Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0025 | 0.0096 | 0.0184 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0033 | 0.0219 | 0.0666 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 0.375 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.0219 | 0.0666 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0025 | 0.0096 | 0.0491 |
Onchocerca volvulus | 0.0048 | 0.0453 | 1 | |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3292 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0662 | 0.201 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0662 | 1 |
Brugia malayi | hypothetical protein | 0.0238 | 0.3292 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 0.375 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0662 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.0219 | 0.0422 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0025 | 0.0096 | 0.029 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0662 | 0.201 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.0208 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0662 | 0.201 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0032 | 0.0208 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0025 | 0.0096 | 0.4607 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 0.375 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0025 | 0.0096 | 0.0096 |
Echinococcus multilocularis | expressed protein | 0.0033 | 0.0219 | 0.0666 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0662 | 0.201 |
Mycobacterium ulcerans | 20-beta-hydroxysteroid dehydrogenase FabG3 | 0.0025 | 0.0096 | 0.0096 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0364 | 0.5191 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0364 | 0.5191 | 0.5191 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0025 | 0.0096 | 0.0184 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0453 | 0.6844 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0025 | 0.0096 | 0.0184 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0662 | 0.201 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0025 | 0.0096 | 0.0096 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0453 | 0.1376 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0148 | 0.1947 | 1 |
Leishmania major | pteridine reductase 1 | 0.0025 | 0.0096 | 0.4607 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Trypanosoma brucei | pteridine reductase 1 | 0.0025 | 0.0096 | 0.4607 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0025 | 0.0096 | 0.1445 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 0.375 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0238 | 0.3292 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0238 | 0.3292 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0032 | 0.0208 | 0.04 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0662 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0025 | 0.0096 | 0.4607 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0032 | 0.0208 | 1 |
Echinococcus granulosus | expressed protein | 0.0033 | 0.0219 | 0.0666 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0684 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0025 | 0.0096 | 0.4607 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0364 | 0.5191 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0025 | 0.0096 | 0.4607 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0453 | 0.6844 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.0208 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0.0096 | 0.029 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0025 | 0.0096 | 0.0184 |
Leishmania major | oxidoreductase-like protein | 0.0025 | 0.0096 | 0.4607 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.0025 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | oxidoreductase | 0.0025 | 0.0096 | 0.029 |
Schistosoma mansoni | dihydropteridine reductase | 0.0025 | 0.0096 | 0.1445 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0025 | 0.0096 | 0.029 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0025 | 0.0096 | 0.4607 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0025 | 0.0096 | 0.0096 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0.0096 | 0.029 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 0.375 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0662 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0684 | 1 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0.0096 | 0.029 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0662 | 0.201 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0662 | 0.201 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0148 | 0.1947 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0025 | 0.0096 | 0.0096 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0219 | 0.0422 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0025 | 0.0096 | 0.0096 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 0.375 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 0.375 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0025 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0096 | 0.029 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 0.375 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.0025 | 0.0096 | 0.0096 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0025 | 0.0096 | 0.4607 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0025 | 0.0096 | 0.0096 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0025 | 0.0096 | 0.0184 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0032 | 0.0208 | 0.1066 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0364 | 0.5191 | 0.5191 |
Schistosoma mansoni | rotamase | 0.0033 | 0.0219 | 0.3312 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0025 | 0.0096 | 0.0096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0662 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0025 | 0.0096 | 0.4607 |
Mycobacterium ulcerans | oxidoreductase | 0.0025 | 0.0096 | 0.0096 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0364 | 0.5191 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0364 | 0.5191 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0364 | 0.5191 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0364 | 0.5191 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0025 | 0.0096 | 0.0096 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0364 | 0.5191 | 0.5145 |
Trichomonas vaginalis | rotamase, putative | 0.0032 | 0.0208 | 0.04 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0025 | 0.0096 | 0.0184 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0025 | 0.0096 | 0.0096 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0.0096 | 0.029 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0025 | 0.0096 | 0.4607 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0148 | 0.1947 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0662 | 0.201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.