Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0235 | 0.3728 | 0.4452 |
Echinococcus multilocularis | geminin | 0.0198 | 0.2996 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.0834 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0243 | 0.3893 | 0.4398 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0526 | 0.9467 | 1 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0073 | 0.0545 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0292 | 0.4852 | 0.581 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0169 | 0.2432 | 0.7702 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0166 | 0.2371 | 0.2593 |
Mycobacterium ulcerans | thioesterase | 0.0243 | 0.3893 | 0.4682 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0283 | 0.4676 | 0.5799 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0239 | 0.3804 | 0.4587 |
Leishmania major | hypothetical protein, conserved | 0.0088 | 0.0834 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0292 | 0.4852 | 0.4555 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.1845 | 0.1582 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0073 | 0.0545 | 0.1592 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.031 | 0.5209 | 0.6522 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0283 | 0.4676 | 0.5799 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0193 | 0.2904 | 0.3299 |
Loa Loa (eye worm) | acyl carrier protein | 0.0134 | 0.1746 | 0.1462 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.1845 | 0.1375 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0088 | 0.0834 | 0.0455 |
Giardia lamblia | Methyltransferase like 2 | 0.0088 | 0.0834 | 1 |
Toxoplasma gondii | 3-oxoacyl-acyl-carrier protein synthase I/II, putative | 0.0073 | 0.0545 | 0.0905 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0092 | 0.0908 | 0.0558 |
Brugia malayi | AMP-binding enzyme family protein | 0.009 | 0.087 | 0.0343 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0208 | 0.3195 | 0.6072 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0046 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.021 | 0.3232 | 0.3791 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0118 | 0.1427 | 0.128 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0292 | 0.4852 | 0.6023 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.031 | 0.5209 | 0.6337 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0436 | 0.7695 | 1 |
Echinococcus granulosus | geminin | 0.0198 | 0.2996 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0273 | 0.4474 | 0.4155 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0292 | 0.4852 | 0.6044 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0073 | 0.0545 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0235 | 0.3728 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.031 | 0.5209 | 0.6541 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.031 | 0.5209 | 0.6541 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0243 | 0.3893 | 0.4711 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0148 | 0.2008 | 0.3757 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.009 | 0.087 | 0.0454 |
Loa Loa (eye worm) | acetyltransferase | 0.0169 | 0.2432 | 0.2297 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0092 | 0.0908 | 0.0508 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.009 | 0.087 | 0.0505 |
Mycobacterium tuberculosis | Conserved protein | 0.0088 | 0.0834 | 0.0455 |
Loa Loa (eye worm) | hypothetical protein | 0.049 | 0.8761 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.031 | 0.5209 | 0.6522 |
Mycobacterium ulcerans | thioesterase TesA | 0.0243 | 0.3893 | 0.4682 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0292 | 0.4852 | 0.581 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0436 | 0.7695 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0235 | 0.3728 | 0.4452 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.031 | 0.5209 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0273 | 0.4474 | 0.4782 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0292 | 0.4852 | 0.6023 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0073 | 0.0545 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0292 | 0.4852 | 0.6023 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0189 | 0.2832 | 0.5364 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2324 | 0.2164 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0073 | 0.0545 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.1845 | 0.1582 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0073 | 0.0545 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.2996 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0288 | 0.4775 | 0.5149 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.2996 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.01 | 0.1079 | 0.0795 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.031 | 0.5209 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.031 | 0.5209 | 0.6522 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0073 | 0.0545 | 0.5 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0273 | 0.4474 | 0.5519 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0292 | 0.4852 | 0.6044 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0292 | 0.4852 | 0.6023 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0169 | 0.2432 | 0.1996 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0292 | 0.4852 | 0.6023 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0088 | 0.0834 | 0.0306 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0436 | 0.7695 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0292 | 0.4852 | 0.6044 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.031 | 0.5209 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.031 | 0.5209 | 0.6541 |
Onchocerca volvulus | 0.0508 | 0.9109 | 0.9285 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0164 | 0.2339 | 0.7747 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0193 | 0.2904 | 0.2941 |
Schistosoma mansoni | methyltransferase-related | 0.0088 | 0.0834 | 0.1179 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0436 | 0.7695 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0073 | 0.0545 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0193 | 0.2904 | 0.3299 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0169 | 0.2432 | 0.7702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.