Detailed information for compound 579800

Basic information

Technical information
  • TDR Targets ID: 579800
  • Name: cyclopenta-1,3-diene; 1-cyclopenta-2,4-dien-1 -yl-2-hydroxy-ethanone; ruthenium
  • MW: 289.292 | Formula: C12H12O2Ru--
  • H donors: 1 H acceptors: 2 LogP: 2.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [CH-]1C=CC=C1.OCC(=O)[C-]1C=CC=C1.[Ru]
  • InChi: 1S/C7H7O2.C5H5.Ru/c8-5-7(9)6-3-1-2-4-6;1-2-4-5-3-1;/h1-4,8H,5H2;1-5H;/q2*-1;
  • InChiKey: LSBWGDUMGJFJLK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • cyclopenta-1,3-diene; 1-(1-cyclopenta-2,4-dienyl)-2-hydroxyethanone; ruthenium
  • cyclopenta-1,3-diene; 1-cyclopenta-2,4-dien-1-yl-2-hydroxyethanone; ruthenium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0036 0.0234 0.0401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0036 0.0036
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0234 0.0267
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.2504 0.4054
Plasmodium falciparum serine repeat antigen 9 0.0036 0.0234 0.0401
Giardia lamblia Cathepsin L precursor 0.0036 0.0234 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0257 0.0257
Plasmodium vivax SET domain protein, putative 0.003 0.0036 0.0062
Toxoplasma gondii cathepsin CPL 0.0193 0.5834 1
Toxoplasma gondii cathepsin B 0.0036 0.0234 0.0401
Echinococcus granulosus cathepsin b 0.0036 0.0234 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0193 0.5834 0.5834
Giardia lamblia Cysteine protease 0.0036 0.0234 0.5
Giardia lamblia Cathepsin B precursor 0.0036 0.0234 0.5
Brugia malayi Cathepsin L-like precursor 0.0193 0.5834 0.6656
Schistosoma mansoni cathepsin F (C01 family) 0.0129 0.3564 0.3564
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0036 0.0234 0.5
Plasmodium vivax vivapain-2 0.0193 0.5834 1
Echinococcus granulosus cathepsin L cysteine protease 0.0099 0.2504 0.2504
Loa Loa (eye worm) hypothetical protein 0.0036 0.0234 0.0234
Brugia malayi follicle stimulating hormone receptor 0.0233 0.7268 0.8293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0234 0.0234
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 1 1
Onchocerca volvulus 0.0193 0.5834 0.7813
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0257 0.0041
Loa Loa (eye worm) fibroinase 0.0193 0.5834 0.5834
Plasmodium vivax serine-repeat antigen (SERA) 0.0036 0.0234 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Giardia lamblia Cathepsin B precursor 0.0036 0.0234 0.5
Onchocerca volvulus 0.0036 0.0234 0.0266
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.2504 0.4054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0606 0.0606
Entamoeba histolytica cysteine proteinase, putative 0.0193 0.5834 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.5834 0.6564
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0036 0.0234 0.0401
Schistosoma mansoni hypothetical protein 0.0171 0.504 0.504
Leishmania major cathepsin L-like protease 0.0193 0.5834 1
Plasmodium falciparum serine repeat antigen 8 0.0036 0.0234 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Onchocerca volvulus 0.0036 0.0257 0.0297
Brugia malayi cathepsin L-like precursor 0.0129 0.3564 0.4066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0257 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0036 0.0234 0.0234
Trypanosoma cruzi cysteine peptidase, putative 0.0099 0.2504 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0064 0.1237 0.1411
Schistosoma mansoni cathepsin F (C01 family) 0.0193 0.5834 0.5834
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0193 0.5834 0.6564
Giardia lamblia Cathepsin B precursor 0.0036 0.0234 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.3564 0.3564
Brugia malayi beta-lactamase family protein 0.0036 0.0257 0.0293
Brugia malayi cathepsin B-like cysteine proteinase 0.0036 0.0234 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Trichomonas vaginalis set domain proteins, putative 0.0239 0.7457 0.8467
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.5834 0.6564
Trichomonas vaginalis esterase, putative 0.0036 0.0257 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.5834 0.6564
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.5834 1
Onchocerca volvulus Cathepsin L homolog 0.0193 0.5834 0.7813
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0036 0.0234 0.0401
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0036 0.0234 0.0401
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0036 0.0234 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0606 0.0691
Echinococcus granulosus cathepsin L 0.0036 0.0234 0.0234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0606 0.0606
Giardia lamblia Cathepsin B precursor 0.0036 0.0234 0.5
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Brugia malayi Pre-SET motif family protein 0.003 0.0036 0.0042
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Brugia malayi glutaminase DH11.1 0.0275 0.8765 1
Onchocerca volvulus 0.0193 0.5834 0.7813
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0036 0.0234 0.0234
Leishmania major hypothetical protein, conserved 0.0036 0.0257 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0099 0.2504 0.2857
Loa Loa (eye worm) hypothetical protein 0.0036 0.0234 0.0234
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0234 0.0266
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0099 0.2504 0.2504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.7268 0.7268
Loa Loa (eye worm) cysteine protease 0.0193 0.5834 0.5834
Mycobacterium ulcerans glutaminase 0.0275 0.8765 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0257 0.0027
Giardia lamblia Cysteine protease 0.0036 0.0234 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Onchocerca volvulus 0.0193 0.5834 0.7813
Leishmania major cathepsin L-like protease 0.0193 0.5834 1
Giardia lamblia Cathepsin L precursor 0.0036 0.0234 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0234 0.0234
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Trypanosoma cruzi cysteine proteinase, putative 0.0099 0.2504 0.4054
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0036 0.0234 0.0401
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.6426 0.6426
Giardia lamblia Cathepsin B precursor 0.0036 0.0234 0.5
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0036 0.0234 0.5
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.5834 0.6564
Echinococcus multilocularis cathepsin L 0.0036 0.0234 0.0234
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0036 0.0234 0.0401
Leishmania major cysteine peptidase A (CPA) 0.0193 0.5834 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0193 0.5834 0.5834
Onchocerca volvulus 0.0036 0.0257 0.0297
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0257 0.0257
Brugia malayi beta-lactamase family protein 0.0036 0.0257 0.0293
Brugia malayi Cathepsin L-like precursor 0.0193 0.5834 0.6656
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0257 0.0027
Echinococcus multilocularis cathepsin b 0.0036 0.0234 0.0234
Echinococcus multilocularis cysteine protease 0.0193 0.5834 0.5834
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0257 0.0441
Brugia malayi cathepsin L precursor 0.0036 0.0234 0.0267
Plasmodium falciparum serine repeat antigen 6 0.0036 0.0234 0.0401
Plasmodium vivax unspecified product 0.0099 0.2504 0.4292
Brugia malayi cathepsin Z-like cysteine proteinase 0.0036 0.0234 0.0267
Giardia lamblia Cathepsin B precursor 0.0036 0.0234 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Plasmodium vivax unspecified product 0.0064 0.1237 0.212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.2504 0.2661
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0234 0.0234
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0036 0.0234 0.0401
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0234 0.0234
Brugia malayi Cathepsin L-like precursor 0.0129 0.3564 0.4066
Brugia malayi Cathepsin L-like precursor 0.0193 0.5834 0.6656
Toxoplasma gondii cathepsin CPC2 0.0036 0.0234 0.0401
Onchocerca volvulus 0.0129 0.3564 0.4753
Toxoplasma gondii ABC1 family protein 0.0036 0.0257 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Echinococcus granulosus geminin 0.0171 0.504 0.504
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0036 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0036 0.0036
Giardia lamblia Cathepsin L-like protease 0.0036 0.0234 0.5
Leishmania major cathepsin L-like protease 0.0193 0.5834 1
Schistosoma mansoni cathepsin S (C01 family) 0.0036 0.0234 0.0234
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.5834 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0036 0.0036
Giardia lamblia Hypothetical protein 0.0036 0.0234 0.5
Mycobacterium leprae Probable lipase LipE 0.0036 0.0257 0.5
Brugia malayi Cathepsin L-like precursor 0.0193 0.5834 0.6656
Trypanosoma cruzi cysteine protease, putative 0.0099 0.2504 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0234 0.0234
Echinococcus granulosus cathepsin L 0.0099 0.2504 0.2504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Loa Loa (eye worm) hypothetical protein 0.0036 0.0234 0.0234
Toxoplasma gondii cathepsin CPC1 0.0036 0.0234 0.0401
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0234 0.0234
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.2504 0.4054
Loa Loa (eye worm) hypothetical protein 0.0129 0.3564 0.3564
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0257 0.0257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.5834 0.6564
Loa Loa (eye worm) cathepsin B 0.0036 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0036 0.0234 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.3564 0.3903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Plasmodium falciparum serine repeat antigen 4 0.0036 0.0234 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.2504 0.4292
Brugia malayi Cathepsin L-like precursor 0.0193 0.5834 0.6656
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0234 0.0267
Loa Loa (eye worm) hypothetical protein 0.0036 0.0234 0.0234
Echinococcus granulosus cathepsin l1 0.0193 0.5834 0.5834
Trichomonas vaginalis glutaminase, putative 0.0275 0.8765 1
Trypanosoma cruzi cruzipain precursor, putative 0.0193 0.5834 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0606 0.0606
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0036 0.0234 0.0401
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0036 0.0062
Leishmania major cathepsin L-like protease 0.0193 0.5834 1
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0036 0.0234 0.0234
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0036 0.0036
Giardia lamblia Hypothetical protein 0.0036 0.0234 0.5
Plasmodium vivax vivapain-3 0.0099 0.2504 0.4292
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.5834 0.6564
Echinococcus granulosus cathepsin l cysteine peptidase 0.0193 0.5834 0.5834
Brugia malayi cathepsin L-like cysteine proteinase 0.0036 0.0234 0.0267
Loa Loa (eye worm) glutaminase 2 0.0275 0.8765 0.8765
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.5834 0.6564
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0099 0.2504 0.2504
Loa Loa (eye worm) hypothetical protein 0.0036 0.0234 0.0234
Brugia malayi beta-lactamase 0.0036 0.0257 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0036 0.0234 0.0234
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0099 0.2504 0.2661
Brugia malayi Pre-SET motif family protein 0.021 0.6426 0.7332
Onchocerca volvulus Cathepsin L homolog 0.0193 0.5834 0.7813
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0606 0.0606
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0036 0.0234 0.0401
Giardia lamblia Cathepsin B precursor 0.0036 0.0234 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0099 0.2504 0.2857
Loa Loa (eye worm) hypothetical protein 0.0064 0.1237 0.1237
Echinococcus granulosus cathepsin L cysteine proteinase 0.0193 0.5834 0.5834
Echinococcus granulosus cathepsin b 0.0036 0.0234 0.0234
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0064 0.1237 0.1411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Echinococcus multilocularis cathepsin L 0.0099 0.2504 0.2504
Leishmania major cathepsin L-like protease 0.0193 0.5834 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0036 0.0036
Entamoeba histolytica cysteine proteinase 1, putative 0.0099 0.2504 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0234 0.0267
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0257 0.0027
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0036 0.0234 0.0401
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.5834 0.6564
Loa Loa (eye worm) hypothetical protein 0.0036 0.0257 0.0257
Echinococcus multilocularis cathepsin L cysteine protease 0.0193 0.5834 0.5834
Giardia lamblia Cathepsin L-like protease 0.0036 0.0234 0.5
Onchocerca volvulus 0.0193 0.5834 0.7813
Leishmania major cathepsin L-like protease 0.0193 0.5834 1
Schistosoma mansoni cathepsin B (C01 family) 0.0036 0.0234 0.0234
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0257 0.5
Schistosoma mansoni glutaminase 0.0275 0.8765 0.8765
Loa Loa (eye worm) beta-lactamase 0.0036 0.0257 0.0257
Leishmania major cathepsin L-like protease 0.0193 0.5834 1
Plasmodium falciparum serine repeat antigen 3 0.0036 0.0234 0.0401
Entamoeba histolytica cysteine protease, putative 0.0193 0.5834 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0193 0.5834 0.6564
Plasmodium falciparum serine repeat antigen 7 0.0036 0.0234 0.0401
Plasmodium falciparum cysteine proteinase falcipain 3 0.0193 0.5834 1
Plasmodium falciparum serine repeat antigen 2 0.0036 0.0234 0.0401
Brugia malayi Papain family cysteine protease containing protein 0.0193 0.5834 0.6656
Brugia malayi Cathepsin L-like cysteine proteinase 0.0129 0.3564 0.4066
Toxoplasma gondii preprocathepsin c precursor, putative 0.0036 0.0234 0.0401
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0036 0.0234 0.0234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.5834 0.6564
Giardia lamblia Cathepsin B precursor 0.0036 0.0234 0.5
Leishmania major cathepsin L-like protease 0.0193 0.5834 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0036 0.0234 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0129 0.3564 0.5946
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0234 0.0267
Brugia malayi Cathepsin L-like precursor 0.0129 0.3564 0.4066
Entamoeba histolytica cysteine proteinase 2 0.0099 0.2504 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Giardia lamblia Encystation-specific protease 0.0036 0.0234 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0257 0.0293
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0193 0.5834 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0129 0.3564 0.3564
Brugia malayi Cathepsin L-like precursor 0.0193 0.5834 0.6656
Loa Loa (eye worm) ctsf protein 0.0193 0.5834 0.5834
Brugia malayi fibroinase precursor 0.0036 0.0234 0.0267
Onchocerca volvulus 0.0193 0.5834 0.7813
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0036 0.0036
Onchocerca volvulus Cathepsin F homolog 0.0193 0.5834 0.7813
Echinococcus multilocularis snurportin 1 0.031 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1237 0.1237
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0234 0.0234
Brugia malayi RNA, U transporter 1 0.0083 0.1906 0.2174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Loa Loa (eye worm) hypothetical protein 0.0064 0.1237 0.1237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0606 0.0606
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1237 0.1791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0099 0.2504 0.4292
Giardia lamblia Cysteine protease 0.0036 0.0234 0.5
Schistosoma mansoni cathepsin s 0.0064 0.1237 0.1237
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0036 0.0234 0.0234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0606 0.0606
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0234 0.0234
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.7211 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0257 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.5834 0.6564
Echinococcus multilocularis cathepsin b 0.0036 0.0234 0.0234
Plasmodium vivax vivapain-1 0.0099 0.2504 0.4292
Loa Loa (eye worm) glutaminase 0.0275 0.8765 0.8765
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.5834 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0257 0.0257
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0099 0.2504 0.2504
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0193 0.5834 0.5834
Onchocerca volvulus 0.0239 0.7457 1
Echinococcus multilocularis cysteine protease 0.0193 0.5834 0.5834
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0257 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.5834 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0099 0.2504 0.4054
Plasmodium falciparum serine repeat antigen 5 0.0036 0.0234 0.0401
Trypanosoma cruzi cysteine proteinase, putative 0.0099 0.2504 0.4054
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0036 0.0234 0.0234
Echinococcus multilocularis geminin 0.0171 0.504 0.504
Onchocerca volvulus 0.0193 0.5834 0.7813
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0193 0.5834 1
Giardia lamblia Cathepsin L precursor 0.0036 0.0234 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0257 0.0257
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0036 0.0234 0.0401
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0036
Giardia lamblia Cathepsin L precursor 0.0036 0.0234 0.5
Plasmodium falciparum cysteine proteinase falcipain 1 0.0099 0.2504 0.4292
Schistosoma mansoni cathepsin F (C01 family) 0.0193 0.5834 0.5834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Entamoeba histolytica cysteine proteinase, putative 0.0129 0.3564 0.5946
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0193 0.5834 0.5834
Onchocerca volvulus 0.0036 0.0257 0.0297
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0036 0.0234 0.0401
Brugia malayi cathepsin Z-like cysteine proteinase 0.0036 0.0234 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.3564 0.3903
Schistosoma mansoni hypothetical protein 0.031 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0257 0.0027
Plasmodium vivax unspecified product 0.0036 0.0234 0.0401
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0036 0.0234 0.0234
Schistosoma mansoni cathepsin C 0.0036 0.0234 0.0234
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0257 0.0441
Plasmodium vivax vivapain-2 0.0193 0.5834 1
Giardia lamblia Cathepsin L precursor 0.0036 0.0234 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0099 0.2504 0.4054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0606 0.0606
Onchocerca volvulus 0.0193 0.5834 0.7813
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0036 0.0234 0.0401
Plasmodium vivax serine-repeat antigen (SERA) 0.0036 0.0234 0.0401
Giardia lamblia Cathepsin L precursor 0.0036 0.0234 0.5
Echinococcus granulosus cysteine protease 0.0099 0.2504 0.2504
Echinococcus granulosus cathepsin l1 0.0129 0.3564 0.3564
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.1237 0.1237
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0193 0.5834 0.5834
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0257 0.0041
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0234 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0257 0.0257
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0606 0.0606
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0193 0.5834 0.5834
Plasmodium falciparum serine repeat antigen 1 0.0036 0.0234 0.0401
Brugia malayi Cathepsin L-like precursor 0.0064 0.1237 0.1411
Entamoeba histolytica cysteine protease, putative 0.0099 0.2504 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.5834 1
Entamoeba histolytica cysteine proteinase, putative 0.0193 0.5834 1
Giardia lamblia Cysteine protease 0.0036 0.0234 0.5
Trypanosoma brucei cysteine peptidase C (CPC) 0.0036 0.0234 0.0401
Schistosoma mansoni hypothetical protein 0.0171 0.504 0.504
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0036 0.0234 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.1237 0.1791

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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