Detailed information for compound 574122

Basic information

Technical information
  • TDR Targets ID: 574122
  • Name: 2-[(2-aminocyclopentanecarbonyl)amino]-2-[6-( 2-aminopurin-9-yl)-4-(1,2-dihydroxyethyl)-4,5 -dihydroxy-tetrahydropyran-2-yl]acetic acid
  • MW: 495.486 | Formula: C20H29N7O8
  • H donors: 8 H acceptors: 10 LogP: -4.64 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCC(C1(O)CC(OC(C1O)n1cnc2c1nc(N)nc2)C(C(=O)O)NC(=O)C1CCCC1N)O
  • InChi: 1S/C20H29N7O8/c21-9-3-1-2-8(9)16(31)25-13(18(32)33)11-4-20(34,12(29)6-28)14(30)17(35-11)27-7-24-10-5-23-19(22)26-15(10)27/h5,7-9,11-14,17,28-30,34H,1-4,6,21H2,(H,25,31)(H,32,33)(H2,22,23,26)
  • InChiKey: BHAUQSKSOITMND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[(2-aminocyclopentyl)-oxomethyl]amino]-2-[6-(2-amino-9-purinyl)-4-(1,2-dihydroxyethyl)-4,5-dihydroxy-2-tetrahydropyranyl]acetic acid
  • 2-[(2-azanylcyclopentyl)carbonylamino]-2-[6-(2-azanylpurin-9-yl)-4-(1,2-dihydroxyethyl)-4,5-dihydroxy-oxan-2-yl]ethanoic acid
  • 2-[(2-aminocyclopentanecarbonyl)amino]-2-[6-(2-aminopurin-9-yl)-4-(1,2-dihydroxyethyl)-4,5-dihydroxyoxan-2-yl]acetic acid
  • amipurimycin
  • 2-[(2-aminocyclopentyl)carbonylamino]-2-[6-(2-aminopurin-9-yl)-4-(1,2-dihydroxyethyl)-4,5-dihydroxy-oxan-2-yl]ethanoic acid
  • 61991-08-0
  • 9H-Purin-2-amine, 9-[6-[[(2-aminocyclopentyl)carbonyl]amino]-4,6-dideoxy-3-C-(1,2-dihydroxyethyl)heptopyranuronosyl]-
  • AIDS-166731
  • AIDS166731
  • Ampurimycin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0409
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0186 0.0775 0.0759
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0072 0.1657
Brugia malayi beta-lactamase family protein 0.0037 0.0057 0.0144
Schistosoma mansoni cpg binding protein 0.0037 0.0058 0.004
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0072 0.1657
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0131 0.0113
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0115 0.0208
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0308 0.1011
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0205 0.121
Plasmodium falciparum thioredoxin reductase 0.004 0.0072 0.0237
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0056 0.0039
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Brugia malayi Pre-SET motif family protein 0.0123 0.0469 0.1181
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0175 0.0723 0.0706
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0131 0.0113
Loa Loa (eye worm) hypothetical protein 0.0175 0.0723 0.1819
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0131 0.0113
Onchocerca volvulus Huntingtin homolog 0.0126 0.0485 0.1026
Plasmodium vivax thioredoxin reductase, putative 0.0116 0.0436 0.1429
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0072 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0052 0.0034
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.1323 0.4199
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0057 0.0002
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0148 0.013
Loa Loa (eye worm) bromodomain containing protein 0.0055 0.0142 0.0357
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0131 0.3005
Loa Loa (eye worm) glutathione reductase 0.0116 0.0436 0.1097
Schistosoma mansoni bromodomain containing protein 0.0197 0.0829 0.0812
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0205 0.0188
Onchocerca volvulus 0.0037 0.0057 0.008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0264 0.1149 0.3648
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0057 0.0002
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Schistosoma mansoni zinc finger protein 0.0062 0.0179 0.0161
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0133 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Loa Loa (eye worm) hypothetical protein 0.0149 0.0595 0.1496
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0148 0.013
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0018 0.0058
Onchocerca volvulus 0.0969 0.4539 1
Schistosoma mansoni hypothetical protein 0.0085 0.0288 0.0271
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0057 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0057 0.0187
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0469 0.118
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0018 0.0058
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0148 0.0371
Plasmodium vivax 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, putative 0.066 0.3051 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0131 0.033
Plasmodium falciparum glutathione reductase 0.0116 0.0436 0.1429
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0131 0.0167
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0072 0.1657
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.002 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0723 0.0706
Brugia malayi Bromodomain containing protein 0.0118 0.0449 0.113
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0072 0.0237
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0072 0.1657
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.1035 0.2605
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.0186 0.0468
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0115 0.0097
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0021 0.0053
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0148 0.013
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0115 0.0097
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0205 0.0517
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0288 0.0271
Loa Loa (eye worm) hypothetical protein 0.0056 0.0148 0.0371
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.1311
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.004 0.0072 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0723 0.0706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0469 0.0452
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0288 0.0725
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0057 0.0039
Echinococcus granulosus neuropeptide receptor A26 0.0482 0.2196 0.2183
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0308 0.0291
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0595 0.0578
Brugia malayi jmjC domain containing protein 0.0116 0.0435 0.1095
Wolbachia endosymbiont of Brugia malayi 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.066 0.3051 1
Onchocerca volvulus 0.0037 0.0057 0.008
Loa Loa (eye worm) hypothetical protein 0.0153 0.0615 0.1548
Mycobacterium tuberculosis Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) 0.0529 0.2422 0.79
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0205 0.471
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.1293
Echinococcus multilocularis neuropeptide receptor A26 0.0482 0.2196 0.2183
Toxoplasma gondii ABC1 family protein 0.0037 0.0057 0.0187
Brugia malayi PHD-finger family protein 0.0089 0.0308 0.0776
Echinococcus granulosus histone lysine methyltransferase setb 0.0175 0.0723 0.0706
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0264 0.1149 0.3648
Mycobacterium leprae Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) 0.0529 0.2422 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0264 0.1149 0.3648
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0292 0.1285 0.1269
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0264 0.1149 0.4618
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0068 0.005
Schistosoma mansoni hypothetical protein 0.0064 0.0186 0.0169
Trypanosoma brucei trypanothione reductase 0.0116 0.0436 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0056 0.0038
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0131 0.3005
Leishmania major hypothetical protein, conserved 0.0047 0.0107 0.245
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0072 0.0237
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1323 1
Brugia malayi Pre-SET motif family protein 0.0851 0.3974 1
Onchocerca volvulus 0.0123 0.0469 0.0992
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0072 0.0055
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0131 0.3005
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0072 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0076 0.0059
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0053 0.0133 0.0115
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0148 0.013
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0072 0.0237
Trypanosoma cruzi ISWI complex protein 0.0047 0.0107 0.245
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0056 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Echinococcus granulosus jumonji domain containing protein 0.0124 0.0477 0.046
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0409
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0056 0.0039
Giardia lamblia PHD finger protein 15 0.0089 0.0308 0.199
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0068 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0072 0.1657
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0057 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0056 0.0039
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0205 0.471
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0057 0.0039
Leishmania major trypanothione reductase 0.0116 0.0436 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.0585 0.223
Echinococcus multilocularis microtubule associated protein 2 0.2105 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0052 0.0034
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0294 0.1291 0.4122
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0071 0.0223 0.0205
Plasmodium falciparum thioredoxin reductase 0.0116 0.0436 0.1429
Trypanosoma cruzi ISWI complex protein 0.0047 0.0107 0.245
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0089 0.0308 0.0776
Echinococcus multilocularis zinc finger protein 0.0062 0.0179 0.0161
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0072 0.1657
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0018 0.0058
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0308 0.0291
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0115 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Onchocerca volvulus 0.0037 0.0057 0.008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Onchocerca volvulus Alhambra homolog 0.0089 0.0308 0.0636
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0111 0.0414 0.0397
Brugia malayi hypothetical protein 0.0126 0.0485 0.1219
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.0585 0.1762
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0131 0.3005
Treponema pallidum hypothetical protein 0.066 0.3051 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0522 0.1313
Loa Loa (eye worm) hypothetical protein 0.0219 0.0931 0.2343
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.0808 0.0792
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0131 0.3005
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.1293
Schistosoma mansoni hypothetical protein 0.042 0.19 0.1886
Plasmodium vivax glutathione reductase, putative 0.0116 0.0436 0.1429
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0308 0.1011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Loa Loa (eye worm) beta-lactamase 0.0037 0.0057 0.0144
Schistosoma mansoni hypothetical protein 0.0085 0.0288 0.0271
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.0469 0.0452
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0115 0.0097
Brugia malayi MH2 domain containing protein 0.0123 0.0469 0.118
Brugia malayi AF-10 protein 0.0029 0.002 0.0049
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.0808 0.0792
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0021 0.0053
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0056 0.0039
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0056 0.0039
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0072 0.0055
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0131 0.3005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0264 0.1149 0.3648
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.002 0.0449
Loa Loa (eye worm) hypothetical protein 0.0085 0.0288 0.0725
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0131 0.3005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0056 0.0039
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0292 0.1285 0.1269
Brugia malayi hypothetical protein 0.0036 0.0052 0.013
Brugia malayi PHD-finger family protein 0.0037 0.0056 0.0141
Leishmania major hypothetical protein, conserved 0.0029 0.0018 0.0409
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0115 0.0097
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.004 0.0072 0.005
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0115 0.0097
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0054 0.0037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0205 0.0188
Loa Loa (eye worm) MBCTL1 0.0056 0.0148 0.0371
Echinococcus granulosus peregrin 0.0097 0.0344 0.0326
Echinococcus granulosus neuropeptide s receptor 0.0482 0.2196 0.2183
Toxoplasma gondii 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase domain-containing protein 0.066 0.3051 1
Echinococcus multilocularis neuropeptide s receptor 0.0482 0.2196 0.2183
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1016 0.3202
Echinococcus multilocularis thioredoxin glutathione reductase 0.0117 0.0444 0.0426
Plasmodium vivax JmjC domain containing protein 0.0029 0.0018 0.0058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0113 0.0284
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0072 0.1657
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0294 0.1291 0.5217
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0057 0.0002
Schistosoma mansoni hypothetical protein 0.0047 0.0107 0.0089
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0289
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0288 0.0271
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0186 0.0775 0.0759
Plasmodium falciparum glutathione reductase 0.004 0.0072 0.0237
Trichomonas vaginalis set domain proteins, putative 0.0969 0.4539 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Schistosoma mansoni hypothetical protein 0.0036 0.0052 0.0034
Schistosoma mansoni hypothetical protein 0.0029 0.002 0.0002
Trypanosoma brucei protein kinase, putative 0.0052 0.0131 0.3005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.0435 0.0418
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0205 0.471
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0057 0.0144
Mycobacterium tuberculosis Probable dehydrogenase 0.0264 0.1149 0.3648
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0308 0.0291
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0115 0.0289
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0057 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Brugia malayi beta-lactamase 0.0037 0.0057 0.0144
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0308 0.1011
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0072 0.1657
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.1311
Schistosoma mansoni microtubule-associated protein tau 0.2105 1 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0288 0.0271
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0131 0.0167
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0116 0.0436 0.1266
Brugia malayi Bromodomain containing protein 0.0234 0.1003 0.2523
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0851 0.3974 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0445 0.0428
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0294 0.1291 0.4122
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0028 0.0093
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0052 0.0034
Echinococcus multilocularis dnaJ subfamily B 0.042 0.19 0.1886
Schistosoma mansoni hypothetical protein 0.0089 0.0308 0.0291
Brugia malayi follicle stimulating hormone receptor 0.024 0.1035 0.2605
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0288 0.0271
Loa Loa (eye worm) hypothetical protein 0.0126 0.0485 0.1221
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0202 0.0184
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1323 1
Echinococcus multilocularis jumonji domain containing protein 0.0124 0.0477 0.046
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0131 0.0113
Onchocerca volvulus Huntingtin homolog 0.0126 0.0485 0.1026
Echinococcus granulosus muscleblind protein 0.0149 0.0595 0.0578
Echinococcus granulosus fetal alzheimer antigen falz 0.0071 0.0223 0.0205
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0131 0.0167
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0072 0.0237
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0205 0.471
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0131 0.0167
Schistosoma mansoni zinc finger protein 0.0047 0.0107 0.0089
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0205 0.0188
Brugia malayi beta-lactamase family protein 0.0037 0.0057 0.0144
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.164 0.7768 0.7764
Echinococcus granulosus dnaJ subfamily B 0.042 0.19 0.1886
Brugia malayi MAP kinase sur-1 0.0052 0.0131 0.033
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0111 0.0414 0.0397
Chlamydia trachomatis 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.066 0.3051 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0054 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Brugia malayi Bromodomain containing protein 0.0097 0.0344 0.0865
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0021 0.0053
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.0469 0.1538
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0072 0.0237
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0056 0.0142
Trichomonas vaginalis esterase, putative 0.0037 0.0057 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0117 0.0444 0.0426
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.0435 0.0418
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.0585 0.1762
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0028 0.0093
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Onchocerca volvulus 0.0049 0.0115 0.0208
Schistosoma mansoni methyl-cpg binding protein mbd 0.0053 0.0133 0.0115
Mycobacterium ulcerans flavoprotein disulfide reductase 0.004 0.0072 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0018 0.0409
Echinococcus granulosus methyl CpG binding domain protein 2 0.0053 0.0133 0.0115
Leishmania major hypothetical protein, conserved 0.0037 0.0057 0.1311
Echinococcus granulosus cpg binding protein 0.0037 0.0058 0.004
Brugia malayi PHD-finger family protein 0.0079 0.0258 0.0649
Loa Loa (eye worm) hypothetical protein 0.0126 0.0485 0.1219
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0288 0.0271
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0056 0.1293
Echinococcus multilocularis peregrin 0.0097 0.0344 0.0326
Schistosoma mansoni hypothetical protein 0.0085 0.0288 0.0271
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.004 0.0072 0.005
Mycobacterium tuberculosis Probable reductase 0.0264 0.1149 0.3648
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0072 0.0237
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0131 0.0113
Echinococcus granulosus zinc finger protein 0.0062 0.0179 0.0161
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0057 0.0039
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0072 0.0182
Toxoplasma gondii thioredoxin reductase 0.0116 0.0436 0.1429
Trypanosoma brucei ISWI complex protein 0.0047 0.0107 0.245
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.1323 1
Plasmodium falciparum 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.066 0.3051 1
Brugia malayi mbt repeat family protein 0.0049 0.0115 0.0289
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.1293
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0469 0.118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0141
Brugia malayi Thioredoxin reductase 0.0116 0.0436 0.1097
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.0469 0.0452
Echinococcus granulosus lysine specific demethylase 5A 0.0116 0.0435 0.0418
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0072 0.0125
Schistosoma mansoni cpg binding protein 0.0037 0.0058 0.004
Plasmodium vivax SET domain protein, putative 0.0123 0.0469 0.1538
Brugia malayi CXXC zinc finger family protein 0.003 0.0021 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1323 0.2826
Echinococcus multilocularis muscleblind protein 0.0149 0.0595 0.0578
Brugia malayi jmjC domain containing protein 0.0292 0.1285 0.3233
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0205 0.0672
Plasmodium falciparum phd finger protein, putative 0.0089 0.0308 0.1011
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0071 0.0223 0.0205
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0131 0.0429
Schistosoma mansoni cpg binding protein 0.003 0.0021 0.0003
Schistosoma mansoni hypothetical protein 0.0298 0.1312 0.1296
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0057 0.1311
Trypanosoma cruzi trypanothione reductase, putative 0.0116 0.0436 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0184 0.0765 0.1926
Brugia malayi jmjC domain containing protein 0.0029 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0119 0.045 0.1132
Schistosoma mansoni jumonji domain containing protein 0.0232 0.0996 0.098
Brugia malayi mbt repeat family protein 0.0049 0.0115 0.0289
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0131 0.0589
Loa Loa (eye worm) hypothetical protein 0.0126 0.0485 0.1219
Loa Loa (eye worm) hypothetical protein 0.0149 0.0595 0.1496
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.002 0.0449
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0057 0.0144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0072 0.1657
Brugia malayi glutathione reductase 0.0116 0.0436 0.1097
Loa Loa (eye worm) jmjC domain-containing protein 0.0116 0.0435 0.1095
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0288 0.0725
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0148 0.013
Loa Loa (eye worm) thioredoxin reductase 0.0116 0.0436 0.1097
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0018 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0294 0.1291 0.4122
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0115 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0045
Echinococcus multilocularis lysine specific demethylase 5A 0.0108 0.0399 0.0382
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0144
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0056 0.0039
Mycobacterium ulcerans 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.066 0.3051 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0072 0.1657
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0205 0.0517
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0072 0.0055
Brugia malayi Muscleblind-like protein 0.0149 0.0595 0.1496
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0308 0.0776
Echinococcus multilocularis cpg binding protein 0.0037 0.0058 0.004
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0288 0.0271

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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