Detailed information for compound 574160

Basic information

Technical information
  • TDR Targets ID: 574160
  • Name: 4-methoxypyridine
  • MW: 109.126 | Formula: C6H7NO
  • H donors: 0 H acceptors: 1 LogP: 0.82 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccncc1
  • InChi: 1S/C6H7NO/c1-8-6-2-4-7-5-3-6/h2-5H,1H3
  • InChiKey: XQABVLBGNWBWIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 620-08-6
  • pyridine, 4-methoxy-
  • InChI=1/C6H7NO/c1-8-6-2-4-7-5-3-6/h2-5H,1H
  • M113
  • EINECS 210-624-7
  • 460621_ALDRICH
  • AC-907/25004551
  • .gamma.-Methoxypyridine
  • ZINC00330918

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.033 0.5
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.1733 0.3032
Loa Loa (eye worm) hypothetical protein 0.0129 0.5196 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0815 0.123
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.2787 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.1654 0.2862
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1444 0.244
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4958 1
Brugia malayi jmjC domain containing protein 0.0062 0.1733 0.3021
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0035 0.033 0.1182
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.1654 0.2863
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.1733 0.3032
Toxoplasma gondii ABC1 family protein 0.0035 0.033 0.1182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.033 0.0203
Onchocerca volvulus Huntingtin homolog 0.0129 0.5196 1
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.1733 0.3032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.102 0.1584
Loa Loa (eye worm) hypothetical protein 0.0082 0.2787 0.5145
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.039 0.0331
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.2787 1
Onchocerca volvulus Huntingtin homolog 0.0129 0.5196 1
Loa Loa (eye worm) RNA binding protein 0.0125 0.4958 0.9521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0815 0.1048
Brugia malayi beta-lactamase family protein 0.0035 0.033 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0815 0.1048
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.2787 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.033 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.4958 0.9521
Entamoeba histolytica hypothetical protein 0.0036 0.039 0.5
Brugia malayi jmjC domain containing protein 0.0062 0.1733 0.3021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.102 0.1584
Mycobacterium leprae Probable lipase LipE 0.0035 0.033 0.1182
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.033 0.5
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.2787 0.5309
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.1322 0.2144
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.4958 0.9521
Entamoeba histolytica hypothetical protein 0.0036 0.039 0.5
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4958 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.2787 0.5
Loa Loa (eye worm) beta-lactamase 0.0035 0.033 0.0193
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.033 0.0193
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0193
Echinococcus multilocularis tar DNA binding protein 0.0125 0.4958 1
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.1322 0.2144
Loa Loa (eye worm) TAR-binding protein 0.0125 0.4958 0.9521
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.1733 0.3021
Brugia malayi hypothetical protein 0.0036 0.039 0.0315
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0815 0.1048
Brugia malayi beta-lactamase 0.0035 0.033 0.0193
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.033 0.5
Entamoeba histolytica hypothetical protein 0.0036 0.039 0.5
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.2787 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.2787 0.5
Brugia malayi beta-lactamase family protein 0.0035 0.033 0.0193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.033 0.0203
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.2787 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.102 0.1584
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.033 0.0193
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0193
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.2787 0.5309
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.039 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.033 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.1654 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.1654 0.539
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4958 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.1654 0.2862
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.1733 0.3032
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.033 0.5
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4958 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.1654 0.3007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0815 0.1171
Loa Loa (eye worm) hypothetical protein 0.0129 0.5196 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.2787 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.2787 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.2787 0.5404
Brugia malayi TAR-binding protein 0.0125 0.4958 0.9521
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.2787 1
Schistosoma mansoni jumonji domain containing protein 0.0062 0.1733 0.3173
Trichomonas vaginalis esterase, putative 0.0035 0.033 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0815 0.1171
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.1654 0.137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0815 0.123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.1733 0.3173
Brugia malayi Probable ClpP-like protease 0.0082 0.2787 0.5145
Brugia malayi RNA binding protein 0.0125 0.4958 0.9521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0815 0.1048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.039 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.033 0.5
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.1322 0.1026
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0193
Entamoeba histolytica hypothetical protein 0.0036 0.039 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.1654 0.539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0815 0.123
Echinococcus granulosus tar DNA binding protein 0.0125 0.4958 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.1322 0.1026
Mycobacterium leprae conserved hypothetical protein 0.0035 0.033 0.1182
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.033 0.5
Schistosoma mansoni hypothetical protein 0.0036 0.039 0.0331
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.1733 0.3173
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.2787 1
Brugia malayi hypothetical protein 0.0129 0.5196 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.102 0.1584
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.1322 0.4744
Loa Loa (eye worm) hypothetical protein 0.0035 0.033 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0125 0.4958 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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