Detailed information for compound 579927

Basic information

Technical information
  • TDR Targets ID: 579927
  • Name: 2-[[4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl ]sulfinyl]ethanol
  • MW: 372.438 | Formula: C19H20N2O4S
  • H donors: 2 H acceptors: 3 LogP: 2.03 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCS(=O)c1nc(c([nH]1)c1ccc(cc1)OC)c1ccc(cc1)OC
  • InChi: 1S/C19H20N2O4S/c1-24-15-7-3-13(4-8-15)17-18(14-5-9-16(25-2)10-6-14)21-19(20-17)26(23)12-11-22/h3-10,22H,11-12H2,1-2H3,(H,20,21)
  • InChiKey: FBTNERVLZODKEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4,5-bis(4-methoxyphenyl)-2-(2-hydroxyethylsulfinyl)imidazole
  • 73181-83-6
  • BMHSI
  • Ethanol, 2-((4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl)sulfinyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.007 0.1202 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0905 0.1886
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.018 0.345 0.3362
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0768 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0206 0.0132
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0524 0.0397
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.1796 0.204
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.028 0.0186
Loa Loa (eye worm) hypothetical protein 0.0045 0.0697 0.1186
Loa Loa (eye worm) oxidoreductase 0.0026 0.0305 0.0345
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0524 0.0397
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0319 0.0189
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0029 0.0375 0.1816
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0374 0.0493
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.003 0.0392 0.1932
Brugia malayi Bromodomain containing protein 0.0078 0.1368 0.2851
Schistosoma mansoni bromodomain containing protein 0.0066 0.1125 0.1039
Entamoeba histolytica hypothetical protein 0.007 0.1202 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2151 0.431
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0403 0.0839
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0319 0.0146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1751 0.3452
Schistosoma mansoni hypothetical protein 0.0021 0.0206 0.0112
Echinococcus multilocularis cpg binding protein 0.0033 0.0448 0.032
Onchocerca volvulus 0.0047 0.0729 0.9157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0246 0.4799 1
Schistosoma mansoni cpg binding protein 0.0033 0.0448 0.0355
Echinococcus multilocularis GPCR, family 2 0.0031 0.0403 0.0274
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0091 0.1631 0.1827
Schistosoma mansoni survival motor neuron protein 0.0047 0.0729 0.0639
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0145 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0574 0.0923
Brugia malayi PHD-finger family protein 0.0027 0.0329 0.0686
Schistosoma mansoni cpg binding protein 0.0033 0.0448 0.0355
Schistosoma mansoni hypothetical protein 0.0501 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0403 0.0274
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.1796 0.204
Loa Loa (eye worm) hypothetical protein 0.0246 0.4799 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.3678 0.3593
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0026 0.0305 0.0176
Loa Loa (eye worm) hypothetical protein 0.0228 0.4438 0.9226
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.018 0.345 0.3362
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0382 0.7561 1
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0319 0.0018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0753 0.1307
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.1127 0.2349
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0382 0.7561 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0319 0.1451
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.1631 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1636 0.3205
Schistosoma mansoni hypothetical protein 0.0066 0.1127 0.1041
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.8263 0.824
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0905 0.0783
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0319 0.1451
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0768 0.0679
Brugia malayi mbt repeat family protein 0.0049 0.0768 0.16
Loa Loa (eye worm) hypothetical protein 0.0041 0.0623 0.1028
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0026 0.0305 0.0637
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0026 0.0305 0.0176
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0319 0.0018
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0099 0.1796 0.2055
Schistosoma mansoni hypothetical protein 0.0047 0.0729 0.0639
Schistosoma mansoni hypothetical protein 0.0295 0.5793 0.5753
Echinococcus granulosus dnaJ subfamily B 0.0416 0.8263 0.824
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0099 0.1796 0.204
Schistosoma mansoni hypothetical protein 0.0031 0.0403 0.031
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0091 0.1631 0.1519
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0099 0.1796 0.2055
Echinococcus granulosus flap endonuclease 1 0.0026 0.0319 0.0189
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0382 0.7561 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0059 0.0989 0.0942
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0956 0.0897
Loa Loa (eye worm) hypothetical protein 0.0072 0.1245 0.2365
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0905 0.0783
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0091 0.1631 0.3194
Schistosoma mansoni hypothetical protein 0.0031 0.0403 0.031
Schistosoma mansoni hypothetical protein 0.0031 0.0403 0.031
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0026 0.0305 0.1366
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0403 0.0274
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0403 0.0554
Brugia malayi MH2 domain containing protein 0.0116 0.2151 0.4482
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1636 0.1524
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0132 0.0037
Echinococcus granulosus tumor protein p63 0.0326 0.6437 0.6389
Echinococcus granulosus zinc finger protein 0.0022 0.0218 0.0087
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0026 0.0305 0.0637
Echinococcus multilocularis zinc finger protein 0.0022 0.0218 0.0087
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0026 0.0305 0.0345
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0768 0.0644
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0753 0.0664
Brugia malayi glucose-6-phosphate dehydrogenase 0.0091 0.1631 0.34
Entamoeba histolytica hypothetical protein 0.007 0.1202 1
Schistosoma mansoni hypothetical protein 0.0031 0.0403 0.031
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.028 0.015
Echinococcus multilocularis geminin 0.0501 1 1
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0026 0.0305 0.0212
Entamoeba histolytica hypothetical protein 0.007 0.1202 1
Schistosoma mansoni zinc finger protein 0.0022 0.0218 0.0124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0305 0.0345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1636 0.1555
Schistosoma mansoni hypothetical protein 0.007 0.1202 0.1117
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0768 0.0679
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1042 0.0955
Loa Loa (eye worm) hypothetical protein 0.0055 0.0905 0.1633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1636 0.1555
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.1202 0.1085
Brugia malayi mbt repeat family protein 0.0049 0.0768 0.16
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0905 0.0817
Trichomonas vaginalis hypothetical protein 0.0382 0.7561 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1636 0.1524
Schistosoma mansoni hypothetical protein 0.0416 0.8263 0.8246
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0026 0.0305 0.1366
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0403 0.0839
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0319 0.1451
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2151 0.431
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0768 0.0644
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0382 0.7561 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0091 0.1631 0.1827
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0145 0.005
Plasmodium falciparum flap endonuclease 1 0.0026 0.0319 0.0018
Onchocerca volvulus 0.0048 0.0753 0.9679
Schistosoma mansoni flap endonuclease-1 0.0024 0.0267 0.0173
Loa Loa (eye worm) hypothetical protein 0.0031 0.0403 0.0554
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.1051 0.0931
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0768 0.0644
Brugia malayi CXXC zinc finger family protein 0.0029 0.0374 0.078
Trypanosoma brucei pteridine reductase 1 0.0026 0.0305 0.1366
Brugia malayi Bromodomain containing protein 0.0039 0.0573 0.1194
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0319 0.0373
Loa Loa (eye worm) MBCTL1 0.0055 0.0905 0.1633
Schistosoma mansoni dihydropteridine reductase 0.0026 0.0305 0.0212
Schistosoma mansoni transcription factor LCR-F1 0.007 0.1202 0.1117
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.1051 0.0931
Echinococcus granulosus GPCR family 2 0.0031 0.0403 0.0274
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1751 0.365
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0026 0.0305 0.1366
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0099 0.1796 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0768 0.1339
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0905 0.0783
Onchocerca volvulus 0.0049 0.0768 1
Trypanosoma brucei oxidoreductase-like protein 0.0026 0.0305 0.1366
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1636 0.341
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.028 0.015
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.1631 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0091 0.1631 1
Brugia malayi hypothetical protein 0.0228 0.4438 0.9249
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0382 0.7561 1
Schistosoma mansoni hypothetical protein 0.0501 1 1
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0091 0.1631 0.1519
Brugia malayi Flap endonuclease-1 0.0026 0.0319 0.0664
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1636 0.1555
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0768 0.0644
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0026 0.0305 0.1366
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0132 0.0037
Leishmania major oxidoreductase-like protein 0.0026 0.0305 0.1366
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0091 0.1631 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.1202 0.1085
Leishmania major pteridine reductase 1 0.0026 0.0305 0.1366
Onchocerca volvulus 0.0029 0.0374 0.1485
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0382 0.7561 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0145 0.005
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0768 0.1339
Echinococcus multilocularis tumor protein p63 0.0326 0.6437 0.6389
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0026 0.0305 0.1366
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0059 0.0989 0.0942
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0768 0.0679
Loa Loa (eye worm) retinol dehydrogenase 12 0.0026 0.0305 0.0345
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.4438 0.4364
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.3678 0.3593
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0026 0.0305 0.1366
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1636 0.1524
Echinococcus granulosus cpg binding protein 0.0033 0.0448 0.032
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0091 0.1631 0.1551
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0729 0.1519
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.4438 0.4364
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0032 0.0421 0.0159
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0905 0.0783
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0026 0.0305 0.1366
Plasmodium falciparum enoyl-acyl carrier reductase 0.0382 0.7561 1
Schistosoma mansoni cpg binding protein 0.0029 0.0374 0.0281
Brugia malayi hypothetical protein 0.007 0.1202 0.2505
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0099 0.1796 0.2055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1636 0.1524
Loa Loa (eye worm) hypothetical protein 0.0066 0.1127 0.2111
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0382 0.7561 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0145 0.0013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.