Detailed information for compound 57942

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.16 | Formula: C16H11BrO4
  • H donors: 1 H acceptors: 3 LogP: 3.59 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CBr)cc2c1C(=O)c1c(C2=O)cccc1O
  • InChi: 1S/C16H11BrO4/c1-21-12-6-8(7-17)5-10-14(12)16(20)13-9(15(10)19)3-2-4-11(13)18/h2-6,18H,7H2,1H3
  • InChiKey: OPPWKFBLDSSZLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0141 0.1652 0.3338
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.018 0.2148 0.5061
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0352 0.0897
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Brugia malayi putative neuropeptide receptor NPR1 0.018 0.2148 0.5061
Echinococcus multilocularis neuropeptide s receptor 0.0624 0.7793 0.7793
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.1415 0.1413
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Onchocerca volvulus 0.018 0.2148 0.5058
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2057 0.6338
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Echinococcus multilocularis G protein coupled receptor 139 0.018 0.2148 0.2147
Brugia malayi neuropeptide F receptor 0.018 0.2148 0.5061
Loa Loa (eye worm) hypothetical protein 0.0159 0.1882 0.4432
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1214 0.2739
Onchocerca volvulus 0.018 0.2148 0.5058
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1945 0.5981
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0063 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0294 0.0542
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3035 0.9458
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Schistosoma mansoni biogenic amine (5HT) receptor 0.018 0.2148 0.3986
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0352 0.0351
Toxoplasma gondii thioredoxin reductase 0.0047 0.0457 0.0648
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Schistosoma mansoni cpg binding protein 0.0032 0.0276 0.0508
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0197 0.0461
Brugia malayi hypothetical protein 0.0246 0.299 0.7045
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Schistosoma mansoni opsin-like receptor 0.018 0.2148 0.3986
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0352 0.0674
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3035 0.9458
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0113
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0071 0.5
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Schistosoma mansoni hypothetical protein 0.018 0.2148 0.3986
Onchocerca volvulus 0.018 0.2148 0.5058
Echinococcus multilocularis neuropeptide receptor A26 0.0624 0.7793 0.7793
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1415 0.3219
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0113
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0071 0.0127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0063 0.0062
Echinococcus granulosus neuropeptide receptor 0.018 0.2148 0.2755
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0352 0.0649
Brugia malayi beta-lactamase family protein 0.0038 0.0352 0.0829
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0006
Schistosoma mansoni neuropeptide receptor 0.018 0.2148 0.3986
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.018 0.2148 0.5059
Schistosoma mansoni amine GPCR 0.018 0.2148 0.3986
Echinococcus granulosus serotonin receptor 0.018 0.2148 0.2755
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.018 0.2148 0.3986
Schistosoma mansoni rhodopsin-like orphan GPCR 0.018 0.2148 0.3986
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.018 0.2148 0.5059
Leishmania major hypothetical protein, conserved 0.0038 0.0352 0.0472
Onchocerca volvulus 0.018 0.2148 0.5058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0006
Echinococcus granulosus neuropeptide receptor 0.018 0.2148 0.2755
Schistosoma mansoni cpg binding protein 0.0031 0.0254 0.0467
Schistosoma mansoni hypothetical protein 0.0034 0.0292 0.0538
Echinococcus granulosus sex peptide receptor 0.018 0.2148 0.2755
Echinococcus granulosus dro:myosuppressin receptor 0.018 0.2148 0.2755
Brugia malayi G protein-coupled receptor F59B2.13 0.018 0.2148 0.5061
Schistosoma mansoni adenoreceptor 0.018 0.2148 0.3986
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0485 0.603 1
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0345 0.4245 1
Onchocerca volvulus 0.0026 0.0197 0.0458
Echinococcus granulosus dnaJ subfamily B 0.0435 0.5387 0.6911
Schistosoma mansoni neuropeptide receptor 0.018 0.2148 0.3986
Echinococcus granulosus neuropeptides capa receptor 0.018 0.2148 0.2755
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0071 0.0089
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0026 0.0031
Trichomonas vaginalis set domain proteins, putative 0.0263 0.3205 1
Echinococcus granulosus tm gpcr rhodopsin 0.018 0.2148 0.2755
Brugia malayi Dopamine receptor protein 2 0.018 0.2148 0.5061
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.018 0.2148 0.3986
Echinococcus multilocularis allatostatin A receptor 0.018 0.2148 0.2147
Mycobacterium tuberculosis Conserved protein 0.0038 0.0352 0.0674
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0003 0.0002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0026 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1945 0.5981
Echinococcus granulosus rhodopsin orphan GPCR 0.018 0.2148 0.2755
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.018 0.2148 0.2755
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.1415 0.2255
Echinococcus multilocularis g-protein coupled receptor 0.018 0.2148 0.2147
Schistosoma mansoni biogenic amine receptor 0.018 0.2148 0.3986
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0352 0.0674
Brugia malayi nuclear hormone receptor 0.0011 0.0003 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.018 0.2148 0.2147
Loa Loa (eye worm) hypothetical protein 0.0034 0.0294 0.069
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0003 0.0001
Brugia malayi Dihydrofolate reductase 0.0141 0.1652 0.3891
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0352 0.0897
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Brugia malayi Thioredoxin reductase 0.0047 0.0457 0.1077
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.1415 0.3219
Echinococcus granulosus g protein coupled receptor 0.018 0.2148 0.2755
Loa Loa (eye worm) hypothetical protein 0.0159 0.1882 0.4432
Onchocerca volvulus 0.018 0.2148 0.5058
Onchocerca volvulus 0.018 0.2148 0.5058
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0352 0.0674
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0352 0.0674
Schistosoma mansoni neuropeptide receptor 0.018 0.2148 0.3986
Echinococcus granulosus g protein coupled receptor 0.018 0.2148 0.2755
Leishmania major trypanothione reductase 0.0047 0.0457 0.0648
Schistosoma mansoni myosin xvIII 0.018 0.2148 0.3986
Echinococcus granulosus 7tm_1 domain containing protein 0.018 0.2148 0.2755
Schistosoma mansoni rhodopsin-like orphan GPCR 0.018 0.2148 0.3986
Schistosoma mansoni rhodopsin-like orphan GPCR 0.018 0.2148 0.3986
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0002
Schistosoma mansoni opsin-like receptor 0.018 0.2148 0.3986
Echinococcus granulosus rhodopsin orphan GPCR 0.018 0.2148 0.2755
Brugia malayi nuclear receptor NHR-88 0.0011 0.0003 0.0006
Echinococcus multilocularis neuropeptide FF receptor 2 0.018 0.2148 0.2147
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0352 0.0674
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.018 0.2148 0.2147
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1365 0.3099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.018 0.2148 0.3986
Schistosoma mansoni intermediate filament proteins 0.0026 0.0197 0.0361
Brugia malayi G protein-coupled receptor 0.018 0.2148 0.5061
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Echinococcus granulosus tm gpcr rhodopsin 0.018 0.2148 0.2755
Schistosoma mansoni neuropeptide F-like receptor 0.018 0.2148 0.3986
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.018 0.2148 0.5061
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.3035 0.7149
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1214 0.2739
Schistosoma mansoni neuropeptide receptor 0.018 0.2148 0.3986
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.027 0.0345
Echinococcus multilocularis neuropeptide receptor 0.018 0.2148 0.2147
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0352 0.0897
Echinococcus multilocularis rhodopsin orphan GPCR 0.018 0.2148 0.2147
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Schistosoma mansoni opsin-like receptor 0.018 0.2148 0.3986
Echinococcus granulosus intermediate filament protein 0.0026 0.0197 0.0251
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0345 0.4245 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0063 0.0079
Plasmodium falciparum thioredoxin reductase 0.0047 0.0457 0.0648
Echinococcus multilocularis sex peptide receptor 0.018 0.2148 0.2147
Echinococcus granulosus neuropeptide FF receptor 2 0.018 0.2148 0.2755
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.018 0.2148 0.2147
Echinococcus granulosus hypothetical protein 0.018 0.2148 0.2755
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0294 0.0375
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0485 0.603 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.018 0.2148 0.2147
Loa Loa (eye worm) hypothetical protein 0.0246 0.299 0.7044
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0457 0.0925
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0591 0.0873
Echinococcus granulosus muscleblind protein 0.0159 0.1882 0.2414
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0352 0.0674
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.1415 0.1814
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0113
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0057
Loa Loa (eye worm) dihydrofolate reductase 0.0141 0.1652 0.3889
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.2801 0.6597
Echinococcus granulosus rhodopsin orphan GPCR 0.018 0.2148 0.2755
Onchocerca volvulus 0.018 0.2148 0.5058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0006
Echinococcus granulosus tm gpcr rhodopsin 0.018 0.2148 0.2755
Brugia malayi Dopamine receptor protein 1 0.018 0.2148 0.5061
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0191 0.0244
Onchocerca volvulus 0.018 0.2148 0.5058
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0352 0.0826
Echinococcus granulosus rhodopsin orphan GPCR 0.018 0.2148 0.2755
Loa Loa (eye worm) follicle stimulating hormone receptor 0.018 0.2148 0.5059
Brugia malayi RE15519p 0.018 0.2148 0.5061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0026 0.0191 0.0351
Brugia malayi hypothetical protein 0.0057 0.0591 0.1393
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1945 0.5981
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0002
Echinococcus multilocularis g protein coupled receptor 0.018 0.2148 0.2147
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0003 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.018 0.2148 0.3986
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1214 0.2739
Echinococcus multilocularis rhodopsin orphan GPCR 0.018 0.2148 0.2147
Onchocerca volvulus 0.018 0.2148 0.5058
Echinococcus multilocularis serotonin receptor 0.018 0.2148 0.2147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0352 0.0826
Echinococcus granulosus neuropeptides capa receptor 0.018 0.2148 0.2755
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Echinococcus granulosus thymidylate synthase 0.0345 0.4245 0.5446
Echinococcus granulosus rhodopsin orphan GPCR 0.018 0.2148 0.2755
Trichomonas vaginalis esterase, putative 0.0038 0.0352 0.0897
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0254 0.0594
Plasmodium vivax SET domain protein, putative 0.0034 0.0294 0.0375
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0591 0.0873
Brugia malayi Melatonin receptor type 1A 0.018 0.2148 0.5061
Schistosoma mansoni hypothetical protein 0.0435 0.5387 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0003 0.0001
Loa Loa (eye worm) thymidylate synthase 0.0345 0.4245 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0003 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0591 0.0873
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0003 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.018 0.2148 0.3986
Schistosoma mansoni amine GPCR 0.018 0.2148 0.3986
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.018 0.2148 0.2147
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0352 0.0897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.018 0.2148 0.3986
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1945 0.5981
Leishmania major hypothetical protein, conserved 0.0057 0.0591 0.0873
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1415 0.2623
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.018 0.2148 0.5059
Echinococcus granulosus biogenic amine 5HT receptor 0.018 0.2148 0.2755
Echinococcus multilocularis cpg binding protein 0.0032 0.0276 0.0274
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0006
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.018 0.2148 0.3986
Schistosoma mansoni peptide (allatostatin)-like receptor 0.018 0.2148 0.3986
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.018 0.2148 0.3986
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.018 0.2148 0.2147
Onchocerca volvulus 0.0034 0.0294 0.0688
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Brugia malayi G-protein coupled receptor 0.018 0.2148 0.5061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.018 0.2148 0.3986
Brugia malayi Dopamine receptor 0.018 0.2148 0.5061
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Schistosoma mansoni hypothetical protein 0.018 0.2148 0.3986
Brugia malayi gonadotropin-releasing hormone receptor 2 0.018 0.2148 0.5061
Brugia malayi Serotonin receptor 0.018 0.2148 0.5061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0294 0.0542
Loa Loa (eye worm) hypothetical protein 0.0026 0.0191 0.0447
Echinococcus multilocularis neuropeptide Y receptor 0.018 0.2148 0.2147
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0485 0.603 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0352 0.0826
Mycobacterium ulcerans hypothetical protein 0.0038 0.0352 0.0674
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0457 0.0456
Echinococcus multilocularis g protein coupled receptor 0.018 0.2148 0.2147
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1945 0.5981
Mycobacterium tuberculosis Conserved protein 0.0038 0.0352 0.0674
Schistosoma mansoni amine GPCR 0.018 0.2148 0.3986
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Echinococcus multilocularis thymidylate synthase 0.0345 0.4245 0.4244
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.1949 0.5993
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0352 0.0897
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0003 0.0001
Onchocerca volvulus Neuropeptide F receptor homolog 0.018 0.2148 0.5058
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0352 0.045
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0352 0.0829
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0591 0.0873
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0006
Schistosoma mansoni biogenic amine (5HT) receptor 0.018 0.2148 0.3986
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0591 0.0873
Mycobacterium ulcerans thymidylate synthase 0.0345 0.4245 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0457 0.0585
Brugia malayi glutathione reductase 0.0047 0.0457 0.1077
Echinococcus multilocularis rhodopsin orphan GPCR 0.018 0.2148 0.2147
Echinococcus granulosus orexin receptor type 2 0.018 0.2148 0.2755
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0063 0.0079
Brugia malayi AKH receptor 0.018 0.2148 0.5061
Echinococcus multilocularis neuropeptides capa receptor 0.018 0.2148 0.2147
Echinococcus granulosus neuropeptide receptor A26 0.0624 0.7793 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0294 0.0542
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0294 0.0542
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0352 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0002
Schistosoma mansoni lamin 0.0026 0.0197 0.0361
Plasmodium falciparum glutathione reductase 0.0047 0.0457 0.0648
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0345 0.4245 0.7879
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0457 0.0648
Schistosoma mansoni growth hormone secretagogue receptor 0.018 0.2148 0.3986
Schistosoma mansoni lamin 0.0026 0.0197 0.0361
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0071 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0197 0.0464
Loa Loa (eye worm) neuropeptide F receptor 0.018 0.2148 0.5059
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.018 0.2148 0.2755
Echinococcus multilocularis rhodopsin orphan GPCR 0.018 0.2148 0.2147
Echinococcus multilocularis neuropeptide receptor 0.018 0.2148 0.2147
Brugia malayi thymidylate synthase 0.0345 0.4245 1
Brugia malayi follicle stimulating hormone receptor 0.018 0.2148 0.5061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0352 0.0826
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0352 0.0674
Brugia malayi CXXC zinc finger family protein 0.0031 0.0254 0.0598
Echinococcus multilocularis GPCR, family 2 0.0016 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0043 0.0099
Brugia malayi steroid hormone receptor 0.0011 0.0003 0.0006
Echinococcus granulosus allatostatin A receptor 0.018 0.2148 0.2755
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2057 0.6338
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0006
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0164 0.1949 0.3152
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0003 0.0001
Onchocerca volvulus 0.0031 0.0254 0.0592
Schistosoma mansoni neuropeptide F-like receptor 0.018 0.2148 0.3986
Echinococcus granulosus cpg binding protein 0.0032 0.0276 0.0352
Echinococcus multilocularis orexin receptor type 2 0.018 0.2148 0.2147
Echinococcus multilocularis lamin dm0 0.0026 0.0197 0.0196
Echinococcus multilocularis muscleblind protein 0.0159 0.1882 0.1881
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0457 0.0648
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.018 0.2148 0.3986
Loa Loa (eye worm) neuropeptide F receptor 0.018 0.2148 0.5059
Schistosoma mansoni cpg binding protein 0.0032 0.0276 0.0508
Onchocerca volvulus 0.0026 0.0197 0.0458
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Echinococcus granulosus alpha 1A adrenergic receptor 0.018 0.2148 0.2755
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.3035 0.715
Brugia malayi hypothetical protein 0.0164 0.1949 0.4592
Mycobacterium tuberculosis Probable reductase 0.0106 0.1214 0.2739
Echinococcus multilocularis neuropeptides capa receptor 0.018 0.2148 0.2147
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0616 0.0915
Echinococcus multilocularis G-protein coupled receptor, putative 0.018 0.2148 0.2147
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1365 0.3099
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.018 0.2148 0.3986
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Onchocerca volvulus Huntingtin homolog 0.0246 0.299 0.7043
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) hypothetical protein 0.0246 0.299 0.7044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.018 0.2148 0.3986
Echinococcus granulosus neuropeptide Y receptor 0.018 0.2148 0.2755
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0294 0.0293
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.018 0.2148 0.3986
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0197 0.0461
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0141 0.1652 0.3787
Echinococcus multilocularis dro:myosuppressin receptor 0.018 0.2148 0.2147
Loa Loa (eye worm) G-protein coupled receptor 0.018 0.2148 0.5059
Brugia malayi Tachykinin-like peptides receptor 99D 0.018 0.2148 0.5061
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Onchocerca volvulus 0.018 0.2148 0.5058
Loa Loa (eye worm) beta-lactamase 0.0038 0.0352 0.0826
Echinococcus multilocularis dihydrofolate reductase 0.0141 0.1652 0.165
Brugia malayi dihydrofolate reductase family protein 0.0141 0.1652 0.3891
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3035 0.9458
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Toxoplasma gondii ABC1 family protein 0.0038 0.0352 0.0472
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0352 0.0674
Onchocerca volvulus 0.018 0.2148 0.5058
Treponema pallidum NADH oxidase 0.0016 0.0071 0.5
Schistosoma mansoni biogenic amine receptor 0.018 0.2148 0.3986
Brugia malayi Pre-SET motif family protein 0.0034 0.0294 0.0693
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Schistosoma mansoni hypothetical protein 0.018 0.2148 0.3986
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1415 0.3219
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0352 0.0472
Onchocerca volvulus Huntingtin homolog 0.0246 0.299 0.7043
Trypanosoma brucei trypanothione reductase 0.0047 0.0457 0.0648
Brugia malayi Pre-SET motif family protein 0.0231 0.2801 0.6598
Loa Loa (eye worm) G-protein coupled receptor 0.018 0.2148 0.5059
Schistosoma mansoni neuropeptide f receptor 76f 0.018 0.2148 0.3986
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0063 0.0149
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0461
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.018 0.2148 0.2147
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0352 0.0674
Echinococcus granulosus somatostatin receptor 0.018 0.2148 0.2755
Schistosoma mansoni hypothetical protein 0.0016 0.0063 0.0113
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0017 0.0039
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.018 0.2148 0.2755
Echinococcus multilocularis lamin 0.0026 0.0197 0.0196
Echinococcus multilocularis rhodopsin orphan GPCR 0.018 0.2148 0.2147
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3035 0.9458
Loa Loa (eye worm) hypothetical protein 0.0038 0.0352 0.0826
Onchocerca volvulus 0.0038 0.0352 0.0824
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0003 0.0006
Echinococcus granulosus neuropeptide s receptor 0.0624 0.7793 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0003 0.0002
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0485 0.603 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0352 0.0472
Echinococcus multilocularis alpha 1A adrenergic receptor 0.018 0.2148 0.2147
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0043 0.0102
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0352 0.0649
Brugia malayi Serotonin receptor 0.018 0.2148 0.5061
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1214 0.2739
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0489 0.1152
Echinococcus granulosus neuropeptide Y receptor 0.018 0.2148 0.2755
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0591 0.0873
Schistosoma mansoni rhodopsin-like orphan GPCR 0.018 0.2148 0.3986
Echinococcus granulosus G protein coupled receptor 139 0.018 0.2148 0.2755
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0003 0.0001
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0003 0.0001
Brugia malayi ecdysteroid receptor 0.0011 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Brugia malayi beta-lactamase 0.0038 0.0352 0.0829
Echinococcus multilocularis fmrfamide receptor 0.018 0.2148 0.2147
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0457 0.1074
Onchocerca volvulus 0.018 0.2148 0.5058
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1365 0.2601
Mycobacterium ulcerans lipase LipD 0.0038 0.0352 0.0674
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0071 0.0069
Onchocerca volvulus 0.0345 0.4245 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0071 0.0167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0071 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.018 0.2148 0.2755
Brugia malayi G-protein coupled receptor 0.018 0.2148 0.5061
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0352 0.0472
Brugia malayi ORL1-like opioid receptor 0.018 0.2148 0.5061
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.018 0.2148 0.2147
Echinococcus multilocularis serotonin receptor 0.018 0.2148 0.2147
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0003 0.0006
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.018 0.2148 0.2755
Chlamydia trachomatis dihydrofolate reductase 0.0141 0.1652 1
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) hypothetical protein 0.0034 0.0292 0.0685
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Onchocerca volvulus 0.0038 0.0352 0.0824
Brugia malayi neuropeptide F receptor 0.018 0.2148 0.5061
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0489 0.1149
Schistosoma mansoni dihydrofolate reductase 0.0141 0.1652 0.3063
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1365 0.3099
Echinococcus multilocularis tachykinin peptides receptor 99D 0.018 0.2148 0.2147
Onchocerca volvulus 0.018 0.2148 0.5058
Schistosoma mansoni amine GPCR 0.018 0.2148 0.3986
Echinococcus multilocularis muscleblind protein 1 0.0159 0.1882 0.1881
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.1945 0.4579
Echinococcus granulosus fmrfamide receptor 0.018 0.2148 0.2755
Loa Loa (eye worm) hypothetical protein 0.0049 0.0489 0.1149
Schistosoma mansoni biogenic amine receptor 0.018 0.2148 0.3986
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Schistosoma mansoni amine GPCR 0.018 0.2148 0.3986
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Echinococcus granulosus GPCR family 2 0.0016 0.0063 0.0079
Echinococcus granulosus tachykinin peptides receptor 99D 0.018 0.2148 0.2755
Schistosoma mansoni alpha-1 adrenergic receptor 0.018 0.2148 0.3986
Onchocerca volvulus 0.018 0.2148 0.5058
Onchocerca volvulus 0.0038 0.0352 0.0824
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0003 0.0001
Mycobacterium tuberculosis Hypothetical protein 0.0164 0.1949 0.45
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0003 0.0001
Echinococcus multilocularis fmrfamide receptor 0.018 0.2148 0.2147
Onchocerca volvulus 0.018 0.2148 0.5058
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.018 0.2148 0.2147
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0485 0.603 1
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3035 0.9458
Brugia malayi sulfakinin receptor protein 0.018 0.2148 0.5061
Brugia malayi Serotonin/octopamine receptor family protein 7 0.018 0.2148 0.5061
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.018 0.2148 0.3986
Loa Loa (eye worm) melatonin receptor type 1A 0.018 0.2148 0.5059
Echinococcus granulosus lamin 0.0026 0.0197 0.0251
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1214 0.2214
Echinococcus granulosus peptide allatostatin:somatostatin 0.018 0.2148 0.2755
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Brugia malayi putative neuropeptide receptor 0.018 0.2148 0.5061
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0591 0.0873
Echinococcus granulosus thyrotropin releasing hormone receptor 0.018 0.2148 0.2755
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0591 0.1389
Echinococcus multilocularis biogenic amine (5HT) receptor 0.018 0.2148 0.2147
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0292 0.0688
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3035 0.9458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.018 0.2148 0.2147
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0294 0.0293
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.018 0.2148 0.2147
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0003 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0003 0.0001
Brugia malayi hypothetical protein 0.0037 0.0334 0.0787
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0489 0.1152
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0294 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.018 0.2148 0.3986
Schistosoma mansoni histamine h1 receptor 0.018 0.2148 0.3986
Echinococcus granulosus dihydrofolate reductase 0.0141 0.1652 0.2118
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Mycobacterium ulcerans beta-lactamase 0.0038 0.0352 0.0674
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0352 0.0826
Brugia malayi Muscleblind-like protein 0.0159 0.1882 0.4434
Echinococcus multilocularis rhodopsin orphan GPCR 0.018 0.2148 0.2147
Echinococcus multilocularis musashi 0.0026 0.0197 0.0196
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0141 0.1652 0.3787
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0003 0.0006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.1415 0.2255
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Echinococcus granulosus g protein coupled receptor 0.018 0.2148 0.2755
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0704 0.1302
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0485 0.603 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Echinococcus granulosus 7TM GPCR rhodopsin 0.018 0.2148 0.2755
Echinococcus multilocularis somatostatin receptor 0.018 0.2148 0.2147
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.018 0.2148 0.2147
Echinococcus multilocularis g protein coupled receptor 0.018 0.2148 0.2147
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.018 0.2148 0.5059
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.018 0.2148 0.5058
Plasmodium vivax glutathione reductase, putative 0.0047 0.0457 0.0648
Onchocerca volvulus 0.018 0.2148 0.5058
Echinococcus multilocularis neuropeptide Y receptor 0.018 0.2148 0.2147
Schistosoma mansoni hypothetical protein 0.018 0.2148 0.3986
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.018 0.2148 0.2755
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1945 0.5981
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1415 0.3219
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.2971 0.6947
Echinococcus granulosus lamin dm0 0.0026 0.0197 0.0251
Loa Loa (eye worm) TYRA-2 protein 0.018 0.2148 0.5059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0352 0.0826
Echinococcus multilocularis dnaJ subfamily B 0.0435 0.5387 0.5386
Echinococcus granulosus g-protein coupled receptor 0.018 0.2148 0.2755
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.018 0.2148 0.2147
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0063 0.0146
Brugia malayi intermediate filament protein 0.0026 0.0197 0.0464
Brugia malayi GnHR receptor homolog 0.018 0.2148 0.5061
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1415 0.2623
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.018 0.2148 0.3986
Echinococcus granulosus rhodopsin orphan GPCR 0.018 0.2148 0.2755
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.018 0.2148 0.3986
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0017 0.0039
Onchocerca volvulus 0.0263 0.3205 0.7549
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Mycobacterium tuberculosis Conserved protein 0.0038 0.0352 0.0674
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1214 0.2739
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1945 0.5981
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.018 0.2148 0.5061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.018 0.2148 0.5059
Brugia malayi hypothetical protein 0.018 0.2148 0.5061
Brugia malayi larval opioid receptor 0.018 0.2148 0.5061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0002
Brugia malayi beta-lactamase family protein 0.0038 0.0352 0.0829
Onchocerca volvulus 0.018 0.2148 0.5058
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.018 0.2148 0.2755
Loa Loa (eye worm) glutathione reductase 0.0047 0.0457 0.1074
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0191 0.019

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) = 0.0000071 M Inhibitory activity against human acute promyelocytic leukemia cells(HL-60) cell growth on 72 hr of exposure of the compound. ChEMBL. 2738893
ID50 (functional) = 0.0000071 M Inhibitory activity against human acute promyelocytic leukemia cells(HL-60) cell growth on 72 hr of exposure of the compound. ChEMBL. 2738893
ID50 (functional) = 0.0000088 M Inhibitory activity against murine L1210 leukemic cell growth ChEMBL. 2738893
ID50 (functional) = 0.0000088 M Inhibitory activity against murine L1210 leukemic cell growth ChEMBL. 2738893
ID50 (functional) = 0.000012 M Inhibitory activity against [3H]-TdR incorporation into DNA in HL-60 cells during the initial 30-min period . ChEMBL. 2738893
Ratio (functional) = 1.7 Ratio for human acute promyelocytic leukemia cells(HL-60) cell growth inhibition and [3H]-TdR incorporation into DNA in HL-60 cells ChEMBL. 2738893

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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