Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.2409 | 0.3527 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0014 | 0.0145 | 0.0071 |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 0.6777 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.032 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.0908 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2409 | 0.2409 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.032 | 0.0682 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.032 | 0.032 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.001 | 0.0038 | 0.0056 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2283 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.032 | 0.032 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.032 | 0.0468 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.0908 | 0.1329 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.1187 | 0.1738 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.3595 | 0.3595 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.0908 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3595 | 0.3595 |
Onchocerca volvulus | 0.003 | 0.0628 | 0.0926 | |
Echinococcus multilocularis | geminin | 0.0347 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.002 | 0.032 | 0.2338 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0014 | 0.0145 | 0.0071 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0628 | 0.0628 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.009 | 0.2404 | 0.8837 |
Treponema pallidum | NADH oxidase | 0.0014 | 0.0145 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2409 | 0.2409 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.032 | 0.032 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2283 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.032 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.032 | 0.0468 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.032 | 0.2338 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2283 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0628 | 0.0919 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.032 | 0.0468 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2409 | 0.2409 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.0908 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.032 | 0.032 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0014 | 0.0145 | 0.1601 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.032 | 0.2338 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.3595 | 0.3595 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0628 | 0.6911 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0014 | 0.0145 | 0.0145 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.032 | 0.032 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2409 | 0.2409 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2409 | 0.2409 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.009 | 0.2404 | 0.8837 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.0924 | 0.0924 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.0908 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.032 | 0.032 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.3595 | 0.5263 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.032 | 0.0263 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3595 | 0.3595 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.001 | 0.0038 | 0.0056 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.0908 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0.0145 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.032 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.032 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0014 | 0.0145 | 0.0071 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.1187 | 0.1187 |
Mycobacterium tuberculosis | Probable reductase | 0.009 | 0.2404 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.01 | 0.2701 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0014 | 0.0145 | 0.0213 |
Brugia malayi | RNA binding protein | 0.013 | 0.3595 | 0.5263 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.032 | 0.0468 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0628 | 0.6322 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0014 | 0.0145 | 0.5 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0014 | 0.0145 | 0.0071 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.032 | 0.032 |
Brugia malayi | TAR-binding protein | 0.013 | 0.3595 | 0.5263 |
Onchocerca volvulus | 0.0238 | 0.6777 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.6831 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.024 | 0.6831 | 0.6831 |
Brugia malayi | hypothetical protein | 0.024 | 0.6831 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.032 | 0.0682 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0628 | 0.0628 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0628 | 0.0628 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.032 | 0.2338 |
Leishmania major | trypanothione reductase | 0.0039 | 0.0908 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.5923 | 0.867 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3595 | 0.3595 |
Brugia malayi | glutathione reductase | 0.0039 | 0.0908 | 0.1329 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.032 | 0.032 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.032 | 0.032 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2283 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.3595 | 0.5263 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.009 | 0.2404 | 0.8837 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0628 | 0.0628 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0014 | 0.0145 | 0.0145 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3595 | 0.3595 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.01 | 0.2701 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2283 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.024 | 0.6831 | 0.6831 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.009 | 0.2404 | 0.8837 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.032 | 0.0263 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.0924 | 0.0924 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.0908 | 0.1329 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.009 | 0.2404 | 0.8837 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.0908 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.3595 | 0.5263 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0628 | 0.0628 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0014 | 0.0145 | 0.1601 |
Brugia malayi | N-terminal motif family protein | 0.0178 | 0.5005 | 0.7326 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.032 | 0.2283 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0014 | 0.0145 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.5005 | 0.7326 |
Schistosoma mansoni | hypothetical protein | 0.0347 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.032 | 0.2283 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.01 | 0.2701 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.5923 | 0.867 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.2409 | 0.3527 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.0908 | 0.2985 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3595 | 0.3595 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.032 | 0.2283 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.0908 | 0.1329 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.01 | 0.2701 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.032 | 0.2338 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0628 | 0.0628 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0628 | 0.0628 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1187 | 0.1187 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.0908 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.3595 | 0.5263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2409 | 0.2409 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2409 | 0.2409 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.032 | 0.2338 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0628 | 0.0919 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0014 | 0.0145 | 0.0145 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0178 | 0.5005 | 0.7385 |
Onchocerca volvulus | 0.0049 | 0.1187 | 0.1752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.