Detailed information for compound 57358

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.487 | Formula: C21H22N4O7S
  • H donors: 5 H acceptors: 9 LogP: 1.39 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1nc(O)c2c(n1)ccc(c2)CN(c1ccc(s1)C(=O)N[C@@H](C(=O)O)CCC(=O)O)C
  • InChi: 1S/C21H22N4O7S/c1-25(9-11-2-3-13-12(8-11)19(29)24-16(10-26)22-13)17-6-5-15(33-17)20(30)23-14(21(31)32)4-7-18(27)28/h2-3,5-6,8,14,26H,4,7,9-10H2,1H3,(H,23,30)(H,27,28)(H,31,32)(H,22,24,29)/t14-/m1/s1
  • InChiKey: ICHJJRIRWZJCEP-CQSZACIVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus thymidylate synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Loa Loa (eye worm) Smad1 0.0024 0.0279 0.0391
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0258 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.043 0.043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Brugia malayi Cell division protein ftsZ 0.0053 0.0859 0.123
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.018 0.0417
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1761 0.4075
Leishmania major p-glycoprotein 0.0011 0.0014 0.0033
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0441 0.1021
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.002 0.0013
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1167 0.1167
Onchocerca volvulus 0.0068 0.1167 0.31
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.018 0.018
Loa Loa (eye worm) tubulin alpha 2 0.0116 0.2153 0.3108
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.018 0.018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0525 0.0525
Loa Loa (eye worm) beta-tubulin 0.0223 0.4321 0.625
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni patched 1 0.0042 0.0638 0.0638
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0129 0.0308
Leishmania major beta tubulin 0.0223 0.4321 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.018 0.018
Schistosoma mansoni tubulin subunit delta 0.0053 0.0859 0.0859
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.002 0.0047
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Echinococcus multilocularis G-protein coupled receptor, putative 0.0068 0.1167 0.1167
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.018 0.0245
Trichomonas vaginalis tubulin epsilon chain, putative 0.0223 0.4321 1
Echinococcus granulosus neuropeptide receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0116 0.2153 0.3108
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0002
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.3458 0.9243
Schistosoma mansoni tubulin subunit alpha 0.0169 0.3218 0.3218
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1167 0.1167
Schistosoma mansoni hypothetical protein 0.004 0.0608 0.0608
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Echinococcus multilocularis tubulin delta chain 0.0053 0.0859 0.0859
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.018 0.0417
Loa Loa (eye worm) alpha-tubulin 0.0169 0.3218 0.4651
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0068 0.1167 0.1167
Schistosoma mansoni adenoreceptor 0.0068 0.1167 0.1167
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Brugia malayi Dopamine receptor protein 1 0.0068 0.1167 0.1676
Echinococcus granulosus tachykinin peptides receptor 99D 0.0068 0.1167 0.1167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Plasmodium falciparum tubulin gamma chain 0.0121 0.2247 0.52
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0195 0.374 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.018 0.0385
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0068 0.1167 0.1678
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.002 0.002
Entamoeba histolytica P-glycoprotein-5 0.0011 0.0014 0.0033
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0068 0.1167 0.1678
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Onchocerca volvulus 0.0068 0.1167 0.31
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0441 0.1021
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Loa Loa (eye worm) ctsf protein 0.0023 0.0258 0.036
Leishmania major beta tubulin 0.0223 0.4321 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0441 0.1021
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Loa Loa (eye worm) BEN-1 protein 0.0223 0.4321 0.625
Echinococcus granulosus neuropeptide s receptor 0.0068 0.1167 0.1167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0708 0.0708
Loa Loa (eye worm) cysteine protease 0.0023 0.0258 0.036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus multilocularis neuropeptide receptor A26 0.0068 0.1167 0.1167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Loa Loa (eye worm) hypothetical protein 0.0031 0.043 0.0609
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0258 0.0258
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0195 0.0451
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1167 0.1167
Brugia malayi Tubulin beta chain 0.0053 0.0859 0.123
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0268 0.0621
Leishmania major beta tubulin 0.0223 0.4321 1
Brugia malayi MH2 domain containing protein 0.0024 0.0279 0.0389
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0011 0.0014 0.0033
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.002 0.002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0014 0.0014
Plasmodium falciparum phosphodiesterase delta, putative 0.0011 0.002 0.0047
Loa Loa (eye worm) tubulin beta-4 chain 0.0223 0.4321 0.625
Schistosoma mansoni opsin-like receptor 0.0068 0.1167 0.1167
Onchocerca volvulus 0.0023 0.0258 0.0661
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0268 0.0621
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.018 0.018
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1167 0.1678
Echinococcus multilocularis GPCR, family 2 0.0031 0.043 0.043
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0279 0.0279
Brugia malayi N-terminal motif family protein 0.0181 0.3458 0.4997
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0441 0.0623
Entamoeba histolytica tubulin family protein 0.0223 0.4321 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.002 0.0047
Schistosoma mansoni Smad4 0.0011 0.0011 0.0011
Entamoeba histolytica P-glycoprotein 5, putative 0.0011 0.0014 0.0033
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Plasmodium falciparum phosphodiesterase gamma, putative 0.0011 0.002 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Echinococcus granulosus cathepsin L cysteine protease 0.0023 0.0258 0.0258
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Schistosoma mansoni smad1 5 8 and 0.0024 0.0279 0.0279
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1167 0.1167
Leishmania major beta tubulin 0.0223 0.4321 1
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0441 0.1145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.0258 0.0258
Plasmodium vivax phosphodiesterase gamma, putative 0.0011 0.002 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1111
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0023 0.0258 0.036
Onchocerca volvulus 0.0023 0.0258 0.0661
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0129 0.0308
Echinococcus multilocularis expressed conserved protein 0.0091 0.1642 0.1642
Plasmodium falciparum cysteine proteinase falcipain 1 0.0221 0.4267 0.9875
Plasmodium vivax vivapain-1 0.0221 0.4267 0.9875
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0148 0.036
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0195 0.0195
Onchocerca volvulus 0.0068 0.1182 0.314
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1167 0.1167
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Trypanosoma brucei unspecified product 0.0013 0.006 0.014
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis geminin 0.0503 1 1
Schistosoma mansoni hypothetical protein 0.004 0.0608 0.0608
Echinococcus granulosus somatostatin receptor 0.0068 0.1167 0.1167
Echinococcus granulosus thymidylate synthase 0.0195 0.374 0.374
Onchocerca volvulus 0.0068 0.1167 0.31
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0047
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1167 0.1167
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Loa Loa (eye worm) hypothetical protein 0.0181 0.3458 0.4999
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0268 0.0372
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0093 0.1672 0.3868
Echinococcus granulosus serotonin receptor 0.0068 0.1167 0.1167
Echinococcus granulosus tubulin alpha 0.0121 0.2247 0.2247
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.018 0.0417
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.1649 0.1649
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1167 0.1167
Onchocerca volvulus 0.0011 0.0014 0.0008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0187 0.359 0.519
Loa Loa (eye worm) tubulin alpha 2 0.0048 0.0766 0.1096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus granulosus transcription factor btf3 0.0034 0.0493 0.0493
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0116 0.2153 0.4967
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Brugia malayi Tubulin beta-1 chain 0.0223 0.4321 0.6249
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0068 0.1167 0.1167
Plasmodium falciparum alpha tubulin 2 0.0169 0.3218 0.7448
Loa Loa (eye worm) hypothetical protein 0.01 0.1831 0.264
Echinococcus multilocularis tubulin alpha 1C chain 0.0169 0.3218 0.3218
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0258 0.0357
Brugia malayi neuropeptide F receptor 0.0068 0.1167 0.1676
Schistosoma mansoni alpha tubulin 0.0169 0.3218 0.3218
Echinococcus granulosus Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0441 0.1021
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0014 0.0014
Plasmodium falciparum tubulin beta chain 0.0223 0.4321 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0068 0.1167 0.1678
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Echinococcus multilocularis dna polymerase kappa 0.0019 0.018 0.018
Echinococcus granulosus neuropeptide receptor A26 0.0068 0.1167 0.1167
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0268 0.0717
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.002 0.0047
Trypanosoma brucei tubulin gamma chain 0.0121 0.2247 0.52
Onchocerca volvulus 0.0195 0.374 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Mycobacterium tuberculosis Hypothetical protein 0.0093 0.1672 0.4448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Trypanosoma brucei epsilon tubulin 0.0121 0.2247 0.52
Plasmodium vivax tubulin gamma chain, putative 0.0121 0.2247 0.52
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0148 0.0344
Giardia lamblia Epsilon tubulin 0.0053 0.0859 0.1951
Leishmania major beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Entamoeba histolytica P-glycoprotein-1 0.0011 0.0014 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.018 0.0417
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0441 0.0441
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0011 0.002 0.0047
Echinococcus granulosus Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Plasmodium vivax unspecified product 0.0221 0.4267 0.9875
Schistosoma mansoni biogenic amine receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis tubulin alpha chain, putative 0.0068 0.1182 0.2712
Mycobacterium ulcerans thymidylate synthase 0.0195 0.374 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0195 0.0268
Echinococcus granulosus g protein coupled receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Schistosoma mansoni smad 0.0024 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus granulosus g protein coupled receptor 0.0068 0.1167 0.1167
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Echinococcus multilocularis protein patched 0.0042 0.0638 0.0638
Trichomonas vaginalis tubulin epsilon chain, putative 0.0223 0.4321 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0092 0.0213
Onchocerca volvulus 0.0068 0.1167 0.31
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Brugia malayi multidrug resistance protein 3 0.0011 0.0014 0.0004
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Echinococcus multilocularis dro:myosuppressin receptor 0.0068 0.1167 0.1167
Brugia malayi sulfakinin receptor protein 0.0068 0.1167 0.1676
Loa Loa (eye worm) thymidylate synthase 0.0195 0.374 0.5408
Echinococcus multilocularis G protein coupled receptor 139 0.0068 0.1167 0.1167
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0258 0.0357
Trypanosoma brucei epsilon tubulin 0.0121 0.2247 0.52
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Brugia malayi Tubulin gamma chain 0.0121 0.2247 0.3242
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.018 0.0417
Onchocerca volvulus 0.0068 0.1167 0.31
Brugia malayi MH2 domain containing protein 0.0024 0.0279 0.0389
Schistosoma mansoni alpha tubulin 0.0169 0.3218 0.3218
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0441 0.1021
Schistosoma mansoni neuropeptide receptor 0.0068 0.1167 0.1167
Onchocerca volvulus Neuropeptide F receptor homolog 0.0068 0.1167 0.31
Brugia malayi Doublecortin family protein 0.002 0.0195 0.0266
Echinococcus multilocularis Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Leishmania major beta tubulin 0.0223 0.4321 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0068 0.1167 0.1167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1167 0.1167
Echinococcus multilocularis protein dispatched 1 0.0048 0.0758 0.0758
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.1649 0.1649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.002 0.002
Trypanosoma brucei tubulin delta chain 0.0053 0.0859 0.1989
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1167 0.1167
Onchocerca volvulus 0.0023 0.0258 0.0661
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0121 0.2247 0.52
Loa Loa (eye worm) MH2 domain-containing protein 0.0351 0.6908 1
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0525 0.0525
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0441 0.1021
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0011 0.0002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1167 0.1167
Giardia lamblia Beta tubulin 0.0223 0.4321 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0068 0.1167 0.31
Brugia malayi Tubulin beta chain 0.0068 0.1182 0.1698
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0638 0.0638
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Schistosoma mansoni tubulin subunit alpha 0.0053 0.0859 0.0859
Schistosoma mansoni smad1 5 8 and 0.0024 0.0279 0.0279
Schistosoma mansoni rab6-interacting 0.002 0.0195 0.0195
Onchocerca volvulus 0.0023 0.0258 0.0661
Echinococcus multilocularis tubulin gamma 1 chain 0.0121 0.2247 0.2247
Brugia malayi putative neuropeptide receptor 0.0068 0.1167 0.1676
Echinococcus multilocularis transcription factor btf3 0.0034 0.0493 0.0493
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0016
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0148 0.0344
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.002 0.0047
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0258 0.0258
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Trichomonas vaginalis tubulin epsilon chain, putative 0.0053 0.0859 0.1962
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.1649 0.1649
Trypanosoma cruzi cysteine protease, putative 0.0023 0.0258 0.0596
Schistosoma mansoni Smad4 0.0011 0.0011 0.0011
Trypanosoma brucei beta tubulin 0.0121 0.2247 0.52
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Entamoeba histolytica cysteine proteinase 2 0.0023 0.0258 0.0596
Echinococcus granulosus G protein coupled receptor 139 0.0068 0.1167 0.1167
Trichomonas vaginalis tubulin gamma chain, putative 0.0121 0.2247 0.5184
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0638 0.0638
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0859 0.1962
Schistosoma mansoni tubulin subunit gamma 0.0121 0.2247 0.2247
Trichomonas vaginalis tubulin alpha chain, putative 0.0223 0.4321 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0268 0.0717
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.002 0.0014
Loa Loa (eye worm) TYRA-2 protein 0.0068 0.1167 0.1678
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Brugia malayi Tachykinin-like peptides receptor 99D 0.0068 0.1167 0.1676
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.2188 0.2188
Onchocerca volvulus 0.0023 0.0258 0.0661
Plasmodium vivax vivapain-2 0.0023 0.0258 0.0596
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.002 0.0047
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0119
Loa Loa (eye worm) fibroinase 0.0023 0.0258 0.036
Echinococcus granulosus hypothetical protein 0.0068 0.1167 0.1167
Brugia malayi Cathepsin L-like precursor 0.0015 0.0092 0.0117
Echinococcus multilocularis Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.2604 0.2604
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Onchocerca volvulus 0.0023 0.0258 0.0661
Schistosoma mansoni alpha-1 adrenergic receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) tubulin gamma chain 0.0121 0.2247 0.3243
Schistosoma mansoni biogenic amine receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0051 0.0828 0.1187
Toxoplasma gondii cathepsin CPL 0.0023 0.0258 0.0596
Brugia malayi larval opioid receptor 0.0068 0.1167 0.1676
Brugia malayi MH1 domain containing protein 0.0024 0.0279 0.0389
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Trichomonas vaginalis tubulin beta chain, putative 0.0068 0.1182 0.2712
Brugia malayi tubulin alpha-2 chain 0.0169 0.3218 0.465
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.002 0.0013
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0011 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Plasmodium vivax delta tubulin, putative 0.0053 0.0859 0.1989
Loa Loa (eye worm) hypothetical protein 0.0042 0.0638 0.0911
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Echinococcus granulosus tubulin subunit beta 0.0223 0.4321 0.4321
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0011 0.0014 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0268 0.0717
Brugia malayi ABC transporter family protein 0.0011 0.0014 0.0004
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.008 0.1423 0.1423
Onchocerca volvulus 0.0023 0.0268 0.0689
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.018 0.0417
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0195 0.0195
Echinococcus multilocularis beta tubulin 0.0223 0.4321 0.4321
Echinococcus granulosus tubulin beta 4A class IVa 0.0223 0.4321 0.4321
Echinococcus granulosus tubulin gamma 1 chain 0.0121 0.2247 0.2247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Trypanosoma brucei unspecified product 0.0013 0.006 0.014
Loa Loa (eye worm) alpha-tubulin 0.0169 0.3218 0.4651
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Brugia malayi G protein-coupled receptor 0.0068 0.1167 0.1676
Trichomonas vaginalis tubulin alpha chain, putative 0.0068 0.1182 0.2712
Brugia malayi Serotonin receptor 0.0068 0.1167 0.1676
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi isocitrate dehydrogenase 0.0032 0.0441 0.0623
Onchocerca volvulus 0.0068 0.1167 0.31
Trypanosoma brucei beta tubulin 0.0223 0.4321 1
Echinococcus granulosus alpha tubulin 0.0169 0.3218 0.3218
Echinococcus granulosus RUN 0.002 0.0195 0.0195
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0195 0.0195
Schistosoma mansoni smad 0.0011 0.0011 0.0011
Brugia malayi MH1 domain containing protein 0.0013 0.0063 0.0075
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Brugia malayi Tubulin alpha-2 chain 0.0169 0.3218 0.465
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0014 0.0033
Brugia malayi RNA recognition motif domain containing protein 0.0187 0.359 0.5189
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0148 0.0397
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.0077
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.018 0.0482
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis serotonin receptor 0.0068 0.1167 0.1167
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Brugia malayi Tubulin alpha chain 0.0169 0.3218 0.465
Brugia malayi hypothetical protein 0.0151 0.2861 0.4132
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0195 0.0195
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.002 0.002
Brugia malayi putative neuropeptide receptor NPR1 0.0068 0.1167 0.1676
Leishmania major beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Entamoeba histolytica hypothetical protein 0.0036 0.0525 0.1214
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Entamoeba histolytica cysteine proteinase 1, putative 0.0023 0.0258 0.0596
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.018 0.0417
Leishmania major DNA polymerase kappa, putative 0.0019 0.018 0.0417
Schistosoma mansoni tubulin subunit alpha 0.0169 0.3218 0.3218
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0011 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.002 0.0014
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Loa Loa (eye worm) RNA binding protein 0.0187 0.359 0.519
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0195 0.374 0.8655
Echinococcus granulosus cysteine protease 0.0023 0.0258 0.0258
Schistosoma mansoni growth hormone secretagogue receptor 0.0068 0.1167 0.1167
Brugia malayi neuropeptide F receptor 0.0068 0.1167 0.1676
Trypanosoma brucei alpha tubulin 0.0169 0.3218 0.7448
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Echinococcus multilocularis tubulin beta 1 chain 0.0223 0.4321 0.4321
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0068 0.1167 0.1167
Plasmodium vivax tubulin beta chain, putative 0.0223 0.4321 1
Leishmania major cysteine peptidase A (CPA) 0.0023 0.0258 0.0596
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0279 0.0391
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Loa Loa (eye worm) nuclear factor I 0.0013 0.0063 0.0077
Echinococcus granulosus peroxisome assembly protein 26 0.0169 0.3218 0.3218
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Echinococcus multilocularis tubulin subunit TubB 0.0169 0.3218 0.3218
Echinococcus granulosus cathepsin l1 0.0023 0.0258 0.0258
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Loa Loa (eye worm) tubulin alpha chain 0.0169 0.3218 0.4651
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0011 0.0014 0.0033
Brugia malayi G protein-coupled receptor F59B2.13 0.0068 0.1167 0.1676
Plasmodium vivax vivapain-3 0.0023 0.0258 0.0596
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.043 0.043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Onchocerca volvulus 0.0068 0.1167 0.31
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1761 0.1761
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0047
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0014 0.0014
Onchocerca volvulus 0.002 0.0195 0.0492
Trypanosoma cruzi tubulin gamma chain 0.0121 0.2247 0.52
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0023 0.0258 0.0596
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0708 0.0708
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis peroxisome assembly protein 26 0.0169 0.3218 0.3218
Onchocerca volvulus 0.0068 0.1167 0.31
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus multilocularis somatostatin receptor 0.0068 0.1167 0.1167
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0279 0.0279
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0493 0.1141
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1791 0.1791
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.0258 0.0258
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0053 0.0859 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1167 0.1167
Mycobacterium ulcerans hypothetical protein 0.0023 0.0268 0.0717
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1167 0.1678
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Schistosoma mansoni rab6-interacting 0.002 0.0195 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.006 0.014
Trypanosoma cruzi zeta tubulin, putative 0.0053 0.0859 0.1989
Giardia lamblia Beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis neuropeptide s receptor 0.0068 0.1167 0.1167
Onchocerca volvulus 0.0068 0.1167 0.31
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.018 0.018
Echinococcus granulosus orexin receptor type 2 0.0068 0.1167 0.1167
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0638 0.0911
Loa Loa (eye worm) tubulin alpha-2 chain 0.0169 0.3218 0.4651
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Echinococcus granulosus 7tm_1 domain containing protein 0.0068 0.1167 0.1167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) tubulin alpha 2 0.0116 0.2153 0.3108
Schistosoma mansoni neuropeptide receptor 0.0068 0.1167 0.1167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0708 0.0708
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.008 0.1423 0.2047
Brugia malayi MH1 domain containing protein 0.0013 0.0063 0.0075
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0068 0.1167 0.1167
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.018 0.0417
Echinococcus granulosus neuropeptide FF receptor 2 0.0068 0.1167 0.1167
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0068 0.1167 0.1167
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0023 0.0258 0.0596
Brugia malayi MH2 domain containing protein 0.0351 0.6908 1
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1167 0.1167
Echinococcus granulosus 7TM GPCR rhodopsin 0.0068 0.1167 0.1167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.002 0.0047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0011 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1167 0.1167
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0011 0.002 0.0047
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.043 0.043
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0011 0.002 0.002
Echinococcus granulosus beta tubulin 0.0223 0.4321 0.4321
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus GPCR family 2 0.0031 0.043 0.043
Echinococcus granulosus fmrfamide receptor 0.0068 0.1167 0.1167
Schistosoma mansoni hypothetical protein 0.0031 0.043 0.043
Plasmodium vivax tubulin alpha chain, putative 0.0169 0.3218 0.7448
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0007
Trypanosoma brucei unspecified product 0.0019 0.018 0.0417
Trichomonas vaginalis tubulin, putative 0.0068 0.1182 0.2712
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0031 0.043 0.043
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0068 0.1167 0.1167
Toxoplasma gondii alpha-tubulin I, putative 0.0169 0.3218 0.7448
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1802 0.2596
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1802 0.2598
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1167 0.1167
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0441 0.1021
Echinococcus multilocularis cysteine protease 0.0023 0.0258 0.0258
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0493 0.1141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Brugia malayi Dopamine receptor 0.0068 0.1167 0.1676
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0258 0.0357
Schistosoma mansoni lipoxygenase 0.0118 0.2188 0.2188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Brugia malayi hypothetical protein 0.002 0.0195 0.0266
Entamoeba histolytica P-glycoprotein-2, putative 0.0011 0.0014 0.0033
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0091 0.1649 0.1649
Leishmania major zeta tubulin, putative 0.0053 0.0859 0.1989
Plasmodium falciparum cysteine proteinase falcipain 3 0.0023 0.0258 0.0596
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Schistosoma mansoni tubulin subunit alpha 0.0169 0.3218 0.3218
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0011 0.002 0.0047
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0148 1
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0195 0.0451
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.2604 0.2604
Echinococcus granulosus tubulin alpha 3 chain 0.0169 0.3218 0.3218
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0011 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0441 0.0441
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0068 0.1182 0.2712
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0493 0.07
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0258 0.0596
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Giardia lamblia Alpha-tubulin 0.0169 0.3218 0.7435
Echinococcus granulosus neuropeptide receptor 0.0068 0.1167 0.1167
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0129 0.0308
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0014 0.0014
Echinococcus multilocularis tubulin subunit beta 0.0223 0.4321 0.4321
Echinococcus granulosus tubulin delta chain 0.0053 0.0859 0.0859
Trypanosoma brucei epsilon tubulin 0.0121 0.2247 0.52
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0268 0.0717
Schistosoma mansoni hypothetical protein 0.0031 0.043 0.043
Onchocerca volvulus 0.0068 0.1167 0.31
Schistosoma mansoni cathepsin s 0.0015 0.0092 0.0092
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0068 0.1167 0.1678
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Entamoeba histolytica P-glyco protein 6, putative 0.0011 0.0014 0.0033
Giardia lamblia Gamma tubulin 0.0121 0.2247 0.5177
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0014 0.0033
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1167 0.1167
Plasmodium falciparum multidrug resistance protein 1 0.0011 0.0014 0.0033
Schistosoma mansoni neuropeptide f receptor 76f 0.0068 0.1167 0.1167
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0268 0.0621
Trypanosoma cruzi tubulin delta chain 0.0053 0.0859 0.1989
Trypanosoma brucei alpha tubulin 0.0169 0.3218 0.7448
Schistosoma mansoni hypothetical protein 0.002 0.0195 0.0195
Schistosoma mansoni hypothetical protein 0.0503 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0068 0.1167 0.1678
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.002 0.002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0068 0.1167 0.1167
Brugia malayi CHE-14 protein 0.0042 0.0638 0.0909
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.002 0.0014
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0223 0.4321 0.4321
Trypanosoma cruzi cruzipain precursor, putative 0.0015 0.0092 0.0213
Schistosoma mansoni histamine h1 receptor 0.0068 0.1167 0.1167
Treponema pallidum cell division protein FtsZ 0.0053 0.0859 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0268 0.0375
Brugia malayi GnHR receptor homolog 0.0068 0.1167 0.1676
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis tubulin gamma chain, putative 0.0121 0.2247 0.5184
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1167 0.1167
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.002 0.0047
Echinococcus multilocularis sex peptide receptor 0.0068 0.1167 0.1167
Plasmodium falciparum tubulin delta chain, putative 0.0053 0.0859 0.1989
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0258 0.0258
Echinococcus granulosus alpha 1A adrenergic receptor 0.0068 0.1167 0.1167
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Loa Loa (eye worm) BEN-1 protein 0.0223 0.4321 0.625
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Echinococcus multilocularis tubulin alpha 1C chain 0.0169 0.3218 0.3218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Trypanosoma brucei alpha tubulin 0.0169 0.3218 0.7448
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0279 0.0279
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1167 0.1167
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0047
Trypanosoma brucei beta tubulin 0.0223 0.4321 1
Onchocerca volvulus 0.0068 0.1167 0.31
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0068 0.1167 0.1167
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.018 0.0245
Echinococcus granulosus cathepsin L 0.0023 0.0258 0.0258
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Mycobacterium leprae cell division protein FtsZ 0.0053 0.0859 0.1703
Loa Loa (eye worm) hypothetical protein 0.0023 0.0258 0.036
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Brugia malayi ORL1-like opioid receptor 0.0068 0.1167 0.1676
Schistosoma mansoni hypothetical protein 0.0031 0.043 0.043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Brugia malayi RE15519p 0.0068 0.1167 0.1676
Onchocerca volvulus 0.0151 0.2861 0.7642
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0441 0.1021
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1167 0.1675
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Leishmania major DNA polymerase eta, putative 0.0019 0.018 0.0417
Mycobacterium ulcerans cell division protein FtsZ 0.0053 0.0859 0.2298
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.018 0.0247
Plasmodium vivax tubulin epsilon chain, putative 0.0121 0.2247 0.52
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Schistosoma mansoni hypothetical protein 0.004 0.0608 0.0608
Trypanosoma cruzi epsilon tubulin, putative 0.0121 0.2247 0.52
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0053 0.0859 0.1989
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0.0014 0.0007
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) transcription factor SMAD2 0.0351 0.6908 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0169 0.3218 0.3218
Echinococcus granulosus tubulin alpha 1C chain 0.0169 0.3218 0.3218
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0258 0.036
Trypanosoma brucei beta tubulin 0.0223 0.4321 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.018 0.0445
Echinococcus granulosus tubulin alpha 1C chain 0.0169 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0016
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis thymidylate synthase 0.0195 0.374 0.374
Loa Loa (eye worm) hypothetical protein 0.0019 0.018 0.0247
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0258 0.0661
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Echinococcus multilocularis Smad4 0.0024 0.0279 0.0279
Trichomonas vaginalis tubulin beta chain, putative 0.0223 0.4321 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0708 0.0708
Schistosoma mansoni tubulin subunit epsilon 0.0121 0.2247 0.2247
Trichomonas vaginalis tubulin, putative 0.0068 0.1182 0.2712
Giardia lamblia Alpha-tubulin 0.0169 0.3218 0.7435
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1167 0.1167
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1167 0.1167
Trichomonas vaginalis tubulin epsilon chain, putative 0.0169 0.3218 0.7439
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0119
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Toxoplasma gondii beta tubulin 0.0223 0.4321 1
Onchocerca volvulus 0.0068 0.1167 0.31
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0441 0.0441
Loa Loa (eye worm) tubulin alpha chain 0.0169 0.3218 0.4651
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.002 0.002
Echinococcus granulosus peptide allatostatin:somatostatin 0.0068 0.1167 0.1167
Echinococcus multilocularis beta tubulin 0.0223 0.4321 0.4321
Trypanosoma cruzi alpha tubulin, putative 0.0169 0.3218 0.7448
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0011 0.002 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0258 0.0258
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0092 0.0119
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.018 0.0445
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0068 0.1167 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1111
Trypanosoma brucei alpha tubulin 0.0169 0.3218 0.7448
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0493 0.1141
Echinococcus granulosus tar DNA binding protein 0.0187 0.359 0.359
Trichomonas vaginalis tubulin gamma chain, putative 0.0053 0.0859 0.1962
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.006 0.014
Schistosoma mansoni opsin-like receptor 0.0068 0.1167 0.1167
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0258 0.0258
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.01 0.1831 0.4217
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0116 0.2153 0.3108
Mycobacterium tuberculosis Cell division protein FtsZ 0.0053 0.0859 0.2268
Loa Loa (eye worm) hypothetical protein 0.0151 0.2861 0.4133
Schistosoma mansoni hypothetical protein 0.0503 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0068 0.1167 0.1167
Brugia malayi Tubulin alpha-2 chain 0.0169 0.3218 0.465
Brugia malayi follicle stimulating hormone receptor 0.0068 0.1167 0.1676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Echinococcus granulosus tubulin beta 1 chain 0.0223 0.4321 0.4321
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0068 0.1167 0.1676
Plasmodium falciparum tubulin epsilon chain, putative 0.0121 0.2247 0.52
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.1649 0.1649
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Leishmania major basic transcription factor 3a, putative 0.0034 0.0493 0.1141
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0493 0.1141
Leishmania major cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0047
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.008 0.1423 0.2049
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0014 0.0014
Leishmania major beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1111
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0493 0.1141
Brugia malayi alpha-tubulin 0.0169 0.3218 0.465
Echinococcus granulosus sex peptide receptor 0.0068 0.1167 0.1167
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.002 0.002
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0015 0.0092 0.0117
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0007
Plasmodium falciparum alpha tubulin 1 0.0169 0.3218 0.7448
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1677
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.002 0.0016
Echinococcus granulosus Smad4 0.0024 0.0279 0.0279
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0068 0.1167 0.1167
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0169 0.3218 0.4651
Onchocerca volvulus 0.0068 0.1167 0.31
Onchocerca volvulus 0.0068 0.1167 0.31
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0708 0.0708
Leishmania major gamma-tubulin 0.0121 0.2247 0.52
Brugia malayi Tubulin alpha chain 0.0053 0.0859 0.123
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0195 0.0195
Onchocerca volvulus 0.0023 0.0258 0.0661
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0493 0.1141
Trypanosoma cruzi epsilon tubulin, putative 0.0121 0.2247 0.52
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Echinococcus multilocularis tubulin alpha 0.0121 0.2247 0.2247
Entamoeba histolytica hypothetical protein 0.0036 0.0525 0.1214
Brugia malayi thymidylate synthase 0.0195 0.374 0.5407
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Echinococcus granulosus expressed conserved protein 0.0091 0.1642 0.1642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus granulosus beta tubulin 0.0223 0.4321 0.4321
Loa Loa (eye worm) tubulin beta chain 0.0223 0.4321 0.625
Echinococcus multilocularis cathepsin L 0.0023 0.0258 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.1672 0.3848
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0268 0.0372
Plasmodium vivax unspecified product 0.0206 0.397 0.9187
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.018 0.0417
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0068 0.1167 0.1167
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0053 0.0859 0.1962
Brugia malayi hypothetical protein 0.0093 0.1672 0.2407
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.002 0.002
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1167 0.1167
Schistosoma mansoni multidrug resistance protein 0.0011 0.0014 0.0014
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0068 0.1167 0.1167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Entamoeba histolytica hypothetical protein 0.0036 0.0525 0.1214
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0068 0.1167 0.1676
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.043 0.043
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.002 0.002
Echinococcus granulosus tubulin subunit TubB 0.0169 0.3218 0.3218
Loa Loa (eye worm) PDE1B protein 0.0011 0.002 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.002 0.0047
Echinococcus multilocularis RUN 0.002 0.0195 0.0195
Entamoeba histolytica hypothetical protein 0.0036 0.0525 0.1214
Schistosoma mansoni opsin-like receptor 0.0068 0.1167 0.1167
Trypanosoma cruzi tubulin delta chain 0.0053 0.0859 0.1989
Entamoeba histolytica tubulin family protein 0.0223 0.4321 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0638 0.1449
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0268 0.0717
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Brugia malayi beta-tubulin, identical 0.0223 0.4321 0.6249
Echinococcus multilocularis tubulin alpha 3 chain 0.0169 0.3218 0.3218
Schistosoma mansoni transcription factor btf3 0.0034 0.0493 0.0493
Echinococcus multilocularis hypothetical protein 0.0169 0.3218 0.3218
Echinococcus multilocularis dna polymerase eta 0.0019 0.018 0.018
Entamoeba histolytica tubulin alpha chain, putative 0.0169 0.3218 0.7448
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0091 0.1649 0.3787
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0.0014 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.018 0.0417
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.002 0.0047
Trichomonas vaginalis tubulin gamma chain, putative 0.0223 0.4321 1
Onchocerca volvulus 0.002 0.0195 0.0492
Echinococcus granulosus Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Echinococcus multilocularis Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0068 0.1167 0.1167
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0068 0.1167 0.1676
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0023 0.0258 0.0596
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0859 0.1962
Brugia malayi G-protein coupled receptor 0.0068 0.1167 0.1676
Trypanosoma brucei zeta tubulin 0.0053 0.0859 0.1989
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0258 0.0661
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1167 0.1167
Brugia malayi RNA binding protein 0.0187 0.359 0.5189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Schistosoma mansoni multidrug resistance protein 0.0011 0.0014 0.0014
Brugia malayi Melatonin receptor type 1A 0.0068 0.1167 0.1676
Brugia malayi tubulin alpha chain - mouse 0.0169 0.3218 0.465
Brugia malayi hypothetical protein 0.0036 0.0525 0.0744
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0441 0.0441
Loa Loa (eye worm) doublecortin family protein 0.002 0.0195 0.0268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis tubulin epsilon chain 0.0121 0.2247 0.2247
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1167 0.1167
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0268 0.0717
Onchocerca volvulus 0.0068 0.1167 0.31
Trypanosoma brucei zeta tubulin, putative 0.0053 0.0859 0.1989
Loa Loa (eye worm) tubulin beta chain 0.0053 0.0859 0.1232
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0638 0.0638
Echinococcus granulosus tubulin alpha 3 chain 0.0169 0.3218 0.3218
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0268 0.0681
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0268 0.0717
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus multilocularis tar DNA binding protein 0.0187 0.359 0.359
Echinococcus granulosus dna polymerase kappa 0.0019 0.018 0.018
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0014 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0258 0.0258
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Brugia malayi hypothetical protein 0.002 0.0195 0.0266
Leishmania major delta tubulin, putative 0.0053 0.0859 0.1989
Schistosoma mansoni smad1 5 8 and 0.0024 0.0279 0.0279
Toxoplasma gondii alpha tubulin TUBA1 0.0169 0.3218 0.7448
Leishmania major epsilon tubulin, putative 0.0121 0.2247 0.52
Schistosoma mansoni lipoxygenase 0.0083 0.1468 0.1468
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1761 0.1761
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1167 0.1167
Echinococcus granulosus g protein coupled receptor 0.0068 0.1167 0.1167
Schistosoma mansoni polycystin 1-related 0.002 0.0195 0.0195
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.043 0.0607
Schistosoma mansoni neuropeptide receptor 0.0068 0.1167 0.1167
Leishmania major beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Brugia malayi Latrophilin receptor protein 2 0.0031 0.043 0.0607
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0068 0.1167 0.1678
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0441 0.0441
Plasmodium vivax unspecified product 0.0015 0.0092 0.0213
Loa Loa (eye worm) hypothetical protein 0.0091 0.1649 0.2376
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0011 0.0011
Loa Loa (eye worm) tubulin alpha-3 chain 0.01 0.1831 0.264
Trichomonas vaginalis tubulin alpha chain, putative 0.0121 0.2247 0.5184
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0011 0.0011
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.002 0.0013
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0195 0.374 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0011 0.002 0.0013
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Plasmodium vivax tubulin alpha chain, putative 0.0169 0.3218 0.7448
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0258 0.0258
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1167 0.1167
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.374
Schistosoma mansoni biogenic amine receptor 0.0068 0.1167 0.1167
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0099 0.1802 0.2598
Entamoeba histolytica hypothetical protein 0.0034 0.0493 0.1141
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0258 0.0565
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0053 0.0859 0.1989
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0011 0.002 0.0047
Giardia lamblia Beta tubulin 0.0223 0.4321 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Onchocerca volvulus 0.0068 0.1167 0.31
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus dna polymerase eta 0.0019 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.002 0.0195 0.0268
Schistosoma mansoni Smad4 0.0024 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus tubulin epsilon chain 0.0121 0.2247 0.2247
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0268 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.006 0.014
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Brugia malayi Serotonin receptor 0.0068 0.1167 0.1676
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0708 0.101
Schistosoma mansoni multidrug resistance protein 0.0011 0.0014 0.0014
Echinococcus granulosus dro:myosuppressin receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0708 0.0708
Entamoeba histolytica tubulin gamma chain 0.0121 0.2247 0.52
Giardia lamblia DINP protein human, muc B family 0.0019 0.018 0.0371
Trypanosoma brucei alpha tubulin, putative 0.0068 0.1182 0.2736
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0268 0.0621
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus granulosus allatostatin A receptor 0.0068 0.1167 0.1167
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0091 0.1649 0.3816
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Schistosoma mansoni smdr2 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Schistosoma mansoni hypothetical protein 0.004 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Schistosoma mansoni neuropeptide receptor 0.0068 0.1167 0.1167
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0011 0.002 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.018 0.0482
Leishmania major beta tubulin 0.0223 0.4321 1
Plasmodium vivax vivapain-2 0.0023 0.0258 0.0596
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0441 0.0441
Giardia lamblia Delta tubulin 0.0053 0.0859 0.1951
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.008 0.1423 0.1423
Toxoplasma gondii beta-1 tubulin, putative 0.0223 0.4321 1
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Loa Loa (eye worm) TAR-binding protein 0.0187 0.359 0.519
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.2188 0.2188
Trichomonas vaginalis tubulin epsilon chain, putative 0.0169 0.3218 0.7439
Loa Loa (eye worm) tubulin beta-1 chain 0.0223 0.4321 0.625
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1167 0.1167
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0016
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.018 0.0385
Echinococcus multilocularis ATP binding cassette sub family B 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1167 0.1167
Brugia malayi AKH receptor 0.0068 0.1167 0.1676
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0092 0.0117
Loa Loa (eye worm) tubulin beta-2A chain 0.0223 0.4321 0.625
Onchocerca volvulus Cathepsin F homolog 0.0023 0.0258 0.0661
Echinococcus multilocularis smad 0.0024 0.0279 0.0279
Echinococcus multilocularis g-protein coupled receptor 0.0068 0.1167 0.1167
Brugia malayi Dopamine receptor protein 2 0.0068 0.1167 0.1676
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) hypothetical protein 0.0023 0.0268 0.0375
Brugia malayi G-protein coupled receptor 0.0068 0.1167 0.1676
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1167 0.1167
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.043 0.0609
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0493 0.1141
Leishmania major beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Trypanosoma cruzi zeta tubulin, putative 0.0053 0.0859 0.1989
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Leishmania major beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0268 0.0621
Echinococcus multilocularis serotonin receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis cysteine protease 0.0023 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Schistosoma mansoni myosin xvIII 0.0068 0.1167 0.1167
Leishmania major beta tubulin 0.0223 0.4321 1
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1167 0.1678
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Onchocerca volvulus 0.0068 0.1167 0.31
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1167 0.1678
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Schistosoma mansoni tubulin subunit beta 0.0053 0.0859 0.0859
Entamoeba histolytica tubulin alpha-1 chain 0.0169 0.3218 0.7448
Brugia malayi Smad1 0.0024 0.0279 0.0389
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0441 0.0625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0525 0.0525
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0195 0.0195
Schistosoma mansoni alpha tubulin 0.0169 0.3218 0.3218
Trichomonas vaginalis tubulin, putative 0.0053 0.0859 0.1962
Schistosoma mansoni loxhd1 0.002 0.0195 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0268 0.0681
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0258 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Brugia malayi MH1 domain containing protein 0.0024 0.0279 0.0389
Echinococcus multilocularis orexin receptor type 2 0.0068 0.1167 0.1167
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0279 0.0391
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma brucei beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis tubulin, putative 0.0223 0.4321 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis tubulin alpha chain, putative 0.0068 0.1182 0.2712
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1802 0.2596
Schistosoma mansoni hypothetical protein 0.0036 0.0525 0.0525
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0708 0.1013
Plasmodium vivax multidrug resistance protein 1, putative 0.0011 0.0014 0.0033
Brugia malayi beta-NAC-like protein 0.0034 0.0493 0.0698
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0068 0.1167 0.1676
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus smad 0.0024 0.0279 0.0279
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0129 0.0308
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1167 0.1167
Trypanosoma cruzi beta tubulin, putative 0.0223 0.4321 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0268 0.0621
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0169 0.3218 0.7439
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0023 0.0268 0.0375
Loa Loa (eye worm) hypothetical protein 0.0097 0.1761 0.2538
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.018 0.0417
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0441 0.1021
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0258 0.0258
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1761 0.2537
Echinococcus multilocularis allatostatin A receptor 0.0068 0.1167 0.1167
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Brugia malayi TAR-binding protein 0.0187 0.359 0.5189
Toxoplasma gondii beta-tubulin, putative 0.0223 0.4321 1
Echinococcus granulosus g-protein coupled receptor 0.0068 0.1167 0.1167

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.78 uM In vitro inhibition of L1210 cell growth in culture. ChEMBL. 2033585
IC50 (functional) = 0.78 uM In vitro inhibition of L1210 cell growth in culture. ChEMBL. 2033585
IC50 (binding) = 1.36 uM In vitro inhibition of partially purified L1210 thymidylate synthase (TS). ChEMBL. 2033585
IC50 (binding) = 1.36 uM In vitro inhibition of partially purified L1210 thymidylate synthase (TS). ChEMBL. 2033585

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 2033585

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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