Detailed information for compound 579705

Basic information

Technical information
  • TDR Targets ID: 579705
  • Name: sodium 2-[[(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,1 4S,17R)-3,12-dihydroxy-10,13-dimethyl-spiro[1 ,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahyd rocyclopenta[a]phenanthrene-7,3'-diazirine]-1 7-yl]pentanoyl]amino]ethanesulfonate
  • MW: 548.691 | Formula: C26H43N3NaO6S
  • H donors: 3 H acceptors: 6 LogP: 2.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]1CC[C@]2([C@@H](C1)CC1([C@@H]3[C@@H]2C[C@H](O)[C@]2([C@H]3CC[C@@H]2[C@@H](CCC(=O)NCCS(=O)(=O)[O-])C)C)N=N1)C.[NaH+]
  • InChi: 1S/C26H43N3O6S.Na/c1-15(4-7-22(32)27-10-11-36(33,34)35)18-5-6-19-23-20(13-21(31)25(18,19)3)24(2)9-8-17(30)12-16(24)14-26(23)28-29-26;/h15-21,23,30-31H,4-14H2,1-3H3,(H,27,32)(H,33,34,35);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21+,23+,24+,25-;/m1./s1
  • InChiKey: SBGNLQGGOAWPRY-ITLHHNROSA-M  


Substructure search Similarity search

Network

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Synonyms

  • sodium 2-[[(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-17-spiro[1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-7,3'-diazirine]yl]-1-oxopentyl]amino]ethanesulfonate
  • sodium 2-[[(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-spiro[1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-7,3'-1,2-diazirine]-17-yl]pentanoyl]amino]ethanesulfonate
  • sodium 2-[[(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylspiro[1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-7,3'-diazirine]-17-yl]pentanoyl]amino]ethanesulfonate
  • (7,7-azo-3,12-dihydroxy-5-cholan-24-oyl)-2-aminoethanesulfonic acid
  • 72741-86-7
  • 7,7-Azo-TC
  • 7-Adtc
  • Ethanesulfonic acid, 2-(((3alpha,5beta,12alpha)-7-azi-3,12-dihydroxy-24-oxocholan-24-yl)amino)-, monosodium salt

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0026 0.0274 0.0755
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0434 0.1116
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0434 0.081
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0482 0.0968
Brugia malayi hypothetical protein 0.0016 0.0034 0.0034
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.2493 0.6632
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0434 0.1116
Mycobacterium tuberculosis Conserved protein 0.0035 0.0482 0.0968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0053 0.0875 0.1789
Toxoplasma gondii ABC1 family protein 0.0035 0.0482 0.166
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.2493 0.2468
Mycobacterium ulcerans polyketide synthase 0.0053 0.0875 0.2573
Brugia malayi nuclear hormone receptor 0.0033 0.0434 0.0434
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0082 0.0098
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0081 0.0097
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0077 0.0077
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.0482
Loa Loa (eye worm) fatty acid synthase 0.0049 0.079 0.079
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.016 0.0121
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.1425 0.2057
Echinococcus granulosus lamin dm0 0.0027 0.028 0.0246
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.1322 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Mycobacterium leprae Probable polyketide synthase Pks1 0.0053 0.0875 0.6337
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0015 0.0024 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0839 0.1712
Brugia malayi conserved hypotetical protein 0.0016 0.0034 0.0034
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0081 0.0097
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.2493 0.2468
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.005 0.0805 0.2362
Onchocerca volvulus 0.0027 0.028 0.0498
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0077 0.0043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0077
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0081 0.0097
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0034 0.0045
Mycobacterium ulcerans hypothetical protein 0.0161 0.3332 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0482 0.0968
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0434 0.0434
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0434 0.0401
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.016 0.0298
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0344 0.0311
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0482 0.0968
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0906 0.5
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0026 0.0274 0.0755
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0344 0.0876
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0034 0.0034
Mycobacterium ulcerans polyketide synthase 0.005 0.0805 0.2362
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0653 0.0875
Brugia malayi hypothetical protein 0.0016 0.0034 0.0034
Mycobacterium ulcerans fatty acid synthase Fas 0.0016 0.0032 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0434 0.0434
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0028 0.0319 0.0628
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0482 0.0449
Echinococcus multilocularis muscleblind protein 1 0.0454 1 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0053 0.0875 0.1789
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0434 0.0434
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0434 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0232 0.0434
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.016 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Echinococcus multilocularis geminin 0.0179 0.3751 0.3729
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0026 0.0274 0.0755
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0033 0.0423 0.2941
Brugia malayi hypothetical protein 0.0018 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.0482
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0434 0.0401
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.2961 0.4461
Brugia malayi Methyltransferase-like protein 4 0.0015 0.0017 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0081 0.0081
Schistosoma mansoni nuclear receptor 0.0016 0.0034 0.0045
Mycobacterium ulcerans hypothetical protein 0.0035 0.0482 0.1383
Onchocerca volvulus 0.0072 0.1322 0.2609
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.0482
Trichomonas vaginalis set domain proteins, putative 0.0233 0.4969 1
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0017 0.0065 0.01
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.2493 0.6632
Brugia malayi Pre-SET motif family protein 0.0205 0.4326 0.4326
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0026 0.0274 0.182
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0026 0.0274 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Onchocerca volvulus 0.0035 0.0482 0.0907
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0482 0.0968
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0653 0.0875
Echinococcus granulosus FTZ F1 alpha 0.0411 0.9025 0.9021
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0434 0.081
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.1322 0.1977
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0482 0.0938
Onchocerca volvulus Fatty acid synthase homolog 0.0089 0.1711 0.3398
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.1322 0.9159
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0053 0.0875 0.1789
Toxoplasma gondii type I fatty acid synthase, putative 0.0056 0.0943 0.3571
Loa Loa (eye worm) hypothetical protein 0.0026 0.0269 0.0269
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0081 0.0097
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0034 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0344 0.0876
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0082 0.0001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0434 0.1116
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0482 0.0613
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0077
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.004 0.0585 0.1695
Mycobacterium ulcerans Type I modular polyketide synthase 0.005 0.0805 0.2362
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.2493 0.516
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.2493 0.7464
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0033 0.0423 0.1206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0053 0.0875 0.2573
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0434 0.0401
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.1322 0.3922
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.016 0.0327
Onchocerca volvulus 0.0021 0.016 0.0255
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0032 0.0409 0.1359
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.005 0.0805 0.0805
Onchocerca volvulus 0.003 0.036 0.0661
Loa Loa (eye worm) hypothetical protein 0.0072 0.1322 0.1322
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.1322 0.9159
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.1425 0.2057
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0434 0.0434
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.2493 1
Echinococcus multilocularis lamin 0.0027 0.028 0.0246
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.016 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0839 0.1712
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.005 0.0805 0.1643
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0461 0.0429
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0344 0.0311
Brugia malayi beta-lactamase 0.0035 0.0482 0.0482
Mycobacterium ulcerans lipase LipD 0.0035 0.0482 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0482 0.0482
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0081 0.0047
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0034 0.0034
Brugia malayi hypothetical protein 0.0018 0.0077 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0068 0.1214 0.1214
Brugia malayi nuclear hormone receptor 0.0016 0.0034 0.0034
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0154 0.0112
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0482 0.0482
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0482 0.0938
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0034 0.0034
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0074 0.1363 0.2805
Echinococcus granulosus muscleblind protein 0.0454 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0482 0.1244
Mycobacterium ulcerans Type I modular polyketide synthase 0.005 0.0805 0.2362
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0034 0.0034
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0232 0.0626
Brugia malayi AMP-binding enzyme family protein 0.0072 0.1322 0.1322
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0434 0.0434
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0434 0.1116
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0068 0.1214 0.1214
Mycobacterium leprae Polyketide synthase Pks13 0.0074 0.1363 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.171 0.1681
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.016 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0454 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0434 0.0401
Echinococcus granulosus lamin 0.0027 0.028 0.0246
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.016 0.0289
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.1322 0.3922
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0434
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0232 0.0199
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.016 0.0411
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.2493 0.3752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Mycobacterium ulcerans Type I modular polyketide synthase 0.005 0.0805 0.2362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Onchocerca volvulus 0.0029 0.0344 0.0628
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.171 0.1681
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0026 0.0274 0.0535
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0077
Mycobacterium tuberculosis Conserved protein 0.0035 0.0482 0.0968
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.016 0.0582
Mycobacterium ulcerans thioesterase 0.0041 0.0617 0.1793
Brugia malayi AMP-binding enzyme family protein 0.0072 0.1322 0.1322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0344 0.0876
Schistosoma mansoni hypothetical protein 0.0035 0.0461 0.119
Brugia malayi nuclear receptor NHR-88 0.0016 0.0034 0.0034
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.002 0.0133 0.0242
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0434 0.1116
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.1425 1
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0232 0.0199
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.0482
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0034 0.0045
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0113 0.2236 0.221
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0653 0.0875
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0434 0.1116
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.028 0.028
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0068 0.1214 0.2494
Onchocerca volvulus 0.0033 0.0434 0.081
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0091 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.2493 0.7464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0482 0.1383
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0906 0.2665
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.1322 0.3922
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0232 0.0232
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0434 0.1116
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0461 0.0429
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0081 0.0081
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0034 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0434 0.0434
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0034 0.0034
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.1425 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0077 0.016
Schistosoma mansoni nuclear receptor 0.0016 0.0034 0.0045
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.6616 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.3332 0.6909
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0081 0.0047
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.016 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0434 0.0434
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.004 0.0585 0.4155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.171 0.1681
Brugia malayi Pre-SET motif family protein 0.0029 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0021 0.016 0.016
Mycobacterium ulcerans thioesterase TesA 0.0041 0.0617 0.1793
Brugia malayi tailless protein 0.0016 0.0034 0.0034
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.016 0.0126
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0434 0.1116
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.4326 0.4326
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0906 0.5894
Onchocerca volvulus 0.0035 0.0482 0.0907
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0048 0.0771 0.1571
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0434
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0482 0.0613
Brugia malayi nuclear receptor RXR 0.0018 0.0077 0.0077
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0077 0.016
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0434 0.0434
Giardia lamblia GTOR 0.0018 0.0081 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1322 0.1322
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.016 0.0298
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0482 0.1383
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.016 0.0964
Schistosoma mansoni retinoic acid receptor RXR 0.013 0.2636 0.7014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0434 0.0434
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.171 0.1681
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0434 0.0401
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.016 0.0411
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.171 0.4533
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0866 0.1201
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.016 0.016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0434 0.0401
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.1322 0.3922
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0434 0.1116
Brugia malayi AMP-binding enzyme family protein 0.0021 0.016 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Schistosoma mansoni zinc finger protein 0.0016 0.0034 0.0045
Leishmania major hypothetical protein, conserved 0.0035 0.0482 0.0704
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.1435 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0434 0.0434
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0077 0.0077
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0482 0.0968
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.6616 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.1322 0.2718
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.016 0.0411
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.1322 0.3922
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0026 0.0274 0.0535
Loa Loa (eye worm) hypothetical protein 0.0072 0.1322 0.1322
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0054 0.0906 0.0906
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.032 0.0287
Echinococcus granulosus intermediate filament protein 0.0027 0.028 0.0246
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.016 0.0411
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.016 0.0411
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0026 0.0274 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0434 0.0434
Brugia malayi AMP-binding enzyme family protein 0.0021 0.016 0.016
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.016 0.0298
Mycobacterium leprae Probable lipase LipE 0.0035 0.0482 0.3379
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.004 0.0585 0.1695
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0053 0.0875 0.2573
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.016 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0434 0.0434
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.005 0.0805 0.1643
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0048 0.0771 0.1571
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0034 0.0034
Brugia malayi ecdysteroid receptor 0.0033 0.0434 0.0434
Brugia malayi hypothetical protein 0.0077 0.1425 0.1425
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0274 0.0755
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0434
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0482 0.0449
Brugia malayi MH2 domain containing protein 0.0117 0.2344 0.2344
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0482 0.2541
Brugia malayi nuclear receptor NHR-88 0.0033 0.0434 0.0434
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0026 0.0274 0.0535
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0434 0.0434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.171 0.4533
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0839 0.1712
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.016 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0053 0.0875 0.6337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.005 0.0805 0.581
Schistosoma mansoni lamin 0.0027 0.028 0.0703
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.016 0.0121
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.016 0.0411
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0434
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2344 0.2344
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0081 0.0172
Echinococcus granulosus retinoic acid receptor rxr beta a 0.013 0.2636 0.2611
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0482 0.0968
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0232 0.0576
Mycobacterium ulcerans polyketide synthase Pks9 0.0033 0.0423 0.1206
Loa Loa (eye worm) hypothetical protein 0.0054 0.0906 0.0906
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.016 0.0411
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0036 0.0488 0.0981
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.016 0.0411
Brugia malayi intermediate filament protein 0.0027 0.028 0.028
Schistosoma mansoni coup transcription factor 0.0033 0.0434 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.1322 0.2718
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.016 0.0964
Loa Loa (eye worm) hypothetical protein 0.0077 0.1425 0.1425
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0434 0.0401
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.016 0.0298
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0434 0.0401
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Brugia malayi beta-lactamase family protein 0.0035 0.0482 0.0482
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0434 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0434 0.0434
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.016 0.0126
Toxoplasma gondii type I fatty acid synthase, putative 0.0035 0.048 0.1654
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0482 0.0968
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.2493 0.7464
Onchocerca volvulus 0.0233 0.4969 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0482 0.0938
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0482 0.0938
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0094 0.1815 0.1815
Schistosoma mansoni hypothetical protein 0.0179 0.3751 1
Echinococcus multilocularis muscleblind protein 0.0454 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0434
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.016 0.0411
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.028 0.028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0434 0.0401
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0081 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.1425 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0077
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0034 0.0045
Brugia malayi hypothetical protein 0.005 0.0806 0.0806
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0041 0.0617 0.4398
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0081 0.0047
Onchocerca volvulus 0.0108 0.2124 0.4234
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0344 0.0876
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0344 0.0311
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0482 0.0613
Echinococcus granulosus geminin 0.0179 0.3751 0.3729
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.016 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Leishmania major hypothetical protein, conserved 0.0077 0.1425 0.2134
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0906 0.1852
Schistosoma mansoni intermediate filament proteins 0.0027 0.028 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0434 0.0434
Loa Loa (eye worm) beta-lactamase 0.0035 0.0482 0.0482
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.1322 0.9687
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.1322 0.1977
Loa Loa (eye worm) hypothetical protein 0.0054 0.0906 0.0906
Toxoplasma gondii propionate-CoA ligase 0.0021 0.016 0.0327
Brugia malayi AMP-binding enzyme family protein 0.0021 0.016 0.016
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0434 0.0401
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.171 0.171
Mycobacterium ulcerans polyketide synthase Pks13 0.0074 0.1363 0.4048
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0434 0.1116
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0077 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0434 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0434 0.0434
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0093 0.0158
Brugia malayi steroid hormone receptor 0.0033 0.0434 0.0434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.171 0.4533
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.6616 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.016 0.0217
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.6616 1
Onchocerca volvulus 0.0068 0.1214 0.2391
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0232 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0482 0.0482
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0482 0.1244
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0482 0.3379
Brugia malayi nuclear receptor NHR-67 0.0016 0.0034 0.0034
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0016 0.0032 0.003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0026 0.0274 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0077 0.0077
Schistosoma mansoni lamin 0.0027 0.028 0.0703
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0482 0.0968
Loa Loa (eye worm) hypothetical protein 0.0028 0.0309 0.0309
Plasmodium vivax SET domain protein, putative 0.0029 0.0344 0.1455
Brugia malayi beta-lactamase family protein 0.0035 0.0482 0.0482
Mycobacterium tuberculosis Probable thioesterase TesA 0.0041 0.0617 0.1251
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.005 0.0805 0.581
Loa Loa (eye worm) oxidoreductase 0.0021 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0054 0.0906 0.0906
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0434 0.0434
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0653 0.0875
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0434 0.0401
Loa Loa (eye worm) hypothetical protein 0.0054 0.0906 0.0906
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0232 0.0231
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0053 0.0875 0.6337
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0434 0.0401
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0081 0.0172
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0344 0.109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.016 0.0298
Mycobacterium ulcerans hypothetical protein 0.0072 0.1322 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.005 0.0805 0.1643
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0081 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0072 0.1322 0.1322
Loa Loa (eye worm) hypothetical protein 0.0029 0.0344 0.0344
Brugia malayi ecdysone receptor 0.0016 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0086 0.1639 0.1639
Mycobacterium ulcerans beta-lactamase 0.0035 0.0482 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.1425 0.5573
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0034 0.0045
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.016 0.0217
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0034 0.0034
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.016 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Loa Loa (eye worm) hypothetical protein 0.0454 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0434 0.0401
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.1425 0.2057
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0034 0.0045
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.1322 0.9687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0434 0.0434
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0074 0.1363 0.2805
Loa Loa (eye worm) hypothetical protein 0.0021 0.0154 0.0154
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.171 0.171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0041 0.06 0.1214
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0434
Onchocerca volvulus 0.0035 0.0482 0.0907
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0434 0.081
Schistosoma mansoni hypothetical protein 0.0179 0.3751 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.016 0.016
Echinococcus multilocularis musashi 0.0027 0.028 0.0246
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.1322 0.1977
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.016 0.0327
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.016 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.016 0.0411
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0434
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.016 0.0411
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.2961 0.4407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0434 0.0434
Loa Loa (eye worm) acyl carrier protein 0.0023 0.0196 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Trichomonas vaginalis esterase, putative 0.0035 0.0482 0.0938
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0434 0.0401
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0434 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0434 0.0434
Echinococcus multilocularis lamin dm0 0.0027 0.028 0.0246
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0315 0.0967
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0839 0.1712
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.2961 0.4407
Brugia malayi nuclear receptor RXR 0.0016 0.0034 0.0034
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0906 0.5894
Toxoplasma gondii hypothetical protein 0.0049 0.0796 0.2965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0081 0.013
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.4816 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0482 0.0938
Loa Loa (eye worm) DR-78 0.0016 0.0034 0.0034
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2344 0.2344
Entamoeba histolytica hypothetical protein 0.0024 0.0232 0.1114
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.1322 0.3922
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0081 0.0047
Onchocerca volvulus 0.0027 0.028 0.0498
Loa Loa (eye worm) intermediate filament protein 0.0027 0.028 0.028

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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