Detailed information for compound 578334

Basic information

Technical information
  • TDR Targets ID: 578334
  • Name: 2-cyclohexylsulfanylethanol
  • MW: 160.277 | Formula: C8H16OS
  • H donors: 1 H acceptors: 1 LogP: 2 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCSC1CCCCC1
  • InChi: 1S/C8H16OS/c9-6-7-10-8-4-2-1-3-5-8/h8-9H,1-7H2
  • InChiKey: YXZOWAVBWUAUGP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(cyclohexylthio)ethanol
  • 2-phenylmercaptoethanol
  • 3778-81-2
  • NSC403999
  • NSC56553

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0089 0.3071
Echinococcus granulosus neuropeptide receptor A26 0.045 0.2354 0.2339
Echinococcus multilocularis snurportin 1 0.0298 0.1519 0.1503
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.029 0.0271
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1488 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.2523 0.23
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0089 0.007
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1838 1 1
Schistosoma mansoni hypothetical protein 0.0047 0.0133 0.0114
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0089 0.007
Chlamydia trachomatis glutamate symporter 0.1838 1 1
Schistosoma mansoni alpha-glucosidase 0.0151 0.0704 0.0686
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0815 0.4363 0.4352
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0186 0.0899 0.6042
Echinococcus granulosus excitatory amino acid transporter 2 0.1838 1 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0029 0.001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.029 0.0271
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0089 0.331
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0146 0.0127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0725 0.0448
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.1488 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.1519 0.1505
Echinococcus multilocularis muscleblind protein 0.016 0.0759 0.0741
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.029 0.1785
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.029 1
Echinococcus multilocularis neutral amino acid transporter A 0.1838 1 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0759 0.0743
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0102 0.0685
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0089 0.0687
Brugia malayi beta-lactamase 0.0075 0.029 0.0271
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0019 0.0003
Toxoplasma gondii ABC1 family protein 0.0075 0.029 0.2994
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0089 0.0598
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0089 0.3071
Trichomonas vaginalis esterase, putative 0.0075 0.029 1
Schistosoma mansoni alpha glucosidase 0.0039 0.0089 0.007
Brugia malayi beta-lactamase family protein 0.0075 0.029 0.0271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0146 0.0127
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1838 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.0839 0.0821
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0102 0.0685
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.029 1
Brugia malayi hypothetical protein 0.0229 0.1138 0.1121
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0133 0.0114
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.029 0.0271
Echinococcus granulosus Excitatory amino acid transporter 0.1838 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0089 0.331
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0839 0.0821
Echinococcus multilocularis excitatory amino acid transporter 2 0.1838 1 1
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1838 1 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0019 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0186 0.0899 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0089 0.3071
Brugia malayi MH2 domain containing protein 0.0245 0.1227 0.121
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.2354 0.2339
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1838 1 1
Echinococcus multilocularis muscleblind protein 1 0.016 0.0759 0.0741
Echinococcus granulosus muscleblind protein 0.016 0.0759 0.0741
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1138 0.1121
Brugia malayi hypothetical protein 0.0071 0.0269 0.025
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0638 0.4291
Loa Loa (eye worm) hypothetical protein 0.0075 0.029 0.0273
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0142 0.0123
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0089 0.007
Echinococcus granulosus Excitatory amino acid transporter 0.1838 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.1227 0.1212
Loa Loa (eye worm) hypothetical protein 0.0075 0.029 0.0273
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0638 0.4291
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0815 0.4363 0.4352
Brugia malayi follicle stimulating hormone receptor 0.0251 0.1258 0.1241
Onchocerca volvulus 0.0075 0.029 0.0271
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0815 0.4363 0.4352
Onchocerca volvulus 0.0075 0.029 0.0271
Echinococcus granulosus neutral amino acid transporter A 0.1838 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1138 0.1121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0186 0.0899 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0146 0.0127
Trypanosoma brucei glucosidase, putative 0.0039 0.0089 0.041
Entamoeba histolytica hypothetical protein 0.0071 0.0269 1
Plasmodium vivax hypothetical protein, conserved 0.0075 0.029 1
Echinococcus granulosus excitatory amino acid transporter 3 0.1838 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0638 0.4177
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0089 0.3071
Entamoeba histolytica hypothetical protein 0.0071 0.0269 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0089 0.3071
Echinococcus granulosus excitatory amino acid transporter 2 0.1838 1 1
Treponema pallidum glutamate/aspartate transporter 0.0815 0.4363 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0089 0.3071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0057 0.0041
Onchocerca volvulus 0.0075 0.029 0.0271
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1838 1 1
Mycobacterium ulcerans hypothetical protein 0.0154 0.0725 0.7139
Echinococcus granulosus snurportin 1 0.0298 0.1519 0.1503
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.0839 0.0823
Echinococcus granulosus neutral amino acid transporter A 0.1838 1 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0029 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0269 0.025
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1488 1
Plasmodium falciparum importin beta, putative 0.0028 0.0029 0.5
Schistosoma mansoni hypothetical protein 0.0071 0.0269 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0089 0.0598
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0269 0.025
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0102 0.0499
Echinococcus multilocularis neutral amino acid transporter A 0.1838 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0186 0.0899 0.0882
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0146 0.0127
Echinococcus granulosus sodium:dicarboxylate symporter 0.1838 1 1
Brugia malayi beta-lactamase family protein 0.0075 0.029 0.0271
Brugia malayi Muscleblind-like protein 0.016 0.0759 0.0741
Loa Loa (eye worm) hypothetical protein 0.0075 0.029 0.0273
Loa Loa (eye worm) hypothetical protein 0.0048 0.0142 0.0125
Echinococcus multilocularis excitatory amino acid transporter 2 0.1838 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0089 0.0072
Schistosoma mansoni aldehyde dehydrogenase 0.0186 0.0899 0.0882
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0089 0.0598
Loa Loa (eye worm) hypothetical protein 0.0075 0.029 0.0273
Schistosoma mansoni importin beta-1 0.0028 0.0029 0.001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0186 0.0899 0.0628
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0839 0.0821
Entamoeba histolytica hypothetical protein 0.0071 0.0269 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0146 0.0127
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.0839 0.0821
Echinococcus granulosus neutral amino acid transporter 0.1838 1 1
Schistosoma mansoni hypothetical protein 0.0298 0.1519 0.1503
Schistosoma mansoni aldehyde dehydrogenase 0.0186 0.0899 0.0882
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0012
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0089 0.3071
Treponema pallidum glutamate transporter 0.0815 0.4363 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0146 0.0127
Echinococcus granulosus importin subunit beta 1 0.0028 0.0029 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0146 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0089 0.3071
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.1258 0.1243
Echinococcus multilocularis excitatory amino acid transporter 3 0.1838 1 1
Onchocerca volvulus 0.0101 0.0432 0.0414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0146 0.0127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0186 0.0899 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.1227 0.1212
Echinococcus multilocularis Excitatory amino acid transporter 0.1838 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0146 0.0129
Schistosoma mansoni survival motor neuron protein 0.0047 0.0133 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0186 0.0899 1
Loa Loa (eye worm) excitatory amino acid transporter 0.1838 1 1
Echinococcus multilocularis neuropeptide s receptor 0.045 0.2354 0.2339
Schistosoma mansoni alpha-glucosidase 0.0151 0.0704 0.0686
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.1488 1
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1838 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0057 0.0038
Brugia malayi RNA, U transporter 1 0.0079 0.0313 0.0294
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.029 0.0273
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.029 1
Leishmania major hypothetical protein, conserved 0.0075 0.029 0.1946
Loa Loa (eye worm) hypothetical protein 0.016 0.0759 0.0743
Echinococcus multilocularis Excitatory amino acid transporter 0.1838 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.029 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0152 0.1018
Toxoplasma gondii hypothetical protein 0.0047 0.0135 0.122
Mycobacterium leprae conserved hypothetical protein 0.0075 0.029 0.5
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0815 0.4363 0.4352
Onchocerca volvulus 0.0047 0.0133 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0057 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0142 0.0123
Loa Loa (eye worm) beta-lactamase 0.0075 0.029 0.0273
Mycobacterium leprae Probable lipase LipE 0.0075 0.029 0.5
Echinococcus multilocularis neutral amino acid transporter A 0.1838 1 1
Entamoeba histolytica hypothetical protein 0.0071 0.0269 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.029 1
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.029 0.1946
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.029 0.0271
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0102 0.0685
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.029 0.0271
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0269 0.025
Loa Loa (eye worm) hypothetical protein 0.0229 0.1138 0.1123
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.029 0.1946
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0142 0.0125
Loa Loa (eye worm) hypothetical protein 0.0075 0.029 0.0273
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0186 0.0899 0.0882
Loa Loa (eye worm) hypothetical protein 0.0075 0.029 0.0273
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0089 0.3071
Echinococcus granulosus neuropeptide s receptor 0.045 0.2354 0.2339

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.