Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.065 | 0.2423 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0075 | 0.065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.065 | 0.2423 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.0324 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0075 | 0.065 | 0.2423 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0075 | 0.065 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0424 | 0.491 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0329 | 0.0995 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0504 | 0.1876 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0242 | 0.2684 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0075 | 0.065 | 0.0626 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0329 | 0.067 |
Onchocerca volvulus | 0.0075 | 0.065 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.065 | 0.2423 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0185 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.1068 | 0.1427 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.041 | 0.041 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.3307 | 1 |
Onchocerca volvulus | 0.0048 | 0.0329 | 0.5058 | |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.019 | 0.2053 | 0.4182 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0075 | 0.065 | 0.1967 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0075 | 0.065 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0324 | 0.1206 |
Trichomonas vaginalis | esterase, putative | 0.0075 | 0.065 | 0.5 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.041 | 0.0835 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.065 | 0.0626 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0143 | 0.1485 | 0.3025 |
Plasmodium vivax | hypothetical protein, conserved | 0.0075 | 0.065 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.0633 | 0.2357 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0075 | 0.065 | 0.0626 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0185 | 0.0185 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.1068 | 0.1427 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0143 | 0.1485 | 0.5532 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0143 | 0.1485 | 0.1485 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0143 | 0.1485 | 0.3025 |
Brugia malayi | beta-lactamase family protein | 0.0075 | 0.065 | 0.2423 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.065 | 0.2423 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0075 | 0.065 | 0.0626 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.1068 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.041 | 0.1528 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0185 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.065 | 0.2423 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0075 | 0.065 | 0.1325 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.0633 | 0.2357 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0075 | 0.065 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0185 | 0.0559 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0143 | 0.1485 | 0.4491 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.1068 | 0.1427 |
Brugia malayi | beta-lactamase | 0.0075 | 0.065 | 0.2423 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.0324 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0075 | 0.065 | 0.0626 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0109 | 0.1068 | 0.7386 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0185 | 0.5 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.041 | 0.1528 |
Mycobacterium ulcerans | hypothetical protein | 0.0075 | 0.065 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.065 | 0.0626 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0075 | 0.065 | 0.0626 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.1216 | 0.171 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0329 | 0.0329 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0075 | 0.065 | 0.0626 |
Mycobacterium ulcerans | lipase LipD | 0.0075 | 0.065 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.065 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0143 | 0.1485 | 0.1485 |
Loa Loa (eye worm) | beta-lactamase | 0.0075 | 0.065 | 0.2423 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0075 | 0.065 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.019 | 0.2053 | 0.2053 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0185 | 0.5 |
Brugia malayi | Fli-1 protein | 0.0222 | 0.2445 | 0.9109 |
Loa Loa (eye worm) | fli-1 protein | 0.0222 | 0.2445 | 0.9109 |
Schistosoma mansoni | ets-related | 0.0222 | 0.2445 | 0.7394 |
Brugia malayi | follicle stimulating hormone receptor | 0.0242 | 0.2684 | 1 |
Onchocerca volvulus | 0.0075 | 0.065 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0075 | 0.065 | 1 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0329 | 0.1225 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0329 | 0.0329 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.1216 | 1 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0329 | 0.1225 |
Onchocerca volvulus | 0.0075 | 0.065 | 1 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0075 | 0.065 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0073 | 0.0633 | 0.0633 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.041 | 0.0835 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0329 | 0.5058 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.065 | 0.2423 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0075 | 0.065 | 0.1967 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0143 | 0.1485 | 0.5532 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0075 | 0.065 | 0.2423 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.041 | 0.1528 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0185 | 0.0559 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0075 | 0.065 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.041 | 0.124 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0329 | 0.0995 |
Schistosoma mansoni | gabp alpha | 0.0073 | 0.0633 | 0.1913 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0476 | 0.5542 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.065 | 1 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0073 | 0.0633 | 0.1289 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0075 | 0.065 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.1216 | 0.171 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0075 | 0.065 | 0.065 |
Mycobacterium ulcerans | beta-lactamase | 0.0075 | 0.065 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0185 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0143 | 0.1485 | 0.4491 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.1216 | 0.171 |
Toxoplasma gondii | ABC1 family protein | 0.0075 | 0.065 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0143 | 0.1485 | 0.4491 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0329 | 0.1225 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0075 | 0.065 | 0.2423 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0075 | 0.065 | 0.0626 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0073 | 0.0633 | 0.2357 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0324 | 0.1206 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0324 | 0.066 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.041 | 0.041 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0324 | 0.1206 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0329 | 0.0995 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0329 | 0.067 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0185 | 0.0689 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0324 | 0.1206 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.065 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0329 | 0.1225 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.1068 | 0.1427 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.1068 | 0.1427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.