Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.1028 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0394 | 0.0394 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4707 | 0.712 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.107 | 0.0778 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1028 | 0.0984 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4707 | 0.712 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.4043 | 0.4043 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1202 | 0.1202 |
Loa Loa (eye worm) | TAR-binding protein | 0.0137 | 0.4707 | 0.4707 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1202 | 0.1202 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.1576 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0882 | 0.0882 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0882 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.1919 | 0.2258 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.4043 | 0.4014 |
Echinococcus granulosus | lamin | 0.0031 | 0.0624 | 0.0624 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.1028 | 0.1028 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0064 | 0.0064 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0624 | 0.0624 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0882 | 0.7218 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0882 | 0.0882 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0394 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0882 | 0.0882 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0624 | 0.0624 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0882 | 0.0838 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0624 | 0.0624 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0137 | 0.4707 | 0.4707 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0394 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.1576 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0882 | 0.0882 |
Onchocerca volvulus | 0.0038 | 0.0882 | 0.271 | |
Brugia malayi | hypothetical protein | 0.0025 | 0.0394 | 0.0348 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.107 | 0.4435 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.6358 | 1 |
Echinococcus granulosus | geminin | 0.018 | 0.6358 | 0.6358 |
Echinococcus multilocularis | geminin | 0.018 | 0.6358 | 0.6358 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0243 | 0.8776 | 1 |
Brugia malayi | TAR-binding protein | 0.0137 | 0.4707 | 0.4681 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0882 | 0.3201 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0624 | 0.0624 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0882 | 0.7218 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0064 | 0.0016 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0882 | 0.3201 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.1919 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4707 | 0.712 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1202 | 0.1202 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.107 | 0.0778 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0.107 | 0.1815 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0624 | 0.0624 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0038 | 0.0897 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0882 | 0.0882 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0624 | 0.0579 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0882 | 0.0838 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.107 | 1 |
Onchocerca volvulus | 0.0038 | 0.0882 | 0.271 | |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0882 | 0.0838 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.1919 | 0.1919 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0882 | 0.0882 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0882 | 0.0882 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1919 | 1 |
Brugia malayi | Inositol-1 | 0.0043 | 0.107 | 0.1027 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.107 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.107 | 0.107 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0038 | 0.0897 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1576 | 0.166 |
Loa Loa (eye worm) | RNA binding protein | 0.0137 | 0.4707 | 0.4707 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0882 | 0.7218 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.107 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1202 | 0.1202 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.1919 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4707 | 0.712 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.107 | 0.4435 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1919 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4707 | 0.712 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.1919 | 0.1314 |
Onchocerca volvulus | 0.0038 | 0.0882 | 0.271 | |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.107 | 0.107 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0882 | 0.0882 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1202 | 0.1008 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.107 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.4043 | 0.4043 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0624 | 0.0624 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1202 | 0.1202 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0882 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.6358 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.1028 | 0.1028 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0275 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0624 | 0.0624 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.107 | 0.107 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0602 | 0.0602 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.107 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1202 | 0.1008 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.1576 | 0.166 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.107 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0137 | 0.4707 | 0.4681 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0882 | 0.0882 |
Brugia malayi | RNA binding protein | 0.0137 | 0.4707 | 0.4681 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1919 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.1028 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0882 | 0.0882 |
Echinococcus granulosus | tar DNA binding protein | 0.0137 | 0.4707 | 0.4707 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0882 | 0.045 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1202 | 0.1008 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1202 | 0.116 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.107 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.1919 | 0.1919 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0624 | 0.0624 |
Echinococcus multilocularis | tar DNA binding protein | 0.0137 | 0.4707 | 0.4707 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0624 | 0.0579 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.1919 | 0.2258 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0882 | 0.0838 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0275 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.