Detailed information for compound 575850

Basic information

Technical information
  • TDR Targets ID: 575850
  • Name: strictamine
  • MW: 322.401 | Formula: C20H22N2O2
  • H donors: 0 H acceptors: 1 LogP: 1.75 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1C2CC3C4=Nc5c(C14CCN3CC2=CC)cccc5
  • InChi: 1S/C20H22N2O2/c1-3-12-11-22-9-8-20-14-6-4-5-7-15(14)21-18(20)16(22)10-13(12)17(20)19(23)24-2/h3-7,13,16-17H,8-11H2,1-2H3/b12-3+
  • InChiKey: LITYYRLWHAQJQS-KGVSQERTSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6475-05-4
  • Akuammilan-17-oic acid, methyl ester
  • Akuammiline, deacetyldeformo-
  • Deacetyldeformoakuammiline
  • NSC180521
  • Strictamin
  • Vincamidin
  • Vincamidine
  • Vincamidine hydrate
  • NSC180523

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0182 0.0182
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0587 0.5443
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3301 0.3301
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0587 0.7169
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0148 0.1806
Brugia malayi RNA binding protein 0.0062 0.3301 0.3755
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0819 1
Echinococcus granulosus cpg binding protein 0.0029 0.1449 0.1449
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0819 1
Loa Loa (eye worm) hypothetical protein 0.016 0.8791 1
Schistosoma mansoni ap endonuclease 0.0018 0.0819 0.0819
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.2729 0.3104
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.2762 1
Trypanosoma brucei cytochrome P450, putative 0.0023 0.1079 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0182 0.0182
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.1079 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0819 0.7592
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.1079 0.1227
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3301 0.3301
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0587 0.7169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0148 0.1806
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3301 0.3301
Loa Loa (eye worm) cytochrome P450 0.0014 0.0587 0.0668
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0587 0.7169
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0819 0.0932
Echinococcus multilocularis muscleblind protein 0.016 0.8791 0.8791
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3301 0.3301
Echinococcus multilocularis geminin 0.0181 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0819 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.1079 0.1227
Leishmania major cytochrome p450-like protein 0.0014 0.0587 0.5443
Onchocerca volvulus 0.0028 0.136 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0148 0.1806
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0587 0.7169
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0587 0.5443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.2548 0.2548
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0587 0.2126
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0587 0.7169
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.1079 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0819 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0148 0.1806
Schistosoma mansoni cytochrome P450 0.0014 0.0587 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0148 0.1806
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0587 0.7169
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0587 0.5443
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0278 0.0278
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0819 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0587 0.7169
Echinococcus multilocularis muscleblind protein 1 0.016 0.8791 0.8791
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0587 0.0587
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.2548 0.2548
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0148 0.1806
Brugia malayi Cytochrome P450 family protein 0.0023 0.1079 0.1227
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0587 0.7169
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0587 0.7169
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0587 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.1079 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0819 0.0932
Echinococcus multilocularis 0.0014 0.0587 0.0587
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0819 0.5
Schistosoma mansoni cpg binding protein 0.0028 0.136 0.136
Brugia malayi Cytochrome P450 family protein 0.0023 0.1079 0.1227
Echinococcus granulosus muscleblind protein 0.016 0.8791 0.8791
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3301 0.3755
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0587 0.5443
Brugia malayi CXXC zinc finger family protein 0.0028 0.136 0.1547
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3301 0.3301
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0819 1
Brugia malayi cytochrome P450 0.0014 0.0587 0.0668
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0587 0.7169
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0819 0.7592
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0148 0.1806
Schistosoma mansoni hypothetical protein 0.0181 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0819 0.7592
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.136 0.1547
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0148 0.1806
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.2548 0.2548
Echinococcus granulosus tar DNA binding protein 0.0062 0.3301 0.3301
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3301 0.3301
Schistosoma mansoni cpg binding protein 0.0029 0.1449 0.1449
Loa Loa (eye worm) hypothetical protein 0.016 0.8791 1
Brugia malayi Cytochrome P450 family protein 0.0014 0.0587 0.0668
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0587 0.7169
Trichomonas vaginalis helicase, putative 0.0006 0.0148 0.1806
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0819 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0587 0.7169
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0819 0.4716
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0587 0.7169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.2548 0.2899
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0148 0.1806
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0182 0.0182
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0148 0.1806
Mycobacterium leprae putative cytochrome p450 0.0014 0.0587 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0587 0.7169
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0587 0.7169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.2548 0.2548
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.3117 0.3117
Brugia malayi Cytochrome P450 family protein 0.0052 0.2729 0.3104
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0587 0.7169
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0587 0.7169
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3301 0.3755
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.2548 0.2899
Brugia malayi TAR-binding protein 0.0062 0.3301 0.3755
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0018 0.0018
Schistosoma mansoni ap endonuclease 0.0018 0.0819 0.0819
Brugia malayi Muscleblind-like protein 0.016 0.8791 1
Leishmania major cytochrome p450-like protein 0.0014 0.0587 0.5443
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0819 0.0819
Leishmania major cytochrome p450-like protein 0.0023 0.1079 1
Loa Loa (eye worm) CYP4Cod1 0.0023 0.1079 0.1227
Schistosoma mansoni hypothetical protein 0.0014 0.0587 0.0587
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0148 0.1806
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0182 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0148 0.1806
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0271 0.0309
Schistosoma mansoni hypothetical protein 0.0181 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0285 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0148 0.1806
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3301 0.3755
Schistosoma mansoni cpg binding protein 0.0029 0.1449 0.1449
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0587 0.7169
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0182 0.0182
Echinococcus multilocularis cpg binding protein 0.0029 0.1449 0.1449
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0148 0.1806
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.2548 0.2548
Loa Loa (eye worm) RNA binding protein 0.0062 0.3301 0.3755
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0587 0.7169
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0278 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0148 0.1806
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0148 0.1806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0148 0.1806
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0819 0.7592
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0819 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0819 0.0819
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0587 0.7169
Toxoplasma gondii exonuclease III APE 0.0018 0.0819 0.2966
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0587 0.5443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.2548 0.2548
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0278 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.2548 0.2548

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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