Detailed information for compound 575981

Basic information

Technical information
  • TDR Targets ID: 575981
  • Name: 1-(9H-fluoren-2-yl)propan-1-one
  • MW: 222.282 | Formula: C16H14O
  • H donors: 0 H acceptors: 1 LogP: 3.7 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)c1ccc2c(c1)Cc1c2cccc1
  • InChi: 1S/C16H14O/c1-2-16(17)12-7-8-15-13(10-12)9-11-5-3-4-6-14(11)15/h3-8,10H,2,9H2,1H3
  • InChiKey: SBNTYLXCXQZVTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(9H-fluoren-2-yl)-1-propanone
  • 1-(fluoren-2-yl)-2-propan-1-one
  • 65007-01-4
  • 1-EFK
  • 1-Propanone, 1-(9H-fluoren-2-yl)-
  • Ethyl fluorenyl ketone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0022 0.0022
Echinococcus granulosus importin subunit beta 1 0.0062 0.0251 0.025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0197 0.0929 1
Entamoeba histolytica hypothetical protein 0.005 0.0193 0.1368
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0184 0.0863 0.0862
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0032
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0026 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0074 0.0073
Echinococcus multilocularis excitatory amino acid transporter 2 0.2012 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0074 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0193 0.0819
Loa Loa (eye worm) glutathione reductase 0.0038 0.0135 0.0134
Echinococcus granulosus neutral amino acid transporter A 0.2012 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0324 0.1535
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0144 0.0135
Mycobacterium tuberculosis Conserved protein 0.0184 0.0863 0.0854
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0122 0.0122
Toxoplasma gondii ABC1 family protein 0.0184 0.0863 0.929
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.2012 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0044 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0032
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0133 0.0132
Trypanosoma brucei protein kinase, putative 0.0027 0.008 0.0374
Toxoplasma gondii exonuclease III APE 0.004 0.0144 0.1551
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0254 0.0254
Brugia malayi hypothetical protein 0.0014 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0825 0.4068 0.4068
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0098 0.0431 0.043
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0799 0.0798
Trypanosoma cruzi Emopamil binding protein, putative 0.0161 0.0748 0.3559
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0002 0.0024
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0324 0.0323
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0138 0.0136
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0659 0.065
Plasmodium falciparum thioredoxin reductase 0.0038 0.0135 0.5355
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.1408 0.3197
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0324 0.1535
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0122 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0197 0.0929 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0027 0.008 0.0859
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.017 0.1144
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.017 0.0168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Echinococcus granulosus geminin 0.0188 0.0883 0.0882
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0074 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0133 0.0624
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0074 0.0074
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.001 0.0103
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0144 0.0143
Trypanosoma brucei trypanothione reductase 0.0038 0.0135 0.0637
Loa Loa (eye worm) hypothetical protein 0.0184 0.0863 0.0862
Echinococcus granulosus phd:f box containing protein 0.0016 0.0022 0.002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0043 0.016 0.0159
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.2012 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0035
Loa Loa (eye worm) hypothetical protein 0.0076 0.0324 0.0323
Loa Loa (eye worm) RecQ helicase 0.0023 0.0059 0.0058
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0135 0.1564
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0324 0.0323
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0045 0.0168 0.0167
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0126 0.0572 0.057
Schistosoma mansoni nuclear receptor 0.0012 0.0005 0.0005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0014 0.0054
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0324 0.0323
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.001 0.0008
Mycobacterium tuberculosis Probable lipase LipE 0.0184 0.0863 0.0854
Schistosoma mansoni hypothetical protein 0.0188 0.0883 0.0883
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0074 0.0069
Onchocerca volvulus 0.0184 0.0863 0.0859
Trichomonas vaginalis CMGC family protein kinase 0.0027 0.008 0.0336
Mycobacterium tuberculosis Probable hydrolase 0.0184 0.0863 0.0854
Trypanosoma cruzi Emopamil binding protein, putative 0.0161 0.0748 0.3559
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0503 0.5414
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.001 0.0039
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0184 0.0863 0.0854
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.001 0.0332
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0122 0.0121
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0069 0.273
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0074 0.0073
Chlamydia trachomatis neutral amino acid transporter 0.0892 0.4401 0.4395
Brugia malayi Pre-SET motif family protein 0.0421 0.2048 0.2047
Echinococcus multilocularis survival motor neuron protein 1 0.0254 0.1211 0.121
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.016
Plasmodium falciparum importin beta, putative 0.0062 0.0251 1
Schistosoma mansoni coup transcription factor 0.0026 0.0074 0.0074
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0799 0.0798
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0059 0.0247
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0381 0.0372
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0324 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.025 0.025
Trypanosoma brucei glucosidase, putative 0.0038 0.0133 0.0628
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.017 0.0168
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0074 0.0073
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0022 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0144 0.0135
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.001 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0074 0.0073
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0251 0.2701
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0144 0.0322
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0027 0.008 0.037
Schistosoma mansoni DNA helicase recq5 0.0023 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0044 0.0162 0.0161
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Brugia malayi small heat shock protein 0.031 0.1492 0.1491
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0027 0.008 0.037
Schistosoma mansoni cpg binding protein 0.0061 0.0249 0.0249
Brugia malayi jmjC domain containing protein 0.0016 0.0022 0.002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0005 0.0004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0184 0.0863 0.0854
Brugia malayi CHE-14 protein 0.0042 0.0152 0.0151
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0197 0.0929 0.0928
Brugia malayi beta-lactamase family protein 0.0184 0.0863 0.0862
Echinococcus multilocularis geminin 0.0188 0.0883 0.0882
Onchocerca volvulus 0.0058 0.0233 0.0228
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0005 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0135 0.0633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1408 0.602
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0197 0.0929 0.0928
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0014 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.0197 0.0929 0.0929
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0074 0.0074
Echinococcus granulosus Excitatory amino acid transporter 0.2012 1 1
Plasmodium vivax hypothetical protein, conserved 0.0184 0.0863 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0074 0.0073
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0074 0.0073
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0074 0.0074
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1176 0.582 0.5816
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0144 0.1669
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0233 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.025 0.025
Brugia malayi nuclear hormone receptor 0.0026 0.0074 0.0073
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.001 0.0035
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0059 0.0058
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0431 0.043
Leishmania major GTP-binding protein, putative 0.0045 0.017 0.0803
Loa Loa (eye worm) hypothetical protein 0.0184 0.0863 0.0862
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0251 0.119
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0069 0.0805
Echinococcus multilocularis muscleblind protein 0.0324 0.1565 0.1564
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.227 0.2268
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0145
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.1408 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0135 0.0125
Leishmania major C-8 sterol isomerase-like protein 0.0431 0.2099 1
Echinococcus granulosus expressed conserved protein 0.0092 0.0401 0.04
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0074 0.0073
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0005 0.0005
Brugia malayi nuclear receptor NHR-67 0.0012 0.0005 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0074 0.0073
Treponema pallidum glutamate/aspartate transporter 0.0892 0.4401 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0251 0.025
Echinococcus multilocularis GPCR, family 2 0.0043 0.016 0.0159
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0913 0.0912
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0059 0.0247
Plasmodium falciparum thioredoxin reductase 0.0013 0.001 0.0332
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0005 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0126 0.0572 0.057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0324 0.1381
Schistosoma mansoni ran 0.0045 0.017 0.017
Entamoeba histolytica hypothetical protein 0.0036 0.0122 0.0867
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0059 0.0247
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0022 0.002
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0005 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0913 0.0913
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0074 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0032
Mycobacterium leprae Probable lipase LipE 0.0184 0.0863 1
Schistosoma mansoni hypothetical protein 0.0052 0.0202 0.0202
Plasmodium vivax SET domain protein, putative 0.0061 0.025 0.2903
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0074 0.0073
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0202 0.02
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0043 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.0863 0.3687
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0074 0.0074
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0238 0.0237
Schistosoma mansoni hypothetical protein 0.0657 0.3229 0.3229
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0059 0.0276
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0059 0.0058
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0022 0.002
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0022 0.0022
Schistosoma mansoni DNA helicase recq1 0.0023 0.0059 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0133 0.0564
Trichomonas vaginalis CMGC family protein kinase 0.0027 0.008 0.0336
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0022 0.002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0184 0.0863 0.0862
Echinococcus granulosus jun protein 0.0045 0.0168 0.0167
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0027 0.008 0.037
Onchocerca volvulus 0.0479 0.2338 0.2335
Onchocerca volvulus Excitatory amino acid transporter homolog 0.2012 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.031 0.1492 0.1491
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0431 0.306
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0027 0.008 0.0374
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0035
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0324 0.2301
Echinococcus granulosus muscleblind protein 0.0324 0.1565 0.1564
Trichomonas vaginalis CMGC family protein kinase 0.0027 0.008 0.0336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0032
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0069 0.0325
Schistosoma mansoni aldehyde dehydrogenase 0.0197 0.0929 0.0929
Onchocerca volvulus 0.0035 0.012 0.0115
Toxoplasma gondii aldehyde dehydrogenase 0.0197 0.0929 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0184 0.0863 0.0854
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0913 0.0912
Loa Loa (eye worm) hypothetical protein 0.0094 0.0412 0.0411
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0005 0.0004
Schistosoma mansoni alpha-glucosidase 0.0147 0.068 0.068
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.1172 0.1171
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0022 0.002
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0238 0.0238
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0027 0.008 0.0374
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0005 0.0004
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0324 0.1539
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0059 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0012 0.0011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0152 0.0151
Trichomonas vaginalis importin beta-1, putative 0.005 0.0193 0.0819
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0074 0.0073
Brugia malayi hypothetical protein 0.0025 0.0069 0.0068
Plasmodium vivax transportin, putative 0.0012 0.0001 0.0015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.017 0.0168
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0144 0.0961
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0014 0.0054
Mycobacterium tuberculosis Conserved protein 0.0184 0.0863 0.0854
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0027 0.008 0.037
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.0863 0.3687
Onchocerca volvulus 0.0052 0.0202 0.0197
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.001 0.0039
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.017 0.1826
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0059 0.2316
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0032
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0074 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.0863 0.3687
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0074 0.0073
Mycobacterium tuberculosis Probable esterase LipL 0.0184 0.0863 0.0854
Entamoeba histolytica hypothetical protein 0.0036 0.0122 0.0867
Mycobacterium ulcerans aldehyde dehydrogenase 0.0197 0.0929 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0032
Entamoeba histolytica Ran family GTPase 0.0045 0.017 0.1205
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.025 0.0249
Schistosoma mansoni importin beta-1 0.0062 0.0251 0.0251
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.043 0.042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0184 0.0863 0.0862
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0161 0.0748 0.3559
Loa Loa (eye worm) hypothetical protein 0.0043 0.016 0.0159
Plasmodium vivax JmjC domain containing protein 0.0016 0.0022 0.0252
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0074 0.0073
Onchocerca volvulus 0.0061 0.025 0.0246
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0238 0.0237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0913 0.0913
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.025 0.2697
Echinococcus granulosus snurportin 1 0.0657 0.3229 0.3228
Brugia malayi jmjC domain containing protein 0.0016 0.0022 0.002
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0074 0.0073
Leishmania major hypothetical protein, conserved 0.0161 0.0748 0.3562
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0431 0.2099 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0324 0.0324
Schistosoma mansoni hypothetical protein 0.0188 0.0883 0.0883
Echinococcus multilocularis neutral amino acid transporter A 0.2012 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0799 0.0798
Echinococcus multilocularis neutral amino acid transporter A 0.2012 1 1
Schistosoma mansoni nuclear receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0005 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0133 0.0564
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0324 0.0323
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0074 0.0069
Schistosoma mansoni importin-beta 2 0.0012 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.0863 0.0863
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0022 0.0022
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0133 0.0132
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0133 0.0628
Brugia malayi hypothetical protein 0.0035 0.012 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.0863 0.3687
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0069 0.0748
Loa Loa (eye worm) hypothetical protein 0.0184 0.0863 0.0862
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.002
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0657 0.3229 0.3228
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.001 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0032
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0011
Brugia malayi jmjC domain containing protein 0.0016 0.0022 0.002
Schistosoma mansoni hypothetical protein 0.0037 0.0126 0.0126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1408 0.602
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0133 0.0564
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Schistosoma mansoni ran 0.0045 0.017 0.017
Loa Loa (eye worm) histone methyltransferase 0.002 0.0044 0.0042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0074 0.0074
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0133 0.0564
Brugia malayi hypothetical protein 0.0254 0.1211 0.121
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0044 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0074 0.0073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.0913 0.0912
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0005 0.0005
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.017 0.0803
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Schistosoma mansoni cpg binding protein 0.0061 0.0249 0.0249
Echinococcus multilocularis dnaJ subfamily B 0.0825 0.4068 0.4067
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0043 0.016 0.0159
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1408 1
Echinococcus granulosus survival motor neuron protein 1 0.0254 0.1211 0.121
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0027 0.008 0.0078
Entamoeba histolytica hypothetical protein 0.0036 0.0122 0.0867
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0251 0.025
Echinococcus granulosus GPCR family 2 0.0043 0.016 0.0159
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0799 0.0798
Mycobacterium ulcerans hypothetical protein 0.0184 0.0863 0.9283
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.0863 0.4106
Brugia malayi RNA, U transporter 1 0.0175 0.0818 0.0817
Mycobacterium leprae conserved hypothetical protein 0.0184 0.0863 1
Echinococcus granulosus neutral amino acid transporter 0.2012 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0193 0.0819
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0059 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0569 0.0569
Brugia malayi nuclear receptor NHR-88 0.0012 0.0005 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1408 0.602
Echinococcus granulosus neutral amino acid transporter A 0.2012 1 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0431 0.2099 0.2098
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0014 0.0056
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0035
Trichomonas vaginalis esterase, putative 0.0184 0.0863 0.3687
Entamoeba histolytica HEAT repeat domain containing protein 0.0012 0.0001 0.0009
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0022 0.0818
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0022 0.0022
Toxoplasma gondii thioredoxin reductase 0.0038 0.0135 0.1453
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.001 0.0039
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0014 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1408 0.602
Echinococcus granulosus microtubule associated protein 2 0.0766 0.377 0.377
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0051 0.02 0.0198
Echinococcus granulosus Excitatory amino acid transporter 0.2012 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.064 0.0639
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.001 0.0035
Echinococcus multilocularis protein dispatched 1 0.0048 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Brugia malayi follicle stimulating hormone receptor 0.0246 0.1172 0.1171
Brugia malayi hypothetical protein 0.0012 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0074 0.0073
Echinococcus multilocularis expressed conserved protein 0.0092 0.0401 0.04
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0133 0.0564
Brugia malayi jmjC domain containing protein 0.0062 0.0254 0.0253
Echinococcus multilocularis protein patched 0.0042 0.0152 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0074 0.0073
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0324 0.1539
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0144 0.0676
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0254 0.0253
Brugia malayi ecdysteroid receptor 0.0026 0.0074 0.0073
Brugia malayi Muscleblind-like protein 0.0324 0.1565 0.1564
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.064 0.0639
Brugia malayi hypothetical protein 0.0014 0.0012 0.0011
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0074 0.0073
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0152 0.0151
Trichomonas vaginalis helicase, putative 0.0013 0.0009 0.0032
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1408 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.2012 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0233 0.0232
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0144 0.0143
Treponema pallidum glutamate transporter 0.0892 0.4401 1
Brugia malayi tailless protein 0.0012 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0381 0.0372
Echinococcus multilocularis Excitatory amino acid transporter 0.2012 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0381 0.0372
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.008 0.008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0074 0.0069
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0005 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0073
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0032
Loa Loa (eye worm) hypothetical protein 0.0324 0.1565 0.1564
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0073
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0381 0.0372
Brugia malayi Pre-SET motif family protein 0.0061 0.025 0.0249
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0144 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0032
Plasmodium vivax importin-beta 2, putative 0.0062 0.0251 0.2907
Onchocerca volvulus 0.0184 0.0863 0.0859
Leishmania major hypothetical protein, conserved 0.0016 0.0022 0.0097
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0074 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0043 0.016 0.0159
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0197 0.0929 0.092
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0014 0.0054
Echinococcus multilocularis mitogen activated protein kinase 0.0027 0.008 0.0078
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0005 0.0004
Schistosoma mansoni alpha glucosidase 0.0038 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0042 0.0152 0.0151
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0184 0.0863 0.9283
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0074 0.0073
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0011
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0197 0.0929 0.4422
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0045 0.0168 0.0167
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0074 0.0074
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0133 0.0945
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.001 0.0103
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0324 0.0324
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0133 0.0564
Echinococcus granulosus excitatory amino acid transporter 3 0.2012 1 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0038 0.0037
Brugia malayi latrophilin 2 splice variant baaae 0.0094 0.0412 0.0411
Echinococcus multilocularis excitatory amino acid transporter 3 0.2012 1 1
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.2012 1 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0022 0.0097
Loa Loa (eye worm) hypothetical protein 0.022 0.1041 0.104
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0892 0.4401 0.4401
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0144 0.0611
Mycobacterium tuberculosis Probable lipase LipD 0.0184 0.0863 0.0854
Echinococcus granulosus excitatory amino acid transporter 2 0.2012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0074 0.0073
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0022 0.002
Leishmania major importin beta-1 subunit, putative 0.005 0.0193 0.0912
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.001 0.0111
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0001 0.0014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0074 0.0073
Schistosoma mansoni microtubule-associated protein tau 0.0766 0.377 0.377
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0074 0.0073
Schistosoma mansoni ap endonuclease 0.004 0.0144 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0005 0.0004
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0059 0.0354
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0059 0.0058
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0152 0.0151
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0074 0.0073
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0145
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0005 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0074 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.0863 0.4106
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0059 0.0058
Brugia malayi ecdysone receptor 0.0012 0.0005 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0133 0.0624
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0038 0.0037
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0002 0.0026
Echinococcus multilocularis cpg binding protein 0.0061 0.0249 0.0248
Echinococcus multilocularis Excitatory amino acid transporter 0.2012 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0074 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0913 0.0912
Trypanosoma brucei Emopamil binding protein, putative 0.0161 0.0748 0.3562
Chlamydia trachomatis glutamate symporter 0.2012 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0431 0.043
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0012 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0184 0.0863 0.0862
Giardia lamblia Kinase, CMGC MAPK 0.0027 0.008 0.0502
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0074 0.0073
Brugia malayi bZIP transcription factor family protein 0.0045 0.0168 0.0167
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0026 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0014 0.0054
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0161 0.0748 0.3562
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.016
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0059 0.0276
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0005 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0022 0.002
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0059 0.0271
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0014 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1408 0.602
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0144 0.1462
Entamoeba histolytica hypothetical protein 0.0036 0.0122 0.0867
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0003 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0144 0.0611
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0005 0.0005
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0144 0.5718
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0059 0.0637
Brugia malayi conserved hypotetical protein 0.0012 0.0005 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0074 0.0073
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.001 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.022 0.1045 0.1044
Plasmodium vivax glutathione reductase, putative 0.0038 0.0135 0.1564
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0074 0.0073
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0133 0.0564
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0012 0.0011
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0892 0.4401 0.4401
Trichomonas vaginalis set domain proteins, putative 0.0479 0.2338 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.043 0.042
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0238 0.0237
Schistosoma mansoni hypothetical protein 0.0094 0.0412 0.0412
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0014 0.0099
Echinococcus granulosus sodium:dicarboxylate symporter 0.2012 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0184 0.0863 0.0862
Mycobacterium tuberculosis Probable reductase 0.0088 0.0381 0.0372
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0026 0.0025
Mycobacterium ulcerans esterase/lipase LipP 0.0184 0.0863 0.9283
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.043 0.1013
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0005 0.0004
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0161 0.0748 0.3559
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0074 0.0073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0913 0.0912
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0133 0.0132
Echinococcus granulosus excitatory amino acid transporter 2 0.2012 1 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0014 0.006
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0014 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0059 0.0058
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0022 0.002
Echinococcus multilocularis neutral amino acid transporter A 0.2012 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0074 0.0073
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0068
Schistosoma mansoni survival motor neuron protein 0.0052 0.0202 0.0202
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0005 0.0004
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.2012 1 1
Loa Loa (eye worm) hypothetical protein 0.0254 0.1211 0.121
Leishmania major hypothetical protein, conserved 0.0184 0.0863 0.4108
Plasmodium falciparum glutathione reductase 0.0038 0.0135 0.5355
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0144 0.068
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0431 0.2099 0.2098
Loa Loa (eye worm) hypothetical protein 0.0324 0.1565 0.1564
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0145
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0571 0.0569
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0014 0.0054
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0059 0.0637
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0324 0.0323
Brugia malayi MH2 domain containing protein 0.0126 0.0571 0.0569
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0014 0.0054
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0133 0.0132
Echinococcus multilocularis beta LACTamase domain containing family member 0.0184 0.0863 0.0862
Brugia malayi glutathione reductase 0.0038 0.0135 0.0134
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0152 0.0151
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0005 0.0004
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0659 0.7062
Trichomonas vaginalis CMGC family protein kinase 0.0027 0.008 0.0336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1408 0.602
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0005 0.0004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0254 0.0254
Onchocerca volvulus 0.0099 0.0438 0.0434
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0022 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0032
Brugia malayi jmjC domain containing protein 0.0016 0.0022 0.002
Brugia malayi Thioredoxin reductase 0.0038 0.0135 0.0134
Brugia malayi nuclear receptor RXR 0.0012 0.0005 0.0004
Schistosoma mansoni zinc finger protein 0.0012 0.0005 0.0005
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0381 0.0372
Schistosoma mansoni ap endonuclease 0.004 0.0144 0.0144
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0069 0.0321
Schistosoma mansoni jun-related protein 0.0037 0.0126 0.0126
Schistosoma mansoni alpha-glucosidase 0.0147 0.068 0.068
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0005 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0043 0.016 0.0159
Trypanosoma brucei hypothetical protein, conserved 0.0184 0.0863 0.4108
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0799 0.0798
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0011
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0133 0.0945
Brugia malayi beta-lactamase family protein 0.0184 0.0863 0.0862
Onchocerca volvulus 0.0184 0.0863 0.0859
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0138 0.0136
Brugia malayi nuclear receptor RXR 0.0014 0.0012 0.0011
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.017 0.6744
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0012 0.0012
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1617 0.8026 0.8026
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0032
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0135 0.0134
Brugia malayi beta-lactamase 0.0184 0.0863 0.0862
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.025 0.025
Schistosoma mansoni hypothetical protein 0.0036 0.0122 0.0122
Loa Loa (eye worm) beta-lactamase 0.0184 0.0863 0.0862
Leishmania major trypanothione reductase 0.0038 0.0135 0.0637
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.2048 0.2047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0074 0.0074
Schistosoma mansoni patched 1 0.0042 0.0152 0.0152
Treponema pallidum NADH oxidase 0.0013 0.001 0.0017
Mycobacterium tuberculosis Conserved protein 0.0184 0.0863 0.0854
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0005 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0035
Echinococcus multilocularis jun protein 0.0045 0.0168 0.0167
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.001 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0152 0.0647
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0005 0.0004
Loa Loa (eye worm) excitatory amino acid transporter 0.2012 1 1
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.016
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0892 0.4401 0.44
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.025 0.0249
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1408 0.602
Echinococcus multilocularis snurportin 1 0.0657 0.3229 0.3228
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0251 0.119
Trichomonas vaginalis ran, putative 0.0045 0.017 0.072
Trypanosoma brucei C-8 sterol isomerase, putative 0.0431 0.2099 1
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.227 0.2268
Brugia malayi hypothetical protein 0.0036 0.0122 0.0121
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0145
Schistosoma mansoni cpg binding protein 0.0058 0.0233 0.0233
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0059 0.0058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.0863 0.0863
Leishmania major hypothetical protein, conserved 0.0025 0.0069 0.0325
Brugia malayi Importin beta-1 subunit 0.0062 0.0251 0.025
Echinococcus multilocularis muscleblind protein 1 0.0324 0.1565 0.1564
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0059 0.2316
Loa Loa (eye worm) hypothetical protein 0.0184 0.0863 0.0862
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.022 0.1041 0.104
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0892 0.4401 0.44
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0026 0.0026
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0005 0.0005
Echinococcus granulosus neuropeptide s receptor 0.0465 0.227 0.2268
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0002 0.0016
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.043 0.042
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0074 0.0074
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.0913 0.0912
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0438 0.0438
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0027 0.008 0.0374
Loa Loa (eye worm) hypothetical protein 0.0061 0.025 0.0249
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0074 0.0073
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0022 0.0093
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.001 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0133 0.0564
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0659 0.5766
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0073
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0324 0.0323
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0005 0.0004
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0022 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0074 0.0073
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.017 0.0168
Echinococcus granulosus dnaJ subfamily B 0.0825 0.4068 0.4067
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0069 0.273
Loa Loa (eye worm) DR-78 0.0012 0.0005 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0074 0.0073
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0144 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0004
Echinococcus granulosus bloom syndrome protein 0.0023 0.0059 0.0058
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.001 0.0332
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0133 0.1433
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0133 0.0564
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0144 0.0676
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.025 0.0249
Onchocerca volvulus 0.0026 0.0074 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.001 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1408 0.602
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0073
Echinococcus granulosus mitogen activated protein kinase 3 0.0027 0.008 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0022 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0913 0.0913
Brugia malayi steroid hormone receptor 0.0026 0.0074 0.0073
Plasmodium falciparum glutathione reductase 0.0013 0.001 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0137 0.063 0.0629
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0431 0.043
Onchocerca volvulus 0.0161 0.0748 0.0744
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.017 0.1966
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0137 0.063 0.0629
Echinococcus multilocularis microtubule associated protein 2 0.0766 0.377 0.377
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0073
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0324 0.1381
Brugia malayi hypothetical protein 0.0016 0.0025 0.0023
Brugia malayi hypothetical protein 0.0012 0.0005 0.0004
Brugia malayi jmjC domain containing protein 0.0059 0.0238 0.0237
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0073
Brugia malayi MAP kinase sur-1 0.0027 0.008 0.0078
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0059 0.042
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.0863 0.3687
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0144 0.068
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0022 0.0234
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0014 0.0054
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0254 0.0253
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.227 0.2268
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0324 0.1381
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.017 0.0798
Echinococcus multilocularis mitogen activated protein kinase 3 0.0027 0.008 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0074 0.0073
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0074 0.0074
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0571 0.0569
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0011
Echinococcus multilocularis sodium:dicarboxylate symporter 0.2012 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0073
Brugia malayi CXXC zinc finger family protein 0.0058 0.0233 0.0231
Echinococcus granulosus mitogen activated protein kinase 0.0027 0.008 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0012 0.0011
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.001 0.0035
Brugia malayi nuclear hormone receptor 0.0012 0.0005 0.0004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0012 0.0011
Brugia malayi nuclear receptor NHR-88 0.0026 0.0074 0.0073
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0069 0.0321
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.017 0.0798
Echinococcus granulosus cpg binding protein 0.0061 0.0249 0.0248
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0324 0.2248
Mycobacterium ulcerans beta-lactamase 0.0184 0.0863 0.9283
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0059 0.0058
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.001 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0032
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0144 0.0143
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0043 0.016 0.0159
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0001 0.0014
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0014 0.0013
Mycobacterium ulcerans lipase LipD 0.0184 0.0863 0.9283
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0193 0.0908
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0022 0.0093

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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