Detailed information for compound 575072

Basic information

Technical information
  • TDR Targets ID: 575072
  • Name: potassium 2-phenylindol-1-ide
  • MW: 232.342 | Formula: C14H11KN
  • H donors: 1 H acceptors: 0 LogP: 3.53 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)c1[n-]c2c(c1)cccc2.[KH+]
  • InChi: 1S/C14H10N.K/c1-2-6-11(7-3-1)14-10-12-8-4-5-9-13(12)15-14;/h1-10H;/q-1;+1
  • InChiKey: OAWIDQALIUMZJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • alpha-phenylindole
  • 63467-59-4
  • 1H-Indole, 2-phenyl-, potassium salt

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.4481 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3582 0.3582
Brugia malayi RNA binding protein 0.0062 0.3582 0.5122
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3582 0.5122
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.4481 0.5
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.2851 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0144 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0288 0.0108
Trichomonas vaginalis helicase, putative 0.0006 0.0144 0.5
Schistosoma mansoni smad1 5 8 and 0.0008 0.0243 0.0243
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.4481 1
Brugia malayi MH1 domain containing protein 0.0008 0.0243 0.0316
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3582 0.5122
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.4481 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0288 0.0108
Brugia malayi Probable ClpP-like protease 0.0077 0.4481 0.6415
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0144 0.5
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.2851 0.4744
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.4481 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0144 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3582 0.3582
Schistosoma mansoni Smad4 0.0008 0.0243 0.0243
Echinococcus multilocularis geminin 0.0166 1 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0243 0.0062
Echinococcus granulosus tar DNA binding protein 0.0062 0.3582 0.3463
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0144 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0144 0.5
Schistosoma mansoni hypothetical protein 0.0166 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0144 0.5
Schistosoma mansoni smad1 5 8 and 0.0008 0.0243 0.0243
Schistosoma mansoni hypothetical protein 0.0166 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.6972 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.4481 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0144 0.5
Schistosoma mansoni smad 0.0008 0.0243 0.0243
Echinococcus granulosus peptidase Clp S14 family 0.005 0.2851 0.2718
Echinococcus multilocularis cpg binding protein 0.003 0.1587 0.1431
Echinococcus multilocularis Smad4 0.0008 0.0243 0.0062
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0144 0.5
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.4481 0.4378
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.4481 0.4481
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0144 0.5
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.2851 0.2718
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0144 0.5
Schistosoma mansoni cpg binding protein 0.003 0.1587 0.1587
Schistosoma mansoni cpg binding protein 0.003 0.1587 0.1587
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0288 0.0382
Brugia malayi Smad1 0.0008 0.0243 0.0316
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.4481 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3582 0.3582
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0144 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0281 0.0372
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0144 0.5
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3582 0.5122
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0144 0.5
Brugia malayi MH1 domain containing protein 0.0008 0.0243 0.0316
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.2851 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0144 0.5
Onchocerca volvulus 0.0028 0.1488 0.5
Brugia malayi MH2 domain containing protein 0.0117 0.6972 1
Brugia malayi TAR-binding protein 0.0062 0.3582 0.5122
Loa Loa (eye worm) hypothetical protein 0.0077 0.4481 0.6415
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3582 0.3463
Loa Loa (eye worm) Smad1 0.0008 0.0243 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0144 0.5
Schistosoma mansoni cpg binding protein 0.0028 0.1488 0.1488
Echinococcus granulosus Smad4 0.0008 0.0243 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3582 0.3582
Loa Loa (eye worm) RNA binding protein 0.0062 0.3582 0.5122
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0144 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0182 0.0182
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.3042 0.5359
Brugia malayi MH2 domain containing protein 0.0008 0.0243 0.0316
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.4481 1
Echinococcus granulosus smad 0.0008 0.0243 0.0062
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0243 0.0316
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.4481 0.4378
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.6972 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0243 0.0062
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0243 0.0316
Echinococcus multilocularis smad 0.0008 0.0243 0.0062
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0243 0.0062
Echinococcus granulosus cpg binding protein 0.003 0.1587 0.1431
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.4481 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.4481 0.5
Brugia malayi CXXC zinc finger family protein 0.0028 0.1488 0.2108
Brugia malayi MH2 domain containing protein 0.0008 0.0243 0.0316
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.1488 0.2108
Schistosoma mansoni smad1 5 8 and 0.0008 0.0243 0.0243
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0243 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3582 0.3582
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.3435 0.3435
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0144 0.5
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0243 0.0243
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.4481 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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