Detailed information for compound 578467

Basic information

Technical information
  • TDR Targets ID: 578467
  • Name: 1-(2-nitroimidazol-1-yl)-3-(1-piperidyl)propa n-2-ol hydrochloride
  • MW: 290.747 | Formula: C11H19ClN4O3
  • H donors: 1 H acceptors: 4 LogP: 1.18 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(Cn1ccnc1[N+](=O)[O-])CN1CCCCC1.Cl
  • InChi: 1S/C11H18N4O3.ClH/c16-10(8-13-5-2-1-3-6-13)9-14-7-4-12-11(14)15(17)18;/h4,7,10,16H,1-3,5-6,8-9H2;1H
  • InChiKey: SKUVJFHTKRTQQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(2-nitro-1-imidazolyl)-3-(1-piperidyl)-2-propanol hydrochloride
  • 1-(2-nitroimidazol-1-yl)-3-piperidin-1-yl-propan-2-ol hydrochloride
  • 1-(2-nitroimidazol-1-yl)-3-piperidino-propan-2-ol hydrochloride
  • 1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol hydrochloride
  • pimonidazole
  • 1-(2-nitro-1-imidazolyl)-3-(1-piperidyl)propan-2-ol hydrochloride
  • 70132-51-3
  • 1-Piperidineethanol, alpha-((2-nitro-1H-imidazol-1-yl)methyl)-, monohydrochloride
  • Pimonidazole hydrochloride
  • Ro 03-8799
  • alpha-((2-Nitro-1H-imidazol-1-yl)methyl)-1-piperidineethanol hydrochloride
  • Ro-038799
  • 1-Piperidineethanol, .alpha.-[(2-nitro-1H-imidazol-1-yl)methyl]-, monohydrochloride
  • NSC318502

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans beta-lactamase 0.0075 0.0599 0.4012
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0027 0.0027
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0599 0.0599
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0301 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0163 0.0163
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0301 0.2621
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.1062 0.9932
Leishmania major GTP-binding protein, putative 0.0045 0.0301 0.2639
Onchocerca volvulus 0.0031 0.0163 0.0163
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0173 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0017 0.0017
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0027 0.0027
Echinococcus granulosus ubiquitin specific protease 41 0.0081 0.0664 0.0664
Onchocerca volvulus 0.0075 0.0599 0.0599
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0538 0.0538
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.1062 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0522 0.0522
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0453 0.4352 0.4352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.3072 0.6048
Entamoeba histolytica hypothetical protein 0.0049 0.0346 0.0996
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0163 0.0163
Echinococcus multilocularis snurportin 1 0.0651 0.632 0.632
Loa Loa (eye worm) hypothetical protein 0.0075 0.0599 0.0599
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1267 0.1267
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0163 0.0163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0163 0.0163
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0163 0.0163
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0453 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0027
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0163 0.0163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.3072 0.6048
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0664 1
Schistosoma mansoni hypothetical protein 0.0032 0.0173 0.0173
Leishmania major trypanothione reductase 0.0041 0.0266 0.2305
Trypanosoma brucei trypanothione reductase 0.0041 0.0266 0.3747
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0301 0.0301
Schistosoma mansoni hypothetical protein 0.0651 0.632 0.632
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0163 0.0163
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1022 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0163 0.0163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0346 0.0603
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.046 0.4156
Echinococcus granulosus neuropeptide s receptor 0.0513 0.4946 0.4946
Echinococcus granulosus muscleblind protein 0.0152 0.1369 0.1369
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0017 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0599 0.0599
Schistosoma mansoni cpg binding protein 0.0067 0.0519 0.0519
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1267 0.1267
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0163 0.0163
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.1062 0.1022
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1062 0.1062
Mycobacterium tuberculosis Conserved protein 0.0075 0.0599 0.0557
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0664 1
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0027 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1267 0.1267
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0301 0.0301
Trichomonas vaginalis esterase, putative 0.0075 0.0599 0.1108
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0027 0.0027
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0044 0.0387
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Giardia lamblia Fructose-bisphosphate aldolase 0.0324 0.3072 1
Plasmodium vivax importin-beta 2, putative 0.0061 0.046 0.7577
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.3072 0.6048
Schistosoma mansoni ap endonuclease 0.0019 0.0044 0.0044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.0793 0.0752
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0027 0.0027
Echinococcus granulosus cpg binding protein 0.0067 0.0519 0.0519
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0163 0.0163
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1022 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.2458 0.2458
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0081 0.0664 0.0664
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0081 0.0664 0.6151
Brugia malayi hypothetical protein 0.0028 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0901 0.8803 0.8803
Brugia malayi nuclear receptor NHR-88 0.0031 0.0163 0.0163
Brugia malayi ecdysteroid receptor 0.0031 0.0163 0.0163
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0035 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0081 0.0664 0.0664
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0599 0.1108
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.046 0.4422 0.4422
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0081 0.0664 0.0664
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0163 0.0163
Mycobacterium tuberculosis Conserved protein 0.0075 0.0599 0.0557
Brugia malayi jmjC domain containing protein 0.0017 0.0027 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0132 0.2421
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0502 0.0502
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0017 0.0017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0073 0.0073
Brugia malayi Muscleblind-like protein 0.0152 0.1369 0.1369
Echinococcus multilocularis neuropeptide receptor A26 0.0513 0.4946 0.4946
Schistosoma mansoni hypothetical protein 0.0069 0.0541 0.0541
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0301 0.4779
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0266 0.4173
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0173 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0599 0.1108
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0027 0.0027
Mycobacterium tuberculosis Conserved protein 0.0075 0.0599 0.0557
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0599 0.0557
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0032 0.0173 0.0173
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0081 0.0664 0.2046
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0163 0.0163
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0044 0.0263
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.0897 0.3605
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0538 0.0538
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0044 0.0293
Loa Loa (eye worm) hypothetical protein 0.0069 0.0541 0.0541
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0483 0.0483
Schistosoma mansoni hypothetical protein 0.0032 0.0173 0.0173
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0173 0.0173
Echinococcus granulosus neutral amino acid transporter A 0.1022 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.0793 0.0752
Brugia malayi jmjC domain containing protein 0.0069 0.0538 0.0538
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0599 0.1108
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0081 0.0664 0.0664
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0081 0.0664 0.0664
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0163 0.0163
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0081 0.0664 0.0664
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0075 0.0599 0.0599
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0301 0.6307
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0075 0.0599 0.0599
Echinococcus multilocularis importin subunit beta 1 0.0061 0.046 0.046
Brugia malayi jmjC domain containing protein 0.0017 0.0027 0.0027
Brugia malayi hypothetical protein 0.0016 0.0017 0.0017
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0163 0.0163
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0301 0.4291
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0651 0.632 0.632
Schistosoma mansoni ran 0.0045 0.0301 0.0301
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0599 0.8979
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0163 0.0163
Echinococcus multilocularis muscleblind protein 0.0152 0.1369 0.1369
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0173 0.0173
Brugia malayi jmjC domain containing protein 0.0017 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0172 0.1561 0.1561
Echinococcus multilocularis excitatory amino acid transporter 2 0.1022 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0163 0.0163
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0301 0.0301
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0163 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1062 0.7363
Loa Loa (eye worm) beta-lactamase 0.0075 0.0599 0.0599
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0163 0.0163
Schistosoma mansoni cpg binding protein 0.0063 0.0483 0.0483
Treponema pallidum glutamate/aspartate transporter 0.0453 0.4352 1
Schistosoma mansoni ap endonuclease 0.0019 0.0044 0.0044
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0152 0.1369 0.1369
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0044 0.0044
Toxoplasma gondii thioredoxin reductase 0.0041 0.0266 0.2289
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0163 0.0163
Brugia malayi nuclear receptor RXR 0.0016 0.0017 0.0017
Trichomonas vaginalis set domain proteins, putative 0.0523 0.5051 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.4609 0.4585
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0081 0.0664 0.1238
Toxoplasma gondii ABC1 family protein 0.0075 0.0599 0.5485
Plasmodium falciparum importin beta, putative 0.0061 0.046 1
Echinococcus multilocularis geminin 0.0172 0.1561 0.1561
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0035 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0599 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0132 0.1647
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0044 0.0263
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.1062 0.1062
Mycobacterium ulcerans hypothetical protein 0.0075 0.0599 0.4012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0599 0.0599
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0163 0.0163
Echinococcus multilocularis cpg binding protein 0.0067 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.046 0.6804
Brugia malayi hypothetical protein 0.0016 0.0017 0.0017
Brugia malayi RNA, U transporter 1 0.0173 0.1577 0.1577
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0599 0.4012
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0599 0.1108
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0044 0.0044
Loa Loa (eye worm) excitatory amino acid transporter 0.1022 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.0897 0.0857
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0386 0.0386
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.3072 0.6048
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0266 0.0223
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0163
Echinococcus granulosus excitatory amino acid transporter 2 0.1022 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0075 0.0599 0.0599
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0266 0.0266
Plasmodium falciparum glutathione reductase 0.0041 0.0266 0.5508
Echinococcus granulosus snurportin 1 0.0651 0.632 0.632
Brugia malayi Pre-SET motif family protein 0.046 0.4422 0.4422
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0266 0.3747
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1062 0.1062
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0599 0.0557
Onchocerca volvulus 0.0075 0.0599 0.0599
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0163
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0132 0.2421
Plasmodium vivax SET domain protein, putative 0.0067 0.0522 0.8648
Brugia malayi CXXC zinc finger family protein 0.0063 0.0483 0.0483
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0599 0.0557
Toxoplasma gondii exonuclease III APE 0.0019 0.0044 0.0161
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0538 0.0538
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0484 0.0484
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0599 0.0557
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0132 0.1835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0522 0.0522
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0027 0.0027
Echinococcus multilocularis neutral amino acid transporter A 0.1022 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.0793 0.0752
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1062 0.7363
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0081 0.0664 0.0664
Brugia malayi jmjC domain containing protein 0.0017 0.0027 0.0027
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0599 0.0557
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0859 0.0859
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0163 0.0163
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0859 0.0859
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.046 0.6804
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0094 0.0793 0.2341
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0163 0.0163
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0541 0.0541
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0502 0.0502
Brugia malayi hypothetical protein 0.0018 0.0034 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1062 0.7363
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0163
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0132 0.1006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0017 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0163 0.0163
Plasmodium falciparum thioredoxin reductase 0.0041 0.0266 0.5508
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0163 0.0163
Echinococcus granulosus Excitatory amino acid transporter 0.1022 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0664 0.1238
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0599 0.0599
Schistosoma mansoni ran 0.0045 0.0301 0.0301
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0502 0.0502
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0163 0.0163
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0073 0.0073
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0324 0.3072 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0163 0.0163
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0067 0.0522 0.0522
Brugia malayi jmjC domain containing protein 0.0065 0.0502 0.0502
Chlamydia trachomatis glutamate symporter 0.1022 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0859 0.0859
Echinococcus granulosus excitatory amino acid transporter 2 0.1022 1 1
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0027 0.0027
Echinococcus granulosus geminin 0.0172 0.1561 0.1561
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.1069 1
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0027 0.0027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0163 0.0163
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0899 0.8782 0.8782
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0032 0.0173 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0599 0.8979
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0163 0.0163
Onchocerca volvulus 0.0053 0.0386 0.0386
Leishmania major hypothetical protein, conserved 0.0028 0.0132 0.1013
Brugia malayi hypothetical protein 0.0262 0.2458 0.2458
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0163 0.0163
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0599 0.8979
Schistosoma mansoni importin beta-1 0.0061 0.046 0.046
Onchocerca volvulus 0.0523 0.5051 0.5051
Schistosoma mansoni survival motor neuron protein 0.0053 0.0386 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0163 0.0163
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0599 0.0599
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.3072 0.6048
Brugia malayi beta-lactamase family protein 0.0075 0.0599 0.0599
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0163
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0027 0.0027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0346 0.0603
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0044 0.0044
Brugia malayi Importin beta-1 subunit 0.0061 0.046 0.046
Schistosoma mansoni hypothetical protein 0.0053 0.0386 0.0386
Schistosoma mansoni coup transcription factor 0.0031 0.0163 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1267 0.1267
Echinococcus multilocularis excitatory amino acid transporter 3 0.1022 1 1
Schistosoma mansoni hypothetical protein 0.0032 0.0173 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0163 0.0163
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0262 0.2458 0.2458
Echinococcus granulosus neuropeptide receptor A26 0.0513 0.4946 0.4946
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0035 0.0035
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0027 0.0027
Brugia malayi beta-lactamase 0.0075 0.0599 0.0599
Echinococcus multilocularis ubiquitin specific protease 41 0.0081 0.0664 0.0664
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0173 0.0173
Echinococcus granulosus sodium:dicarboxylate symporter 0.1022 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0163 0.0163
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0081 0.0664 0.2046
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0081 0.0664 0.0664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.3072 0.6048
Echinococcus multilocularis excitatory amino acid transporter 2 0.1022 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.046 0.046
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1022 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0044 0.0044
Echinococcus granulosus GPCR family 2 0.0032 0.0173 0.0173
Trichomonas vaginalis ran, putative 0.0045 0.0301 0.0512
Echinococcus granulosus neutral amino acid transporter A 0.1022 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0173 0.0173
Onchocerca volvulus 0.0075 0.0599 0.0599
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1267 0.1267
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0158 0.1427 1
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0163 0.0163
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0132 0.1647
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.3072 0.6048
Treponema pallidum fructose-bisphosphate aldolase 0.0324 0.3072 0.703
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1022 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.1062 0.1062
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0075 0.0599 0.0599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0163 0.0163
Echinococcus multilocularis muscleblind protein 1 0.0152 0.1369 0.1369
Echinococcus granulosus importin subunit beta 1 0.0061 0.046 0.046
Leishmania major hypothetical protein, conserved 0.0075 0.0599 0.5523
Leishmania major importin beta-1 subunit, putative 0.0049 0.0346 0.3078
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0163 0.0163
Echinococcus granulosus neutral amino acid transporter 0.1022 1 1
Echinococcus granulosus dnaJ subfamily B 0.0901 0.8803 0.8803
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.0897 0.0857
Brugia malayi Pre-SET motif family protein 0.0067 0.0522 0.0522
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0599 0.0557
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0035 0.0035
Echinococcus granulosus Excitatory amino acid transporter 0.1022 1 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0453 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0075 0.0599 0.0599
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0163 0.0163
Onchocerca volvulus 0.0067 0.0522 0.0522
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0324 0.3072 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.0522 0.4744
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0453 0.4352 0.4352
Mycobacterium tuberculosis Probable reductase 0.0094 0.0793 0.0752
Schistosoma mansoni hypothetical protein 0.0172 0.1561 0.1561
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0132 0.1647
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0522 0.0522
Plasmodium vivax glutathione reductase, putative 0.0041 0.0266 0.4173
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0346 0.5004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0067 0.0522 0.0522
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0081 0.0664 0.1238
Echinococcus multilocularis Excitatory amino acid transporter 0.1022 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1267 0.1267
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0044 0.0162
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0044 0.0263
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0301 0.0301
Echinococcus multilocularis microtubule associated protein 2 0.07 0.6805 0.6805
Treponema pallidum glutamate transporter 0.0453 0.4352 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0163
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.0522 0.0522
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0017 0.0017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.0793 0.0752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0163 0.0163
Brugia malayi Thioredoxin reductase 0.0041 0.0266 0.0266
Brugia malayi glutathione reductase 0.0041 0.0266 0.0266
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0163 0.0163
Echinococcus multilocularis dnaJ subfamily B 0.0901 0.8803 0.8803
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0158 0.1427 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0158 0.1427 0.1388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Echinococcus multilocularis Excitatory amino acid transporter 0.1022 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.1212 0.1212
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1267 0.1267
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0859 0.0859
Brugia malayi beta-lactamase family protein 0.0075 0.0599 0.0599
Mycobacterium ulcerans lipase LipD 0.0075 0.0599 0.4012
Brugia malayi nuclear hormone receptor 0.0031 0.0163 0.0163
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0163 0.0163
Loa Loa (eye worm) glutathione reductase 0.0041 0.0266 0.0266
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0599 0.0599
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.0897 0.0857
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0301 0.4291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1267 0.1267
Echinococcus granulosus phd:f box containing protein 0.0017 0.0027 0.0027
Echinococcus multilocularis neutral amino acid transporter A 0.1022 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0163
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0538 0.0538
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.0793 0.0752
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0163
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0017 0.0017
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0599 0.0557
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0271 0.0271
Echinococcus granulosus excitatory amino acid transporter 3 0.1022 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.2458 0.2458
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0027 0.0027
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0163 0.0163
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0163 0.0163
Brugia malayi steroid hormone receptor 0.0031 0.0163 0.0163
Entamoeba histolytica Ran family GTPase 0.0045 0.0301 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0163 0.0163
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0163 0.0163
Echinococcus multilocularis neuropeptide s receptor 0.0513 0.4946 0.4946
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0163 0.0163
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1022 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0599 0.1108
Schistosoma mansoni cpg binding protein 0.0067 0.0519 0.0519
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0163 0.0163
Echinococcus granulosus microtubule associated protein 2 0.07 0.6805 0.6805
Echinococcus multilocularis GPCR, family 2 0.0032 0.0173 0.0173
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0073 0.0073
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0301 0.4291
Onchocerca volvulus 0.0063 0.0483 0.0483
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0346 0.0603
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1022 1 1
Schistosoma mansoni microtubule-associated protein tau 0.07 0.6805 0.6805
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0152 0.1369 0.1369
Echinococcus multilocularis neutral amino acid transporter A 0.1022 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.3072 0.6048
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0599 0.4012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1267 0.1267

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.