Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3849 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.3849 | 0.3849 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.3849 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.3849 | 0.3849 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.3849 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3849 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2503 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.3849 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2503 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.3849 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.2503 | 0.2503 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.2503 | 0.6502 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.3849 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.3849 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3849 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.2503 | 0.6502 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2503 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2503 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.2503 | 0.6502 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.3849 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.3849 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.3849 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.3849 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.2503 | 0.6502 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.3849 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.3849 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.3849 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.3849 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.3849 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.3849 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.