Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0468 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0333 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0333 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0333 | 0 | 0.5 |
Onchocerca volvulus | 0.0333 | 0 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0468 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0333 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0333 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0468 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0468 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0333 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0468 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0333 | 0 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0333 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | The compound was tested for inhibition of human renal renin at the pH optimum 6.0; ND means no data | ChEMBL. | 3305946 |
Inhibition (binding) | 0 % | The compound was tested for inhibition of pepsin at the concentration of 10e-5 M; ND means no data | ChEMBL. | 3305946 |
Inhibition (binding) | = 21 % | Inhibition of human renal renin at the concentration of 10e-5 M. | ChEMBL. | 3305946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.