TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 215.294 | Formula: C13H17N3
H donors: 1 H acceptors: 0 LogP: 1.33 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CN1c2ccccc2C[C@@]1(C)C1=NCCN1
InChi: 1S/C13H17N3/c1-13(12-14-7-8-15-12)9-10-5-3-4-6-11(10)16(13)2/h3-6H,7-9H2,1-2H3,(H,14,15)/t13-/m0/s1
InChiKey: GLBSIVJNXQFLOX-ZDUSSCGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Adrenergic receptor alpha-2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Adrenergic receptor alpha-2	450 aa	420 aa	19.8 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Adrenergic receptor alpha-2	450 aa	476 aa	21.0 %
Loa Loa (eye worm)	TYRA-2 protein	Adrenergic receptor alpha-2	450 aa	488 aa	23.8 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Adrenergic receptor alpha-2	450 aa	433 aa	27.9 %
Echinococcus multilocularis	fmrfamide receptor	Adrenergic receptor alpha-2	450 aa	366 aa	19.9 %
Schistosoma mansoni	amine GPCR	Adrenergic receptor alpha-2	450 aa	439 aa	29.2 %
Echinococcus multilocularis	serotonin receptor	Adrenergic receptor alpha-2	450 aa	426 aa	31.9 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Adrenergic receptor alpha-2	450 aa	473 aa	24.1 %
Echinococcus granulosus	biogenic amine 5HT receptor	Adrenergic receptor alpha-2	450 aa	423 aa	31.7 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Adrenergic receptor alpha-2	450 aa	378 aa	20.9 %
Echinococcus multilocularis	alpha 1A adrenergic receptor	Adrenergic receptor alpha-2	450 aa	478 aa	20.7 %
Onchocerca volvulus		Adrenergic receptor alpha-2	450 aa	467 aa	25.1 %
Echinococcus multilocularis	neuropeptides capa receptor	Adrenergic receptor alpha-2	450 aa	486 aa	20.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cpg binding protein	0.0029	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0492	0.0747	0.0793
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0105	0.0106
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0014	0.2863
Schistosoma mansoni	loxhd1	0.0019	0.0018	0.0019
Brugia malayi	hypothetical protein	0.0019	0.0018	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0492	0.0747	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0117	0.0125
Schistosoma mansoni	adenoreceptor	0.0075	0.0105	0.0112
Echinococcus granulosus	serotonin transporter	0.0492	0.0747	0.0747
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Brugia malayi	Dopamine receptor protein 1	0.0075	0.0105	0.0112
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0105	0.0106
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0105	0.0105
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0117	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	hypothetical protein	0.0019	0.0018	0.0019
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0018	0.0019
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0014	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0005	0.0006
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0014	0.0014
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0105	0.0112
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0075	0.0105	0.0112
Leishmania major	cathepsin L-like protease	0.0062	0.0084	1
Onchocerca volvulus		0.0029	0.0034	0.0036
Echinococcus granulosus	expressed protein	0.0008	0.0001	0.0001
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0044	0.514
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Brugia malayi	Serotonin receptor	0.3907	0.6016	0.6382
Echinococcus granulosus	neuropeptide Y receptor	0.0075	0.0105	0.0105
Schistosoma mansoni	ferritin light chain	0.0008	0.0001	0.0001
Onchocerca volvulus		0.0026	0.0029	0.0031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0105	0.0112
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0083	0.0117	0.0117
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0002	0.0006
Echinococcus multilocularis	sodium bile acid cotransporter	0.6118	0.9426	0.9537
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0083	0.0117	0.0125
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0117	0.0125
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.03	0.0318
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0044	0.0046
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0075	0.0105	0.0106
Schistosoma mansoni	sodium/chloride dependent transporter	0.0492	0.0747	0.0793
Brugia malayi	follicle stimulating hormone receptor	0.0075	0.0105	0.0112
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0008	0.0008
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0005	0.0006
Echinococcus multilocularis	expressed protein	0.0008	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0016	0.0014	0.0014
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0044	0.5447
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0075	0.0105	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Plasmodium falciparum	amino acid transporter, putative	0.0083	0.0117	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0018	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0016	0.0014	0.0014
Schistosoma mansoni	opsin-like receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0018	0.0018
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0083	0.0117	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0014	0.1044
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0053	0.0071	0.0072
Onchocerca volvulus		0.0083	0.0117	0.0125
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0044	0.5131
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	ferritin	0.0008	0.0001	0.0001
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0083	0.0117	1
Schistosoma mansoni	hypothetical protein	0.0395	0.0598	0.0635
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0019	0.0018	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus granulosus	somatostatin receptor	0.0075	0.0105	0.0105
Echinococcus multilocularis	fmrfamide receptor	0.0075	0.0105	0.0106
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus multilocularis	dro:myosuppressin receptor	0.0075	0.0105	0.0106
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0105	0.0106
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0002	0.0006
Schistosoma mansoni	ferritin	0.0008	0.0001	0.0001
Echinococcus multilocularis	sodium bile acid cotransporter	0.6118	0.9426	0.9537
Onchocerca volvulus		0.0028	0.0032	0.0033
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0004	0.0004
Plasmodium vivax	vivapain-2	0.0016	0.0014	0.1044
Echinococcus granulosus	sodium bile acid cotransporter	0.6118	0.9426	0.9426
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0018	0.1426
Echinococcus multilocularis	RUN	0.0019	0.0018	0.0018
Echinococcus granulosus	g protein coupled receptor	0.0075	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0001	0.0001
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0044	0.514
Loa Loa (eye worm)	serotonin transporter b	0.0492	0.0747	0.0793
Echinococcus multilocularis	ferritin	0.0008	0.0001	0.0001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0079	0.0079
Brugia malayi	G-protein coupled receptor	0.0075	0.0105	0.0112
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0083	0.0117	0.0117
Echinococcus multilocularis	cysteine protease	0.0016	0.0014	0.0014
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0083	0.0117	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0492	0.0747	0.0793
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0014	0.0014
Brugia malayi	neuropeptide F receptor	0.0075	0.0105	0.0112
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0105	0.0105
Plasmodium falciparum	transporter, putative	0.0083	0.0117	1
Schistosoma mansoni	sodium-bile acid cotransporter related	0.6118	0.9426	1
Schistosoma mansoni	rab6-interacting	0.0019	0.0018	0.0019
Echinococcus granulosus	dnaJ subfamily B	0.0395	0.0598	0.0598
Brugia malayi	G-protein coupled receptor	0.0075	0.0105	0.0112
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0075	0.0105	0.0112
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.001	0.0011
Brugia malayi	Serotonin receptor	0.0075	0.0105	0.0112
Schistosoma mansoni	sodium-bile acid cotransporter	0.3637	0.5599	0.594
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0005	0.0006
Treponema pallidum	sodium- and chloride- dependent transporter	0.0492	0.0747	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0083	0.0117	0.0125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0014	0.1044
Schistosoma mansoni	histamine h1 receptor	0.0075	0.0105	0.0112
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0018	0.0018
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.0343	1
Schistosoma mansoni	polycystin 1-related	0.0019	0.0018	0.0019
Brugia malayi	hypothetical protein	0.0019	0.0018	0.0019
Loa Loa (eye worm)	fibroinase	0.0016	0.0014	0.0014
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0014	0.0014
Echinococcus granulosus	7tm_1 domain containing protein	0.0075	0.0105	0.0105
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0105	0.0105
Echinococcus granulosus	dro:myosuppressin receptor	0.0075	0.0105	0.0105
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0018	0.0018
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0075	0.0105	0.0106
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0044	0.0046
Schistosoma mansoni	sodium-bile acid cotransporter related	0.2481	0.3816	0.4048
Schistosoma mansoni	ferritin light chain	0.0008	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0014	0.0014
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0079	1
Schistosoma mansoni	cpg binding protein	0.0029	0.0034	0.0036
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0075	0.0105	0.0105
Echinococcus granulosus	neuropeptides capa receptor	0.0075	0.0105	0.0105
Brugia malayi	Sodium Bile acid symporter family protein	0.6118	0.9426	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0075	0.0105	0.0112
Schistosoma mansoni	lipoxygenase	0.0019	0.0018	0.0019
Schistosoma mansoni	cpg binding protein	0.0028	0.0032	0.0033
Echinococcus granulosus	cathepsin L	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0117	0.0125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0005	0.0119
Leishmania major	cathepsin L-like protease	0.0062	0.0084	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0044	0.0044
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0001	0.0001
Brugia malayi	Dopamine receptor	0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0075	0.0105	0.0106
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0014	0.0014
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0075	0.0105	0.0112
Schistosoma mansoni	biogenic amine receptor	0.0075	0.0105	0.0112
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0105	0.0112
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0034	0.0034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0105	0.0105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0083	0.0117	0.0125
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0075	0.0105	0.0112
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0044	0.2898
Onchocerca volvulus		0.0083	0.0117	0.0125
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0075	0.0105	0.0105
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0075	0.0105	0.0105
Echinococcus granulosus	tm gpcr rhodopsin	0.0875	0.1339	0.1339
Brugia malayi	larval opioid receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	TK/FAK protein kinase	0.0247	0.037	0.0392
Schistosoma mansoni	amine GPCR	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0083	0.0117	0.0125
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0083	0.0117	1
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0029	0.0031
Echinococcus multilocularis	neuropeptides capa receptor	0.0075	0.0105	0.0106
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus multilocularis	somatostatin receptor	0.0075	0.0105	0.0106
Loa Loa (eye worm)	cysteine protease	0.0016	0.0014	0.0014
Plasmodium vivax	hypothetical protein, conserved	0.0083	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0083	0.0117	0.0117
Brugia malayi	Protein kinase domain containing protein	0.0247	0.037	0.0392
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus granulosus	neuropeptide FF receptor 2	0.0075	0.0105	0.0105
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0083	0.0117	0.0119
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0105	0.0112
Echinococcus multilocularis	cpg binding protein	0.0029	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0014	0.0014
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0032	0.0033
Echinococcus granulosus	orexin receptor type 2	0.0075	0.0105	0.0105
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0044	0.4291
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.0063	0.7525
Loa Loa (eye worm)	TYRA-2 protein	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0002	0.0002
Plasmodium vivax	amine transporter, putative	0.0083	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus multilocularis	allatostatin A receptor	0.0075	0.0105	0.0106
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0004	0.0004
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0044	0.9984
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0075	0.0105	0.0106
Onchocerca volvulus		0.0016	0.0014	0.0014
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0044	0.5131
Schistosoma mansoni	neuropeptide receptor	0.0075	0.0105	0.0112
Echinococcus granulosus	tm gpcr rhodopsin	0.0075	0.0105	0.0105
Schistosoma mansoni	hypothetical protein	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0008	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.0076	0.8997
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0044	0.0044
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus granulosus	neuropeptide s receptor	0.0075	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus granulosus	sodium and chloride dependent glycine	0.0083	0.0117	0.0117
Schistosoma mansoni	lipoxygenase	0.0053	0.0071	0.0075
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0001	0.0001
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0081	0.0086
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0075	0.0105	0.0105
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0075	0.0105	0.0112
Schistosoma mansoni	neuropeptide receptor	0.0075	0.0105	0.0112
Schistosoma mansoni	ferritin	0.0008	0.0001	0.0001
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0492	0.0747	0.0793
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0044	0.1244
Onchocerca volvulus		0.0026	0.0029	0.0031
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0014	0.0014
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0031
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0034	0.0036
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0044	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0018	0.0018
Echinococcus multilocularis	cathepsin L	0.0008	0.0002	0.0002
Echinococcus multilocularis	conserved hypothetical protein	0.6415	0.9884	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.001	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0002	0.0002
Echinococcus granulosus	neuropeptide receptor	0.0075	0.0105	0.0105
Echinococcus granulosus	sex peptide receptor	0.0075	0.0105	0.0105
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0044	0.0046
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0075	0.0105	0.0112
Schistosoma mansoni	sodium/chloride dependent transporter	0.0083	0.0117	0.0125
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0075	0.0105	0.0106
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0014	0.2863
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0014	0.0014
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0075	0.0105	0.0106
Schistosoma mansoni	ferritin	0.0008	0.0001	0.0001
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0075	0.0105	0.0112
Echinococcus multilocularis	neuropeptide Y receptor	0.0075	0.0105	0.0106
Echinococcus granulosus	cathepsin L cysteine protease	0.0008	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus granulosus	serotonin receptor	0.0075	0.0105	0.0105
Schistosoma mansoni	growth hormone secretagogue receptor	0.0075	0.0105	0.0112
Leishmania major	cathepsin L-like protease	0.0062	0.0084	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0014	0.0014
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0105	0.0112
Schistosoma mansoni	lamin	0.0026	0.0029	0.0031
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0018	0.0019
Echinococcus granulosus	intermediate filament protein	0.0026	0.0029	0.0029
Loa Loa (eye worm)	G-protein coupled receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0016	0.0014	0.0014
Echinococcus multilocularis	protein tyrosine kinase	0.0244	0.0365	0.037
Onchocerca volvulus		0.0016	0.0014	0.0014
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0002	0.0002
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0083	0.0117	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Schistosoma mansoni	lamin	0.0026	0.0029	0.0031
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0034	0.0036
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0079	0.008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0014	0.0361
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0018	0.0018
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0084	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0105	0.0106
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0034	0.0036
Onchocerca volvulus		0.0229	0.0343	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0016	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0075	0.0105	0.0112
Schistosoma mansoni	opsin-like receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0075	0.0105	0.0106
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0075	0.0105	0.0112
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0044	0.1243
Onchocerca volvulus		0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0044	0.1244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0105	0.0112
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0492	0.0747	0.0793
Schistosoma mansoni	opsin-like receptor	0.0075	0.0105	0.0112
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0075	0.0105	0.0105
Onchocerca volvulus		0.0011	0.0005	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus multilocularis	g-protein coupled receptor	0.0075	0.0105	0.0106
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0079	0.0084
Brugia malayi	Pre-SET motif family protein	0.0029	0.0034	0.0036
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0034	0.0036
Loa Loa (eye worm)	inositol-1	0.0036	0.0044	0.0046
Brugia malayi	ORL1-like opioid receptor	0.0075	0.0105	0.0112
Echinococcus multilocularis	sex peptide receptor	0.0075	0.0105	0.0106
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0044	0.5131
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0075	0.0105	0.0112
Echinococcus multilocularis	g protein coupled receptor	0.0075	0.0105	0.0106
Echinococcus multilocularis	neuropeptide Y receptor	0.0075	0.0105	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0014	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0044	0.514
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus multilocularis	orexin receptor type 2	0.0075	0.0105	0.0106
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0044	0.0044
Echinococcus granulosus	tm gpcr rhodopsin	0.0075	0.0105	0.0105
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus multilocularis	lamin dm0	0.0026	0.0029	0.0029
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0875	0.1339	0.1355
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0014	0.0014
Echinococcus granulosus	cathepsin l1	0.0016	0.0014	0.0014
Echinococcus multilocularis	sodium bile acid cotransporter	0.6118	0.9426	0.9537
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0105	0.0106
Brugia malayi	sulfakinin receptor protein	0.0075	0.0105	0.0112
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0053	0.0071	0.0071
Echinococcus multilocularis	g protein coupled receptor	0.0075	0.0105	0.0106
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0005	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus granulosus	fmrfamide receptor	0.0075	0.0105	0.0105
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0083	0.0117	0.0125
Schistosoma mansoni	amine GPCR	0.0075	0.0105	0.0112
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0044	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0105	0.0105
Schistosoma mansoni	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus multilocularis	neuropeptide receptor A26	0.0075	0.0105	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0044	0.0046
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0492	0.0747	0.0793
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0014	0.0014
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0075	0.0105	0.0106
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0075	0.0105	0.0106
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0083	0.0117	0.0125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0105	0.0106
Echinococcus granulosus	protein tyrosine kinase	0.0244	0.0365	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	apoferritin-2	0.0008	0.0001	0.0001
Echinococcus multilocularis	serotonin receptor	0.0075	0.0105	0.0106
Echinococcus granulosus	RUN	0.0019	0.0018	0.0018
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus multilocularis	fmrfamide receptor	0.0075	0.0105	0.0106
Schistosoma mansoni	myosin xvIII	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0034	0.0036
Schistosoma mansoni	rab6-interacting	0.0019	0.0018	0.0019
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0075	0.0105	0.0112
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0105	0.0112
Brugia malayi	GnHR receptor homolog	0.0075	0.0105	0.0112
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0075	0.0105	0.0112
Echinococcus granulosus	lamin dm0	0.0026	0.0029	0.0029
Echinococcus multilocularis	serotonin transporter	0.0492	0.0747	0.0756
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0083	0.0117	0.0125
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0083	0.0117	0.0125
Echinococcus granulosus	g protein coupled receptor	0.0075	0.0105	0.0105
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0083	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0117	0.0125
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0079	0.6311
Echinococcus multilocularis	neuropeptide s receptor	0.0075	0.0105	0.0106
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0014	0.0014
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0075	0.0105	0.0105
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0075	0.0105	0.0112
Loa Loa (eye worm)	neuropeptide F receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0028	0.003
Onchocerca volvulus		0.0492	0.0747	0.0793
Loa Loa (eye worm)	neuropeptide F receptor	0.0075	0.0105	0.0112
Brugia malayi	intermediate filament protein	0.0026	0.0029	0.0031
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0044	0.4301
Brugia malayi	cathepsin L-like precursor	0.0011	0.0005	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus multilocularis	cysteine protease	0.0016	0.0014	0.0014
Echinococcus granulosus	neuropeptide receptor A26	0.0075	0.0105	0.0105
Loa Loa (eye worm)	ctsf protein	0.0016	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0075	0.0105	0.0106
Schistosoma mansoni	biogenic amine receptor	0.0075	0.0105	0.0112
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0014	0.0014
Echinococcus multilocularis	G protein coupled receptor 139	0.0075	0.0105	0.0106
Brugia malayi	neuropeptide F receptor	0.0075	0.0105	0.0112
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0105	0.0106
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0079	0.0084
Echinococcus granulosus	g-protein coupled receptor	0.0075	0.0105	0.0105
Echinococcus multilocularis	dnaJ subfamily B	0.0395	0.0598	0.0605
Echinococcus granulosus	sodium and chloride dependent glycine	0.0083	0.0117	0.0117
Brugia malayi	hypothetical protein	0.0083	0.0117	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0019	0.0018	0.0019
Schistosoma mansoni	cpg binding protein	0.0029	0.0034	0.0036
Onchocerca volvulus		0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0044	0.1244
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0084	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0014	0.0014
Echinococcus multilocularis	serotonin receptor	0.0075	0.0105	0.0106
Schistosoma mansoni	biogenic amine receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0004	0.0004
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0075	0.0105	0.0112
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0032	0.0032
Schistosoma mansoni	amine GPCR	0.0075	0.0105	0.0112
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0008	0.0008
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0083	0.0117	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0105	0.0112
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0117	0.0125
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0038	0.4706
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0083	0.0117	0.0125
Plasmodium vivax	SET domain protein, putative	0.0029	0.0034	0.2809
Loa Loa (eye worm)	hypothetical protein	0.6118	0.9426	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0002	0.0002
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0083	0.0117	0.0119
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0105	0.0105
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0075	0.0105	0.0106
Echinococcus granulosus	neuropeptides capa receptor	0.0075	0.0105	0.0105
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0079	0.9347
Schistosoma mansoni	amine GPCR	0.0075	0.0105	0.0112
Echinococcus multilocularis	g protein coupled receptor	0.0075	0.0105	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0003	0.0004
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0083	0.0117	0.0119
Echinococcus granulosus	G protein coupled receptor 139	0.0075	0.0105	0.0105
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0075	0.0105	0.0105
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0044	0.1243
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0083	0.0117	0.0119
Loa Loa (eye worm)	melatonin receptor type 1A	0.0075	0.0105	0.0112
Schistosoma mansoni	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	apoferritin-2	0.0008	0.0001	0.0001
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Onchocerca volvulus		0.0016	0.0014	0.0014
Brugia malayi	putative neuropeptide receptor NPR1	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0038	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0044	0.1243
Echinococcus granulosus	g protein coupled receptor	0.0075	0.0105	0.0105
Schistosoma mansoni	hypothetical protein	0.0075	0.0105	0.0112
Schistosoma mansoni	amine GPCR	0.0075	0.0105	0.0112
Echinococcus granulosus	ferritin	0.0008	0.0001	0.0001
Brugia malayi	Inositol-1	0.0036	0.0044	0.0046
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0075	0.0105	0.0112
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0018	0.1426
Echinococcus granulosus	neuropeptide receptor	0.0075	0.0105	0.0105
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0034	0.0035
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0075	0.0105	0.0106
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	G-protein coupled receptor	0.0075	0.0105	0.0112
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0075	0.0105	0.0105
Schistosoma mansoni	neuropeptide F-like receptor	0.0075	0.0105	0.0112
Brugia malayi	putative neuropeptide receptor	0.0075	0.0105	0.0112
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0014	0.0014
Brugia malayi	RE15519p	0.0075	0.0105	0.0112
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0075	0.0105	0.0106
Echinococcus multilocularis	lamin	0.0026	0.0029	0.0029
Echinococcus granulosus	lamin	0.0026	0.0029	0.0029
Brugia malayi	Pre-SET motif family protein	0.0202	0.03	0.0318
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0018	0.0018
Brugia malayi	hypothetical protein	0.0075	0.0105	0.0112
Onchocerca volvulus		0.0075	0.0105	0.0112
Schistosoma mansoni	neuropeptide f receptor 76f	0.0075	0.0105	0.0112
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0005	0.0006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0075	0.0105	0.0105
Toxoplasma gondii	hypothetical protein	0.0083	0.0117	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0044	0.0046
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0005	0.0006
Echinococcus granulosus	cathepsin l1	0.0011	0.0005	0.0005
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0014	0.0361
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0079	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0034	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0014	0.0361
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0044	0.0044
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0083	0.0117	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0014	0.0014
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0075	0.0105	0.0106
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0044	0.5
Loa Loa (eye worm)	norepinephrine transporter	0.0492	0.0747	0.0793
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0083	0.0117	0.0125
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0044	0.0046
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0029	0.0031
Plasmodium vivax	vivapain-2	0.0016	0.0014	0.1044
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0083	0.0117	0.0119
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0044	0.0044
Echinococcus multilocularis	musashi	0.0026	0.0029	0.0029
Schistosoma mansoni	neuropeptide F-like receptor	0.0075	0.0105	0.0112
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0014	0.1044
Brugia malayi	Dopamine receptor protein 2	0.0075	0.0105	0.0112
Schistosoma mansoni	tyrosine kinase	0.0244	0.0365	0.0388
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0075	0.0105	0.0112
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0029	0.0031
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0083	0.0117	0.0125
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0075	0.0105	0.0112
Schistosoma mansoni	sodium/chloride dependent transporter	0.0083	0.0117	0.0125
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus granulosus	biogenic amine 5HT receptor	0.0075	0.0105	0.0105
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0034	0.1971
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0044	0.0044
Schistosoma mansoni	neuropeptide receptor	0.0075	0.0105	0.0112
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0075	0.0105	0.0112
Onchocerca volvulus		0.6118	0.9426	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0014	0.0361
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0075	0.0105	0.0112
Echinococcus granulosus	allatostatin A receptor	0.0075	0.0105	0.0105
Echinococcus multilocularis	neuropeptide receptor	0.0075	0.0105	0.0106
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0075	0.0105	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0005	0.0119
Schistosoma mansoni	neuropeptide receptor	0.0075	0.0105	0.0112
Echinococcus multilocularis	neuropeptide receptor	0.0075	0.0105	0.0106
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0007	0.0008
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0014	0.2863
Echinococcus granulosus	7TM GPCR rhodopsin	0.0075	0.0105	0.0105
Brugia malayi	Melatonin receptor type 1A	0.0075	0.0105	0.0112
Brugia malayi	Doublecortin family protein	0.0019	0.0018	0.0019
Brugia malayi	AKH receptor	0.0075	0.0105	0.0112
Brugia malayi	G protein-coupled receptor	0.0075	0.0105	0.0112
Toxoplasma gondii	hypothetical protein	0.0083	0.0117	1
Onchocerca volvulus		0.0075	0.0105	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0105	0.0112
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0029	0.0031
Echinococcus granulosus	biogenic amine 5HT receptor	0.0075	0.0105	0.0105
Echinococcus granulosus	sodium bile acid cotransporter	0.6118	0.9426	0.9426
Echinococcus granulosus	neuropeptide Y receptor	0.0075	0.0105	0.0105
Echinococcus multilocularis	neuropeptides capa receptor	0.0075	0.0105	0.0106
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0083	0.0117	0.0125
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0075	0.0105	0.0105
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0079	1
Echinococcus granulosus	sodium bile acid cotransporter	0.6118	0.9426	0.9426
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0014	0.0014
Onchocerca volvulus		0.0075	0.0105	0.0112
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0005	0.0911
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0083	0.0117	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0007	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0117	0.0125
Echinococcus granulosus	cysteine protease	0.0008	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0005	0.0006
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0071	0.5563
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0084	1
Onchocerca volvulus		0.0075	0.0105	0.0112
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0044	0.0044

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 8.8 mg kg-1	Antagonistic activity against clonidine-induced antinociception in mouse after po administration	ChEMBL.	2887657
ED50 (functional)	= 8.8 mg kg-1	Antagonistic activity against clonidine-induced antinociception in mouse after po administration	ChEMBL.	2887657
IC50 (functional)	> 300 nM	Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens.	ChEMBL.	2887657
IC50 (functional)	> 300 nM	Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens.	ChEMBL.	2887657
Kd (functional)	= 7.55	The compound was evaluated for the alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidin	ChEMBL.	2887657
Ki (binding)	= 3.4 nM	Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]-clonidine from rat brain cortical membranes	ChEMBL.	2887657
Ki (binding)	= 3.4 nM	Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]-clonidine from rat brain cortical membranes	ChEMBL.	2887657
pA2 (functional)	= 7.55	The compound was evaluated for the alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidin	ChEMBL.	2887657

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL41171

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 57692