Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldo-keto reductase | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.025 | 0.3098 | 0.3098 |
Trypanosoma brucei | prostaglandin f synthase | 0.025 | 0.3098 | 1 |
Schistosoma mansoni | pol-related | 0.025 | 0.3098 | 1 |
Giardia lamblia | Aldose reductase | 0.025 | 0.3098 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0073 | 0.0808 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.025 | 0.3098 | 1 |
Onchocerca volvulus | 0.025 | 0.3098 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.025 | 0.3098 | 0.5484 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0335 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0335 | 0.0335 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.025 | 0.3098 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0073 | 0.0808 | 0.2607 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0476 | 0.1537 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0229 | 0.2827 | 0.2827 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0073 | 0.0808 | 0.1711 |
Loa Loa (eye worm) | oxidoreductase | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.4093 | 0.4093 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Loa Loa (eye worm) | oxidoreductase | 0.025 | 0.3098 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0073 | 0.0808 | 0.2607 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0073 | 0.0808 | 0.1711 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.025 | 0.3098 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0073 | 0.0808 | 0.2607 |
Onchocerca volvulus | 0.0047 | 0.0476 | 0.1537 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.025 | 0.3098 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0449 | 0.5648 | 0.5648 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0476 | 0.1537 |
Entamoeba histolytica | aldose reductase, putative | 0.025 | 0.3098 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.025 | 0.3098 | 0.5484 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0632 | 0.1075 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0335 | 0.1082 |
Onchocerca volvulus | 0.025 | 0.3098 | 1 | |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0073 | 0.0808 | 0.1711 |
Echinococcus granulosus | aldo keto reductase | 0.025 | 0.3098 | 0.5484 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0073 | 0.0808 | 0.1711 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0073 | 0.0808 | 0.143 |
Giardia lamblia | Aldose reductase | 0.025 | 0.3098 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.025 | 0.3098 | 0.5484 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0632 | 0.1075 |
Trypanosoma cruzi | aldo-keto reductase | 0.025 | 0.3098 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0073 | 0.0808 | 0.2607 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0335 | 0.1082 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0073 | 0.0808 | 0.1711 |
Plasmodium vivax | aldehyde reductase, putative | 0.0073 | 0.0808 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.025 | 0.3098 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.0808 | 0.1711 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0178 | 0.2164 | 0.6678 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0073 | 0.0808 | 0.0808 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.025 | 0.3098 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0449 | 0.5648 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.025 | 0.3098 | 0.5484 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.4093 | 0.7247 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.025 | 0.3098 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.025 | 0.3098 | 0.5484 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0229 | 0.2827 | 0.5004 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0476 | 0.1537 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1739 | 0.5615 |
Echinococcus granulosus | hypothetical protein | 0.025 | 0.3098 | 0.5484 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0073 | 0.0808 | 0.1711 |
Echinococcus multilocularis | geminin | 0.0164 | 0.199 | 0.199 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.025 | 0.3098 | 0.5484 |
Echinococcus multilocularis | aldo keto reductase | 0.025 | 0.3098 | 0.3098 |
Loa Loa (eye worm) | oxidoreductase | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.025 | 0.3098 | 0.3098 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0073 | 0.0808 | 0.1711 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0335 | 0.0593 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0632 | 0.1119 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0073 | 0.0808 | 0.5 |
Brugia malayi | hypothetical protein | 0.0229 | 0.2827 | 0.9126 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0632 | 0.1075 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.025 | 0.3098 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.025 | 0.3098 | 0.5484 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0632 | 0.204 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0491 | 0.1586 |
Loa Loa (eye worm) | oxidoreductase | 0.025 | 0.3098 | 1 |
Onchocerca volvulus | 0.0048 | 0.0491 | 0.1586 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0073 | 0.0808 | 0.1711 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.0808 | 0.1711 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.025 | 0.3098 | 0.5484 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.025 | 0.3098 | 0.5484 |
Echinococcus granulosus | geminin | 0.0164 | 0.199 | 0.3523 |
Echinococcus granulosus | neuropeptide s receptor | 0.0449 | 0.5648 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Onchocerca volvulus | 0.025 | 0.3098 | 1 | |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.1739 | 0.1739 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0073 | 0.0808 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.025 | 0.3098 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0632 | 0.204 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.025 | 0.3098 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.025 | 0.3098 | 0.5484 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.025 | 0.3098 | 0.3098 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.1739 | 0.5615 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.025 | 0.3098 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.1739 | 0.3079 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.025 | 0.3098 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.025 | 0.3098 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.025 | 0.3098 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.025 | 0.3098 | 1 |
Toxoplasma gondii | aldo-keto reductase | 0.0073 | 0.0808 | 0.1711 |
Onchocerca volvulus | 0.025 | 0.3098 | 1 | |
Onchocerca volvulus | 0.025 | 0.3098 | 1 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0491 | 0.1586 |
Schistosoma mansoni | aldo-keto reductase | 0.025 | 0.3098 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0073 | 0.0808 | 0.1711 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0449 | 0.5648 | 0.5648 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.1739 | 0.1739 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0335 | 0.1082 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0632 | 0.1229 |
Onchocerca volvulus | 0.0073 | 0.0808 | 0.2607 | |
Echinococcus multilocularis | aldehyde reductase | 0.0178 | 0.2164 | 0.2164 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.025 | 0.3098 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0178 | 0.2164 | 0.3831 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0073 | 0.0808 | 0.1711 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.199 | 0.6424 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1739 | 0.5615 |
Echinococcus multilocularis | aldo keto reductase | 0.025 | 0.3098 | 0.3098 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0335 | 0.1082 |
Mycobacterium ulcerans | oxidoreductase | 0.025 | 0.3098 | 1 |
Mycobacterium leprae | Possible oxidoreductase | 0.0073 | 0.0808 | 0.1853 |
Mycobacterium tuberculosis | Conserved protein | 0.0073 | 0.0808 | 0.1853 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.025 | 0.3098 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0632 | 0.1075 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0073 | 0.0808 | 0.1711 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.025 | 0.3098 | 0.5484 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0073 | 0.0808 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.2827 | 0.9126 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0632 | 0.1075 |
Onchocerca volvulus | 0.025 | 0.3098 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.025 | 0.3098 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0632 | 0.0632 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.199 | 0.6424 |
Leishmania major | aldo-keto reductase-like protein | 0.025 | 0.3098 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.