Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0321 | 1 | 1 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0231 | 0.469 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0034 | 0.0622 | 0.0711 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0034 | 0.0622 | 0.0711 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.6805 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Onchocerca volvulus | 0.0034 | 0.0622 | 1 | |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0231 | 0.6279 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5283 | 0.5283 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.0034 | 0.0622 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0427 | 0.1854 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5283 | 0.5283 |
Schistosoma mansoni | lamin | 0.0028 | 0.0427 | 0.0425 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0427 | 0.1854 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.6805 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0034 | 0.0622 | 0.0711 |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.0622 | 0.062 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0034 | 0.0622 | 0.0711 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0022 | 0.0231 | 0.0337 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 0.6805 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0034 | 0.0622 | 0.062 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0427 | 0.0425 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0034 | 0.0622 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0034 | 0.0622 | 0.062 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0149 | 0.4024 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0059 | 0.0257 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0231 | 0.6279 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0231 | 0.0229 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0034 | 0.0622 | 0.062 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0149 | 0.3005 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Mycobacterium tuberculosis | Probable transmembrane multidrug efflux pump | 0.0034 | 0.0622 | 0.0912 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0367 | 0.5885 |
Echinococcus granulosus | geminin | 0.0177 | 0.5283 | 0.5283 |
Trichomonas vaginalis | ran, putative | 0.0022 | 0.0231 | 0.0124 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0149 | 0.0147 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0015 | 0.0002 | 0.0008 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0034 | 0.0622 | 0.0622 |
Schistosoma mansoni | ran | 0.0022 | 0.0231 | 0.0229 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.0034 | 0.0622 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0034 | 0.0622 | 0.0711 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1251 | 0.5434 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0034 | 0.0622 | 0.0622 |
Trichomonas vaginalis | taga, putative | 0.0034 | 0.0622 | 0.0711 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0427 | 0.0427 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0059 | 0.0057 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0034 | 0.0622 | 0.0711 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0059 | 0.0057 |
Trichomonas vaginalis | ABC transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Leishmania major | p-glycoprotein | 0.0034 | 0.0622 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0034 | 0.0622 | 0.062 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.0034 | 0.0622 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0034 | 0.0622 | 0.062 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0034 | 0.0622 | 0.062 |
Echinococcus granulosus | importin subunit beta 1 | 0.003 | 0.049 | 0.0489 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0034 | 0.0622 | 0.0711 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0059 | 0.0057 |
Leishmania major | GTP-binding protein, putative | 0.0022 | 0.0231 | 0.3695 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 0.6805 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.0034 | 0.0622 | 0.0711 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0231 | 0.0337 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0149 | 0.0147 |
Trichomonas vaginalis | ABC transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.6805 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.6805 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.6805 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.6805 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0015 | 0.0002 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0059 | 0.0057 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0427 | 0.0425 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0034 | 0.0622 | 0.062 |
Brugia malayi | ABC transporter family protein | 0.0034 | 0.0622 | 0.2701 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0015 | 0.0002 | 0.0002 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0062 | 0.027 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0367 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0367 | 0.0537 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0427 | 0.0425 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1251 | 0.1251 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0034 | 0.0622 | 0.0711 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0059 | 0.0059 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0231 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0427 | 0.0427 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0034 | 0.0622 | 0.062 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0149 | 0.2368 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0699 | 0.3038 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0149 | 0.0216 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0305 | 0.4882 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0034 | 0.0622 | 0.0711 |
Echinococcus granulosus | lamin | 0.0028 | 0.0427 | 0.0425 |
Onchocerca volvulus | 0.0028 | 0.0427 | 0.6853 | |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.0622 | 0.062 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1251 | 0.1251 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0699 | 0.0699 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.061 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.041 | 0.041 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0305 | 0.8296 |
Entamoeba histolytica | Ran family GTPase | 0.0022 | 0.0231 | 0.3695 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.049 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.003 | 0.049 | 0.0718 |
Entamoeba histolytica | P-glycoprotein-1 | 0.0034 | 0.0622 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0034 | 0.0622 | 0.062 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.0034 | 0.0622 | 0.0912 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0149 | 0.0147 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0034 | 0.0622 | 0.0711 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.0034 | 0.0622 | 0.0912 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0367 | 0.0537 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0149 | 0.0216 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0059 | 0.0057 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0622 | 0.0622 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0034 | 0.0622 | 1 |
Plasmodium falciparum | importin beta, putative | 0.003 | 0.049 | 0.0718 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0367 | 0.7469 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Echinococcus multilocularis | snurportin 1 | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0059 | 0.0059 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0034 | 0.0622 | 0.062 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0034 | 0.0622 | 0.0912 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0059 | 0.0057 |
Brugia malayi | Importin beta-1 subunit | 0.003 | 0.049 | 0.213 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0149 | 0.0216 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0367 | 0.0537 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0699 | 0.0698 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0231 | 0.0231 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0034 | 0.0622 | 0.062 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0149 | 0.2368 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0059 | 0.0057 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0305 | 0.0234 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0305 | 0.4882 |
Schistosoma mansoni | multidrug resistance protein | 0.0034 | 0.0622 | 0.062 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0059 | 0.0057 |
Echinococcus multilocularis | geminin | 0.0177 | 0.5283 | 0.5283 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.0034 | 0.0622 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0305 | 0.0234 |
Schistosoma mansoni | ran | 0.0022 | 0.0231 | 0.0229 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0305 | 0.0234 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0427 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0367 | 0.0367 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0034 | 0.0622 | 0.0711 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0002 | 0.0002 |
Schistosoma mansoni | smdr2 | 0.0034 | 0.0622 | 0.062 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0034 | 0.0622 | 0.062 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0034 | 0.0622 | 0.0711 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0034 | 0.0622 | 0.0711 |
Onchocerca volvulus | 0.0028 | 0.0427 | 0.6853 | |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0015 | 0.0002 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.049 | 0.049 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.0034 | 0.0622 | 0.0912 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0034 | 0.061 | 0.0608 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0024 | 0.0285 | 0.0284 |
Entamoeba histolytica | P-glycoprotein-5 | 0.0034 | 0.0622 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0427 | 0.0425 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0034 | 0.0622 | 0.0711 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0024 | 0.0285 | 0.0206 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0024 | 0.0285 | 0.0284 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0149 | 0.0216 |
Schistosoma mansoni | importin beta-1 | 0.003 | 0.049 | 0.0489 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0367 | 0.1593 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.6805 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0149 | 0.0216 |
Schistosoma mansoni | lamin | 0.0028 | 0.0427 | 0.0425 |
Trichomonas vaginalis | abcb9, putative | 0.0034 | 0.0622 | 0.0711 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0149 | 0.0645 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0059 | 0.0057 |
Loa Loa (eye worm) | oxidoreductase | 0.0015 | 0.0002 | 0.0002 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0149 | 0.0216 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0231 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0059 | 0.0057 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Plasmodium vivax | importin-beta 2, putative | 0.003 | 0.049 | 0.0718 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0149 | 0.4024 |
Echinococcus multilocularis | importin subunit beta 1 | 0.003 | 0.049 | 0.0489 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0034 | 0.0622 | 0.0711 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0034 | 0.0622 | 0.0711 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0427 | 0.0425 |
Brugia malayi | multidrug resistance protein 3 | 0.0034 | 0.0622 | 0.2701 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0427 | 0.0427 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0231 | 0.0229 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.049 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0024 | 0.0285 | 0.0284 |
Schistosoma mansoni | hypothetical protein | 0.0321 | 1 | 1 |
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.0034 | 0.0622 | 0.0912 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0034 | 0.061 | 0.0608 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0367 | 0.0537 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0059 | 0.0257 |
Trichomonas vaginalis | abcb9, putative | 0.0034 | 0.0622 | 0.0711 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0231 | 0.1003 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0367 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0034 | 0.0622 | 0.062 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1251 | 0.5434 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0622 | 0.0622 |
Brugia malayi | RNA, U transporter 1 | 0.0086 | 0.2303 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0149 | 0.0149 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0034 | 0.0622 | 0.062 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0149 | 0.0147 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium tuberculosis | 6263 | |
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-06 | References: | 17034137 17227913 | |
growth (GO:0040007) | decreased (PATO:0000468) | inferred from in vitro culture assay (ECO:0000182) | Mycobacterium tuberculosis | 6263 | ||
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-06 | References: | 17034137 |
2 literature references were collected for this gene.