Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Brugia malayi | Smad1 | 0.0008 | 0.0104 | 0.0104 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.2581 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.087 | 0.5844 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0104 | 0.0404 |
Schistosoma mansoni | smad | 0.0008 | 0.0104 | 0.0404 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.149 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2581 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.2581 | 0.2581 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2581 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2581 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.2581 | 1 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0104 | 0.0404 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.149 | 0.5772 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0957 | 1 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0104 | 0.0404 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.149 | 0.149 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.149 | 0.149 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.0957 | 0.6421 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.149 | 1 |
Echinococcus granulosus | smad | 0.0008 | 0.0104 | 0.0404 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.149 | 0.149 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0104 | 0.0404 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.149 | 0.5772 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0104 | 0.0104 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2581 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.149 | 0.149 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.2581 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0957 | 0.6421 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0104 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.149 | 1 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0104 | 0.0404 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.149 | 0.149 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.149 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.149 | 0.5772 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0957 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0104 | 0.0404 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0104 | 0.0404 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0104 | 0.0104 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0957 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2581 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0104 | 0.0104 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0104 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.087 | 0.5844 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.149 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.087 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.149 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.149 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.149 | 0.149 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.149 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0104 | 0.0104 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0104 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0957 | 0.0957 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.149 | 1 |
Echinococcus multilocularis | smad | 0.0008 | 0.0104 | 0.0404 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.149 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.149 | 1 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.149 | 1 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0104 | 0.0404 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0104 | 0.0104 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.087 | 0.5844 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0024 | 0.149 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.