Detailed information for compound 575177

Basic information

Technical information
  • TDR Targets ID: 575177
  • Name: 3,5-dihydro-2H-pyrazolo[1,5-a]imidazole
  • MW: 109.129 | Formula: C5H7N3
  • H donors: 1 H acceptors: 0 LogP: -0.4 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CN=c2n1[nH]cc2
  • InChi: 1S/C5H7N3/c1-2-7-8-4-3-6-5(1)8/h1-2,7H,3-4H2
  • InChiKey: QEFHOXDSUONGRN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3-dihydro-1H-imidazo(1,2-b)pyrazole
  • imidazopyrazole
  • 6714-29-0
  • NSC174124
  • NCI60_004236
  • 1H-Imidazo(1,2-b)pyrazole, 2,3-dihydro-
  • 1H-Pyrazolo(2,3-a)imidazole, 2,3-dihydro-
  • AI3-63108
  • BRN 0742753
  • EINECS 229-769-2
  • Imidazolepyrazole
  • NSC 174124
  • NSC 641280
  • Pyrazolo(2,3-a)imidazolidine
  • 1H-Imidazo[1,2-b]pyrazole, 2,3-dihydro-
  • 1H-Pyrazolo[2,3-a]imidazole, 2,3-dihydro-
  • 2,3-Dihydro-1H-imidazo[1,2-b]pyrazole
  • BA 21381
  • IMPY
  • Imidazole-Pyrazole
  • NSC51143
  • Pyrazolo[2,3-a]imidazolidine
  • AIDS-027544
  • AIDS027544
  • NSC 51143

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Chlamydia trachomatis enoyl-acyl-carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium vivax enoyl-acyl carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium berghei enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium yoelii enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium knowlesi enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Trichomonas vaginalis hypothetical protein Get druggable targets OG5_130466 All targets in OG5_130466
Neospora caninum enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Toxoplasma gondii enoyl-acyl carrier reductase ENR Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium falciparum enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase Get druggable targets OG5_130466 All targets in OG5_130466
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans oxidoreductase 0.0015 0.0218 0.0294
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0015 0.0218 0.0294
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0038 0.0715 0.1216
Brugia malayi steroid hormone receptor 0.0011 0.0132 0.0225
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0207 0.0281
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Schistosoma mansoni DNA polymerase eta 0.0151 0.3227 0.3227
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0552 0.0691
Leishmania major DNA damage repair protein, putative 0.003 0.0552 0.0691
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0207 0.0219
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0015 0.0218 0.036
Onchocerca volvulus 0.0015 0.0207 0.106
Brugia malayi DnaJ domain containing protein 0.006 0.1222 0.2085
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0015 0.0218 0.0157
Trypanosoma cruzi DNA damage repair protein, putative 0.003 0.0552 0.0691
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.3418 0.4614
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0018 0.028 0.028
Echinococcus multilocularis dna polymerase kappa 0.0127 0.2697 0.2697
Echinococcus granulosus discoidin domain containing receptor 2 0.0012 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1949 0.1949
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0218 0.036
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0207 0.0207
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0797 0.1485
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0207 0.0337
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0223 0.4838 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0037 0.0708 0.1207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0218 0.0371
Trypanosoma brucei DNA polymerase IV, putative 0.0127 0.2697 0.3628
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Mycobacterium tuberculosis Conserved hypothetical protein 0.0097 0.2039 0.4161
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0797 0.0797
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0218 0.0294
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0218 0.0294
Brugia malayi polk-prov protein 0.006 0.1209 0.2063
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0132 0.0225
Trypanosoma brucei unspecified product 0.012 0.2534 0.3404
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0015 0.0218 0.0061
Brugia malayi hypothetical protein 0.0006 0.0014 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Loa Loa (eye worm) hypothetical protein 0.0018 0.028 0.0478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0132 0.0225
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0015 0.0218 0.0234
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0207 0.0337
Brugia malayi hypothetical protein 0.0006 0.0014 0.0024
Trypanosoma brucei chrX additional, unordered contigs 0.003 0.0552 0.0691
Plasmodium falciparum enoyl-acyl carrier reductase 0.0223 0.4838 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0337 0.7353 1
Mycobacterium ulcerans glutaminase 0.027 0.5864 1
Plasmodium falciparum DNA repair protein REV1, putative 0.003 0.0552 0.0869
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0797 0.0797
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Schistosoma mansoni kinase 0.0047 0.0933 0.0933
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0987 0.426
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0062 0.0062
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0132 0.0132
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0015 0.0218 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.2203 0.2951
Toxoplasma gondii hypothetical protein 0.0054 0.1087 0.2009
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0905 0.1481
Mycobacterium ulcerans hypothetical protein 0.003 0.0552 0.0868
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0015 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0015 0.0207 0.0352
Echinococcus multilocularis discoidin domain containing receptor 2 0.0012 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0207 0.0352
Leishmania major DNA polymerase kappa, putative 0.0105 0.2203 0.2951
Loa Loa (eye worm) TK/ALK protein kinase 0.0018 0.028 0.0478
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0132 0.0132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0987 0.1966
Onchocerca volvulus 0.005 0.0987 0.5066
Echinococcus multilocularis discoidin domain receptor 0.0012 0.0144 0.0144
Onchocerca volvulus 0.0015 0.0207 0.106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0132 0.0132
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0207 0.0275
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0014 0.0024
Trypanosoma brucei unspecified product 0.0067 0.137 0.1811
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0207 0.0337
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1949 0.1949
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0015 0.0218 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1949 0.3274
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0015 0.0218 0.036
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0207 0.0219
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0015 0.0218 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0225
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0207 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.1209 0.1591
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0225
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.0207 0.0133
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0987 0.426
Trypanosoma cruzi DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Onchocerca volvulus 0.0017 0.0252 0.1294
Echinococcus granulosus dna polymerase kappa 0.0127 0.2697 0.2697
Onchocerca volvulus 0.0015 0.0218 0.1117
Mycobacterium tuberculosis Probable oxidase 0.0007 0.0047 0.0003
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0207 0.0337
Trypanosoma brucei oxidoreductase-like protein 0.0015 0.0218 0.0234
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0207 0.0219
Loa Loa (eye worm) hypothetical protein 0.005 0.0987 0.1684
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0797 0.0797
Trichomonas vaginalis DNA polymerase eta, putative 0.0127 0.2697 0.456
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0663 0.1289
Schistosoma mansoni hypothetical protein 0.0017 0.0252 0.0252
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0207 0.0352
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.000000000076804
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0132 0.0225
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0207 0.0352
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0207 0.0275
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0592 0.101
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0933 0.1213
Schistosoma mansoni DNA polymerase IV / kappa 0.003 0.0552 0.0552
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0097 0.2039 0.2039
Brugia malayi Protein kinase domain containing protein 0.0012 0.0144 0.0246
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0207 0.0337
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1949 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0015 0.0218 0.0234
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0015 0.0218 0.0234
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0223 0.4838 1
Loa Loa (eye worm) oxidoreductase 0.0015 0.0207 0.0352
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0225
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0132 0.0132
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0218 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0218 0.036
Schistosoma mansoni coup transcription factor 0.0011 0.0132 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0132 0.0132
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0552 0.0691
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.1739 0.2317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0132 0.0225
Schistosoma mansoni hypothetical protein 0.0456 1 1
Onchocerca volvulus 0.0017 0.0252 0.1294
Giardia lamblia DINP protein human, muc B family 0.0105 0.2203 1
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0223 0.4838 1
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0552 0.0691
Onchocerca volvulus 0.0011 0.0132 0.0678
Mycobacterium ulcerans hypothetical protein 0.005 0.0987 0.1617
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.1222 0.2085
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0132 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0132 0.0225
Mycobacterium tuberculosis Conserved hypothetical protein 0.0177 0.3817 0.7871
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0015 0.0218 0.0294
Loa Loa (eye worm) hypothetical protein 0.005 0.0987 0.1684
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0207 0.0352
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0132 0.0132
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0015 0.0218 0.0371
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0097 0.2039 0.2039
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0207 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0132 0.0225
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.3418 0.4614
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.000000000076804
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0207 0.0337
Onchocerca volvulus 0.0015 0.0207 0.106
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0218 0.036
Schistosoma mansoni septate junction protein 0.0012 0.0144 0.0144
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0015 0.0218 0.0218
Brugia malayi hypothetical protein 0.0018 0.028 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0207 0.0275
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0218 0.0294
Loa Loa (eye worm) hypothetical protein 0.0041 0.0797 0.1359
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Loa Loa (eye worm) hypothetical protein 0.0017 0.0252 0.043
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0207 0.0133
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0207 0.0133
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0225
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0132 0.0132
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0552 0.0691
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0014 0.0014
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0797 0.0797
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0797 0.0797
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.0207 0.0133
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0075 0.1537 0.1537
Schistosoma mansoni glutaminase 0.027 0.5864 0.5864
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0207 0.0337
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0933 0.1213
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0207 0.0352
Schistosoma mansoni cpg binding protein 0.0032 0.0592 0.0592
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0207 0.0275
Schistosoma mansoni cpg binding protein 0.0034 0.0633 0.0633
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0207 0.0219
Brugia malayi ecdysteroid receptor 0.0011 0.0132 0.0225
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0225
Brugia malayi SEA domain containing protein 0.0017 0.0252 0.043
Trichomonas vaginalis hypothetical protein 0.0012 0.0144 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0207 0.0275
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0097 0.2039 0.3478
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Loa Loa (eye worm) DOMON domain-containing protein 0.0017 0.0252 0.043
Mycobacterium tuberculosis Possible oxidoreductase 0.0015 0.0218 0.036
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0207 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.1533 0.2034
Giardia lamblia Kinase, PLK 0.0093 0.1949 0.8464
Loa Loa (eye worm) glutaminase 0.027 0.5864 1
Mycobacterium ulcerans DNA polymerase IV 0.0127 0.2697 0.4557
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0218 0.0294
Schistosoma mansoni discoidin domain receptor 0.0012 0.0144 0.0144
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0207 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1949 0.3274
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0014 0.0024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0218 0.0294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0132 0.0132
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0987 0.1617
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0132 0.0225
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0014 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.012 0.2534 0.3404
Loa Loa (eye worm) hypothetical protein 0.0037 0.0708 0.1207
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0132 0.0678
Mycobacterium ulcerans DNA polymerase IV 0.0127 0.2697 0.4557
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0014 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0132 0.0225
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0207 0.0133
Onchocerca volvulus 0.0018 0.028 0.1438
Trypanosoma brucei unspecified product 0.0067 0.137 0.1811
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0987 0.1617
Loa Loa (eye worm) hypothetical protein 0.0018 0.028 0.0478
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1228 0.2309
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0012 0.0144 0.0144
Brugia malayi AMP-binding enzyme family protein 0.005 0.0987 0.1684
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1949 0.3274
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0207 0.0219
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0132 0.0132
Loa Loa (eye worm) oxidoreductase 0.0015 0.0218 0.0371
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0207 0.0275
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0132 0.0678
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.1222 0.2026
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0132 0.0225
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0132 0.0132
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0132 0.0132
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0015 0.0218 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.1533 0.2034
Leishmania major DNA polymerase eta, putative 0.0084 0.1739 0.2317
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.1222 0.1222
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0797 0.0797
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0132 0.0132
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0797 0.0797
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Echinococcus multilocularis dna polymerase eta 0.0151 0.3227 0.3227
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0132 0.0225
Brugia malayi glutaminase DH11.1 0.027 0.5864 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0797 0.1027
Trypanosoma brucei DNA damage repair protein, putative 0.003 0.0552 0.0691
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1949 0.3324
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0132 0.0225
Onchocerca volvulus 0.0017 0.0252 0.1294
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0797 0.1027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0043 0.000000000076804
Mycobacterium ulcerans hypothetical protein 0.0177 0.3817 0.6482
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0132 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Trypanosoma brucei DNA damage repair protein, putative 0.003 0.0552 0.0691
Leishmania major mitochondrial DNA polymerase beta 0.0337 0.7353 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1949 0.9507
Onchocerca volvulus 0.0017 0.0252 0.1294
Plasmodium vivax DNA repair protein REV1, putative 0.003 0.0552 0.0869
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0987 0.1288
Brugia malayi CXXC zinc finger family protein 0.0032 0.0592 0.101
Leishmania major oxidoreductase-like protein 0.0015 0.0218 0.0234
Echinococcus granulosus discoidin domain receptor 0.0012 0.0144 0.0144
Trichomonas vaginalis hypothetical protein 0.0223 0.4838 0.8237
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0207 0.0219
Loa Loa (eye worm) hypothetical protein 0.0037 0.0708 0.1207
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0663 0.1289
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0218 0.0294
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0797 0.1295
Onchocerca volvulus 0.0032 0.0592 0.304
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0059 0.0059
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0015 0.0218 0.0157
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0987 0.1617
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0708 0.1137
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0337 0.7353 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0102 0.0102
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0708 0.1061
Entamoeba histolytica deoxycytidyl transferase, putative 0.0097 0.2039 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0161 0.0242
Loa Loa (eye worm) hypothetical protein 0.0037 0.0708 0.1207
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0059 0.0059
Schistosoma mansoni dock 0.0075 0.1537 0.1537
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0225
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0225
Schistosoma mansoni btb and poz domain-containing protein 0.0012 0.0144 0.0144
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0015 0.0218 0.0218
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0207 0.0337
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0218 0.0371
Trypanosoma brucei polo-like protein kinase 0.0093 0.1949 0.2604
Loa Loa (eye worm) hypothetical protein 0.0017 0.0252 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.1209 0.1591
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0207 0.0352
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0132 0.0132
Trypanosoma cruzi DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Brugia malayi ImpB/MucB/SamB family protein 0.0151 0.3227 0.5503
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0987 0.1617
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0987 0.426
Loa Loa (eye worm) hypothetical protein 0.005 0.0987 0.1684
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0015 0.0218 0.036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0218 0.0371
Loa Loa (eye worm) hypothetical protein 0.0151 0.3227 0.5503
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0105 0.2203 0.4502
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1949 0.3274
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1949 0.3274
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0987 0.1797
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0207 0.0275
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0708 0.1201
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0207 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0132 0.0225
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0132 0.0225
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0218 0.0294
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.006 0.1222 0.1222
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1949 0.3324
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0207 0.0275
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0097 0.2039 0.2039
Onchocerca volvulus 0.0012 0.0144 0.0739
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0014 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0987 0.1288
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0132 0.0225
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0099 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Trypanosoma brucei DNA polymerase eta, putative 0.0151 0.3227 0.4353
Schistosoma mansoni cpg binding protein 0.0034 0.0633 0.0633
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0132 0.0132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0663 0.1289
Onchocerca volvulus 0.0017 0.0252 0.1294
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0218 0.0294
Brugia malayi nuclear receptor RXR 0.0006 0.0014 0.0024
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0207 0.0219
Echinococcus granulosus dna polymerase eta 0.0151 0.3227 0.3227
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0132 0.0225
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0708 0.1383
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.1162 0.1527
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0207 0.0275
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0207 0.0275
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0132 0.0132
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0987 0.1617
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0059 0.0059
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0987 0.1966
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.006 0.1209 0.2063
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0207 0.0219
Echinococcus multilocularis cpg binding protein 0.0034 0.0633 0.0633
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0207 0.0275
Schistosoma mansoni dihydropteridine reductase 0.0015 0.0218 0.0218
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0223 0.4838 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0012 0.0144 0.0173
Schistosoma mansoni discoidin domain receptor 0.0012 0.0144 0.0144
Onchocerca volvulus 0.0015 0.0207 0.106
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0207 0.0133
Echinococcus multilocularis dnaJ subfamily B 0.0456 1 1
Trypanosoma cruzi DNA damage repair protein, putative 0.003 0.0552 0.0691
Brugia malayi AMP-binding enzyme family protein 0.005 0.0987 0.1684
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0223 0.4838 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0552 0.0869
Echinococcus granulosus discoidin domain containing receptor 2 0.0012 0.0144 0.0144
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0132 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0132 0.0225
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0207 0.0275
Trypanosoma cruzi DNA polymerase eta, putative 0.0151 0.3227 0.4353
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0987 0.1617
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0132 0.0132
Brugia malayi nuclear receptor NHR-88 0.0011 0.0132 0.0225
Brugia malayi AMP-binding enzyme family protein 0.005 0.0987 0.1684
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.000000000076804
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.1222 0.1222
Loa Loa (eye worm) retinol dehydrogenase 12 0.0015 0.0218 0.0371
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0207 0.0281
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0207 0.0275
Schistosoma mansoni hypothetical protein 0.0018 0.028 0.028
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0987 0.1288
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0663 0.1289
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0132 0.0132
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0223 0.4838 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1389 0.1389
Onchocerca volvulus 0.0015 0.0218 0.1117
Echinococcus multilocularis discoidin domain containing receptor 2 0.0012 0.0144 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0905 0.1481
Onchocerca volvulus 0.0012 0.0144 0.0739
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0102 0.0102
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0084 0.1739 0.3399
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0132 0.0225
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0032
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0015 0.0218 0.0294
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0132 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Echinococcus multilocularis MAM 0.0018 0.028 0.028
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0797 0.1027
Echinococcus granulosus discoidin domain containing receptor 2 0.0012 0.0144 0.0144
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0223 0.4838 0.8236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0132 0.0225
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0225
Trichomonas vaginalis glutaminase, putative 0.027 0.5864 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0132 0.0132
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0797 0.1359
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0218 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0797 0.1027
Loa Loa (eye worm) hypothetical protein 0.0018 0.028 0.0478
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0207 0.0352
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0797 0.0797
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.000000000076804
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0015 0.0218 0.0234
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0218 0.0294
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1949 0.2604
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1949 0.2604
Loa Loa (eye worm) glutaminase 2 0.027 0.5864 1
Echinococcus granulosus cpg binding protein 0.0034 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0018 0.028 0.0478
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0132 0.0132
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0105 0.2203 0.2951
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.3418 0.4614
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0218 0.0294
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0207 0.0337
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0797 0.1295
Mycobacterium tuberculosis Possible oxidoreductase 0.0015 0.0218 0.036
Onchocerca volvulus 0.0018 0.028 0.1438
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0132 0.0132
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0207 0.0337
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0127 0.2697 0.456
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0987 0.1617
Leishmania major pteridine reductase 1 0.0015 0.0218 0.0234
Echinococcus granulosus MAM 0.0018 0.028 0.028
Trypanosoma brucei DNA polymerase IV, putative 0.0127 0.2697 0.3628
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0132 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0207 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0144 0.0173
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0218 0.0294
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0987 0.1797
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0012 0.0144 0.0173
Leishmania major DNA polymerase eta, putative 0.0151 0.3227 0.4353
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0015 0.0218 0.0157
Trypanosoma brucei pteridine reductase 1 0.0015 0.0218 0.0234
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0132 0.0132
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0207 0.0275
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0024
Echinococcus multilocularis discoidin domain containing receptor 2 0.0012 0.0144 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Brugia malayi ImpB/MucB/SamB family protein 0.0097 0.2039 0.3478
Trypanosoma brucei DNA polymerase kappa, putative 0.0074 0.1533 0.2034
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0218 0.0294
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Loa Loa (eye worm) hypothetical protein 0.0006 0.0014 0.0024
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1949 0.2604
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0207 0.0337
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1949 0.3274
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0012 0.0144 0.0173
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0015 0.0218 0.0234
Brugia malayi Protein kinase domain containing protein 0.0018 0.028 0.0478
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0337 0.7353 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0132 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Brugia malayi CUB domain containing protein 0.0006 0.0018 0.0032
Brugia malayi Muscle positioning protein 4 0.0017 0.0252 0.043
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0132 0.0225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.000000000076804
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0075 0.1537 0.1537
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0015 0.0218 0.0234
Schistosoma mansoni hypothetical protein 0.0012 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0218 0.0294
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0933 0.1213
Trypanosoma cruzi DNA polymerase kappa, putative 0.0127 0.2697 0.3628
Loa Loa (eye worm) histone methyltransferase 0.001 0.0102 0.0174
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0132 0.0132
Leishmania major DNA polymerase kappa, putative 0.003 0.0552 0.0691
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0207 0.0275
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0015 0.0218 0.0157
Echinococcus multilocularis dedicator of cytokinesis protein 0.0063 0.1275 0.1275
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1949 0.3274
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0043 0.000000000076804
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0132 0.0225
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0797 0.322
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1949 0.1949
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0043 0.000000000076804
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0933 0.1213
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0012 0.0144 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0708 0.1207
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0132 0.0132
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0132 0.0225
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0708 0.1201
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0015 0.0218 0.0157
Schistosoma mansoni terminal deoxycytidyl transferase 0.0097 0.2039 0.2039
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0207 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0797 0.1295
Loa Loa (eye worm) hypothetical protein 0.0015 0.0207 0.0352
Brugia malayi nuclear hormone receptor 0.0011 0.0132 0.0225
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0246

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 6263  
Annotator: crowther@u.washington.edu Comment: 2007-12-07 References: 15239654

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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