
Trichomonas vaginalis esterase, putative 0.0041 0.0273 0.0613
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.011 0.011
Schistosoma mansoni jumonji/arid domain-containing protein 0.011 0.1189 0.1189
Schistosoma mansoni zinc finger protein 0.0024 0.0053 0.0053
Onchocerca volvulus 0.0041 0.0273 0.2186
Leishmania major mitochondrial DNA polymerase beta 0.034 0.4229 1
Entamoeba histolytica hypothetical protein 0.0024 0.0053 0.0072
Mycobacterium tuberculosis Conserved protein 0.0041 0.0273 0.0509
Echinococcus multilocularis zinc finger protein 0.0024 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4084 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0078
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0097 0.0097
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0275 0.0619
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.011 0.011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0273 0.0509
Schistosoma mansoni jumonji domain containing protein 0.0028 0.011 0.011
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0275 0.0275
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0184 0.0543
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0418 0.0417
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.064 0.1344
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0357 0.4455 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0273 0.0592
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0679 0.0679
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0163 0.0163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4084 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0695 0.0695
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0127 0.1308
Plasmodium falciparum importin beta, putative 0.0029 0.0127 0.0232
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.298 0.298
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.011 0.0206
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.1861 1
Mycobacterium leprae Probable lipase LipE 0.0041 0.0273 0.1239
Loa Loa (eye worm) doublecortin family protein 0.0022 0.003 0.0078
Mycobacterium tuberculosis Conserved protein 0.0041 0.0273 0.0509
Schistosoma mansoni jumonji domain containing protein 0.0152 0.174 0.174
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.081 0.1728
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0053 0.0072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0124
Brugia malayi Muscleblind-like protein 0.0168 0.1959 0.6546
Schistosoma mansoni alkaline phosphatase 0.0183 0.2156 0.2156
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0275 0.3196
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0183 0.2156 0.2156
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0357 0.4455 1
Echinococcus granulosus peregrin 0.0035 0.0206 0.0206
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0171 0.1872
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0619
Echinococcus granulosus phd:f box containing protein 0.0028 0.011 0.011
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0357 0.4455 1
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0027 0.0098 0.0183
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.081 0.4201
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.011 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0418 0.0417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0418 0.0417
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0273 0.0509
Giardia lamblia PHD finger protein 15 0.0033 0.0171 0.0362
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0507 0.1149
Leishmania major hypothetical protein, conserved 0.0028 0.011 0.0206
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0041 0.0273 0.0593
Brugia malayi CXXC zinc finger family protein 0.0032 0.0164 0.0476
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.064 0.7846
Loa Loa (eye worm) hypothetical protein 0.0074 0.0714 0.1834
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0275 0.0619
Loa Loa (eye worm) hypothetical protein 0.0028 0.011 0.0284
Loa Loa (eye worm) RNA binding protein 0.0071 0.0679 0.1745
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0072 0.0695 0.0695
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0275 0.0619
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0171 0.0439
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0048 0.0083
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.081 0.1773
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0679 0.0679
Echinococcus granulosus phospholipase A 2 activating protein 0.0041 0.0273 0.0273
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0643 0.0643
Onchocerca volvulus 0.0032 0.0164 0.1208
Brugia malayi jmjC domain containing protein 0.011 0.1189 0.3944
Echinococcus granulosus lysosomal alpha glucosidase 0.0183 0.216 0.216
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.035 0.0803
Mycobacterium ulcerans hypothetical protein 0.0179 0.2103 0.4663
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0275 0.0597
Schistosoma mansoni alpha-glucosidase 0.0158 0.1823 0.1823
Loa Loa (eye worm) hypothetical protein 0.005 0.0396 0.1017
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0357 0.4455 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4084 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4084 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0418 0.0417
Echinococcus multilocularis phospholipase A 2 activating protein 0.0041 0.0273 0.0273
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.003 0.0015
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0041 0.0273 0.0701
Echinococcus multilocularis neuropeptide s receptor 0.0522 0.6636 0.6636
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0161 0.1863 0.4374
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0273 0.0509
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0275 0.0706
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0183 0.2156 0.2156
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0357 0.4455 1
Plasmodium vivax JmjC domain containing protein 0.0028 0.011 0.0196
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.011 0.011
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.003 0.003
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0275 0.0619
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0171 0.0332
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.081 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0695 0.0695
Brugia malayi Probable ClpP-like protease 0.0081 0.081 0.2658
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0107 0.0187
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0272 0.0271
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0399 0.1268
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.044 0.0889
Echinococcus granulosus lysine specific demethylase 5A 0.011 0.1189 0.1189
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.011 0.0284
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0097 0.0097
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0171 0.0171
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0649 0.0649
Schistosoma mansoni hypothetical protein 0.0315 0.3893 0.3892
Loa Loa (eye worm) hypothetical protein 0.0245 0.298 0.7655
Onchocerca volvulus 0.0041 0.0273 0.2186
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0619
Entamoeba histolytica hypothetical protein 0.0072 0.0695 0.1653
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0325
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.4084 1
Trypanosoma brucei WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0027 0.0098 0.0177
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0679 0.2218
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.064 0.064
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0171 0.0171
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0649 0.0649
Onchocerca volvulus 0.0106 0.1139 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.011 0.1189 0.1189
Echinococcus multilocularis muscleblind protein 0.0168 0.1959 0.1959
Loa Loa (eye worm) hypothetical protein 0.0034 0.0184 0.0473
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0164 0.0422
Loa Loa (eye worm) hypothetical protein 0.0049 0.0391 0.1005
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0341 0.034
Schistosoma mansoni polycystin 1-related 0.0022 0.003 0.003
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0341 0.034
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0619
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0369 0.0821
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0124
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.1863 0.4374
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.035 0.0803
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.064 0.1344
Echinococcus granulosus neuropeptide receptor A26 0.0522 0.6636 0.6636
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.035 0.0803
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.011 0.011
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.003 0.003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.081 0.1773
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.035 0.0803
Loa Loa (eye worm) hypothetical protein 0.0041 0.0273 0.0701
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4084 1
Onchocerca volvulus 0.0041 0.0273 0.2186
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.003 0.0015
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.011 0.0196
Schistosoma mansoni cpg binding protein 0.0036 0.0217 0.0217
Schistosoma mansoni alpha glucosidase 0.0041 0.0275 0.0275
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.035 0.0803
Echinococcus granulosus snurportin 1 0.0315 0.3893 0.3892
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0679 0.1745
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0127 0.0126
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0369 0.0821
Brugia malayi hypothetical protein 0.0072 0.0695 0.227
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0273 0.0842
Echinococcus multilocularis muscleblind protein 1 0.0168 0.1959 0.1959
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0048 0.0083
Echinococcus granulosus importin subunit beta 1 0.0029 0.0127 0.0126
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.1861 0.4113
Schistosoma mansoni lipoxygenase 0.0022 0.003 0.003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.064 0.064
Schistosoma mansoni importin beta-1 0.0029 0.0127 0.0126
Schistosoma mansoni ran 0.0022 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0041 0.0273 0.0701
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.4084 1
Entamoeba histolytica hypothetical protein 0.0072 0.0695 0.1653
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0679 0.0679
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.064 0.1344
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.3893 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0097 0.0097
Plasmodium falciparum phd finger protein, putative 0.0033 0.0171 0.0332
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0273 0.0701
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0273 0.0273
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0582 0.71
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0273 0.0509
Brugia malayi PHD-finger family protein 0.003 0.0132 0.0367
Brugia malayi WD domain containing protein 0.0041 0.0273 0.0844
Brugia malayi jmjC domain containing protein 0.0028 0.011 0.0293
Entamoeba histolytica hypothetical protein 0.0072 0.0695 0.1653
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.064 0.1466
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0163 0.0163
Treponema pallidum fructose-bisphosphate aldolase 0.0329 0.4084 1
Echinococcus multilocularis phd:f box containing protein 0.0028 0.011 0.011
Plasmodium falciparum polyubiquitin binding protein, putative 0.0041 0.0273 0.0563
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0275 0.085
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0679 0.0679
Trypanosoma brucei glucosidase, putative 0.0041 0.0275 0.0597
Echinococcus multilocularis microtubule associated protein 2 0.0777 1 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0273 0.0509
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.011 0.0206
Schistosoma mansoni hypothetical protein 0.0023 0.0044 0.0044
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0357 0.4455 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0329 0.4084 1
Schistosoma mansoni ran 0.0022 0.0024 0.0024
Brugia malayi Bromodomain containing protein 0.0035 0.0206 0.0617
Schistosoma mansoni alkaline phosphatase 0.0183 0.2156 0.2156
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.044 0.0889
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.216 0.216
Schistosoma mansoni hypothetical protein 0.0033 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.005 0.0399 0.0398
Loa Loa (eye worm) hypothetical protein 0.0028 0.011 0.0284
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0273 0.0613
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.034 0.4229 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.081 0.1767
Brugia malayi Bromodomain containing protein 0.0043 0.0307 0.0958
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0633 0.1625
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.044 0.044
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0038 0.0048
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0273 0.0509
Schistosoma mansoni rab6-interacting 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0171 0.0439
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.081 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0391 0.1005
Brugia malayi beta-lactamase 0.0041 0.0273 0.0842
Brugia malayi hypothetical protein 0.0022 0.003 0.0023
Echinococcus granulosus zinc finger protein 0.0024 0.0053 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4084 1
Schistosoma mansoni hypothetical protein 0.0034 0.0184 0.0184
Loa Loa (eye worm) WD domain-containing protein 0.0027 0.0098 0.0252
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0391 0.1243
Brugia malayi TAR-binding protein 0.0071 0.0679 0.2218
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0183 0.2156 0.2156
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0275 0.0597
Schistosoma mansoni phospholipase A-2-activating protein 0.0027 0.0098 0.0098
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0273 0.0613
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0275 0.0619
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0183 0.2156 0.2156
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0048 0.006
Schistosoma mansoni loxhd1 0.0022 0.003 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0418 0.0417
Echinococcus multilocularis lysine specific demethylase 5A 0.0106 0.1137 0.1137
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0273 0.0273
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0107 0.0323
Loa Loa (eye worm) hypothetical protein 0.0041 0.0273 0.0701
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0357 0.4455 1
Schistosoma mansoni alpha-glucosidase 0.0158 0.1823 0.1823
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0024 0.0024
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0174 0.2032 0.2032
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0619
Schistosoma mansoni cpg binding protein 0.0036 0.0217 0.0217
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.081 0.1728
Echinococcus granulosus muscleblind protein 0.0168 0.1959 0.1959
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0183 0.2156 0.2156
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0095 0.0994 0.0994
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0273 0.0509
Echinococcus granulosus neuropeptide s receptor 0.0522 0.6636 0.6636
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0041 0.0273 0.0593
Schistosoma mansoni phd/f-box containing protein 0.0028 0.011 0.011
Brugia malayi hypothetical protein 0.0022 0.003 0.0023
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.081 0.0809
Toxoplasma gondii ABC1 family protein 0.0041 0.0273 0.3168
Brugia malayi PHD-finger family protein 0.0033 0.0171 0.0498
Brugia malayi Glycosyl hydrolases family 31 protein 0.0183 0.216 0.7228
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.011 0.1104
Brugia malayi jmjC domain containing protein 0.0028 0.011 0.0293
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0053 0.0069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.4084 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0679 0.0679
Mycobacterium ulcerans beta-lactamase 0.0041 0.0273 0.0509
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.003 0.003
Toxoplasma gondii hypothetical protein 0.0055 0.0462 0.5573
Loa Loa (eye worm) jmjC domain-containing protein 0.011 0.1189 0.3056
Loa Loa (eye worm) hypothetical protein 0.0046 0.0343 0.0881
Loa Loa (eye worm) hypothetical protein 0.0168 0.1959 0.5032
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.011 0.0284
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0369 0.0821
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0171 0.1872
Schistosoma mansoni rab6-interacting 0.0022 0.003 0.003
Schistosoma mansoni survival motor neuron protein 0.005 0.0399 0.0398
Mycobacterium ulcerans hypothetical protein 0.0041 0.0273 0.0509
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.081 0.0809
Plasmodium vivax importin-beta 2, putative 0.0029 0.0127 0.0232
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0619
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.3158 0.7057
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0275 0.0275
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.2899 0.7448
Schistosoma mansoni lipoxygenase 0.0062 0.0558 0.0558
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0044 0.0113
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0273 0.1239
Loa Loa (eye worm) beta-lactamase 0.0041 0.0273 0.0701
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0418 0.1073
Schistosoma mansoni bromodomain containing protein 0.0073 0.0703 0.0703
Brugia malayi Bromodomain containing protein 0.0086 0.0877 0.2887
Brugia malayi jmjC domain containing protein 0.0028 0.011 0.0293

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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