Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0125 | 0 | 0.5 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.074 | 0.8112 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.074 | 0.8112 | 0.8112 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0125 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.074 | 0.8112 | 1 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.074 | 0.8112 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0125 | 0 | 0.5 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.074 | 0.8112 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.074 | 0.8112 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.074 | 0.8112 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.074 | 0.8112 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0125 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.074 | 0.8112 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.074 | 0.8112 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0125 | 0 | 0.5 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.074 | 0.8112 | 1 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0125 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.074 | 0.8112 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.074 | 0.8112 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 52 nM | Ability to inhibit the growth of leukemia L1210 cells in vitro. | ChEMBL. | 3625706 |
IC50 (functional) | = 62 nM | Ability to inhibit the growth of human colon tumor HCT-8 cells in vitro. | ChEMBL. | 3625706 |
ILS max (functional) | = 61 | Percent increase in life span, of the drug-treated tumor-bearing animals vs nontreated tumor-bearing controls with LL (Lewis lung carcinoma model) cells. | ChEMBL. | 3625706 |
ILS max (functional) | = 76 | Percent increase in life span, of the drug-treated tumor-bearing animals vs nontreated tumor-bearing controls with P388/ADR cells. | ChEMBL. | 3625706 |
ILS max (functional) | = 189 | Percent increase in life span of the drug-treated tumor-bearing animals vs nontreated tumor-bearing controls with P388 leukemia cells. | ChEMBL. | 3625706 |
Log K (binding) | = 7.69 | Binding constant for DNA by ethidium bromide displacement | ChEMBL. | 3625706 |
OD (functional) | = 8.9 | Optimal dose required to inhibit the P388 intraperitoneal administration. | ChEMBL. | 3625706 |
OD (functional) | = 13.3 | Optimal dose to inhibit the LL (Lewis lung carcinoma model) cells in vivo after intraperitoneal administration. | ChEMBL. | 3625706 |
OD (functional) | = 20 | Optimal dose required to inhibit the P388/ADR cells in vivo after intraperitoneal administration. | ChEMBL. | 3625706 |
Rm | = 0.57 | Lipophilicity (Rm). | ChEMBL. | 3625706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.