Detailed information for compound 576719

Basic information

Technical information
  • TDR Targets ID: 576719
  • Name: [(2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1- yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dih ydrogen phosphate
  • MW: 308.185 | Formula: C8H13N4O7P
  • H donors: 4 H acceptors: 5 LogP: -3.24 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@@H](O[C@@H]1COP(=O)(O)O)n1cnc(nc1=O)N
  • InChi: 1S/C8H13N4O7P/c9-7-10-3-12(8(14)11-7)6-1-4(13)5(19-6)2-18-20(15,16)17/h3-6,13H,1-2H2,(H2,9,11,14)(H2,15,16,17)/t4-,5+,6+/m0/s1
  • InChiKey: JQHZISUSXMJEPR-KVQBGUIXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-3-hydroxy-2-tetrahydrofuranyl]methyl dihydrogen phosphate
  • [(2R,3S,5R)-5-(4-azanyl-2-oxo-1,3,5-triazin-1-yl)-3-hydroxy-oxolan-2-yl]methyl dihydrogen phosphate
  • [(2R,3S,5R)-5-(4-amino-2-keto-s-triazin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
  • [(2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
  • 5-aza-2'-deoxycytidine-5'-monophosphate
  • [(2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-3-hydroxy-oxolan-2-yl]methyl dihydrogen phosphate
  • 66642-55-5
  • 5-Aza-dcmp
  • 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.105 0.1003
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0052 0.0331
Loa Loa (eye worm) hypothetical protein 0.0123 0.4764 0.4745
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.105 0.6625
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.1539 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0052 0.0331
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1539 0.1509
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.1539 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.105 0.1017
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0493 0.0459
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.1584 1
Echinococcus granulosus GPCR family 2 0.0016 0.0139 0.0087
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.105 0.1017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.1539 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0036 0.0343
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.105 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.1007 0.0975
Loa Loa (eye worm) hypothetical protein 0.0089 0.3321 0.3297
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0493 0.4698
Loa Loa (eye worm) TAR-binding protein 0.0129 0.5059 0.5041
Onchocerca volvulus 0.0048 0.1539 0.4166
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0957 0.0924
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0139 0.0104
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0139 0.0087
Schistosoma mansoni hypothetical protein 0.005 0.1589 0.2721
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0052 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.1539 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0052 0.0331
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1662 0.1632
Entamoeba histolytica hypothetical protein 0.0037 0.1042 0.6768
Echinococcus granulosus bloom syndrome protein 0.0024 0.0493 0.0443
Schistosoma mansoni tar DNA-binding protein 0.0129 0.5059 0.8864
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.6714 0.6702
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0052 0.0499
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.105 0.6819
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.105 0.1003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.6714 0.6697
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0036 0.0227
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0052 0.0016
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0052 0.0331
Loa Loa (eye worm) hypothetical protein 0.0048 0.1539 0.1509
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0036 0.0343
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.1539 0.9716
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.1584 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.1042 0.1752
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.027 0.0386
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.5059 0.5041
Loa Loa (eye worm) oxidoreductase 0.0014 0.0052 0.0016
Schistosoma mansoni survival motor neuron protein 0.005 0.1589 0.2721
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0139 0.0104
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.1539 0.9716
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.1539 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0921 0.5844
Schistosoma mansoni tar DNA-binding protein 0.0129 0.5059 0.8864
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.015 0.0639
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0052 0.0499
Onchocerca volvulus 0.005 0.1589 0.4305
Schistosoma mansoni hypothetical protein 0.0037 0.1042 0.1752
Schistosoma mansoni tar DNA-binding protein 0.0129 0.5059 0.8864
Brugia malayi hypothetical protein 0.0037 0.1042 0.1009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0139 0.0087
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0036 0.0227
Entamoeba histolytica hypothetical protein 0.0037 0.1042 0.6768
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0036 0.0234
Mycobacterium ulcerans hypothetical protein 0.0048 0.1539 1
Brugia malayi hypothetical protein 0.0089 0.3321 0.3297
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.1007 0.5
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.1539 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1662 0.1632
Schistosoma mansoni eyes absent homolog 0.0089 0.3321 0.5788
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.1539 1
Loa Loa (eye worm) RecQ helicase 0.0024 0.0493 0.0459
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0036 0.0343
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0365 0.2038
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.6714 0.6697
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.1584 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.105 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.1539 0.1509
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0036 0.0343
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.105 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.6714 0.6702
Schistosoma mansoni hypothetical protein 0.0016 0.0139 0.0154
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0052 0.0331
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.1584 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0036 0.0227
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0493 0.0443
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.1584 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.1042 0.0995
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0139 0.0087
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.105 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.1584 0.1554
Loa Loa (eye worm) hypothetical protein 0.0036 0.1007 0.0975
Schistosoma mansoni hypothetical protein 0.0016 0.0139 0.0154
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.1007 0.6233
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.1539 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.105 1
Brugia malayi RNA binding protein 0.0129 0.5059 0.5041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0921 0.5844
Brugia malayi hypothetical protein 0.0032 0.0822 0.0789
Brugia malayi hypothetical protein 0.0049 0.1584 0.1554
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0052 0.0331
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.6714 0.6697
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0052 0.0331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0957 0.0924
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0052 0.0016
Loa Loa (eye worm) hypothetical protein 0.0051 0.1662 0.1632
Trypanosoma brucei glucosidase, putative 0.0037 0.105 0.6625
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0052 0.0331
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0052 0.0016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0036 0.0343
Loa Loa (eye worm) hypothetical protein 0.0048 0.1539 0.1509
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1589 0.1559
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0052 0.0016
Entamoeba histolytica hypothetical protein 0.0037 0.1042 0.6768
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0139 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.105 0.6625
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.1007 0.6421
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.105 0.6819
Schistosoma mansoni hypothetical protein 0.0035 0.0957 0.1602
Onchocerca volvulus 0.0014 0.0052 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0129 0.5059 0.8864
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0052 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.1539 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.105 0.6625
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0139 0.0087
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0036 0.0343
Schistosoma mansoni alpha-glucosidase 0.0144 0.57 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.1539 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0129 0.5059 0.8864
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1662 0.1632
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.1007 0.6421
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1539 0.1509
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.105 0.651
Leishmania major hypothetical protein, conserved 0.0049 0.1584 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1539 0.1509
Onchocerca volvulus 0.0014 0.0052 0.0046
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0493 0.4698
Loa Loa (eye worm) hypothetical protein 0.0036 0.1007 0.0975
Loa Loa (eye worm) RNA binding protein 0.0129 0.5059 0.5041
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0036 0.0343
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0052 0.0331
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.1584 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.3321 0.3297
Onchocerca volvulus 0.0097 0.3645 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0052 0.034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.1539 1
Onchocerca volvulus 0.0014 0.0052 0.0046
Schistosoma mansoni hypothetical protein 0.0016 0.0139 0.0154
Loa Loa (eye worm) hypothetical protein 0.0036 0.1007 0.0975
Loa Loa (eye worm) hypothetical protein 0.0016 0.0139 0.0104
Echinococcus multilocularis tar DNA binding protein 0.0129 0.5059 0.5033
Onchocerca volvulus 0.0014 0.0052 0.0046
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0036 0.0227
Schistosoma mansoni alpha glucosidase 0.0037 0.105 0.1766
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.1007 0.6233
Entamoeba histolytica hypothetical protein 0.0037 0.1042 0.6768
Echinococcus granulosus survival motor neuron protein 1 0.0243 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.1539 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0052 0.0016
Echinococcus granulosus tar DNA binding protein 0.0129 0.5059 0.5033
Schistosoma mansoni hypothetical protein 0.0016 0.0139 0.0154
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.105 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0142 0.0584
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0399 0.0348
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.105 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.1539 1
Echinococcus multilocularis survival motor neuron protein 1 0.0243 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0921 0.5844
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0921 0.5844
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.1042 0.0995
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0052 0.0016
Loa Loa (eye worm) hypothetical protein 0.0243 1 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0139 0.0087
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.1539 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0399 0.0348
Brugia malayi TAR-binding protein 0.0129 0.5059 0.5041
Loa Loa (eye worm) hypothetical protein 0.0036 0.1007 0.0975
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.5059 0.5041
Schistosoma mansoni alpha-glucosidase 0.0144 0.57 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.105 1
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.1584 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.105 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.1539 0.9716
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0036 0.0343
Schistosoma mansoni hypothetical protein 0.0022 0.0399 0.0613

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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