Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Mus musculus | retinoid X receptor beta | Starlite/ChEMBL | References |
Mus musculus | retinoid X receptor gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor gamma | 340 aa | 338 aa | 24.6 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.178 | 0.178 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 0.4919 | 0.4919 |
Loa Loa (eye worm) | hypothetical protein | 0.0604 | 0.5294 | 0.5294 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0482 | 0.4065 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0458 | 0.382 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0278 | 0.1999 | 0.1999 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0482 | 0.4065 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0604 | 0.5294 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0278 | 0.1999 | 0.3775 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0302 | 0.2243 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 390 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor alpha | ChEMBL. | 15006411 |
EC50 (binding) | = 390 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor alpha | ChEMBL. | 15006411 |
Efficacy (functional) | = 5 % | In vitro agonist efficacy at human Retinoic X receptor alpha expressed in CV1 cells. | ChEMBL. | 15006411 |
Efficacy (functional) | = 5 % | In vitro agonist efficacy at human Retinoic X receptor alpha expressed in CV1 cells. | ChEMBL. | 15006411 |
Efficacy (functional) | = 35 % | In vitro agonist efficacy at human Retinoic X receptor alpha expressed in CV1 cells. | ChEMBL. | 15006411 |
Efficacy (functional) | = 35 % | In vitro agonist efficacy at human Retinoic X receptor alpha expressed in CV1 cells. | ChEMBL. | 15006411 |
IC50 (binding) | 0 nM | Transcriptional activation in CV-1 cells expressing Retinoic X receptor alpha; NC denotes as not calculated | ChEMBL. | 15006411 |
Ki (binding) | nM | Displacement of [3H]-9-cis-RA binding from retinoic X receptor gamma; NT denotes not tested | ChEMBL. | 15006411 |
Ki (binding) | 0 nM | Displacement of [3H]-9-cis-RA binding from Retinoic acid receptor RXR-beta; NT denotes not tested | ChEMBL. | 15006411 |
Ki (binding) | 0 nM | Displacement of [3H]-9-cis-RA binding from retinoic X receptor gamma; NT denotes not tested | ChEMBL. | 15006411 |
Ki (binding) | = 271 nM | Binding affinity against Retinoic acid receptor RXR-alpha by [3H]-9-cis-RA displacement. | ChEMBL. | 15006411 |
Ki (binding) | = 271 nM | Binding affinity against Retinoic acid receptor RXR-alpha by [3H]-9-cis-RA displacement. | ChEMBL. | 15006411 |
Ki (binding) | = 5736 nM | Binding affinity again retinoic acid receptor beta by [3H]-ATRA displacement. | ChEMBL. | 15006411 |
Ki (binding) | = 5736 nM | Binding affinity again retinoic acid receptor beta by [3H]-ATRA displacement. | ChEMBL. | 15006411 |
Ki (binding) | = 6024 nM | Binding affinity against retinoic acid receptor alpha by [3H]-ATRA displacement. | ChEMBL. | 15006411 |
Ki (binding) | = 6024 nM | Binding affinity against retinoic acid receptor alpha by [3H]-ATRA displacement. | ChEMBL. | 15006411 |
Ki (binding) | > 10000 nM | Binding affinity against retinoic acid receptor gamma by [3H]-ATRA displacement. | ChEMBL. | 15006411 |
Ki (binding) | > 10000 nM | Binding affinity against retinoic acid receptor gamma by [3H]-ATRA displacement. | ChEMBL. | 15006411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.