Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 | 0.0014 | 0.0587 | 0.0668 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0014 | 0.0587 | 0.7169 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3301 | 0.3301 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0014 | 0.0587 | 0.7169 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3301 | 0.3301 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0148 | 0.1806 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.1079 | 0.1227 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0819 | 0.7592 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.1079 | 0.1227 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0587 | 0.5443 |
Echinococcus multilocularis | geminin | 0.0181 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0819 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3301 | 0.3301 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 0.8791 | 0.8791 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0819 | 0.0932 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0819 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.8791 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.1449 | 0.1449 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0819 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0819 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3301 | 0.3755 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0148 | 0.1806 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3301 | 0.3301 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0014 | 0.0587 | 0.5443 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0182 | 0.0182 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0014 | 0.0587 | 0.7169 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0182 | 0.0182 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.1079 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0023 | 0.1079 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.2729 | 0.3104 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.2762 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.1079 | 0.1227 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0014 | 0.0587 | 0.0587 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 0.8791 | 0.8791 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0148 | 0.1806 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2548 | 0.2548 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3301 | 0.3755 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.1079 | 0.1227 |
Echinococcus granulosus | muscleblind protein | 0.016 | 0.8791 | 0.8791 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0014 | 0.0587 | 0.5443 |
Echinococcus multilocularis | 0.0014 | 0.0587 | 0.0587 | |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.136 | 0.136 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0819 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0014 | 0.0587 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0014 | 0.0587 | 0.7169 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0014 | 0.0587 | 0.7169 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0023 | 0.1079 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0819 | 0.0932 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.1079 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0819 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0014 | 0.0587 | 0.2126 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0014 | 0.0587 | 0.7169 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0014 | 0.0587 | 0.5443 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2548 | 0.2548 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0148 | 0.1806 |
Onchocerca volvulus | 0.0028 | 0.136 | 1 | |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0014 | 0.0587 | 0.7169 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0819 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0014 | 0.0587 | 0.7169 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0278 | 0.0278 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0148 | 0.1806 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0014 | 0.0587 | 0.5443 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0014 | 0.0587 | 0.7169 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0148 | 0.1806 |
Schistosoma mansoni | cytochrome P450 | 0.0014 | 0.0587 | 0.0587 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2548 | 0.2548 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0014 | 0.0587 | 0.7169 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0014 | 0.0587 | 0.7169 |
Mycobacterium leprae | putative cytochrome p450 | 0.0014 | 0.0587 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0819 | 0.0819 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.8791 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0587 | 0.5443 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0018 | 0.0018 |
Leishmania major | cytochrome p450-like protein | 0.0023 | 0.1079 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0819 | 0.0819 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3301 | 0.3755 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0014 | 0.0587 | 0.7169 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0014 | 0.0587 | 0.7169 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.2548 | 0.2899 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3301 | 0.3755 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.3117 | 0.3117 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.2729 | 0.3104 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0819 | 0.7592 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0819 | 0.7592 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0148 | 0.1806 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Brugia malayi | cytochrome P450 | 0.0014 | 0.0587 | 0.0668 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0014 | 0.0587 | 0.7169 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0819 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3301 | 0.3301 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.136 | 0.1547 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.2548 | 0.2899 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0148 | 0.1806 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0148 | 0.1806 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0182 | 0.0182 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0148 | 0.1806 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0819 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0014 | 0.0587 | 0.7169 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0819 | 0.4716 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0014 | 0.0587 | 0.7169 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0014 | 0.0587 | 0.7169 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3301 | 0.3301 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.8791 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1449 | 0.1449 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.136 | 0.1547 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3301 | 0.3301 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0148 | 0.1806 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0587 | 0.0668 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0819 | 0.7592 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0819 | 0.0819 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0819 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0148 | 0.1806 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0148 | 0.1806 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0148 | 0.1806 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0278 | 0.0278 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0014 | 0.0587 | 0.7169 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0278 | 0.0316 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0014 | 0.0587 | 0.5443 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2548 | 0.2548 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0819 | 0.2966 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0014 | 0.0587 | 0.7169 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3301 | 0.3755 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1449 | 0.1449 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0148 | 0.1806 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0285 | 0.0324 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0148 | 0.1806 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0271 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0587 | 0.0587 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.1079 | 0.1227 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0182 | 0.0182 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0148 | 0.1806 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3301 | 0.3755 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0182 | 0.0182 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0014 | 0.0587 | 0.7169 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2548 | 0.2548 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0148 | 0.1806 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.1449 | 0.1449 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.