Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.724 | 0.9167 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3818 | 0.4014 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7897 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.4721 | 0.5978 |
Brugia malayi | RNA binding protein | 0.0066 | 0.7897 | 0.7673 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.7897 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7897 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.4721 | 0.5978 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0191 | 0.0241 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.7897 | 0.8527 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.3378 | 0.2673 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7897 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.2617 | 0.2684 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.5463 | 0.4979 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0535 | 0.0678 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7897 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2617 | 0.3313 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.7886 | 0.9985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7897 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.7897 | 0.8527 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.7897 | 0.8527 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.7897 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0535 | 0.0678 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.4721 | 0.5978 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4163 | 0.4395 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.4721 | 0.5013 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3391 | 0.3541 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.7897 | 0.7673 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.4721 | 0.5978 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.4721 | 0.4159 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.5463 | 0.4979 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.2951 | 0.3737 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5463 | 0.5833 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.4721 | 0.5978 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.724 | 0.9167 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.4721 | 0.5978 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.7897 | 0.7673 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.9228 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.5463 | 0.5833 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.2617 | 0.183 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.2951 | 0.3737 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0535 | 0.0678 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.4721 | 0.5978 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.7755 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.