Detailed information for compound 573288

Basic information

Technical information
  • TDR Targets ID: 573288
  • Name: 2,3,4,5,6-pentahydroxyhexanal oxime
  • MW: 195.171 | Formula: C6H13NO6
  • H donors: 6 H acceptors: 6 LogP: -3.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: O/N=C/C(C(C(C(CO)O)O)O)O
  • InChi: 1S/C6H13NO6/c8-2-4(10)6(12)5(11)3(9)1-7-13/h1,3-6,8-13H,2H2/b7-1+
  • InChiKey: FQDOAQMGAIINEJ-LREOWRDNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6E)-6-hydroxyiminohexane-1,2,3,4,5-pentol
  • glucosoxime
  • 6-hydroxyiminohexane-1,2,3,4,5-pentol
  • 20275-00-7
  • 6336-64-7
  • 608-81-1
  • AIDS-018496
  • AIDS018496
  • D-Galactose, oxime
  • D-Glucose, oxime
  • Glucose oxime
  • NSC19777
  • NSC21564
  • NSC39317

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0026 0.0519 0.1738
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0009 0.0061 0.0021
Brugia malayi hypothetical protein 0.0225 0.5866 0.7214
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0009 0.0081 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Trypanosoma brucei PAB1-binding protein , putative 0.0019 0.0334 0.1044
Echinococcus granulosus shaker cognate 0.0013 0.0179 0.022
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0026 0.0519 0.1176
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0008 0.0056 0.0069
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0026 0.0519 0.0466
Echinococcus granulosus geminin 0.0076 0.186 0.2289
Brugia malayi hypothetical protein 0.0011 0.0124 0.0135
Brugia malayi Regulator of G protein signaling domain containing protein 0.0011 0.0124 0.0135
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Echinococcus multilocularis sodium leak channel non selective protein 0.0013 0.0179 0.022
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0179 0.022
Schistosoma mansoni high-affinity choline transporter 0.0258 0.6772 0.8334
Loa Loa (eye worm) retinol dehydrogenase 12 0.0026 0.0519 0.0597
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0124 0.0108
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0013 0.0179 0.2471
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.059 0.0709
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.007 0.1715 0.2075
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0008 0.0056 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0201 0.0187
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0009 0.0081 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.03 0.0917
Trypanosoma cruzi trypanothione reductase, putative 0.0009 0.0081 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0124 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0124 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.03 0.0917
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0009 0.0081 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0342 0.0328
Schistosoma mansoni calcium-activated potassium channel 0.007 0.1715 0.211
Plasmodium falciparum glutathione reductase 0.0027 0.0555 0.0502
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0179 0.022
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0009 0.0061 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0124 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0061 0.0046
Loa Loa (eye worm) voltage-dependent calcium channel 0.0108 0.272 0.3318
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0026 0.0519 0.0639
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0378 1 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0514 0.0633
Brugia malayi cation channel family protein 0.0013 0.0179 0.0202
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0011 0.0124 0.0152
Loa Loa (eye worm) voltage-gated potassium channel 0.0013 0.0179 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0081 0.0097
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0026 0.0519 0.0466
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0179 0.022
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0026 0.0519 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0459 0.0565
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.0179 0.022
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0009 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0013 0.0179 0.0202
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0034 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0242 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0459 0.0565
Brugia malayi Sodium:solute symporter family protein 0.0028 0.0596 0.0717
Loa Loa (eye worm) glutathione reductase 0.0027 0.0555 0.0641
Schistosoma mansoni cpg binding protein 0.0023 0.0456 0.0562
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0081 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0459 0.0565
Loa Loa (eye worm) hypothetical protein 0.0095 0.2372 0.2887
Schistosoma mansoni inositol transporter 0.0028 0.0596 0.0733
Schistosoma mansoni transient receptor potential channel 0.0013 0.0179 0.022
Brugia malayi hypothetical protein 0.0019 0.0334 0.0393
Entamoeba histolytica hypothetical protein 0.0011 0.0124 0.0174
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0026 0.0519 0.1738
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0009 0.0081 0.01
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0013 0.0179 0.0202
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0009 0.0061 0.0021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0009 0.0081 0.0097
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0423 0.0478
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0013 0.0179 0.0202
Mycobacterium tuberculosis Possible oxidoreductase 0.0026 0.0519 0.0466
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Echinococcus granulosus two pore calcium channel protein 1 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0124 0.0108
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0026 0.0519 0.0466
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0013 0.0179 0.022
Schistosoma mansoni hypothetical protein 0.007 0.1715 0.211
Loa Loa (eye worm) hypothetical protein 0.0025 0.0489 0.0559
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0081 0.0516
Echinococcus multilocularis two pore calcium channel protein 2 0.0013 0.0179 0.022
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Brugia malayi Pre-SET motif family protein 0.016 0.4137 0.5082
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0179 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0202 0.0187
Loa Loa (eye worm) CYP4Cod1 0.0009 0.0073 0.0045
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0028 0.0596 0.0733
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0009 0.0081 0.0026
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0009 0.0081 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0242 0.0227
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0179 0.022
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0179 0.022
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0026 0.0519 0.9286
Schistosoma mansoni voltage-dependent calcium channel 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0309 0.8127 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0179 0.022
Mycobacterium tuberculosis Probable oxidoreductase 0.0026 0.0519 0.0466
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0334 0.1044
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.03 0.0917
Loa Loa (eye worm) hypothetical protein 0.0026 0.0519 0.0597
Echinococcus multilocularis potassium large conductance calcium activated 0.0013 0.0179 0.022
Loa Loa (eye worm) voltage-gated calcium channel 0.0013 0.0179 0.0176
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0012 0.0156 0.0376
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0309 0.8127 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0023 0.0459 0.0565
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Brugia malayi cation channel family protein 0.0013 0.0179 0.0202
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0519 0.0466
Schistosoma mansoni dihydropteridine reductase 0.0026 0.0519 0.0639
Loa Loa (eye worm) voltage-gated potassium channel 0.0013 0.0179 0.0176
Onchocerca volvulus 0.0026 0.0519 0.0598
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0026 0.0519 0.0466
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0378 1 1
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0124 0.0135
Toxoplasma gondii transporter, cation channel family protein 0.0013 0.0179 0.0124
Schistosoma mansoni ap endonuclease 0.0008 0.0055 0.0068
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.0975 0.0925
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0011 0.0124 0.0152
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0017 0.03 0.0369
Loa Loa (eye worm) hypothetical protein 0.0019 0.0334 0.0368
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0108 0.272 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0013 0.0179 0.022
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0108 0.272 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0459 0.0523
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.1248 0.1498
Echinococcus granulosus solute carrier family 5 0.0028 0.0596 0.0733
Onchocerca volvulus 0.0023 0.0459 0.0493
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0378 0.1212
Schistosoma mansoni calcium-activated potassium channel 0.0013 0.0179 0.022
Echinococcus granulosus axis inhibition protein axin 0.0011 0.0124 0.0152
Brugia malayi PXA domain containing protein 0.0011 0.0124 0.0135
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0013 0.0179 0.022
Echinococcus multilocularis small conductance calcium activated potassium 0.007 0.1715 0.211
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0179 0.022
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0378 0.1212
Echinococcus multilocularis transfer RNA-Gly 0.0013 0.0179 0.022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0081 0.0097
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0013 0.0179 0.022
Brugia malayi Regulator of G protein signaling domain containing protein 0.0011 0.0124 0.0135
Echinococcus granulosus sodium:glucose cotransporter 2 0.0028 0.0596 0.0733
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0013 0.0179 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0081 0.0097
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0026 0.0519 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0342 0.0328
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0026 0.0519 0.0466
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Loa Loa (eye worm) hypothetical protein 0.0028 0.0596 0.0692
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0044 0.1015 0.2436
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Trypanosoma brucei membrane transporter protein, putative 0.0017 0.03 0.0917
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0009 0.0081 0.0026
Echinococcus granulosus sodium channel protein 0.0013 0.0179 0.022
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0179 0.0202
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0013 0.0179 0.0202
Leishmania major cytochrome p450-like protein 0.0009 0.0073 0.0348
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Chlamydia trachomatis oxoacy-ACP reductase 0.0026 0.0519 0.0441
Plasmodium vivax SET domain protein, putative 0.0023 0.0459 0.0406
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0013 0.0179 0.022
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0013 0.0179 0.022
Brugia malayi Pre-SET motif family protein 0.0023 0.0459 0.0548
Treponema pallidum NADH oxidase 0.0009 0.0081 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0061 0.0046
Brugia malayi GH02984p 0.0258 0.6772 0.8331
Mycobacterium ulcerans oxidoreductase 0.0026 0.0519 0.0466
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0013 0.0179 0.022
Echinococcus granulosus TRP transient receptor potential channel 0.0013 0.0179 0.022
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0026 0.0519 0.928
Echinococcus multilocularis ryanodine receptor 44f 0.0013 0.0179 0.022
Mycobacterium tuberculosis Probable dehydrogenase 0.0061 0.1483 0.1435
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0026 0.0519 0.1739
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0026 0.0519 0.0466
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0026 0.0519 0.1738
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.03 0.0917
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0009 0.0061 0.0021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0027 0.0555 0.0502
Leishmania major pteridine reductase 1 0.0026 0.0519 0.9286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0202 0.0187
Loa Loa (eye worm) hypothetical protein 0.0258 0.6772 0.8326
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Echinococcus granulosus cpg binding protein 0.0023 0.0456 0.0562
Echinococcus granulosus sodium:glucose cotransporter 0.0028 0.0596 0.0733
Echinococcus granulosus expressed protein 0.0213 0.5549 0.6828
Plasmodium falciparum thioredoxin reductase 0.0027 0.0555 0.0502
Onchocerca volvulus 0.0182 0.473 0.8002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Trypanosoma brucei membrane transporter protein, putative 0.0017 0.03 0.0917
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Schistosoma mansoni lamin 0.0053 0.1248 0.1536
Loa Loa (eye worm) hypothetical protein 0.0011 0.0124 0.0108
Echinococcus granulosus regulator of G protein signaling 3 0.0011 0.0124 0.0152
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0068 0.1667 0.1621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0237 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0342 0.0328
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0013 0.0179 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0201 0.0187
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0026 0.0519 0.0639
Echinococcus multilocularis regulator of G protein signaling 3 0.0011 0.0124 0.0152
Echinococcus granulosus transient receptor potential gamma protein 0.0013 0.0179 0.022
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0013 0.0179 0.0202
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0124 0.0152
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0519 0.0466
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0179 0.022
Echinococcus multilocularis conserved hypothetical protein 0.0013 0.0179 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0378 0.0363
Loa Loa (eye worm) PXA domain-containing protein 0.0011 0.0124 0.0108
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0009 0.0081 0.0026
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0309 0.8127 1
Echinococcus granulosus hypothetical protein 0.0013 0.0179 0.022
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0026 0.0519 0.0466
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0028 0.0596 0.0733
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0179 0.022
Schistosoma mansoni vesicular amine transporter 0.0013 0.0179 0.022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0026 0.0519 0.0622
Schistosoma mansoni multidrug resistance protein 0.0017 0.03 0.0369
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0124 0.0152
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0026 0.0519 0.928
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0124 0.0108
Leishmania major oxidoreductase-like protein 0.0026 0.0519 0.9286
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0309 0.8127 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0009 0.0081 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0061 0.0046
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0179 0.022
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0013 0.0179 0.022
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0013 0.0179 0.0202
Schistosoma mansoni 60S ribosomal protein L21 0.0013 0.0179 0.022
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0026 0.0519 0.1177
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0013 0.0179 0.0202
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0081 0.0516
Echinococcus multilocularis beta adrenergic receptor kinase 0.0011 0.0124 0.0152
Schistosoma mansoni axis inhibition protein axin 0.0011 0.0124 0.0152
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0179 0.022
Schistosoma mansoni cpg binding protein 0.0022 0.0423 0.052
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0081 0.0097
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0026 0.0519 0.0466
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0081 0.0097
Schistosoma mansoni hypothetical protein 0.0013 0.0179 0.022
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0124 0.0152
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0013 0.0179 0.022
Echinococcus granulosus small conductance calcium activated potassium 0.007 0.1715 0.211
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0124 0.0152
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0013 0.0179 0.0202
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0124 0.0152
Echinococcus granulosus calcium activated potassium channel 0.0013 0.0179 0.022
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0309 0.8127 1
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0179 0.022
Brugia malayi hypothetical protein 0.0069 0.1695 0.2072
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0309 0.8127 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0378 0.0363
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0179 0.022
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0179 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0061 0.0046
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0179 0.022
Echinococcus multilocularis geminin 0.0076 0.186 0.2289
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0009 0.0081 0.0026
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0519 0.0466
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0124 0.0152
Echinococcus multilocularis axis inhibition protein axin 0.0011 0.0124 0.0152
Echinococcus multilocularis short transient receptor potential channel 6 0.0013 0.0179 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0277 0.0263
Toxoplasma gondii NADPH-glutathione reductase 0.0009 0.0081 0.0026
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0011 0.0124 0.0152
Loa Loa (eye worm) hypothetical protein 0.0225 0.5866 0.7206
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0013 0.0179 0.0202
Loa Loa (eye worm) hypothetical protein 0.0095 0.2372 0.2887
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.0179 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.03 0.0917
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0009 0.0073 0.0017
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0179 0.022
Loa Loa (eye worm) RGS-3 protein 0.0011 0.0124 0.0108
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0378 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0009 0.0081 0.0082
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0124 0.0152
Echinococcus multilocularis Regulator of G protein signaling 20 0.0011 0.0124 0.0152
Schistosoma mansoni inositol transporter 0.0028 0.0596 0.0733
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0013 0.0179 0.022
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0334 0.028
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0179 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0519 0.0504
Giardia lamblia DNA repair protein RAD52 0.0155 0.3994 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0378 0.0363
Trichomonas vaginalis set domain proteins, putative 0.0182 0.473 0.4722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0342 0.0328
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0026 0.0519 0.0638
Brugia malayi ion channel NompC 0.0013 0.0179 0.0202
Echinococcus granulosus ryanodine receptor 44f 0.0013 0.0179 0.022
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Echinococcus granulosus two pore calcium channel protein 2 0.0013 0.0179 0.022
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Brugia malayi hypothetical protein 0.0012 0.0155 0.0173
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0008 0.0055 0.0068
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0124 0.0152
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0179 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0124 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0342 0.0328
Echinococcus granulosus axis inhibition protein axin 0.0011 0.0124 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0342 0.0328
Brugia malayi Cyclic-nucleotide gated cation channel 0.0013 0.0179 0.0202
Toxoplasma gondii hypothetical protein 0.0013 0.0179 0.0124
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0009 0.0061 0.0075
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.0179 0.022
Brugia malayi exodeoxyribonuclease III family protein 0.0008 0.0055 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0378 0.0363
Onchocerca volvulus 0.0053 0.1248 0.188
Toxoplasma gondii hypothetical protein 0.0013 0.0179 0.0124
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0023 0.0459 0.0565
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0179 0.022
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0009 0.0081 0.01
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0028 0.0596 0.0543
Brugia malayi PXA domain containing protein 0.0011 0.0124 0.0135
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0061 0.1483 0.1435
Brugia malayi CXXC zinc finger family protein 0.0022 0.0423 0.0503
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0009 0.0081 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0519 0.0504
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0155 0.3994 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0009 0.0061 0.0112
Echinococcus multilocularis calcium activated potassium channel 0.0013 0.0179 0.022
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0026 0.0519 0.1739
Schistosoma mansoni voltage-gated cation channel 0.0309 0.8127 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0008 0.0055 0.0024
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Schistosoma mansoni hypothetical protein 0.0008 0.0056 0.0069
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0179 0.022
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0309 0.8127 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0309 0.8127 1
Entamoeba histolytica hypothetical protein 0.0011 0.0124 0.0174
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0013 0.0179 0.022
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0013 0.0179 0.0176
Echinococcus granulosus voltage gated hydrogen channel 1 0.0013 0.0179 0.022
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0013 0.0179 0.022
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0423 0.0521
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0068 0.1667 0.1621
Schistosoma mansoni axis inhibition protein axin 0.0011 0.0124 0.0152
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0009 0.0081 0.0516
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0519 0.0466
Echinococcus multilocularis axis inhibition protein axin 0.0011 0.0124 0.0152
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0026 0.0519 0.0638
Leishmania major trypanothione reductase 0.0027 0.0555 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Leishmania major hypothetical protein, conserved 0.0013 0.0179 0.2471
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0201 0.0187
Echinococcus multilocularis musashi 0.0053 0.1248 0.1536
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0061 0.1483 0.1016
Echinococcus granulosus Regulator of G protein signaling 20 0.0011 0.0124 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Echinococcus multilocularis regulator of G protein signaling 0.0011 0.0124 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Loa Loa (eye worm) hypothetical protein 0.0181 0.469 0.5753
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0179 0.022
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0013 0.0179 0.022
Loa Loa (eye worm) thioredoxin reductase 0.0027 0.0555 0.0641
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0011 0.0124 0.0152
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0013 0.0179 0.0202
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Schistosoma mansoni transient receptor potential channel 0.0013 0.0179 0.022
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.0179 0.0164
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0009 0.0081 0.0026
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.016 0.4137 0.5069
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0009 0.0081 0.0097
Echinococcus multilocularis cpg binding protein 0.0023 0.0456 0.0562
Echinococcus multilocularis voltage dependent calcium channel 0.0309 0.8127 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.0179 0.022
Echinococcus granulosus lamin dm0 0.0053 0.1248 0.1536
Toxoplasma gondii transporter, cation channel family protein 0.0013 0.0179 0.0124
Echinococcus multilocularis two pore calcium channel protein 1 0.0013 0.0179 0.022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0061 0.1483 0.1435
Echinococcus granulosus voltage dependent calcium channel 0.0108 0.272 0.3347
Trichomonas vaginalis glutathione reductase, putative 0.0009 0.0081 0.0066
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0378 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0013 0.0179 0.022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0519 0.0621
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.111 0.1365
Loa Loa (eye worm) hypothetical protein 0.0011 0.0124 0.0108
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0013 0.0179 0.022
Loa Loa (eye worm) phosphatidylinositol 3 0.0009 0.0061 0.0031
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0011 0.0124 0.0135
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0179 0.022
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0179 0.022
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0179 0.022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0061 0.1483 0.1435
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0202 0.0187
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0124 0.0152
Toxoplasma gondii thioredoxin reductase 0.0027 0.0555 0.0502
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0309 0.8127 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0026 0.0519 0.1739
Echinococcus multilocularis short transient receptor potential channel 6 0.0013 0.0179 0.022
Entamoeba histolytica hypothetical protein 0.0011 0.0124 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0459 0.0565
Echinococcus multilocularis sodium channel protein 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Trypanosoma brucei cytochrome P450, putative 0.0009 0.0073 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0124 0.0109
Echinococcus granulosus regulator of G protein signaling 3 0.0011 0.0124 0.0152
Loa Loa (eye worm) ion channel NompC 0.0013 0.0179 0.0176
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0011 0.0124 0.0108
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0013 0.0179 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0237 0.0223
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0013 0.0179 0.022
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0519 0.0466
Trypanosoma brucei MATE efflux family protein, putative 0.0017 0.03 0.0917
Schistosoma mansoni ap endonuclease 0.0008 0.0055 0.0068
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0013 0.0179 0.022
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0026 0.0519 0.9286
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0179 0.022
Brugia malayi regulator of G-protein signaling rgs-7 0.0011 0.0124 0.0135
Echinococcus granulosus voltage dependent calcium channel 0.0309 0.8127 1
Echinococcus multilocularis shaker cognate 0.0013 0.0179 0.022
Mycobacterium tuberculosis Probable reductase 0.0061 0.1483 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0124 0.0109
Brugia malayi hypothetical protein 0.0013 0.0179 0.0202
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Schistosoma mansoni hypothetical protein 0.0076 0.186 0.2289
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0036 0.0044
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0179 0.022
Echinococcus granulosus intermediate filament protein 0.0053 0.1248 0.1536
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0011 0.0124 0.0152
Trypanosoma cruzi membrane transporter protein, putative 0.0017 0.03 0.0917
Echinococcus granulosus beta-adrenergic receptor kinase 0.0011 0.0124 0.0152
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0555 0.1873
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0028 0.0596 0.0733
Onchocerca volvulus 0.0053 0.1248 0.188
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0179 0.022
Leishmania major hypothetical protein, conserved 0.0017 0.03 0.4894
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0011 0.0124 0.0108
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.059 0.0684
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0026 0.0519 0.1739
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0081 0.0097
Plasmodium vivax thioredoxin reductase, putative 0.0027 0.0555 0.0502
Loa Loa (eye worm) hypothetical protein 0.0025 0.0514 0.0591
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0009 0.0081 0.0097
Trichomonas vaginalis ap endonuclease, putative 0.0008 0.0055 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Trypanosoma brucei pteridine reductase 1 0.0026 0.0519 0.1739
Trichomonas vaginalis ap endonuclease, putative 0.0008 0.0055 0.0041
Schistosoma mansoni sodium/solute symporter 0.0028 0.0596 0.0733
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0179 0.022
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Echinococcus multilocularis voltage dependent calcium channel 0.0309 0.8127 1
Schistosoma mansoni hypothetical protein 0.0076 0.186 0.2289
Onchocerca volvulus 0.0026 0.0519 0.0598
Brugia malayi intermediate filament protein 0.0053 0.1248 0.1521
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0378 1 1
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0013 0.0179 0.022
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.0179 0.022
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0309 0.8127 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0519 0.0504
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0179 0.022
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0309 0.8127 1
Schistosoma mansoni intermediate filament proteins 0.0053 0.1248 0.1536
Trypanosoma brucei oxidoreductase-like protein 0.0026 0.0519 0.1739
Loa Loa (eye worm) hypothetical protein 0.0035 0.0775 0.0913
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0179 0.022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0009 0.0061 0.0057
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0378 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0013 0.0179 0.022
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Schistosoma mansoni two-pore calcium channel 0.0013 0.0179 0.022
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0013 0.0179 0.0463
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0011 0.0124 0.0109
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0026 0.0519 0.0466
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0016 0.0259 0.0318
Loa Loa (eye worm) intermediate filament protein 0.0053 0.1248 0.1498
Echinococcus granulosus lamin 0.0053 0.1248 0.1536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0292 0.0277
Mycobacterium tuberculosis Probable oxidoreductase 0.0068 0.1667 0.1621
Trypanosoma brucei trypanothione reductase 0.0027 0.0555 0.1873
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0179 0.022
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0514 0.0633
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0116 0.0228
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0073 0.0065
Loa Loa (eye worm) phosphatidylinositol 3 0.0026 0.0519 0.0596
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0061 0.1483 0.1435
Brugia malayi olfactory channel protein osm-9 0.0013 0.0179 0.0202
Echinococcus multilocularis transient receptor potential gamma protein 0.0013 0.0179 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0061 0.0046
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0028 0.0596 0.0733
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0179 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0124 0.0109
Echinococcus multilocularis thioredoxin glutathione reductase 0.0027 0.0555 0.0682
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Echinococcus multilocularis expressed protein 0.0213 0.5549 0.6828
Schistosoma mansoni transient receptor potential channel 0.0013 0.0179 0.022
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0334 0.1044
Schistosoma mansoni cpg binding protein 0.0023 0.0456 0.0562
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0013 0.0179 0.0202
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0334 0.028
Echinococcus granulosus high affinity choline transporter 1 0.0258 0.6772 0.8334
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0013 0.0179 0.022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0026 0.0519 0.1738
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0179 0.022
Trichomonas vaginalis hypothetical protein 0.0378 1 1
Brugia malayi Thioredoxin reductase 0.0027 0.0555 0.0666
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0026 0.0519 0.0597
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Onchocerca volvulus 0.0022 0.0423 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0124 0.0109
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0179 0.0176
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0378 0.6469
Leishmania major phosphatidylinositol 3-kinase, putative 0.0009 0.0061 0.0112
Brugia malayi Cytochrome P450 family protein 0.0015 0.0231 0.0267
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Loa Loa (eye worm) ryanodine receptor 0.0013 0.0179 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0378 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0242 0.0227
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0026 0.0519 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0418 0.0404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0081 0.0097
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.0179 0.0124
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.0179 0.022
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.0179 0.022
Onchocerca volvulus 0.0225 0.5866 1
Brugia malayi Cytochrome P450 family protein 0.0009 0.0073 0.0072
Echinococcus multilocularis solute carrier family 5 0.0028 0.0596 0.0733
Brugia malayi glutathione reductase 0.0027 0.0555 0.0666
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0036 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0231 0.0241
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0026 0.0519 0.0466
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0017 0.03 0.0369
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0179 0.022
Entamoeba histolytica hypothetical protein 0.0044 0.1015 0.2436
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0179 0.022
Leishmania major hypothetical protein, unknown function 0.0013 0.0179 0.2471
Echinococcus granulosus sodium leak channel non selective protein 0.0013 0.0179 0.022
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0026 0.0519 0.0466
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0009 0.0061 0.0021
Plasmodium falciparum thioredoxin reductase 0.0009 0.0081 0.0026
Loa Loa (eye worm) calcium channel 0.0309 0.8127 1
Onchocerca volvulus 0.0028 0.0596 0.0733
Schistosoma mansoni transient receptor potential channel 4 0.0013 0.0179 0.022
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0008 0.0055 0.0068
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0026 0.0519 0.0638
Trypanosoma brucei membrane transporter protein, putative 0.0017 0.03 0.0917
Giardia lamblia GTOR 0.0026 0.0519 0.1176
Mycobacterium tuberculosis Possible oxidoreductase 0.0026 0.0519 0.0466
Toxoplasma gondii hypothetical protein 0.0095 0.2372 0.2329
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0009 0.0061 0.0075
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0073 0.0045
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0342 0.0288
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0179 0.022
Plasmodium falciparum enoyl-acyl carrier reductase 0.0378 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Brugia malayi voltage-dependent calcium channel 0.0013 0.0179 0.0202
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0009 0.0081 0.0516
Echinococcus multilocularis lamin dm0 0.0053 0.1248 0.1536
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0124 0.0152
Loa Loa (eye worm) hypothetical protein 0.0011 0.0124 0.0108
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0519 0.0466
Schistosoma mansoni voltage-gated ion channel 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0053 0.1248 0.1498
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0073 0.0045
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0026 0.0519 0.1176
Brugia malayi hypothetical protein 0.0011 0.0124 0.0135
Loa Loa (eye worm) hypothetical protein 0.0025 0.0489 0.0559
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0009 0.0081 0.0026
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0179 0.022
Loa Loa (eye worm) oxidoreductase 0.0026 0.0519 0.0597
Toxoplasma gondii transporter, cation channel family protein 0.0108 0.272 0.268
Plasmodium vivax glutathione reductase, putative 0.0027 0.0555 0.0502
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0334 0.028
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0013 0.0179 0.0124
Echinococcus multilocularis high affinity choline transporter 1 0.0258 0.6772 0.8334
Toxoplasma gondii LsmAD domain-containing protein 0.0019 0.0334 0.028
Trichomonas vaginalis mercuric reductase, putative 0.0009 0.0081 0.0066
Schistosoma mansoni ryanodine receptor related 0.0013 0.0179 0.022
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0124 0.0152
Brugia malayi Cytochrome P450 family protein 0.0009 0.0073 0.0072
Plasmodium falciparum glutathione reductase 0.0009 0.0081 0.0026
Echinococcus granulosus thioredoxin glutathione reductase 0.0027 0.0555 0.0682
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0013 0.0179 0.022
Echinococcus granulosus potassium large conductance calcium activated 0.0013 0.0179 0.022
Echinococcus granulosus short transient receptor potential channel 6 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0052 0.1222 0.1466
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0013 0.0179 0.0202
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0023 0.0459 0.0406
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0073 0.0065
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0519 0.0466
Echinococcus multilocularis lamin 0.0053 0.1248 0.1536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0342 0.0328
Schistosoma mansoni calcium-activated potassium channel 0.0067 0.1623 0.1997
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0108 0.272 0.3318
Leishmania major hypothetical protein, conserved 0.0019 0.0334 0.5573
Echinococcus granulosus sodium:myo inositol cotransporter 0.0028 0.0596 0.0733
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.1248 0.1521
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0026 0.0519 0.0466
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0026 0.0519 0.9286
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0009 0.0081 0.0026
Brugia malayi Transient-receptor-potential like protein 0.0013 0.0179 0.0202
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0023 0.0459 0.0565
Echinococcus multilocularis regulator of G protein signaling 3 0.0011 0.0124 0.0152
Loa Loa (eye worm) hypothetical protein 0.0032 0.0678 0.0793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0202 0.0187
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0179 0.022
Leishmania major hypothetical protein, conserved 0.0017 0.03 0.4894
Brugia malayi A-kinase anchor protein 10, precursor 0.0011 0.0124 0.0135
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0068 0.1667 0.1211
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0176
Schistosoma mansoni lamin 0.0053 0.1248 0.1536
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0179 0.022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0124 0.0108

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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