Detailed information for compound 574111

Basic information

Technical information
  • TDR Targets ID: 574111
  • Name: cobaltous 2-[(N'E)-N'-(5-chloro-1-oxo-2-napht hylidene)hydrazino]-5-nitro-phenolate
  • MW: 744.36 | Formula: C32H18Cl2CoN6O8
  • H donors: 2 H acceptors: 8 LogP: 8.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-]c1cc(ccc1N/N=C\1/C=Cc2c(C1=O)cccc2Cl)[N+](=O)[O-].[O-]c1cc(ccc1N/N=C\1/C=Cc2c(C1=O)cccc2Cl)[N+](=O)[O-].[Co+2]
  • InChi: 1S/2C16H10ClN3O4.Co/c2*17-12-3-1-2-11-10(12)5-7-14(16(11)22)19-18-13-6-4-9(20(23)24)8-15(13)21;/h2*1-8,18,21H;/q;;+2/p-2/b2*19-14+;
  • InChiKey: QHKWRRYLDSFBSC-BFOTTZSISA-L  


Substructure search Similarity search

Network

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Synonyms

  • cobaltous 2-[(N'E)-N'-(5-chloro-1-oxo-2-naphthylidene)hydrazino]-5-nitrophenolate
  • 2-[(2E)-2-(5-chloro-1-oxo-naphthalen-2-ylidene)hydrazinyl]-5-nitro-phenolate; cobalt(2+)
  • cobaltous 2-[(N'E)-N'-(5-chloro-1-keto-2-naphthylidene)hydrazino]-5-nitro-phenolate
  • 2-[(2E)-2-(5-chloro-1-oxonaphthalen-2-ylidene)hydrazinyl]-5-nitrophenolate; cobalt(2+)
  • Orasol Navy Blue 2RB
  • 2-[(2E)-2-(5-chloro-1-oxonaphthalen-2-ylidene)hydrazinyl]-5-nitrophenolate; cobalt(+2) cation
  • 2-[(2E)-2-(5-chloro-1-oxo-naphthalen-2-ylidene)hydrazinyl]-5-nitro-phenolate; cobalt(+2) cation
  • 61969-42-4
  • 1-NAPHTHALENOL, 5-CHLORO-2-((2-HYDROXY-4-NITROPHENYL)AZO)-, COBALT SALT (2:1)
  • 5-Chloro-2-((2-hydroxy-4-nitrophenyl)azo)-1-naphthalenol cobalt
  • C.I. Solvent Blue 53

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0063 0.0159
Schistosoma mansoni hypothetical protein 0.0029 0.002 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0122 0.0105
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0139 0.3215
Echinococcus granulosus neuropeptide receptor A26 0.0481 0.2183 0.2169
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0115 0.0432 0.1243
Brugia malayi jmjC domain containing protein 0.0115 0.0432 0.1087
Brugia malayi PHD-finger family protein 0.0089 0.0305 0.077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Echinococcus multilocularis neuropeptide receptor A26 0.0481 0.2183 0.2169
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0056 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0029 0.0094
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0072 0.1663
Schistosoma mansoni microtubule-associated protein tau 0.2113 1 1
Trypanosoma brucei trypanothione reductase 0.0115 0.0432 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0139 0.0186
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.0285 0.0717
Schistosoma mansoni cpg binding protein 0.0038 0.0063 0.0045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.0072 0.0029
Toxoplasma gondii thioredoxin reductase 0.0115 0.0432 0.1425
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0056 0.0038
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0139 0.0121
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0305 0.077
Leishmania major hypothetical protein, conserved 0.0038 0.0063 0.1462
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Loa Loa (eye worm) MBCTL1 0.0057 0.0156 0.0392
Leishmania major trypanothione reductase 0.0115 0.0432 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0156 0.0138
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0139 0.0186
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0072 0.0036
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.136 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0056 0.1289
Trypanosoma brucei ISWI complex protein 0.0048 0.0109 0.252
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0072 0.0124
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0063 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0176 0.0724 0.0707
Loa Loa (eye worm) hypothetical protein 0.0147 0.0587 0.1479
Giardia lamblia PHD finger protein 15 0.0089 0.0305 0.1915
Schistosoma mansoni zinc finger protein 0.0063 0.0181 0.0163
Brugia malayi PHD-finger family protein 0.0037 0.0056 0.0142
Plasmodium falciparum thioredoxin reductase 0.0115 0.0432 0.1425
Plasmodium falciparum glutathione reductase 0.004 0.0072 0.0237
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0021 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0063 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Schistosoma mansoni hypothetical protein 0.0089 0.0305 0.0288
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0112 0.0416 0.0399
Brugia malayi beta-lactamase family protein 0.0038 0.0063 0.0159
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0305 0.0288
Brugia malayi hypothetical protein 0.013 0.0501 0.1263
Loa Loa (eye worm) jmjC domain-containing protein 0.0183 0.0758 0.1909
Onchocerca volvulus 0.0038 0.0063 0.0082
Onchocerca volvulus Huntingtin homolog 0.013 0.0501 0.1054
Onchocerca volvulus Huntingtin homolog 0.013 0.0501 0.1054
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0415
Onchocerca volvulus 0.0038 0.0063 0.0082
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0415
Schistosoma mansoni hypothetical protein 0.0307 0.1349 0.1333
Brugia malayi Bromodomain containing protein 0.0096 0.0341 0.0859
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0114 0.0287
Echinococcus granulosus lysine specific demethylase 5A 0.0115 0.0432 0.0414
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0072 0.0054
Loa Loa (eye worm) hypothetical protein 0.0057 0.0156 0.0392
Loa Loa (eye worm) hypothetical protein 0.0152 0.0609 0.1534
Echinococcus granulosus zinc finger protein 0.0063 0.0181 0.0163
Brugia malayi CXXC zinc finger family protein 0.003 0.0026 0.0066
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0305 0.0288
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0156 0.0138
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1657 0.7818 0.7814
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0463 0.1167
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0215 0.0542
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0156 0.0138
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0156 0.0138
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0139 0.0638
Schistosoma mansoni zinc finger protein 0.0048 0.0109 0.0091
Echinococcus multilocularis muscleblind protein 0.0147 0.0587 0.057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0854 0.3968 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0139 0.3215
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.0285 0.0267
Brugia malayi follicle stimulating hormone receptor 0.0247 0.1065 0.2684
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0139 0.0458
Treponema pallidum hypothetical protein 0.0657 0.3029 1
Schistosoma mansoni hypothetical protein 0.0036 0.0051 0.0033
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0139 0.3215
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0056 0.0038
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0215 0.498
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0139 0.0121
Loa Loa (eye worm) hypothetical protein 0.0147 0.0587 0.1479
Giardia lamblia Fructose-bisphosphate aldolase 0.0309 0.136 1
Chlamydia trachomatis 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0657 0.3029 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0215 0.498
Trypanosoma cruzi ISWI complex protein 0.0048 0.0109 0.252
Echinococcus granulosus dnaJ subfamily B 0.0432 0.1951 0.1937
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.0285 0.0267
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0215 0.0542
Echinococcus granulosus transcription factor Dp 1 0.004 0.0074 0.0056
Echinococcus multilocularis cpg binding protein 0.0038 0.0063 0.0045
Brugia malayi Bromodomain containing protein 0.0119 0.0452 0.1138
Plasmodium falciparum glutathione reductase 0.0115 0.0432 0.1425
Echinococcus granulosus jumonji domain containing protein 0.0123 0.0472 0.0455
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0055 0.0037
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0051 0.0033
Echinococcus granulosus histone lysine methyltransferase setb 0.0176 0.0724 0.0707
Echinococcus multilocularis zinc finger protein 0.0063 0.0181 0.0163
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0215 0.498
Onchocerca volvulus 0.0038 0.0063 0.0082
Plasmodium falciparum thioredoxin reductase 0.004 0.0072 0.0237
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.0285 0.0267
Echinococcus granulosus muscleblind protein 0.0147 0.0587 0.057
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0156 0.0392
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0139 0.0186
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0072 0.0237
Brugia malayi PHD-finger family protein 0.0079 0.026 0.0656
Schistosoma mansoni cpg binding protein 0.003 0.0026 0.0008
Loa Loa (eye worm) glutathione reductase 0.0115 0.0432 0.1088
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.047 0.0453
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0463 0.1167
Loa Loa (eye worm) beta-lactamase 0.0038 0.0063 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Schistosoma mansoni hypothetical protein 0.0048 0.0109 0.0091
Mycobacterium tuberculosis Probable oxidoreductase 0.0292 0.1278 0.4095
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Schistosoma mansoni hypothetical protein 0.0084 0.0285 0.0267
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0122 0.0105
Onchocerca volvulus 0.0971 0.4533 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0072 0.1663
Onchocerca volvulus 0.0123 0.047 0.0984
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0055 0.0037
Brugia malayi MH2 domain containing protein 0.0122 0.0463 0.1167
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0072 0.0054
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.029 0.1271 0.1256
Loa Loa (eye worm) hypothetical protein 0.0176 0.0724 0.1824
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0072 0.0054
Loa Loa (eye worm) hypothetical protein 0.0127 0.0488 0.1229
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0072 0.0036
Toxoplasma gondii ABC1 family protein 0.0038 0.0063 0.0208
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0056 0.0038
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0262 0.1138 0.4587
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0029 0.0094
Echinococcus multilocularis peregrin 0.0096 0.0341 0.0323
Treponema pallidum fructose-bisphosphate aldolase 0.0309 0.136 0.4357
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0021 0.0053
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0072 0.1663
Brugia malayi Thioredoxin reductase 0.0115 0.0432 0.1088
Mycobacterium tuberculosis Probable dehydrogenase 0.0262 0.1138 0.3622
Loa Loa (eye worm) hypothetical protein 0.005 0.0122 0.0308
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.1065 0.2684
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0122 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Trichomonas vaginalis esterase, putative 0.0038 0.0063 0.0017
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.002 0.0065
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0213 0.0704
Brugia malayi MAP kinase sur-1 0.0054 0.0139 0.035
Brugia malayi Muscleblind-like protein 0.0147 0.0587 0.1479
Mycobacterium ulcerans 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0657 0.3029 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0187 0.0779 0.0762
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0122 0.0105
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0215 0.1253
Loa Loa (eye worm) hypothetical protein 0.013 0.0501 0.1263
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.002 0.0455
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0262 0.1138 0.3622
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.0285 0.0717
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0215 0.0197
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0063 0.0208
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0045
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0122 0.0105
Schistosoma mansoni hypothetical protein 0.0432 0.1951 0.1937
Brugia malayi Pre-SET motif family protein 0.0854 0.3968 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0063 0.0017
Schistosoma mansoni jumonji domain containing protein 0.0231 0.0986 0.0969
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.047 0.0453
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0063 0.0159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0211 0.0193
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0122 0.0308
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0139 0.3215
Mycobacterium tuberculosis Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) 0.0527 0.2405 0.7896
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0445 0.0428
Loa Loa (eye worm) hypothetical protein 0.0089 0.0305 0.077
Schistosoma mansoni hypothetical protein 0.0084 0.0285 0.0267
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0072 0.0181
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0056 0.0038
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0063 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0077 0.0059
Brugia malayi hypothetical protein 0.0036 0.0051 0.0128
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0215 0.498
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0292 0.1278 0.4095
Loa Loa (eye worm) bromodomain containing protein 0.0055 0.0144 0.0363
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0072 0.1663
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0292 0.1278 0.5186
Echinococcus granulosus peregrin 0.0096 0.0341 0.0323
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0056 0.1289
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0045
Brugia malayi glutathione reductase 0.0115 0.0432 0.1088
Mycobacterium tuberculosis Probable reductase 0.0262 0.1138 0.3622
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0072 0.1663
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0432 0.0414
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0063 0.0017
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.002 0.0455
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Echinococcus multilocularis thioredoxin glutathione reductase 0.0117 0.0439 0.0422
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0072 0.0237
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Plasmodium vivax JmjC domain containing protein 0.0029 0.0018 0.0059
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0056 0.1289
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.0604 0.1822
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.047 0.0453
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0122 0.0213
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0187 0.0779 0.0762
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0305 0.1008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.0072 0.0029
Plasmodium falciparum phd finger protein, putative 0.0089 0.0305 0.1008
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0139 0.0186
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0432 0.0414
Schistosoma mansoni apoptosis regulator bax 0.0084 0.0285 0.0267
Loa Loa (eye worm) hypothetical protein 0.0036 0.0056 0.014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0072 0.1663
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.0285 0.0267
Onchocerca volvulus Alhambra homolog 0.0089 0.0305 0.062
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0072 0.1663
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.0832 0.0816
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0142
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0122 0.0105
Trichomonas vaginalis set domain proteins, putative 0.0971 0.4533 1
Echinococcus granulosus neuropeptide s receptor 0.0481 0.2183 0.2169
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0215 0.0197
Brugia malayi jmjC domain containing protein 0.029 0.1271 0.3204
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0139 0.0121
Plasmodium falciparum 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0657 0.3029 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0135 0.0117
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0215 0.0197
Brugia malayi beta-lactamase family protein 0.0038 0.0063 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.0604 0.2308
Plasmodium vivax thioredoxin reductase, putative 0.0115 0.0432 0.1425
Loa Loa (eye worm) hypothetical protein 0.022 0.0935 0.2355
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0063 0.1462
Mycobacterium leprae Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) 0.0527 0.2405 1
Schistosoma mansoni hypothetical protein 0.0064 0.0188 0.0171
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.029 0.1271 0.1256
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.002 0.0065
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0072 0.0237
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.047 0.1551
Brugia malayi mbt repeat family protein 0.005 0.0122 0.0308
Brugia malayi Bromodomain containing protein 0.0235 0.1007 0.2537
Loa Loa (eye worm) hypothetical protein 0.0084 0.0285 0.0717
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0056 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0115 0.0432 0.1087
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.0072 0.0029
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0056 0.0036
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0018 0.0059
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0139 0.3215
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.136 0.2914
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0139 0.0121
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Trypanosoma brucei protein kinase, putative 0.0054 0.0139 0.3215
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.0188 0.0475
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0072 0.0237
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Brugia malayi AF-10 protein 0.0029 0.002 0.005
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0072 0.1663
Brugia malayi beta-lactamase 0.0038 0.0063 0.0159
Brugia malayi Pre-SET motif family protein 0.0123 0.047 0.1184
Trypanosoma cruzi trypanothione reductase, putative 0.0115 0.0432 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0074 0.0056
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0305 0.1008
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0056 0.014
Echinococcus granulosus thioredoxin glutathione reductase 0.0117 0.0439 0.0422
Brugia malayi mbt repeat family protein 0.005 0.0122 0.0308
Echinococcus multilocularis lysine specific demethylase 5A 0.0107 0.0395 0.0378
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0122 0.0105
Loa Loa (eye worm) thioredoxin reductase 0.0115 0.0432 0.1088
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.1045 0.3311
Schistosoma mansoni bromodomain containing protein 0.0199 0.0832 0.0816
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0156 0.0138
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0305 0.0288
Schistosoma mansoni cpg binding protein 0.0038 0.0063 0.0045
Loa Loa (eye worm) hypothetical protein 0.0134 0.0525 0.1322
Toxoplasma gondii 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase domain-containing protein 0.0657 0.3029 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0262 0.1138 0.3622
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0063 0.1462
Echinococcus granulosus cpg binding protein 0.0038 0.0063 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0072 0.0237
Loa Loa (eye worm) hypothetical protein 0.0119 0.0453 0.114
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0587 0.057
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0262 0.1138 0.3622
Trypanosoma cruzi ISWI complex protein 0.0048 0.0109 0.252
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0176 0.0724 0.0707
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.0285 0.0267
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0063 0.0017
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0139 0.3215
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0139 0.3215
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0056 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0063 0.0045
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0135 0.0117
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0051 0.0033
Echinococcus multilocularis jumonji domain containing protein 0.0123 0.0472 0.0455
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0018 0.0059
Wolbachia endosymbiont of Brugia malayi 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0657 0.3029 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0072 0.0225 0.0208
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0072 0.0225 0.0208
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0026 0.0066
Onchocerca volvulus 0.005 0.0122 0.0213
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0056 0.1289
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0063 0.0017
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.004 0.0072 0.0029
Echinococcus granulosus fetal alzheimer antigen falz 0.0072 0.0225 0.0208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1663
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0415
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0018 0.0059
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0072 0.0237
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.136 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0063 0.1462
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0159
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0292 0.1278 0.4095
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.0604 0.1822
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0056 0.0038
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0139 0.035
Plasmodium vivax 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, putative 0.0657 0.3029 1
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0305 0.1008
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.1951 0.1937
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0063 0.0045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0112 0.0416 0.0399
Plasmodium vivax glutathione reductase, putative 0.0115 0.0432 0.1425
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0053 0.0135 0.0117
Plasmodium vivax SET domain protein, putative 0.0123 0.047 0.1551
Leishmania major hypothetical protein, conserved 0.0048 0.0109 0.252
Echinococcus multilocularis microtubule associated protein 2 0.2113 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.0832 0.0816
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0051 0.0033
Leishmania major hypothetical protein, conserved 0.0029 0.0018 0.0415
Loa Loa (eye worm) hypothetical protein 0.013 0.0501 0.1263
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0072 0.1663
Echinococcus multilocularis neuropeptide s receptor 0.0481 0.2183 0.2169
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0262 0.1138 0.3622
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0176 0.0724 0.0707
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0139 0.0121
Schistosoma mansoni hypothetical protein 0.0084 0.0285 0.0267
Echinococcus granulosus methyl CpG binding domain protein 2 0.0053 0.0135 0.0117

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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