Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0107 | 0.1319 | 0.4631 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0447 | 0.1569 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0025 | 0.0089 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0164 | 0.0577 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0025 | 0.0089 | 0.0089 |
Schistosoma mansoni | apoferritin-2 | 0.0025 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.003 | 0.0164 | 0.0577 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0107 | 0.1319 | 1 |
Onchocerca volvulus | 0.0107 | 0.1319 | 0.3708 | |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0164 | 0.0164 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.003 | 0.0164 | 0.0577 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0164 | 0.0577 |
Echinococcus granulosus | ferritin | 0.0025 | 0.0089 | 0.0089 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0685 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.074 | 0.074 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0143 | 0.0143 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0107 | 0.1319 | 0.4631 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.074 | 0.074 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0164 | 0.0164 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0159 | 0.0159 |
Brugia malayi | steroid hormone receptor | 0.003 | 0.0164 | 0.0577 |
Onchocerca volvulus | 0.0107 | 0.1319 | 0.3708 | |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0107 | 0.1319 | 0.132 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0107 | 0.1319 | 0.132 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0107 | 0.1319 | 0.1319 |
Mycobacterium ulcerans | lipase LipD | 0.0107 | 0.1319 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.1319 | 0.4019 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0213 | 0.0749 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.003 | 0.0164 | 0.0577 |
Schistosoma mansoni | ferritin | 0.0025 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.2847 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0107 | 0.1319 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0164 | 0.0577 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.003 | 0.0164 | 0.0577 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.003 | 0.0164 | 0.0164 |
Echinococcus multilocularis | FTZ F1 alpha | 0.003 | 0.0164 | 0.0164 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0025 | 0.0089 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0287 | 0.1008 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.1319 | 0.132 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0159 | 0.0159 |
Loa Loa (eye worm) | beta-lactamase | 0.0107 | 0.1319 | 0.4631 |
Echinococcus multilocularis | expressed protein | 0.0025 | 0.0089 | 0.0089 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.003 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1319 | 0.4631 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.003 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0164 | 0.0577 |
Brugia malayi | nuclear receptor NHR-88 | 0.003 | 0.0164 | 0.0577 |
Mycobacterium leprae | conserved hypothetical protein | 0.0107 | 0.1319 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.003 | 0.0164 | 0.0164 |
Trichomonas vaginalis | ferritin, putative | 0.0025 | 0.0089 | 0.0272 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.003 | 0.0164 | 0.0164 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.003 | 0.0164 | 0.0164 |
Echinococcus granulosus | expressed protein | 0.0025 | 0.0089 | 0.0089 |
Echinococcus multilocularis | ferritin | 0.0025 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1319 | 0.4631 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.003 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.003 | 0.0164 | 0.0577 |
Schistosoma mansoni | thyroid hormone receptor | 0.0408 | 0.5837 | 0.5837 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.003 | 0.0164 | 0.0577 |
Brugia malayi | beta-lactamase family protein | 0.0107 | 0.1319 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0164 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1319 | 0.4631 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0287 | 0.0875 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.003 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0164 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0164 | 0.0577 |
Schistosoma mansoni | nuclear hormone receptor | 0.003 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0159 | 0.0559 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0331 | 0.1009 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0164 | 0.0164 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0107 | 0.1319 | 0.132 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0164 | 0.0164 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0107 | 0.1319 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.1489 | 0.5231 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0107 | 0.1319 | 0.132 |
Schistosoma mansoni | ferritin light chain | 0.0025 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.1489 | 0.5231 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0097 | 0.1172 | 0.1172 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0159 | 0.0159 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0685 | 0.9992 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0447 | 0.1569 |
Schistosoma mansoni | ferritin | 0.0025 | 0.0089 | 0.0089 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.074 | 0.2256 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.003 | 0.0164 | 0.0164 |
Trichomonas vaginalis | esterase, putative | 0.0107 | 0.1319 | 0.4019 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0159 | 0.0159 |
Brugia malayi | nuclear hormone receptor | 0.003 | 0.0164 | 0.0577 |
Onchocerca volvulus | 0.0107 | 0.1319 | 0.3708 | |
Brugia malayi | Steroid receptor seven-up type 2 | 0.003 | 0.0164 | 0.0577 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.003 | 0.0164 | 0.0164 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0159 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0164 | 0.0577 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0118 | 0.0361 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.003 | 0.0164 | 0.0577 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0213 | 0.0749 |
Onchocerca volvulus | 0.0041 | 0.0328 | 0.0531 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0162 | 0.057 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0287 | 0.1008 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.003 | 0.0164 | 0.0577 |
Echinococcus multilocularis | tumor protein p63 | 0.0665 | 0.9704 | 0.9704 |
Plasmodium vivax | hypothetical protein, conserved | 0.0107 | 0.1319 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.003 | 0.0164 | 0.0577 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.1319 | 0.132 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0107 | 0.1319 | 0.132 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.1319 | 0.4019 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.003 | 0.0164 | 0.0577 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0107 | 0.1319 | 0.132 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.003 | 0.0164 | 0.0164 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.1489 | 0.5231 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1172 | 0.4116 |
Onchocerca volvulus | Bile acid receptor homolog | 0.003 | 0.0164 | 0.0007 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.2847 | 1 |
Brugia malayi | ecdysteroid receptor | 0.003 | 0.0164 | 0.0577 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.003 | 0.0164 | 0.0577 |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 0.3281 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.003 | 0.0164 | 0.0164 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0685 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0107 | 0.1319 | 0.4019 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0331 | 0.1009 |
Schistosoma mansoni | hypothetical protein | 0.0378 | 0.5382 | 0.5382 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0107 | 0.1319 | 0.1319 |
Mycobacterium ulcerans | hypothetical protein | 0.0107 | 0.1319 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0331 | 0.0541 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0025 | 0.0089 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.074 | 0.26 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.1319 | 0.132 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.003 | 0.0164 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1319 | 0.4631 |
Toxoplasma gondii | ABC1 family protein | 0.0107 | 0.1319 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0041 | 0.0328 | 0.0328 |
Schistosoma mansoni | ferritin light chain | 0.0025 | 0.0089 | 0.0089 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.074 | 0.074 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.074 | 0.26 |
Leishmania major | hypothetical protein, conserved | 0.0107 | 0.1319 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.003 | 0.0164 | 0.0577 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0107 | 0.1319 | 0.132 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.003 | 0.0164 | 0.0164 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0107 | 0.1319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1319 | 0.4631 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.003 | 0.0164 | 0.0164 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.003 | 0.0164 | 0.0164 |
Brugia malayi | beta-lactamase | 0.0107 | 0.1319 | 0.4631 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.003 | 0.0164 | 0.0577 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0287 | 0.04 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.074 | 0.074 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.003 | 0.0164 | 0.0577 |
Onchocerca volvulus | 0.0238 | 0.3281 | 1 | |
Schistosoma mansoni | coup transcription factor | 0.003 | 0.0164 | 0.0164 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0107 | 0.1319 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.003 | 0.0164 | 0.0577 |
Schistosoma mansoni | ferritin | 0.0025 | 0.0089 | 0.0089 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0164 | 0.0577 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.074 | 0.074 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0213 | 0.0213 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.003 | 0.0164 | 0.0577 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.003 | 0.0164 | 0.0577 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0025 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.003 | 0.0164 | 0.0577 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0107 | 0.1319 | 0.1319 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0378 | 0.5382 | 0.5382 |
Echinococcus granulosus | tumor protein p63 | 0.0665 | 0.9704 | 0.9704 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0408 | 0.5837 | 0.5837 |
Schistosoma mansoni | thyroid hormone receptor | 0.0408 | 0.5837 | 0.5837 |
Schistosoma mansoni | apoferritin-2 | 0.0025 | 0.0089 | 0.0089 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0287 | 0.0875 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.003 | 0.0164 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0447 | 0.1569 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0118 | 0.0361 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.074 | 0.074 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.074 | 0.2256 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0159 | 0.0559 |
Schistosoma mansoni | ferritin | 0.0025 | 0.0089 | 0.0089 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0107 | 0.1319 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.003 | 0.0164 | 0.0164 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0378 | 0.5382 | 0.5382 |
Mycobacterium leprae | Probable lipase LipE | 0.0107 | 0.1319 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0107 | 0.1319 | 0.1319 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.003 | 0.0164 | 0.0577 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.003 | 0.0164 | 0.0164 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.003 | 0.0164 | 0.0164 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.003 | 0.0164 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1319 | 0.4631 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.003 | 0.0164 | 0.0007 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.1319 | 0.4019 |
Onchocerca volvulus | 0.0097 | 0.1172 | 0.3238 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0164 | 0.0577 |
Brugia malayi | beta-lactamase family protein | 0.0107 | 0.1319 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0164 | 0.0577 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0159 | 0.0159 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0107 | 0.1319 | 0.4019 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0447 | 0.1569 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0025 | 0.0089 | 0.0677 |
Echinococcus granulosus | FTZ F1 alpha | 0.003 | 0.0164 | 0.0164 |
Onchocerca volvulus | 0.003 | 0.0164 | 0.0007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.