Detailed information for compound 579021

Basic information

Technical information
  • TDR Targets ID: 579021
  • Name: 1-(bromomethyl)-2,6,7-trimethyl-pyrazolo[1,2- a]pyrazole-3,5-dione
  • MW: 271.111 | Formula: C10H11BrN2O2
  • H donors: 0 H acceptors: 2 LogP: 1.4 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrCc1c(C)c(=O)n2n1c(C)c(c2=O)C
  • InChi: 1S/C10H11BrN2O2/c1-5-7(3)12-8(4-11)6(2)10(15)13(12)9(5)14/h4H2,1-3H3
  • InChiKey: AHEWZZJEDQVLOP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(bromomethyl)-2,6,7-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione
  • 1-(bromomethyl)-2,6,7-trimethyl-pyrazolo[1,2-a]pyrazole-3,5-quinone
  • monobromobimane
  • 71418-44-5
  • 9,10-Dioxa-syn-(bromomethyl,methyl)(methyl,methyl)bimane
  • NSC608544
  • THIOLYTE® MB Reagent
  • THIOLYTE® Monobromobimane Reagent, Fluorescent Labeling Compound
  • B4380_SIAL
  • nchembio801-comp1
  • 1H,7H-Pyrazolo(1,2-a)pyrazole-1,7-dione, 3-(bromomethyl)-2,5,6-trimethyl-
  • 3-(Bromomethyl)-2,5,6-trimethyl-1H,7H-pyrazolo(1,2-a)pyrazole-1,7-dione
  • Bromobimane
  • 69898_FLUKA
  • MBBR
  • Thiolyte MB

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC Curated by TDR Targets References
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans cysteinyl-tRNA synthetase Get druggable targets OG5_237682 All targets in OG5_237682
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC Get druggable targets OG5_237682 All targets in OG5_237682
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC Get druggable targets OG5_237682 All targets in OG5_237682
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 412 aa 353 aa 32.3 %
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 414 aa 378 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0014 0.0008 0.013
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0006 0.0078
Toxoplasma gondii endoplasmic reticulum oxidoreductin, putative 0.0052 0.0063 0.394
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0008 0.0684
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0045 0.0082
Echinococcus granulosus cysteinyl tRNA synthetase 0.0048 0.0058 0.2046
Trichomonas vaginalis helicase, putative 0.0013 0.0007 0.0103
Echinococcus granulosus microsomal glutathione S transferase 3 0.0114 0.0154 0.5709
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0006
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0008 0.0269
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0191 0.0267 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0007 0.0103
Leishmania major DNA polymerase eta, putative 0.0039 0.0045 0.1504
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0008 0.0006
Leishmania major endoplasmic reticulum oxidoreductin, putative 0.0052 0.0063 0.2215
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.6288 0.9177 0.9177
Loa Loa (eye worm) hypothetical protein 0.0054 0.0067 0.2022
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0039
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0103
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0008 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0006
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0045 0.1504
Loa Loa (eye worm) hypothetical protein 0.0048 0.0058 0.1735
Echinococcus multilocularis dna polymerase eta 0.0039 0.0045 0.1542
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0058 0.0109
Schistosoma mansoni brg-1 associated factor 0.0011 0.0004 0.0039
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0045 0.1542
Plasmodium falciparum cysteine--tRNA ligase 0.0048 0.0058 0.9097
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0781 0.1129 0.2337
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0154
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0008 0.0154
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0048 0.0058 0.2011
Schistosoma mansoni DNA polymerase eta 0.0039 0.0045 0.0397
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0037 0.0032
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0008 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0048 0.0058 0.2011
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0103
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0039
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0008 0.0684
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0191 0.0267 0.8478
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0009 0.0079
Echinococcus granulosus geminin 0.0169 0.0235 0.8777
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0009 0.0173
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0057 0.2018
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.3296 0.4805 0.4802
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0126 0.4632
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0008 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0058 0.2003
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0008 0.0154
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.3296 0.4805 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0006
Trypanosoma brucei unspecified product 0.0039 0.0045 0.1504
Loa Loa (eye worm) MBCTL1 0.0054 0.0067 0.2022
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Mycobacterium ulcerans hypothetical protein 0.0048 0.0058 0.0109
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0045 0.1504
Loa Loa (eye worm) hypothetical protein 0.0039 0.0045 0.1307
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0006 0.0049
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.004 0.6064
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0045 0.0397
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0058 0.2038
Trypanosoma cruzi polo-like protein kinase, putative 0.0191 0.0267 1
Echinococcus multilocularis geminin 0.0169 0.0235 0.8777
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0067 0.2385
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.0003
Echinococcus granulosus leucyl tRNA synthetase 0.0048 0.0058 0.2046
Brugia malayi mbt repeat family protein 0.0048 0.0057 0.2018
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0058 0.1914
Plasmodium vivax cysteine--tRNA ligase, putative 0.0048 0.0058 0.9097
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0058 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0037 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0038
Loa Loa (eye worm) hypothetical protein 0.0052 0.0063 0.1907
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0218 0.0307 0.232
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0267 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.013
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0154
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0008 0.0003
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0008 0.0006
Schistosoma mansoni ero1-related 0.0052 0.0063 0.0561
Schistosoma mansoni hypothetical protein 0.0169 0.0235 0.2079
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0006 0.0198
Trypanosoma cruzi DNA repair protein, putative 0.0067 0.0086 0.3078
Toxoplasma gondii MAPEG family protein 0.0114 0.0154 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0058 0.2038
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0008 0.011
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.0003
Schistosoma mansoni cpg binding protein 0.0061 0.0078 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0267 0.2363
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0045 0.1542
Giardia lamblia Cysteinyl-tRNA synthetase 0.0048 0.0058 0.2011
Onchocerca volvulus 0.0048 0.0058 0.2038
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.1156
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0048 0.0058 0.2046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0058 0.1728
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.1156
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0149 0.9623
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0008 0.0154
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0007 0.0103
Loa Loa (eye worm) hypothetical protein 0.0048 0.0058 0.1728
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0045 0.0039
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0008 0.011
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0006 0.0198
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0009 0.0173
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0048 0.0058 0.1922
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0058 0.2003
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0045 0.1542
Echinococcus granulosus dna polymerase kappa 0.0039 0.0045 0.1542
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0045 0.1504
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0154
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0008 0.0269
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0048 0.0058 0.3584
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0008 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0045 0.0082
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0045 0.1504
Echinococcus granulosus Endoplasmic reticulum oxidoreductin 1 0.0052 0.0063 0.2249
Schistosoma mansoni hypothetical protein 0.0169 0.0235 0.2079
Onchocerca volvulus 0.0014 0.0008 0.0154
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0008 0.0154
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.1156
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0014 0.0358
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0007 0.0103
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0048 0.0058 0.2046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0058 0.0103
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0045 0.1504
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0168 0.1486
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.1156
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0057 0.2018
Chlamydia trachomatis cysteine--tRNA ligase 0.0048 0.0058 0.0477
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0073 0.2206
Treponema pallidum recombinase A 0.0218 0.0307 0.232
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0103
Trypanosoma cruzi polo-like protein kinase, putative 0.0191 0.0267 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0008 0.0006
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0045 0.1542
Brugia malayi CXXC zinc finger family protein 0.0058 0.0073 0.2602
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0008 0.0006
Onchocerca volvulus 0.0048 0.0057 0.2018
Echinococcus multilocularis cpg binding protein 0.0061 0.0078 0.2786
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0058 0.0052
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0008 0.011
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0008 0.0074
Onchocerca volvulus Serine\/threonine kinase homolog 0.0191 0.0267 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0057 0.0508
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0267 1
Schistosoma mansoni microsomal glutathione s-transferase 0.0114 0.0154 0.1365
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.004 0.6064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0007 0.0103
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0008 0.0154
Onchocerca volvulus 0.0014 0.0008 0.0154
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0037 0.0032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0058 0.1728
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.1156
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0781 0.1129 1
Schistosoma mansoni cpg binding protein 0.0058 0.0073 0.0643
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0114 0.0154 0.5709
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0027 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Schistosoma mansoni kinase 0.0097 0.013 0.1148
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0058 0.0052
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.004 0.0035
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0067 0.2385
Trypanosoma brucei unspecified product 0.0027 0.0027 0.0827
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0058 0.0109
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0267 1
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0039
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.0003
Schistosoma mansoni Replicative DNA helicase 0.0781 0.1129 1
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0267 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0057 0.0508
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0267 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0008 0.011
Giardia lamblia DINP protein human, muc B family 0.0039 0.0045 0.1504
Trypanosoma cruzi endoplasmic reticulum oxidoreductin, putative 0.0052 0.0063 0.2215
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0008 0.011
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0045 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0103
Echinococcus granulosus cpg binding protein 0.0061 0.0078 0.2786
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0126 0.4632
Schistosoma mansoni hypothetical protein 0.0289 0.041 0.3634
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0191 0.0267 1
Trypanosoma cruzi DNA repair protein, putative 0.0067 0.0086 0.3078
Plasmodium vivax endoplasmic reticulum oxidoreductin, putative 0.0052 0.0063 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0008 0.0006
Trypanosoma brucei polo-like protein kinase 0.0191 0.0267 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0048 0.0058 0.0514
Mycobacterium leprae Conserved hypothetical protein 0.2303 0.3354 0.6975
Entamoeba histolytica serine/threonine protein kinase, putative 0.0191 0.0267 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0045 0.1307
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0027 0.0827
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0007 0.0103
Onchocerca volvulus 0.0014 0.0008 0.0154
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0154
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0262 0.9805
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0103
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0009 0.0173
Brugia malayi polk-prov protein 0.0012 0.0006 0.0045
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0048 0.0058 0.1735
Chlamydia trachomatis replicative DNA helicase 0.0781 0.1129 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0008 0.0269
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0067 0.0593
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0048 0.0058 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0009 0.0173
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0057 0.2018
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0058 0.0109
Loa Loa (eye worm) twinkle helicase 0.0223 0.0314 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0058 0.2038
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.004 0.0072
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0058 0.0109
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0007 0.0103
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0045 0.141
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0008 0.013
Echinococcus multilocularis Endoplasmic reticulum oxidoreductin 1 0.0052 0.0063 0.2249
Brugia malayi Endoplasmic Reticulum Oxidoreductin 1 0.0052 0.0063 0.2249
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.3296 0.4805 1
Plasmodium falciparum cysteine--tRNA ligase 0.0048 0.0058 0.9097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0058 0.1914
Giardia lamblia Kinase, PLK 0.0191 0.0267 1
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0057 0.2018
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0067 0.2385
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0006 0.0078
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0191 0.0267 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0006
Trypanosoma brucei unspecified product 0.0027 0.0027 0.0827
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0006 0.0078
Mycobacterium ulcerans recombinase A 0.0218 0.0307 0.0627
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0014 0.037
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0058 0.2003
Onchocerca volvulus 0.0058 0.0073 0.2602
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0014 0.0314
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0218 0.0307 0.0622
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0008 0.0003
Brugia malayi mbt repeat family protein 0.0048 0.0057 0.2018
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0048 0.0057 0.1711
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0008 0.011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0014 0.037
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0045 0.0397
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0007 0.0103
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0048 0.0058 0.0514
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0008 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0058 0.0109
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0058 0.1914
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0057 0.2018
Leishmania major cysteinyl-tRNA synthetase, putative 0.0048 0.0058 0.2011
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0045 0.1542
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0058 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0103
Echinococcus granulosus dna polymerase eta 0.0039 0.0045 0.1542
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0008 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0037 0.0032
Onchocerca volvulus 0.0048 0.0058 0.2046
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0497 0.0714 0.6321
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0008 0.0003
Treponema pallidum replicative DNA helicase (dnaB) 0.0781 0.1129 1
Plasmodium falciparum endoplasmic reticulum oxidoreductin, putative 0.0052 0.0063 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0007 0.0103
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0057 0.1711
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0057 0.0508
Chlamydia trachomatis recombinase RecA 0.0218 0.0307 0.2686
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0067 0.0086 0.3078
Onchocerca volvulus 0.0014 0.0008 0.0154
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0781 0.1129 0.2342
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0008 0.011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0058 0.0109
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0048 0.0058 0.2046
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0067 0.2385
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0262 0.9805
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0048 0.0058 0.2011
Leishmania major DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0267 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0008 0.013
Brugia malayi serine/threonine-protein kinase plk-2 0.0191 0.0267 1
Trypanosoma brucei pol-associated gene 1 0.0052 0.0063 0.2215
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0027 0.0827
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0006
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0008 0.0006
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0008 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0191 0.0267 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0008 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0045 0.1504
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.004 0.0318
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0045 0.1542
Schistosoma mansoni cpg binding protein 0.0061 0.0078 0.0686
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0045 0.1504
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0008 0.011
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0067 0.2385
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0008 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0045 0.1542

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
response to drug (GO:0042493) increased sensitivity toward (PATO:0001549) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis 257260  
Annotator: crowther@u.washington.edu Comment: 2007-12-26 References: 12384335
response to drug (GO:0042493) increased sensitivity toward (PATO:0001549) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis 6539  
Annotator: crowther@u.washington.edu Comment: 2007-12-26 References: 12384335

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.