Detailed information for compound 578879

Basic information

Technical information
  • TDR Targets ID: 578879
  • Name: (4S)-5-amino-4-[[4-[(2,4-diaminopteridin-6-yl )methyl-methyl-amino]benzoyl]amino]-5-oxo-pen tanoic acid
  • MW: 453.455 | Formula: C20H23N9O4
  • H donors: 5 H acceptors: 8 LogP: -1.11 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CC[C@@H](C(=O)N)NC(=O)c1ccc(cc1)N(Cc1cnc2c(n1)c(N)nc(n2)N)C
  • InChi: 1S/C20H23N9O4/c1-29(9-11-8-24-18-15(25-11)16(21)27-20(23)28-18)12-4-2-10(3-5-12)19(33)26-13(17(22)32)6-7-14(30)31/h2-5,8,13H,6-7,9H2,1H3,(H2,22,32)(H,26,33)(H,30,31)(H4,21,23,24,27,28)/t13-/m0/s1
  • InChiKey: PZTCDGVNNVDWMI-ZDUSSCGKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4S)-5-amino-4-[[[4-[(2,4-diamino-6-pteridinyl)methyl-methylamino]phenyl]-oxomethyl]amino]-5-oxopentanoic acid
  • (4S)-5-azanyl-4-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]-5-oxo-pentanoic acid
  • (4S)-5-amino-4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]-5-keto-valeric acid
  • (4S)-5-amino-4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-oxopentanoic acid
  • methotrexate-alpha-monoamide
  • (4S)-5-amino-4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]phenyl]carbonylamino]-5-oxo-pentanoic acid
  • 71074-47-0
  • Pentanoic acid, 5-amino-4-((4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)amino)-5-oxo-, (S)-
  • NSC281287
  • Pentanoic acid, 5-amino-4-[[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]amino]-5-oxo-, (S)-
  • N-(N'-(2,4-Diamino-6-pteridinyl)methyl-N'-methyl-4-aminobenzoyl)-L-isoglutamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible oxidoreductase 0.0101 0.0129 0.3055
Brugia malayi amine oxidase, flavin-containing family protein 0.0144 0.019 0.0189
Schistosoma mansoni chromatin regulatory protein sir2 0.0104 0.0132 0.0131
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0011 0.001
Onchocerca volvulus 0.003 0.0024 0.0241
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0023 0.0022
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1368 0.1971 0.322
Schistosoma mansoni chromatin regulatory protein sir2 0.0104 0.0132 0.0131
Brugia malayi Protein kinase domain containing protein 0.0045 0.0046 0.0046
Brugia malayi SWIRM domain containing protein 0.0042 0.0042 0.0042
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0032 0.0032
Echinococcus granulosus notch 0.002 0.001 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0007 0.0006
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0008 0.01
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0023 0.0015 0.0252
Echinococcus granulosus sodium:glucose cotransporter 0.0145 0.0192 0.0192
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0011 0.0199
Echinococcus multilocularis discoidin domain receptor 0.0045 0.0046 0.0057
Loa Loa (eye worm) integrin beta-2 0.1913 0.2764 0.2763
Echinococcus granulosus c-Jun N-terminal kinases 0.0232 0.0318 0.0317
Entamoeba histolytica SWIRM domain protein 0.0042 0.0042 0.0369
Brugia malayi EGF-like domain containing protein 0.002 0.001 0.0009
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0302 0.0421 1
Loa Loa (eye worm) DPY-31 protein 0.0027 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0043 0.0043
Echinococcus granulosus protein kinase c iota type 0.0017 0.0005 0.0005
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0232 0.0318 0.0317
Echinococcus multilocularis serine protease inhibitor 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0018
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0072 0.1408
Onchocerca volvulus 0.0035 0.0032 0.0351
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0026 0.0031
Schistosoma mansoni protein arginine n-methyltransferase 0.0108 0.0138 0.0138
Echinococcus multilocularis MAM 0.0075 0.009 0.0112
Schistosoma mansoni site-1 peptidase (S08 family) 0.0302 0.0421 0.042
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0104 0.0132 0.0164
Echinococcus granulosus bloom syndrome protein 0.002 0.0011 0.001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0032 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0074 0.0073
Brugia malayi NAD-dependent deacetylase SIRT1 0.0104 0.0132 0.0131
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0032 0.0569
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0026 0.0025
Loa Loa (eye worm) notch protein 0.002 0.001 0.0009
Echinococcus multilocularis Estrogen regulated protein EP45 0.0017 0.0006 0.0006
Giardia lamblia hypothetical protein 0.005 0.0054 0.0132
Echinococcus granulosus integrin alpha ps 0.0067 0.0078 0.0077
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0108 0.0138 0.1371
Onchocerca volvulus 0.004 0.0039 0.0439
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0208 0.0283 0.6725
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0032 0.0032
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Echinococcus granulosus integrin alpha 3 0.0114 0.0147 0.0146
Brugia malayi Trypsin family protein 0.002 0.001 0.0009
Brugia malayi astacin protease protein 30 0.0027 0.002 0.0019
Echinococcus multilocularis discoidin domain containing receptor 2 0.0045 0.0046 0.0057
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0072 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0011 0.001
Brugia malayi EGF-like domain containing protein 0.002 0.001 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Onchocerca volvulus 0.0027 0.002 0.0186
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0108 0.0138 0.1371
Brugia malayi Pre-SET motif family protein 0.0031 0.0026 0.0025
Brugia malayi Cadherin domain containing protein 0.002 0.001 0.0009
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0027 0.002 0.0024
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0017 0.0005 0.0117
Echinococcus granulosus slit 2 protein 0.002 0.001 0.0009
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.004 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Onchocerca volvulus 0.0542 0.0769 1
Echinococcus granulosus neurogenic locus notch protein 4 0.002 0.001 0.0009
Onchocerca volvulus Putative endochitinase 0.0074 0.0088 0.1084
Brugia malayi Trypsin-like protease protein 5 0.002 0.001 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0072 0.0903
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Trichomonas vaginalis WD repeat domain, putative 0.0278 0.0385 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0302 0.0421 0.0676
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.009 0.0842
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0074 0.0073
Schistosoma mansoni inositol transporter 0.0145 0.0192 0.0192
Trypanosoma cruzi UDP-galactopyranose mutase 0.0101 0.0129 0.1276
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0026 0.045
Giardia lamblia Tenascin-like 0.005 0.0054 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0104 0.0132 0.1309
Onchocerca volvulus 0.002 0.001 0.0057
Loa Loa (eye worm) trypsin family protein 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0075 0.009 0.0089
Echinococcus multilocularis notch 0.002 0.001 0.0011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0032 0.0032
Echinococcus granulosus laminin 0.0027 0.002 0.0019
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0104 0.0132 0.2351
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0192 0.026 0.0413
Brugia malayi transcriptional regulator, Sir2 family protein 0.0104 0.0132 0.0131
Echinococcus granulosus Tolloid protein 1 0.0053 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0045 0.0046 0.0046
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0019 0.0181
Loa Loa (eye worm) serpin protein 6 0.0017 0.0006 0.0005
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0719 0.1026 0.1026
Echinococcus multilocularis protein jagged 2 0.002 0.001 0.0011
Brugia malayi Pepsin A precursor 0.0035 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0034
Brugia malayi serpin (BmSERPIN) 0.0017 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0075 0.009 0.0089
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0703 0.1004 1
Brugia malayi Carm1-pending protein 0.0108 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0039
Toxoplasma gondii subtilisin SUB4 0.0302 0.0421 0.8286
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0027 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Brugia malayi von Willebrand factor type A domain containing protein 0.0023 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.0028
Mycobacterium ulcerans NAD-dependent deacetylase 0.0104 0.0132 0.1661
Toxoplasma gondii subtilisin SUB2 0.0302 0.0421 0.8286
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0074 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0032 0.0626
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0024 0.0023
Schistosoma mansoni c4b-binding protein beta chain 0.004 0.0039 0.0039
Echinococcus multilocularis fibrillin 1 0.0078 0.0095 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0129 0.2292
Mycobacterium ulcerans polyketide synthase MbtD 0.0017 0.0005 0.0056
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0078 0.0094 0.2229
Mycobacterium ulcerans polyketide synthase Pks13 0.0078 0.0094 0.118
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0032 0.0032
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0329 0.0459 0.4575
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0011 0.0013
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0011 0.018
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0232 0.0318 0.0396
Onchocerca volvulus 0.0023 0.0015 0.0119
Brugia malayi Sex muscle abnormal protein 5 0.0146 0.0193 0.0193
Echinococcus multilocularis fat cadherin tumor suppressor 0.002 0.001 0.0011
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0011 0.018
Echinococcus multilocularis integrin beta 2 0.1414 0.2038 0.2544
Treponema pallidum 76K protein 0.0023 0.0015 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0028 0.0221
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0032 0.0032
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Mycobacterium leprae Probable polyketide synthase Pks1 0.0054 0.006 0.1312
Loa Loa (eye worm) serpin 0.0017 0.0006 0.0005
Echinococcus multilocularis bloom syndrome protein 0.002 0.0011 0.0013
Schistosoma mansoni protein kinase 0.0248 0.0342 0.0341
Toxoplasma gondii subtilisin SUB8 0.0302 0.0421 0.8286
Loa Loa (eye worm) TK/ALK protein kinase 0.0075 0.009 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0104 0.0132 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Onchocerca volvulus 0.004 0.0039 0.0439
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0049 0.0061
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0027 0.002 0.0019
Leishmania major arginine N-methyltransferase, type I 0.0108 0.0138 0.1371
Echinococcus multilocularis enteropeptidase 0.002 0.001 0.0012
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0104 0.0132 0.1309
Echinococcus granulosus delta-like protein 1 0.002 0.001 0.0009
Brugia malayi Trypsin family protein 0.002 0.001 0.0009
Giardia lamblia Tenascin-37 0.005 0.0054 0.0132
Onchocerca volvulus 0.0045 0.0046 0.0537
Schistosoma mansoni serpin 0.0017 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0005
Brugia malayi hypothetical protein 0.0101 0.0129 0.0128
Entamoeba histolytica recQ family helicase, putative 0.002 0.0011 0.0051
Schistosoma mansoni protein kinase 0.0248 0.0342 0.0341
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0039
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0023 0.0015 0.0252
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0023 0.0015 0.0252
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0108 0.0138 0.0213
Loa Loa (eye worm) CUB domain-containing protein 0.0027 0.002 0.0019
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0011 0.001
Giardia lamblia Neurogenic locus notch-like protein 0.005 0.0054 0.0132
Plasmodium falciparum subtilisin-like protease 1 0.0302 0.0421 0.7524
Onchocerca volvulus 0.004 0.0039 0.0439
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0032 0.0039
Loa Loa (eye worm) hypothetical protein 0.0238 0.0327 0.0327
Onchocerca volvulus 0.0045 0.0046 0.0537
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0023 0.0015 0.0014
Toxoplasma gondii exonuclease III APE 0.0019 0.0008 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0049 0.0049
Plasmodium vivax subtilisin-like serine protease, putative 0.0302 0.0421 0.7524
Schistosoma mansoni hypothetical protein 0.0075 0.009 0.0089
Onchocerca volvulus 0.0278 0.0385 0.4967
Loa Loa (eye worm) CUTiclin family member 0.0023 0.0015 0.0014
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0015 0.0014
Brugia malayi hypothetical protein 0.004 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0045 0.0046 0.0046
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0045 0.0046 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.0287 0.0286
Schistosoma mansoni hypothetical protein 0.0278 0.0385 0.0384
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.03 0.0417 0.4123
Echinococcus multilocularis CUB 0.0027 0.002 0.0024
Mycobacterium ulcerans thioesterase 0.0045 0.0046 0.0576
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0099 0.0125 0.0125
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.167 0.2411 0.241
Entamoeba histolytica chitinase, putative 0.0074 0.0088 0.0829
Onchocerca volvulus 0.004 0.0039 0.0439
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Brugia malayi hypothetical protein 0.0035 0.0032 0.0032
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0078 0.0094 0.2229
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Onchocerca volvulus 0.004 0.0039 0.0439
Schistosoma mansoni growth factor receptor-bound protein 0.0146 0.0193 0.0193
Onchocerca volvulus 0.002 0.001 0.0057
Onchocerca volvulus 0.002 0.001 0.0052
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0042 0.0042 0.0042
Plasmodium falciparum plasmepsin I 0.0035 0.0032 0.0569
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0074 0.0073
Echinococcus granulosus protein will die slowly 0.0278 0.0385 0.0384
Echinococcus granulosus Furin 1 0.167 0.2411 0.241
Brugia malayi CUB domain containing protein 0.0027 0.002 0.0019
Brugia malayi Calcium binding EGF domain containing protein 0.0046 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0029 0.0282
Onchocerca volvulus 0.0023 0.0015 0.0119
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0019 0.0358
Entamoeba histolytica hypothetical protein, conserved 0.0023 0.0015 0.0091
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0053 0.0058 0.0058
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0052 0.0057 0.1347
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Leishmania major chitinase 0.0074 0.0088 0.0875
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0026 0.0494
Onchocerca volvulus 0.005 0.0054 0.0633
Echinococcus multilocularis integrin alpha ps 0.0067 0.0078 0.0096
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0032 0.0569
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.001 0.0009
Schistosoma mansoni site-1 peptidase (S08 family) 0.0302 0.0421 0.042
Plasmodium falciparum plasmepsin IX 0.0035 0.0032 0.0569
Plasmodium falciparum plasmepsin III 0.0035 0.0032 0.0569
Brugia malayi transcriptional regulator, Sir2 family protein 0.0703 0.1004 0.1003
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0032 0.0569
Echinococcus multilocularis neurogenic locus protein delta 0.002 0.001 0.0011
Brugia malayi Subtilase family protein 0.0302 0.0421 0.042
Echinococcus granulosus glycoprotein Antigen 5 0.002 0.001 0.0009
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0032 0.0032
Brugia malayi hypothetical protein 0.004 0.0039 0.0039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0019 0.0325
Loa Loa (eye worm) chitinase I 0.0074 0.0088 0.0088
Toxoplasma gondii aspartyl protease ASP5 0.0362 0.0507 1
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0011 0.001
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0101 0.0129 0.2964
Echinococcus multilocularis high affinity choline transporter 1 0.0037 0.0035 0.0043
Entamoeba histolytica hypothetical protein 0.0042 0.0042 0.0369
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0302 0.0421 0.0524
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0108 0.0138 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0049 0.0049
Echinococcus multilocularis chromatin regulatory protein sir2 0.0703 0.1004 0.1252
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Plasmodium falciparum plasmepsin IV 0.0035 0.0032 0.0569
Echinococcus granulosus neurogenic locus notch protein 0.002 0.001 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0019 0.0325
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0042 0.0042 0.0042
Loa Loa (eye worm) WD40 repeat protein 0.0278 0.0385 0.0384
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0327 0.0327
Plasmodium vivax plasmepsin IV, putative 0.0035 0.0032 0.0569
Echinococcus multilocularis geminin 0.0345 0.0483 0.0602
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0006 0.0005
Brugia malayi Stress-activated protein kinase jnk-1 0.0232 0.0318 0.0317
Brugia malayi Zona pellucida-like domain containing protein 0.0023 0.0015 0.0014
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0072 0.091
Loa Loa (eye worm) sirtuin 4 0.0104 0.0132 0.0131
Echinococcus granulosus serine protease inhibitor 0.0017 0.0006 0.0005
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0026 0.045
Echinococcus multilocularis slit 2 protein 0.002 0.001 0.0011
Giardia lamblia High cysteine protein 0.005 0.0054 0.0132
Mycobacterium ulcerans polyketide synthase 0.0051 0.0055 0.069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Loa Loa (eye worm) transcriptional regulator 0.0104 0.0132 0.0131
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0027 0.002 0.0019
Schistosoma mansoni atypical protein kinase C 0.0017 0.0005 0.0005
Echinococcus multilocularis protein jagged 1 0.002 0.001 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Brugia malayi notch-like transmembrane receptor 0.002 0.001 0.0009
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0108 0.0138 0.1371
Plasmodium falciparum apical sushi protein 0.004 0.0039 0.069
Toxoplasma gondii bicoid-interacting protein BIN3 0.0108 0.0138 0.2713
Echinococcus granulosus integrin alpha ps 0.0032 0.0027 0.0027
Schistosoma mansoni discoidin domain receptor 0.0045 0.0046 0.0046
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.001 0.0009
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.006 0.0752
Toxoplasma gondii hypothetical protein 0.005 0.0054 0.1052
Toxoplasma gondii F5/8 type C domain-containing protein 0.0045 0.0046 0.0907
Echinococcus granulosus geminin 0.0345 0.0483 0.0482
Plasmodium falciparum plasmepsin V 0.0397 0.0559 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0019 0.0181
Schistosoma mansoni SWI/SNF complex-related 0.0042 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Schistosoma mansoni chromatin regulatory protein sir2 0.0104 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Leishmania major hypothetical protein, conserved 0.0026 0.0019 0.0181
Brugia malayi EGF-like domain containing protein 0.005 0.0054 0.0053
Echinococcus granulosus lysine specific histone demethylase 1A 0.0101 0.0129 0.0128
Echinococcus multilocularis serine:threonine protein kinase N2 0.0084 0.0102 0.0127
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0104 0.0132 0.1309
Leishmania major subtilisin-like serine peptidase 0.0302 0.0421 0.4188
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0072 0.1709
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.167 0.2411 0.3942
Echinococcus multilocularis membrane bound transcription factor site 1 0.0302 0.0421 0.0524
Echinococcus multilocularis integrin alpha ps 0.0067 0.0078 0.0096
Onchocerca volvulus 0.004 0.0039 0.0439
Brugia malayi Zona pellucida-like domain containing protein 0.0023 0.0015 0.0014
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.0132 0.0202
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0043 0.0043 0.0043
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0026 0.0496
Entamoeba histolytica hypothetical protein 0.0073 0.0087 0.0821
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0005
Echinococcus multilocularis Estrogen regulated protein EP45 0.0017 0.0006 0.0006
Schistosoma mansoni laminin gamma-3 chain 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0005
Plasmodium vivax subtilisin-like protease 1 0.0302 0.0421 0.7524
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.002 0.001 0.0009
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0053 0.0058 0.0058
Echinococcus granulosus Mastin 0.002 0.001 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.002
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0208 0.0283 0.3573
Loa Loa (eye worm) hypothetical protein 0.0104 0.0132 0.0131
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0008
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0051 0.0055 0.131
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0027 0.002 0.0019
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0027 0.002 0.0392
Onchocerca volvulus 0.0043 0.0043 0.0494
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0192 0.026 0.4645
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0072 0.0903
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0114 0.0113
Loa Loa (eye worm) integrin alpha pat-2 0.0229 0.0314 0.0314
Echinococcus granulosus integrin beta 2 0.1414 0.2038 0.2037
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0138 0.0182 0.0182
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0129 0.3055
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0026 0.045
Schistosoma mansoni hypothetical protein 0.0032 0.0027 0.0027
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0026 0.0496
Echinococcus multilocularis neurogenic locus notch protein 4 0.002 0.001 0.0011
Schistosoma mansoni septate junction protein 0.0065 0.0075 0.0075
Plasmodium vivax aspartyl protease, putative 0.0035 0.0032 0.0569
Entamoeba histolytica elongation factor-2 kinase, putative 0.0023 0.0015 0.0091
Echinococcus granulosus protein arginine N methyltransferase 7 0.0108 0.0138 0.0138
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0108 0.0138 0.0213
Brugia malayi hypothetical protein 0.004 0.0039 0.0039
Echinococcus granulosus adam 0.005 0.0054 0.0053
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0042 0.0042 0.0052
Toxoplasma gondii rhoptry neck protein RON1 0.004 0.0039 0.076
Echinococcus granulosus Estrogen regulated protein EP45 0.0017 0.0006 0.0005
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0026 0.0031
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0032 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0049 0.0049
Giardia lamblia Tenascin precursor 0.005 0.0054 0.0132
Brugia malayi EGF-like domain containing protein 0.005 0.0054 0.0053
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0032 0.0626
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.004 0.004 0.0827
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0104 0.0132 0.0131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.001 0.0009
Toxoplasma gondii subtilisin SUB7 0.0302 0.0421 0.8286
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.0032 0.0626
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0049 0.0048
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0011 0.0004
Brugia malayi hypothetical protein 0.004 0.0039 0.0039
Echinococcus multilocularis integrin alpha 3 0.0114 0.0147 0.0182
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0302 0.0421 1
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0032 0.0032
Echinococcus granulosus lysine specific histone demethylase 1A 0.0499 0.0707 0.0707
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0302 0.0421 0.5316
Schistosoma mansoni notch 0.002 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0033 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0292 0.0406 0.0406
Echinococcus granulosus protein arginine methyltransferase 0.0192 0.026 0.0259
Echinococcus granulosus neurogenic locus notch protein 0.002 0.001 0.0009
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.002 0.001 0.0009
Mycobacterium ulcerans dehydrogenase 0.0101 0.0129 0.162
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0006 0.0005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0248 0.0342 0.0341
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0033 0.0029 0.0355
Echinococcus granulosus plasminogen activator inhibitor 2 0.0017 0.0006 0.0005
Brugia malayi RNA binding protein 0.0064 0.0074 0.0073
Plasmodium falciparum plasmepsin VII 0.0035 0.0032 0.0569
Brugia malayi transcriptional regulator, Sir2 family protein 0.0104 0.0132 0.0131
Echinococcus granulosus sodium:myo inositol cotransporter 0.0145 0.0192 0.0192
Loa Loa (eye worm) CUTiclin-Like family member 0.0023 0.0015 0.0014
Toxoplasma gondii subtilisin SUB5 0.0302 0.0421 0.8286
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0026 0.0025
Loa Loa (eye worm) glutaminase 0.0557 0.0791 0.079
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0101 0.0129 0.2292
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0108 0.0138 0.1371
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0101 0.0129 0.2292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.167 0.2411 0.3942
Echinococcus granulosus CUB 0.0027 0.002 0.0019
Loa Loa (eye worm) glutaminase 2 0.0557 0.0791 0.079
Brugia malayi von Willebrand factor type A domain containing protein 0.0023 0.0015 0.0014
Giardia lamblia Tenascin-X 0.005 0.0054 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0302 0.0421 0.0676
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.001 0.0009
Loa Loa (eye worm) subtilase 0.0302 0.0421 0.042
Trichomonas vaginalis hypothetical protein 0.005 0.0054 0.0074
Onchocerca volvulus 0.005 0.0054 0.0634
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0034
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0101 0.0129 0.162
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0045 0.0046 0.0062
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0074 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Giardia lamblia High cysteine protein 0.002 0.001 0.0011
Echinococcus granulosus voltage dependent calcium channel subunit 0.0023 0.0015 0.0014
Leishmania major hypothetical protein, conserved 0.0033 0.0029 0.0282
Echinococcus multilocularis fibrillin 2 0.005 0.0054 0.0067
Brugia malayi CUB domain containing protein 0.0027 0.002 0.0019
Echinococcus multilocularis laminin 0.0027 0.002 0.0024
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0026 0.0251
Brugia malayi hypothetical protein 0.0035 0.0032 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0007 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Giardia lamblia Neurogenic locus Notch protein precursor 0.005 0.0054 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0074 0.0073
Onchocerca volvulus 0.0094 0.0117 0.146
Loa Loa (eye worm) hypothetical protein 0.005 0.0054 0.0053
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0054 0.006 0.1312
Plasmodium falciparum thrombospondin-related anonymous protein 0.0023 0.0015 0.0252
Loa Loa (eye worm) hypothetical protein 0.0144 0.019 0.0189
Brugia malayi celfurPC protein 0.5519 0.801 0.801
Brugia malayi serpin 0.0017 0.0006 0.0005
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.002 0.0019
Schistosoma mansoni dihydrofolate reductase 0.0208 0.0283 0.0282
Echinococcus granulosus transmembrane protease serine 3 0.002 0.001 0.0009
Brugia malayi proprotein convertase 2 0.4349 0.6308 0.6308
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0032
Entamoeba histolytica hypothetical protein, conserved 0.0104 0.0132 0.1265
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0039
Brugia malayi hypothetical protein 0.0026 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0027 0.002 0.0019
Brugia malayi dihydrofolate reductase family protein 0.0208 0.0283 0.0282
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0011 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Onchocerca volvulus 0.0035 0.0032 0.0351
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0023 0.0015 0.0018
Echinococcus granulosus solute carrier family 5 0.0145 0.0192 0.0192
Schistosoma mansoni cpg binding protein 0.003 0.0024 0.0023
Schistosoma mansoni hypothetical protein 0.0108 0.0138 0.0138
Schistosoma mansoni serpin 0.0017 0.0006 0.0005
Brugia malayi von Willebrand Factor 0.0023 0.0015 0.0014
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.167 0.2411 0.3942
Toxoplasma gondii kringle domain-containing protein 0.0033 0.0029 0.0559
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0091 0.0114 0.0113
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Loa Loa (eye worm) hypothetical protein 0.0088 0.0108 0.0108
Echinococcus multilocularis cpg binding protein 0.0031 0.0026 0.0032
Schistosoma mansoni discoidin domain receptor 0.0045 0.0046 0.0046
Schistosoma mansoni notch 0.002 0.001 0.0009
Brugia malayi Will die slowly protein 0.0278 0.0385 0.0384
Mycobacterium ulcerans glutaminase 0.0557 0.0791 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Entamoeba histolytica hypothetical protein, conserved 0.0023 0.0015 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Toxoplasma gondii PA14 domain-containing protein 0.0045 0.0046 0.0907
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0032 0.0032
Echinococcus granulosus discoidin domain receptor 0.0045 0.0046 0.0046
Toxoplasma gondii subtilisin SUB6 0.0302 0.0421 0.8286
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0026 0.0031
Mycobacterium ulcerans hypothetical protein 0.002 0.001 0.0118
Loa Loa (eye worm) Carm1-pending protein 0.0108 0.0138 0.0138
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0192 0.026 0.0413
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0104 0.0132 0.3133
Loa Loa (eye worm) hypothetical protein 0.0082 0.01 0.01
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0302 0.0421 1
Echinococcus multilocularis protein jagged 1 0.002 0.001 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0072 0.0071
Schistosoma mansoni tyrosine kinase 0.0469 0.0663 0.0662
Echinococcus granulosus neuroendocrine convertase 2 0.4349 0.6308 0.6308
Echinococcus multilocularis cubilin 0.0027 0.002 0.0024
Onchocerca volvulus 0.002 0.001 0.0052
Loa Loa (eye worm) Notch2 0.002 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0345 0.0483 0.0482
Onchocerca volvulus 0.0027 0.002 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Echinococcus granulosus serine protease inhibitor 0.0017 0.0006 0.0005
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0024 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Plasmodium vivax hypothetical protein, conserved 0.0104 0.0132 0.2351
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0032 0.0032
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Mycobacterium tuberculosis Possible chitinase 0.0063 0.0072 0.1722
Brugia malayi serpin precursor 0.0017 0.0006 0.0005
Trypanosoma cruzi arginine N-methyltransferase, putative 0.03 0.0417 0.4152
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.005 0.0054 0.1282
Plasmodium falciparum subtilisin-like protease 3 0.0302 0.0421 0.7524
Onchocerca volvulus 0.002 0.001 0.0057
Plasmodium vivax LCCL domain-containing protein 0.0045 0.0046 0.0823
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0101 0.0129 0.162
Plasmodium falciparum protoporphyrinogen oxidase 0.0101 0.0129 0.2292
Onchocerca volvulus Neurogenic locus notch homolog 0.002 0.001 0.0052
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0104 0.0132 0.2351
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0144 0.0144
Brugia malayi Integrin beta pat-3 precursor 0.1913 0.2764 0.2763
Trypanosoma brucei subtilisin peptidase 0.0302 0.0421 0.4188
Brugia malayi serpin 0.0017 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0031
Schistosoma mansoni furin-1 (S08 family) 0.2981 0.4318 0.4318
Brugia malayi GH02984p 0.0037 0.0035 0.0034
Onchocerca volvulus 0.004 0.0039 0.0439
Brugia malayi Fibulin-1 precursor 0.0027 0.002 0.0019
Schistosoma mansoni amine oxidase 0.0101 0.0129 0.0128
Brugia malayi hypothetical protein 0.03 0.0417 0.0417
Chlamydia trachomatis dihydrofolate reductase 0.0208 0.0283 1
Plasmodium falciparum plasmepsin X 0.0035 0.0032 0.0569
Leishmania major sir2-family protein-like protein 0.0104 0.0132 0.1309
Onchocerca volvulus Putative endochitinase 0.0074 0.0088 0.1084
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0108 0.0138 0.2713
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0101 0.0129 0.162
Schistosoma mansoni integrin beta subunit 0.1121 0.1612 0.1612
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0087 0.0087
Trichomonas vaginalis glutaminase, putative 0.0557 0.0791 0.1284
Echinococcus multilocularis protein kinase c iota type 0.0017 0.0005 0.0006
Onchocerca volvulus Fatty acid synthase homolog 0.0097 0.0122 0.1524
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.0032 0.0626
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0079 0.0096 0.0955
Brugia malayi EGF-like domain containing protein 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.005 0.0054 0.0053
Brugia malayi CUB domain containing protein 0.0027 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Brugia malayi CXXC zinc finger family protein 0.003 0.0024 0.0023
Toxoplasma gondii subtilisin SUB11 0.0302 0.0421 0.8286
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0302 0.0421 0.4188
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0026 0.045
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.0132 0.0202
Schistosoma mansoni hypothetical protein 0.1368 0.1971 0.1971
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0051 0.0055 0.131
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.0055 0.131
Brugia malayi Dihydrofolate reductase 0.0208 0.0283 0.0282
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.002 0.0375
Echinococcus multilocularis neural cadherin 0.002 0.001 0.0011
Brugia malayi von Willebrand factor type A domain containing protein 0.0023 0.0015 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Echinococcus multilocularis protein kinase c epsilon type 0.0091 0.0114 0.0141
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0015 0.0252
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0032 0.0032
Brugia malayi serpin 0.0017 0.0006 0.0005
Echinococcus granulosus methyltransferase protein 5 0.0108 0.0138 0.0138
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0101 0.0129 0.2292
Schistosoma mansoni amine oxidase 0.0101 0.0129 0.0128
Brugia malayi von Willebrand factor type A domain containing protein 0.0023 0.0015 0.0014
Toxoplasma gondii F5/8 type C domain-containing protein 0.0045 0.0046 0.0907
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0035 0.0676
Loa Loa (eye worm) hypothetical protein 0.005 0.0054 0.0053
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0027 0.002 0.0019
Loa Loa (eye worm) dihydrofolate reductase 0.0208 0.0283 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0327 0.0408
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0011 0.01
Entamoeba histolytica hypothetical protein 0.03 0.0417 0.4123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Onchocerca volvulus 0.0033 0.0029 0.0306
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0079 0.0096 0.189
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0039
Trypanosoma cruzi UDP-galactopyranose mutase 0.0101 0.0129 0.1276
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0005
Echinococcus granulosus high affinity choline transporter 1 0.0037 0.0035 0.0034
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Loa Loa (eye worm) hypothetical protein 0.005 0.0054 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0027 0.002 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0072 0.0903
Brugia malayi Cadherin domain containing protein 0.002 0.001 0.0009
Schistosoma mansoni btb and poz domain-containing protein 0.0045 0.0046 0.0046
Brugia malayi hypothetical protein 0.0017 0.0006 0.0005
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0011 0.01
Echinococcus multilocularis neurogenic locus notch protein 0.002 0.001 0.0011
Brugia malayi serpin 0.0017 0.0006 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0039
Onchocerca volvulus 0.0027 0.002 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0049 0.0049
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0101 0.0129 0.2292
Echinococcus multilocularis neuroendocrine convertase 2 0.4349 0.6308 0.7875
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0045 0.0046 0.1105
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.002 0.0375
Brugia malayi Trypsin family protein 0.002 0.001 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0129 0.2292
Echinococcus granulosus protein kinase c epsilon type 0.0091 0.0114 0.0113
Echinococcus multilocularis dihydrofolate reductase 0.0208 0.0283 0.0353
Trichomonas vaginalis hypothetical protein 0.0045 0.0046 0.0062
Treponema pallidum hypothetical protein 0.0023 0.0015 1
Echinococcus granulosus c4b binding protein beta chain 0.004 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0101 0.0129 0.0128
Loa Loa (eye worm) transcriptional regulator 0.0703 0.1004 0.1003
Toxoplasma gondii EGF family domain-containing protein 0.002 0.001 0.0177
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0074 0.0073
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0027 0.002 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0302 0.0421 0.0676
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0104 0.0132 0.0131
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0703 0.1004 1
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0026 0.0028
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0108 0.0138 0.1371
Brugia malayi EGF-like domain containing protein 0.002 0.001 0.0009
Echinococcus granulosus serine:threonine protein kinase N2 0.0075 0.009 0.0089
Loa Loa (eye worm) microfilarial chitinase 0.0063 0.0072 0.0072
Onchocerca volvulus 0.004 0.0039 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.002 0.0019
Echinococcus granulosus growth factor receptor bound protein 2 0.0146 0.0193 0.0193
Onchocerca volvulus 0.002 0.001 0.0052
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0032 0.0032
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0026 0.045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.167 0.2411 0.3942
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0023 0.0015 0.0252
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0703 0.1004 0.1633
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0072 0.0711
Echinococcus granulosus discoidin domain containing receptor 2 0.0045 0.0046 0.0046
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0074 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0032 0.0032
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.002 0.001 0.0009
Echinococcus granulosus neural cadherin 0.002 0.001 0.0009
Echinococcus granulosus sodium:glucose cotransporter 2 0.0145 0.0192 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0026 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.0055 0.069
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0117 0.0151 0.015
Schistosoma mansoni integrin alpha-ps 0.0067 0.0078 0.0077
Schistosoma mansoni growth factor receptor-bound protein 0.0146 0.0193 0.0193
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0026 0.0025
Onchocerca volvulus 0.0239 0.0329 0.4233
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.0132 0.0202
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0054 0.006 0.0752
Mycobacterium ulcerans thioesterase TesA 0.0045 0.0046 0.0576
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0087 0.0109
Schistosoma mansoni hypothetical protein 0.0027 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0027 0.002 0.0019
Plasmodium falciparum plasmepsin VI 0.0035 0.0032 0.0569
Brugia malayi Delta serrate ligand family protein 0.002 0.001 0.0009
Onchocerca volvulus 0.0023 0.0015 0.0119
Onchocerca volvulus 0.0023 0.0015 0.0119
Echinococcus multilocularis 0.0101 0.0129 0.016
Mycobacterium leprae Polyketide synthase Pks13 0.0078 0.0094 0.2127
Trypanosoma brucei SIR2-like protein 4, putative 0.0104 0.0132 0.1309
Brugia malayi EGF-like domain containing protein 0.002 0.001 0.0009
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0499 0.0707 0.0882
Echinococcus multilocularis growth factor receptor bound protein 2 0.0146 0.0193 0.0241
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.0132 0.0202
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0072 0.0089
Brugia malayi SWIRM domain containing protein 0.0542 0.0769 0.0768
Onchocerca volvulus 0.002 0.001 0.0052
Toxoplasma gondii subtilisin SUB12 0.0302 0.0421 0.8286
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Mycobacterium ulcerans polyketide synthase 0.0054 0.006 0.0752
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0026 0.045
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0026 0.0031
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0008 0.0142
Leishmania major arginine N-methyltransferase-like protein 0.0192 0.026 0.2585
Schistosoma mansoni notch 0.002 0.001 0.0009
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0302 0.0421 1
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0319 0.0445 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0329 0.0459 0.4575
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0248 0.0342 0.0426
Entamoeba histolytica hypothetical protein 0.0073 0.0087 0.0821
Schistosoma mansoni notch 0.002 0.001 0.0009
Brugia malayi endochitinase 0.0074 0.0088 0.0088
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0039 0.0037 0.0881
Toxoplasma gondii aspartyl protease 0.0035 0.0032 0.0626
Brugia malayi CUB domain containing protein 0.0027 0.002 0.0019
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0045 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0302 0.0421 0.042
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0045 0.0046 0.0978
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0108 0.0138 0.0172
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0009
Echinococcus multilocularis Furin 1 0.167 0.2411 0.3009
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0006 0.0005
Brugia malayi Nematode astacin protease protein 30 0.0027 0.002 0.0019
Brugia malayi hypothetical protein 0.0017 0.0006 0.0005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.0079
Brugia malayi Nematode astacin protease protein 30 0.0027 0.002 0.0019
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0039
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0035 0.0043
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0104 0.0132 0.1265
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0033 0.0029 0.0507
Brugia malayi Sushi domain 0.004 0.0039 0.0039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0087 0.0087
Loa Loa (eye worm) serpin 0.0017 0.0006 0.0005
Loa Loa (eye worm) acyl carrier protein 0.0025 0.0017 0.0016
Echinococcus multilocularis neurogenic locus protein delta 0.002 0.001 0.0011
Brugia malayi hypothetical protein 0.0073 0.0087 0.0087
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.0132 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Plasmodium vivax NAD-dependent deacetylase, putative 0.0104 0.0132 0.2351
Onchocerca volvulus Neurogenic locus notch protein homolog 0.002 0.001 0.0052
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.004 0.004 0.0497
Schistosoma mansoni hypothetical protein 0.0073 0.0087 0.0087
Plasmodium vivax aspartyl protease, putative 0.0035 0.0032 0.0569
Echinococcus granulosus discoidin domain containing receptor 2 0.0045 0.0046 0.0046
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0103 0.0131 0.2576
Trypanosoma cruzi arginine N-methyltransferase, putative 0.03 0.0417 0.4152
Loa Loa (eye worm) hypothetical protein 0.0112 0.0144 0.0144
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.002 0.001 0.0009
Echinococcus granulosus epidermal growth factor receptor 0.0469 0.0663 0.0662
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0104 0.0132 0.0164
Brugia malayi Protein kinase domain containing protein 0.0033 0.0029 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.0079
Schistosoma mansoni sodium/solute symporter 0.0037 0.0035 0.0034
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0074 0.0073
Echinococcus granulosus collagen alpha 1VII chain 0.0023 0.0015 0.0014
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0009
Echinococcus granulosus membrane bound transcription factor site 1 0.0302 0.0421 0.042
Brugia malayi AMP-binding enzyme family protein 0.005 0.0054 0.0053
Echinococcus granulosus fibrillin 1 0.0052 0.0056 0.0056
Toxoplasma gondii rhoptry neck protein RON9 0.004 0.0039 0.076
Giardia lamblia Sirtuin type 2 0.0104 0.0132 0.0344
Loa Loa (eye worm) serpin 0.0017 0.0006 0.0005
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0302 0.0421 1
Loa Loa (eye worm) RecQ helicase 0.002 0.0011 0.001
Brugia malayi Cam kinase protein 1 0.0031 0.0026 0.0025
Onchocerca volvulus 0.0137 0.018 0.229
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0302 0.0421 0.042
Echinococcus multilocularis solute carrier family 5 0.0145 0.0192 0.0239
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0302 0.0421 0.042
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0051 0.0055 0.0055
Echinococcus multilocularis protein arginine methyltransferase 0.0192 0.026 0.0324
Loa Loa (eye worm) hypothetical protein 0.0045 0.0046 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0208 0.0283 0.6682
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Brugia malayi von Willebrand factor type A domain containing protein 0.0023 0.0015 0.0014
Toxoplasma gondii subtilisin SUB10 0.0302 0.0421 0.8286
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0075 0.009 0.0089
Echinococcus granulosus tissue type plasminogen activator 0.0033 0.0029 0.0028
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.0132 0.0202
Schistosoma mansoni high-affinity choline transporter 0.0037 0.0035 0.0034
Brugia malayi EGF-like domain containing protein 0.002 0.001 0.0009
Brugia malayi protein kinase C II. 0.0091 0.0114 0.0113
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0072 0.091
Schistosoma mansoni hypothetical protein 0.0027 0.002 0.0019
Echinococcus granulosus fibrillin 2 0.005 0.0054 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0049 0.0061
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0329 0.0459 0.4575
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.03 0.0417 0.4152
Brugia malayi hypothetical protein 0.0238 0.0327 0.0327
Echinococcus granulosus tar DNA binding protein 0.0064 0.0074 0.0073
Brugia malayi EGF-like domain containing protein 0.005 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0026 0.0025
Brugia malayi EGF-like domain containing protein 0.002 0.001 0.0009
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0011 0.0004
Brugia malayi hypothetical protein 0.0075 0.009 0.0089
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0008
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0703 0.1004 0.1252
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0054 0.006 0.1425
Echinococcus multilocularis tissue type plasminogen activator 0.0033 0.0029 0.0035
Schistosoma mansoni hypothetical protein 0.0345 0.0483 0.0482
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0146 0.0193 0.0193
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0192 0.026 0.0324
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0217 0.0297 0.0296
Mycobacterium ulcerans Sir2-like regulatory protein 0.0104 0.0132 0.1661
Echinococcus granulosus enteropeptidase 0.002 0.001 0.0009
Echinococcus granulosus fibropellin Ia 0.002 0.001 0.0009
Schistosoma mansoni egf-like domain protein 0.0027 0.002 0.0019
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0302 0.0421 0.5316
Mycobacterium ulcerans monoamine oxidase 0.0101 0.0129 0.162
Toxoplasma gondii type I fatty acid synthase, putative 0.0054 0.006 0.1172
Loa Loa (eye worm) AMP-binding enzyme family protein 0.005 0.0054 0.0053
Onchocerca volvulus 0.0302 0.0421 0.5439
Brugia malayi von Willebrand factor type A domain containing protein 0.0023 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0008 0.0079
Brugia malayi hypothetical protein 0.0023 0.0015 0.0014
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0054 0.006 0.1425
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0192 0.026 0.0413
Echinococcus multilocularis discoidin domain containing receptor 2 0.0045 0.0046 0.0057
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0026 0.045
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.002 0.001 0.0012
Schistosoma mansoni slit 0.002 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0051 0.0055 0.1195
Echinococcus granulosus cubilin 0.0027 0.002 0.0019
Echinococcus granulosus chromatin regulatory protein sir2 0.0703 0.1004 0.1003
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0032 0.0032
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Leishmania major silent information regulator 2, putative 0.0703 0.1004 1
Echinococcus multilocularis protein will die slowly 0.0278 0.0385 0.048
Echinococcus multilocularis protoporphyrinogen oxidase 0.0101 0.0129 0.016
Plasmodium vivax SET domain protein, putative 0.0031 0.0026 0.0448
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.002 0.001 0.0012
Giardia lamblia hypothetical protein 0.0042 0.0042 0.01
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0023 0.0015 0.0091
Plasmodium falciparum subtilisin-like protease 2 0.0302 0.0421 0.7524
Schistosoma mansoni chromatin regulatory protein sir2 0.0104 0.0132 0.0131
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0027 0.002 0.0019
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0051 0.0055 0.1195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0026 0.0025
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0192 0.026 0.0259
Mycobacterium tuberculosis Probable thioesterase TesA 0.0045 0.0046 0.1095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0049 0.0049
Onchocerca volvulus 0.0027 0.002 0.0186
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.0132 0.0202
Plasmodium falciparum LCCL domain-containing protein 0.0045 0.0046 0.0823
Brugia malayi neuroendocrine convertase 1 precursor 0.4349 0.6308 0.6308
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0042 0.0056
Plasmodium vivax aspartyl protease, putative 0.0035 0.0032 0.0569
Echinococcus granulosus protein jagged 2 0.002 0.001 0.0009
Brugia malayi EGF-like domain containing protein 0.005 0.0054 0.0053
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0108 0.0138 0.0172
Onchocerca volvulus 0.002 0.001 0.0057
Echinococcus multilocularis serine protease inhibitor 0.0017 0.0006 0.0006
Brugia malayi Lectin C-type domain containing protein 0.0027 0.002 0.0019
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.001 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Echinococcus multilocularis fibropellin Ia 0.002 0.001 0.0011
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0079 0.0096 0.0955
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.006 0.1425
Brugia malayi GCC2 and GCC3 family protein 0.006 0.0068 0.0067
Onchocerca volvulus 0.0075 0.009 0.1105
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0008 0.0142
Echinococcus multilocularis transmembrane protease serine 3 0.002 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.006 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0026 0.0025
Echinococcus granulosus protein jagged 1 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0043 0.0043
Plasmodium falciparum cysteine repeat modular protein 1 0.0033 0.0029 0.0507
Entamoeba histolytica hypothetical protein 0.0073 0.0087 0.0821
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4208 0.6103 0.6103
Giardia lamblia Hypothetical protein 0.0703 0.1004 0.2722
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0011 0.001
Toxoplasma gondii histone deacetylase SIR2 0.0104 0.0132 0.2589
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0008 0.0008
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0192 0.026 0.5116
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0108 0.0138 0.0138
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1267 0.1824 0.1824
Echinococcus granulosus cubilin 0.0027 0.002 0.0019
Schistosoma mansoni chromatin regulatory protein sir2 0.0703 0.1004 0.1003
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Loa Loa (eye worm) endoprotease bli-4 0.6887 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.0318 0.0317
Giardia lamblia Furin precursor putative serine protease 0.1368 0.1971 0.5359
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0005
Brugia malayi CUB domain containing protein 0.0027 0.002 0.0019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0064 0.1253
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0049 0.0048
Brugia malayi Trypsin family protein 0.002 0.001 0.0009
Entamoeba histolytica hypothetical protein 0.0073 0.0087 0.0821
Toxoplasma gondii SWIRM domain-containing protein 0.0042 0.0042 0.0825
Onchocerca volvulus 0.0075 0.009 0.1105
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0104 0.0132 0.0344
Echinococcus granulosus cpg binding protein 0.0031 0.0026 0.0026
Echinococcus granulosus dihydrofolate reductase 0.0208 0.0283 0.0282
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0101 0.0129 0.0128
Toxoplasma gondii histone lysine-specific demethylase 0.0101 0.0129 0.2525
Leishmania major UDP-galactopyranose mutase 0.0101 0.0129 0.1276
Brugia malayi TAR-binding protein 0.0064 0.0074 0.0073
Echinococcus multilocularis adam 0.005 0.0054 0.0067
Onchocerca volvulus 0.0023 0.0015 0.0119
Schistosoma mansoni chromatin regulatory protein sir2 0.0703 0.1004 0.1003
Brugia malayi Kelch motif family protein 0.0319 0.0445 0.0445
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.167 0.2411 0.3942
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0108 0.0138 0.1328
Brugia malayi Muscle positioning protein 4 0.002 0.001 0.0009
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0703 0.1004 0.1633
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Onchocerca volvulus 0.0037 0.0035 0.0383
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.0055 0.069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.1971 0.322
Onchocerca volvulus Putative endochitinase 0.0074 0.0088 0.1084
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Chlamydia trachomatis protoporphyrinogen oxidase 0.0101 0.0129 0.4533
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0302 0.0421 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0703 0.1004 0.1003
Brugia malayi Serpin protein 6 0.0017 0.0006 0.0005
Brugia malayi hypothetical protein 0.004 0.0039 0.0039
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0027 0.002 0.0019
Echinococcus granulosus Protein kinase C brain isozyme 0.0018 0.0007 0.0006
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0045 0.0046 0.0062
Echinococcus multilocularis 0.5519 0.801 1
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Loa Loa (eye worm) RNA binding protein 0.0064 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.6887 1 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0018 0.0007 0.0008
Trichomonas vaginalis set domain proteins, putative 0.0239 0.0329 0.0525
Schistosoma mansoni integrin alpha-ps 0.0035 0.0031 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Loa Loa (eye worm) TK/EGFR protein kinase 0.0469 0.0663 0.0662
Onchocerca volvulus 0.002 0.001 0.0057
Onchocerca volvulus Putative endochitinase 0.0074 0.0088 0.1084
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.001 0.0009
Echinococcus granulosus neurogenic locus protein delta 0.002 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0022 0.0013 0.0297
Brugia malayi Angiotensin-converting enzyme family protein 0.0719 0.1026 0.1026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0026 0.0025
Plasmodium vivax apical sushi protein, putative 0.004 0.0039 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Echinococcus granulosus serine protease inhibitor 0.0017 0.0006 0.0005
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0054 0.006 0.1312
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.167 0.2411 0.3942
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0032 0.0032
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0008 1
Brugia malayi glutaminase DH11.1 0.0557 0.0791 0.079
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0027 0.002 0.0019
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0008 0.0008
Echinococcus multilocularis cubilin 0.0027 0.002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0075 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Onchocerca volvulus 0.004 0.0039 0.0439
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0023 0.0015 0.0252
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.023 0.0316 0.0316
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0026 0.045
Loa Loa (eye worm) hypothetical protein 0.2679 0.3878 0.3878
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0032 0.0032
Leishmania major protein kinase, putative 0.0031 0.0026 0.0251
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0031 0.0025 0.0602
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0302 0.0421 0.042
Giardia lamblia Transcriptional regulator, Sir2 family 0.0104 0.0132 0.0344
Toxoplasma gondii protease inhibitor PI1 0.0017 0.0006 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0046 0.0062
Loa Loa (eye worm) hypothetical protein 0.0032 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.03 0.0417 0.0417
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0011 0.0004
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0104 0.0132 0.1309
Trichomonas vaginalis conserved hypothetical protein 0.0302 0.0421 0.0676
Toxoplasma gondii F5/8 type C domain-containing protein 0.0045 0.0046 0.0907
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0039
Echinococcus granulosus protein arginine N methyltransferase 8 0.0192 0.026 0.0259
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.0132 0.0202
Toxoplasma gondii subtilisin SUB1 0.0302 0.0421 0.8286
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1368 0.1971 0.322
Loa Loa (eye worm) hypothetical protein 0.0499 0.0707 0.0707
Loa Loa (eye worm) TK/ROR protein kinase 0.0033 0.0029 0.0028
Onchocerca volvulus 0.002 0.001 0.0057
Mycobacterium leprae Possible secreted protease 0.0302 0.0421 1
Brugia malayi Furin-like cysteine rich region family protein 0.0469 0.0663 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0302 0.0421 0.0676
Mycobacterium ulcerans fatty acid synthase Fas 0.0017 0.0005 0.0062
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0026 0.0025
Loa Loa (eye worm) serpin 0.0017 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4208 0.6103 1
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0499 0.0707 0.0707
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0017 0.0005 0.013
Toxoplasma gondii histone deacetylase SIR2-like 0.0104 0.0132 0.2589
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0104 0.0132 0.1265
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0079 0.0096 0.0955
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Brugia malayi endochitinase 0.0074 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0027 0.002 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0049 0.0049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Toxoplasma gondii microneme protein MIC2 0.0023 0.0015 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Echinococcus multilocularis Mastin 0.002 0.001 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0302 0.0421 0.0676
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0703 0.1004 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0703 0.1004 0.1003
Onchocerca volvulus Putative cubilin 0.0046 0.0048 0.0561
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0017 0.0006 0.0099
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4208 0.6103 1
Echinococcus multilocularis C type lectin domian containing protein 0.004 0.0039 0.0048
Echinococcus multilocularis glycoprotein Antigen 5 0.002 0.001 0.0012
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0023 0.0015 0.0278
Schistosoma mansoni DNA helicase recq5 0.002 0.0011 0.001
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0024 0.0029
Echinococcus granulosus Estrogen regulated protein EP45 0.0017 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0045 0.0046 0.0046
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0027 0.002 0.0019
Mycobacterium ulcerans polyketide synthase Pks9 0.0033 0.0029 0.0355
Onchocerca volvulus 0.004 0.0039 0.0439
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0192 0.026 0.0259
Echinococcus granulosus MAM 0.0075 0.009 0.0089
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0035 0.0032 0.0613
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0074 0.0073
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0499 0.0707 0.0707
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.002 0.001 0.0009
Schistosoma mansoni cpg binding protein 0.0031 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0048 0.0048
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0108 0.0138 0.1371
Onchocerca volvulus 0.0031 0.0026 0.0262
Echinococcus granulosus C type lectin domian containing protein 0.004 0.0039 0.0039
Loa Loa (eye worm) proprotein convertase 2 0.167 0.2411 0.241
Giardia lamblia High cysteine protein 0.005 0.0054 0.0132
Brugia malayi BmSERPIN 0.0017 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Plasmodium vivax subtilisin-like protease 2, putative 0.0302 0.0421 0.7524
Plasmodium falciparum plasmepsin II 0.0035 0.0032 0.0569
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0063 0.0072 0.0072
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0008 0.0029
Echinococcus granulosus discoidin domain containing receptor 2 0.0045 0.0046 0.0046
Brugia malayi Integrin alpha pat-2 precursor 0.0149 0.0197 0.0197
Brugia malayi Protein arginine N-methyltransferase 0.0108 0.0138 0.0138
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0008 0.001
Schistosoma mansoni protein kinase 0.0248 0.0342 0.0341
Brugia malayi serpin 0.0017 0.0006 0.0005
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.0055 0.069
Trypanosoma cruzi subtilisin peptidase 0.0302 0.0421 0.4188
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0052 0.0057 0.1347
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0011 0.0014
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0045 0.0046 0.0062
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0192 0.026 0.4645
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Schistosoma mansoni cell polarity protein 0.002 0.001 0.0009
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0104 0.0132 0.0131
Onchocerca volvulus 0.0023 0.0015 0.0119
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.6887 1 1
Echinococcus granulosus protein jagged 2 0.002 0.001 0.0009
Brugia malayi Protein kinase domain containing protein 0.0075 0.009 0.0089
Echinococcus multilocularis integrin alpha ps 0.0032 0.0027 0.0033
Brugia malayi Endochitinase 0.0074 0.0088 0.0088
Toxoplasma gondii type I fatty acid synthase, putative 0.0038 0.0037 0.0711
Brugia malayi BmSERPIN, truncated 0.0017 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0053 0.0058 0.0058
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0026 0.0025
Mycobacterium ulcerans oxidoreductase 0.0101 0.0129 0.162
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0041 0.0041 0.0971
Schistosoma mansoni DNA helicase recq1 0.002 0.0011 0.001
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.0055 0.069
Brugia malayi hypothetical protein 0.0292 0.0406 0.0406
Brugia malayi Pre-SET motif family protein 0.021 0.0287 0.0286
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1368 0.1971 0.322
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0302 0.0421 0.042
Loa Loa (eye worm) transcriptional regulator 0.0104 0.0132 0.0131
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0009
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0019 0.0325
Giardia lamblia High cysteine membrane protein Group 2 0.2538 0.3673 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0011 0.0199
Echinococcus multilocularis c4b binding protein beta chain 0.004 0.0039 0.0048
Loa Loa (eye worm) hypothetical protein 0.0542 0.0769 0.0768
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0302 0.0421 0.5316
Trichomonas vaginalis hypothetical protein 0.1368 0.1971 0.322
Schistosoma mansoni glutaminase 0.0557 0.0791 0.079
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0008 0.0008
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0217 0.0297 0.0296
Entamoeba histolytica protein kinase, putative 0.0031 0.0026 0.0202
Schistosoma mansoni inositol transporter 0.0145 0.0192 0.0192
Schistosoma mansoni cpg binding protein 0.0031 0.0026 0.0026
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0703 0.1004 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0019 0.0181
Schistosoma mansoni integrin alpha 0.0149 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0101 0.0129 0.0128
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0302 0.0421 0.042
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0019
Brugia malayi serpin 0.0017 0.0006 0.0005
Echinococcus multilocularis neurogenic locus notch protein 0.002 0.001 0.0011
Plasmodium vivax thrombospondin-related anonymous protein 0.0023 0.0015 0.0252
Toxoplasma gondii subtilisin SUB9 0.0302 0.0421 0.8286
Brugia malayi hypothetical protein 0.002 0.001 0.0009
Schistosoma mansoni notch 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0032
Entamoeba histolytica SWIRM domain protein 0.0042 0.0042 0.0369
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0104 0.0132 0.0202
Loa Loa (eye worm) fatty acid synthase 0.0053 0.0058 0.0058
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0023 0.0015 0.0018
Brugia malayi hypothetical protein 0.0027 0.002 0.0019
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0145 0.0192 0.0239
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0026 0.045
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0072 0.0071
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.005 0.0054 0.0074
Schistosoma mansoni notch 0.002 0.001 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Loa Loa (eye worm) cuticular endochitinase 0.0074 0.0088 0.0088
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0026 0.0025
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.002 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0009
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0192 0.026 0.0259
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4208 0.6103 0.7619
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0052 0.0051
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0023 0.0015 0.001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0008 0.02
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0145 0.0192 0.0239
Echinococcus granulosus furin 0.6887 1 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.004 0.004 0.0497
Echinococcus multilocularis Tolloid protein 1 0.0053 0.0058 0.0072
Brugia malayi hypothetical protein 0.004 0.0039 0.0039
Onchocerca volvulus Slit protein homolog 0.002 0.001 0.0052
Brugia malayi hypothetical protein 0.004 0.0039 0.0039
Brugia malayi von Willebrand factor type A domain containing protein 0.0023 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0005
Brugia malayi serpin (BmSERPIN) 0.0017 0.0006 0.0005
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0077 0.0094 0.0093
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0703 0.1004 1
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0023 0.0015 0.0014
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0045 0.0046 0.0988
Echinococcus multilocularis discoidin domain containing receptor 2 0.0045 0.0046 0.0057
Brugia malayi von Willebrand factor type A domain containing protein 0.0023 0.0015 0.0014
Schistosoma mansoni serine protease inhibitors serpins 0.0017 0.0006 0.0005
Plasmodium vivax plasmepsin V, putative 0.0397 0.0559 1
Echinococcus multilocularis epidermal growth factor receptor 0.0469 0.0663 0.0827
Schistosoma mansoni dock 0.0045 0.0046 0.0046
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0023 0.0015 0.0014
Onchocerca volvulus Putative endochitinase 0.0074 0.0088 0.1084
Brugia malayi pregnancy-associated plasma protein-A 0.004 0.0039 0.0039
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0079 0.0096 0.1716
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0079 0.0096 0.1716
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0108 0.0138 0.2713
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0011 0.0013
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0035 0.0034
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0026 0.0496
Plasmodium falciparum LCCL domain-containing protein 0.0045 0.0046 0.0823
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0014
Schistosoma mansoni survival motor neuron protein 0.0049 0.0052 0.0051
Echinococcus granulosus protein jagged 1 0.002 0.001 0.0009
Plasmodium vivax LCCL domain-containing protein 0.0045 0.0046 0.0823
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0033 0.0029 0.0558
Brugia malayi Kringle domain containing protein 0.0033 0.0029 0.0028
Schistosoma mansoni cercarial elastase (S01 family) 0.002 0.001 0.0009
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0108 0.0138 0.0213
Loa Loa (eye worm) CUB domain-containing protein 0.0027 0.002 0.0019
Echinococcus multilocularis protein jagged 2 0.005 0.0054 0.0067
Onchocerca volvulus 0.0049 0.0052 0.0603
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0016 0.0004 0.009
Onchocerca volvulus Arrow homolog 0.0027 0.002 0.0183

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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